183 results about "Muscle degeneration" patented technology

The invention discloses and claims benzimidazole compounds of formula (I):

wherein X is C—R2; Y is C—R2 or C—R3; W and Z are each C—R3; R1 is an optionally substituted aryl, heteroaryl or a saturated 5- or 6-membered monocyclic heterocyclic radical or a bicyclic heterocyclic radical; and A5 is H or alkyl; or a stereoisomer, a racemate, an enantiomer or a diastereoisomer of said compound of formula (I) or a pharmaceutically acceptable salt thereof; the use of compounds of formula (I) for the treatment of a disorder of proliferation of blood vessels, uncontrolled angiogenesis, a fibrotic disorder, a disorder of proliferation of mesangial cells, a metabolic disorder, allergy, asthma, thrombosis, a disease of the nervous system, retinopathy, psoriasis, rheumatoid arthritis, diabetes, muscle degeneration, solid tumors and cancers, pharmaceutical compositions comprising a compound of formula (I) and one or more pharmaceutically acceptable adjuvants or diluents and pharmaceutical compositions comprising a compound of formula (I) and one or more. antimitiotic agents.

The present invention relates to a method of treating and/or ameliorating one or more symptoms of sarcopenia and age-related muscle degeneration in a mammal.

The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel hetereocycles of the general formula (I). Also included is a method of treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection in a mammal comprising administering an effective amount of a compound of formula (I) as described above.

The present invention relates to compounds having the general formula

or a pharmaceutically acceptable salt thereof, wherein R¹ is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R¹ is additionally substituted; and R² is a substituted C_1-6alkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

The invention belongs to the field of traditional Chinese medicines and particularly relates to a medicine for treating and preventing the rheumatism of muscles and bones, which comprises a medicine for oral administration and a medicine for external use, wherein the medicine for the oral administration comprises the following components: sea otter, sea horse, Rhizoma Drynariae, antler glue, Herba Epimedii, fleece-flower root, Eucommia ulmoides, large-leaved gentian, Monkshood, Angelica sinensis, Caulis Spatholobi, Astragalus mongholicus, scorpio, frankincense, myrrh, earthworm, Sweetgum Fruit, notopterygium root, Radix Saposhnikoviae, ground beetle, Manis pentadactyla, pseudo-ginseng, gastrodia elata, rhizoma corydalis and Ligusticum wallichii, and the medicine for the external use comprises the following components: Alangium platanifolium, rhizoma smilacis glabrae, semen brassicae, Eupolyphaga, monkshood, radix aconiti agrestis, phryma leptostachya and curcuma zedoary. The medicinalmaterials are soaked to prepare medicated wine by using 58-62 degrees of white spirit after being ground into powder, and the two medicines are combined for use. The medicine for treating and preventing the rheumatism of the muscles and bones has an obvious effect and especially has an obvious curative effect on the rheumatism of the muscles and bones, such as rheumatism, rheumatoid arthritis, lumbar intervertebral disc protrusion, lumbar muscle degeneration, Ankylosing Spondylitis, femoral head necrosis, arthroedema, sciatica, intermittent claudication, cervical vertebra ache and stiffness, amyotrophy, osteoproliferation, scapulohumeral periarthritis, arthritis, arthromeningitis and the like and has a wide application range, is economic and practical and is convenient to popularize.

The invention discloses a warm compression thermal therapy liquid for treating rheumatoid arthritis, postpartum rheumatism, scapulohumeral periarthritis, lumbar muscle degeneration, sciatica, lumbar vertebra pain, cervical vertebra pain, hemiplegia and stroke. The warm compression thermal therapy liquid is mainly prepared from double-teeth pubescent angelica root, wild ginger, himalayan teasel root, dandelion, longhairy antenoron herb, fortune's drynaria rhizome, Chinese taxillus twig, astragalus, cortex eucommiae, scorpio, red paeony root, white paeony root, orientvine, prepared rehmannia rhizome, achyranthis bidentatae, large-leaved gentian and red-rooted salvia root according to a certain weight proportion. A preparation method of the warm compression thermal therapy liquid comprises the following steps of: preparing the selected Chinese medicines, extracting, purifying and smashing with a smasher; and applying according to three kinds of methods. The warm compression thermal therapy liquid has the effects of clearing and activating the channels and collaterals, regulating tendons and qi, dispelling cold and drawing poison out, can be used for quickly improving microcirculation and enhancing the immunologic function and temperature resistance of an organism, is applied to treatment of a plurality of incurable miscellaneous diseases such as rheumatoid arthritis, scapulohumeral periarthritis, postpartum rheumatism, sciatica, cervical vertebra lumbar vertebra pain, hemiplegia and stroke and the like, and has quick response and a high curative rate.

The invention discloses a directional conductive acupuncture needle, including a needle handle, a needle body and a needle point. The needle body is plated with a nano SiO2 coating, the thickness of the nano SiO2 coating is 100 to 200nm, the needle handle is connected with an electrode of an electric acupuncture apparatus, and a current is led in directionally from the needle point and acts on a deep-seated position of a disease. Due to adoption of an ultrathin nano SiO2 coating, when the directional conductive acupuncture needle cooperates with the electric acupuncture apparatus for use, a current simulation that produces a therapeutic effect is directionally led in to a deep part of a jiaji acupoint from the position of the needle point, and directly acts on the position of a lesion, thereby not only substantially improving the therapeutic effect, but also reducing electric conduction of the needle body in a non-therapeutic position, and thus alleviating discomfort of skin tissues of a patient. The directional conductive acupuncture needle provided by the invention is suitable for applying acusectors to the jiaji acupoint to treat muscle, ligament, nervus, blood vessel stimulation or lesion symptoms caused by spine degeneration, such as cervical spondylosis, lumbar muscle degeneration, protrusion of lumbar intervertebral disc, lumbar vertebra stenosis and other diseases. In addition, the invention also discloses preparation technology of the directional conductive acupuncture needle.

