35 results about "Muscle dysfunction" patented technology

N,N-Disubstituted diazocycloalkanes of the formula I

An electro-stimulation device for the treatment of anterior and posterior pelvic floor muscle dysfunction is reversibly compressible and is fully self-contained. The device requires no external power sources or control and may be inserted into the vagina or anus through the use of an applicator. In the compressed state the device may be of tampon proportions and after use may easily be removed. The device utilizes a compressible electrode component.

The invention provides an interactive type pelvic floor muscle recovering device in the technical field of medical instruments. The interactive type pelvic floor muscle recovering device comprises a myoelectricity collecting module, a muscle force collecting module, a stimulation treating module, a power circuit module, a reset circuit module and a serial communication module. The interactive type pelvic floor muscle recovering device is designed with a C2000DSP chip as the core and used for guiding a patient to correctly contract pelvic floor muscles and for independently restraining abnormal contracting of the detrusor of the bladder. The interactive type pelvic floor muscle recovering device plays a very important role in improving quality of postpartum life of women and preventing and treating postpartum uracratia, pelvic cavity viscera prolapsus and the like, can not only effectively diagnose functional disorders of the pelvic floor muscle, but also conduct rehabilitation, and has the advantages of being portable, low in power consumption and capable of conducting two-way stimulation and the like.

The invention provides an interactive pelvic floor muscle rehabilitation device in the technical field of medical instruments. The rehabilitation device is composed of a power supply circuit module, a myoelectricity collection module, a stimulation circuit module, a reset module and a communication module. The interactive multi-channel medical instrument designed based on a DSP chip as a core is capable of collecting a myoelectricity signal and providing diagnosis information as well as stimulating pelvic floor muscles by currents with different intensities, frequencies, and waveforms to improve the nerve muscle function and promote conduction function rehabilitation, so that the pelvic floor nerves can work normally. Therefore, the rehabilitation device has important significance in improving the living quality of women after delivery and treating post partum urinary incontinence and pelvic organ prolapse; and the pelvic floor muscle dysfunction can be diagnosed effectively and rehabilitation can be realized.

The invention discloses an information data management method of a patient suffering from muscle dysfunction. The information data management method comprises the step of: connecting an ODBC (Open Database Connectivity) with an Access database through VC++ for management, wherein information data of the patient comprise basic information, myodynamia test data, myoelectricity test data, muscular tension test data and myodynamia training data of the patient, management contents comprise the procedures of storing, deleting, inquiring and backing up the information data of the patient; the myodynamia test data, the myoelectricity test data, the muscular tension test data and the myodynamia training data are obtained through a myodynamia testing device, a myoelectricity testing device and a training device and are directly stored into the Access database; the myodynamia test data, the muscular tension test data and the myodynamia training data are reflected on a myodynamia oscillogram; the myoelectricity testing data are reflected on a myoelectricity oscillogram; and the myodynamia oscillogram and the myoelectricity oscillogram are stored by the Access database in an OLE (Object linking and Embedding) manner and can be played back. According to the invention, the myodynamia test data, the myoelectricity test data, the muscular tension test data and the myodynamia training data are stored together, thus a doctor can be helped to make a better evaluation for the muscle function of the patient.

The present invention relates to a novel alkaloid and novel bioactive alkaloid fractions derivable from Ribes preferably selected among Ribes Rubrum and Ribes nigrum; methods of manufacturing such bioactive Ribes alkaloid fractions and their use for the inhibition of IKK-β, PDE4 and/or PDE5 and in addition their promoting effect on mitochondrial biogenesis and function; their therapeutic or non-therapeutic applications as nutritive or medicinal products in the management of conditions associated with impaired mitochondrial function or IKK-β, PDE4 and/or PDE5 activity, such as inflammation, neurodegeneration, dyslipidemia, type 2 diabetes mellitus, impaired wound healing, sarcopenia and other conditions associated with muscle dysfunction or tiredness and fatigue, or where optimization of muscular or cognitive function is desired; extracts, juices or concentrates of Ribes comprising such alkaloids; compostions comprising such alkaloids, including pharmaceutical compositions, nutritive product such as functional foods and nutraceutical compositions, and cosmetic compositions and medical devices.

Disclosed herein are compositions and methods for treatment of muscle dysfunction, including diabetes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the treatment of skeletal musle disorders. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with altered intracellular Ca2+ reulgation and disrupted membrane structure that occurs when the expression levels of MG29 are reduced.

This invention relates to novel heterocyclic compounds having selective affinity for the mGlu5 subtype of metabotropic receptors, pharmaceutical compositions thereof and uses for such compounds and compositions in the treatment of lower urinary tract disorders, such as neuromuscular dysfunction of the lower urinary tract, and in the treatment of migraine and gastroesophagael reflux disease (GERD).

The present invention relates to a peptide comprising a muscle function enhancing amino acid sequence which is derived from the S100 calcium binding protein family. Furthermore, the present invention provides said peptide for medical use, in particular, for treating or preventing disorders associated with muscular malfunction, such as skeletal muscle or cardiac muscle disorders. The present invention also provides a pharmaceutical composition comprising said peptide and a method for treating or preventing disorders associated with muscular malfunction using said peptide or said pharmaceutical composition.

The present invention is directed to the treatment of muscular dysfunction or increasing muscle strength and/or decreasing muscle fatigue in a subject using a composition that includes a biguanide or a pharmaceutically acceptable salt thereof, e.g., at a low dosage.

Disclosed herein are pharmaceutical agents and compositions that activate integrin heterodimers that contain beta-1 integrin protein that specifically bind laminin protein. Such agents and compositions are useful for treating diseases related to muscle malfunction, including muscular dystrophies.

It was found that nucleic acids for the specific targeting sequences or nucleic acids having the specific sequences have superior suppression activities of MURF1 expression. Pharmaceutical compositions including the nucleic acids as active ingredient are useful for treating or preventing disease accompanied by one or more symptoms selected from the group consisting of decrease in muscle mass, decrease in muscle strength and muscle dysfunction.