2 results about "Normal aging" patented technology

The invention discloses an application of a substance taking Angpt18 as a target in preparation of a medicine for treating and delaying senescence, and the key regulation effect of an Angpt18 gene in the occurrence and progression process of normal senescence and senescence-related diseases is found for the first time through systematic and in-depth research; further experiments prove that by inhibiting or down-regulating the expression of the Angpt18 gene, the senescence process can be obviously delayed, and the expressions such as hypomnesia and behavioral ability decline in the senescence process can be effectively improved. Therefore, the Angpt18 gene can be used as an important intervention target for senescence and related diseases thereof, can be used for developing drugs with senescence delaying or treatment effects, can also be used as a biomarker for evaluating the senescence degree and diagnosing and prognosing the related diseases of senescence, and has wide application prospects and clinical transformation values.

This application discloses an intelligent monitoring method and system for the status of medical devices based on the Internet of Things (IoT), relating to the field of medical device monitoring. First, it utilizes information such as the device's service life and operating conditions to train a unique aging model for each device, predicting its normal performance parameters at the current stage of its life cycle. Then, by subtracting this predicted normal aging value from the real-time monitoring data, a clean residual signal is obtained. Subsequent anomaly detection will only target this residual signal; any significant fluctuations will likely point to an impending abnormal failure. This prediction-subtraction-detection model fundamentally solves the problem of aliasing between normal aging and abnormal deviations in data characteristics and adapts to the individual differences of devices, thereby accurately identifying true impending failures and significantly reducing the false alarm rate.