The present invention relates to compounds having the general formula

or a pharmaceutically acceptable salt thereof. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

The invention relates to medical compress patches, in particular to a medical far infrared hot compress patch for soft tissue repairing and a preparation method thereof. The medical far infrared hot compress patch comprises a non-woven fabric bag, a heating layer arranged at the non-woven fabric bag, and a pressure sensitive adhesive tape used for fixing the non-woven fabric bag; the heating layer is composed of 35-45% of reduced iron powder, 0.1-5% of aluminum powder, 5-15% of far infrared ceramic powder, 10-16% of active carbon, 0.5-2% of polymer water-absorbent resin, 1-6% of sodium chloride and rest of purified water by weight. By means of a thermal therapy and infrared therapy combination mode, the medical far infrared hot compress patch for the soft tissue repairing has physical therapy and therapy effects for the inflammation and indisposition due to rheumatic arthritis, cervical spondylosis, lumbar muscle degeneration, lumbar disc herniation, scapulohumeral periarthritis, soft tissue injury, hyperosteogeny, ischialgia, pain from rheumatism, knee injury, chronic prostatitis, chronic mastitis, hyperplasia of mammary glands, chronic gastroenteritis, chronic gynaecology inflammation, cold in uterus, stomach cold, pain from rheumatism and the like.

The invention discloses a traditional Chinese medicine composition for treating soft tissue injury. The traditional Chinese medicine composition is composed of the following raw medicinal materials by weight: 15-30g of myrrh, 15-30g of teasel root, 15-30g of raw rhubarb, 10-20g of red flower, 10-20g of gardenia jasminoides ellis, 10-20g of root of common peony, 10-20g of radix angelicae, 30-60g of rhizoma drynariae, 15-30g of olibanum, 10-20g of peach kernel, and 5-10g of camphorated oil. A preparation method of the traditional Chinese medicine composition is as follows: weighing the raw medicinal materials by weight, cleaning, drying in the shade, grinding into fine powder, adding white spirit with the alcohol strength of 50-55 degrees in the medicinal powder, wherein the weight of the white spirit is 6-7 times of the total weight of the medicinal powder, sealing and soaking for 10-15 days, filtering to remove slag, taking out clear liquor, adding 5-10g of camphorated oil in each 500g of clear liquor to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention is fast in taking effect and short in treatment course in treating soft tissue injury, acute lumbar sprain, acute lumbar muscle degeneration, joint sprain and stiff neck, and is simple in preparation method and low in cost.

The invention discloses an automobile lifting tail plate structure which comprises a bearing platform, a platform support and a tail plate lifting turnover mechanism. The tail plate lifting turnover mechanism is fixedly arranged on a main beam of a compartment of an automobile and is used for enabling the bearing platform to do vertical motion and fixed point turnover motion. The platform support is connected with the tail plate lifting turnover mechanism. The bearing platform is connected with the platform support. After the technical scheme is adopted, the mechanical efficiency is greatly improved; meanwhile, the lifting mechanism moves in the direction perpendicular to the compartment and can adapt to bumpy working terrains; the lifting mechanism continuously ascends to drive the bearing platform to move to the middle of the compartment, and a loading member does not need to bend down, so that the working efficiency is improved, the labor intensity is lowered, occupational diseases such as lumbar muscle degeneration are avoided, and the labor insurance burden on an employer is relieved; and if two layers of compartments exist, the lifting mechanism continuously ascends to the second layer for loading and unloading. The automobile lifting tail plate structure is simple in structure, and uniform and reasonable in stress, so that the fault rate and the maintenance cost of the employer are effectively lowered.

The invention provides rheumatism bone disease plaster, and relates to the field of traditional Chinese medicine compositions. The rheumatism bone disease plaster is prepared from the following raw materials: long-noded pit viper, garter snake, scorpio, scolopendra, gadbee, radix notoginseng, caulis sinomenii, kadsura pepper stem, 4-12 parts of rhizoma chuanxiong, radix clematidis, radix angelicae sinensis, rhizoma curcumae longae, ramulus cinnamomi, herba lycopodii, radix cyathulae, frankincense, myrrh, caulis spatholobi, radix puerariae, radix aconiti preparata, radix aconiti agrestis, rhizoma seu radix notopterygii, radix angelicae pubescentis, ramulus mori, rhizoma corydalis, licorice root, earthworm, semen strychni, rhizoma gastrodiae, sesame oil and yellow lead. The rheumatism bone disease plaster is capable of penetrating through muscle and bone, searching wind, eliminating cold, promoting blood circulation to remove blood stasis, strengthening bone and relaxing tendons, and activating meridians and collaterals; the rheumatism bone disease plaster has excellent effects of treating the diseases such as rheumatoid arthritis caused by wind cold, headache caused by cervical spondylosis, numbness and powerlessness of two legs caused by lumbar spondylosis, blockage of qi and blood and pain caused by dampness cold, arthropathy, traumatic injury sequelae, diseases of tendons and bones caused by wind cold of females in confinement, pain of shoulders and arms, numbness of hands and feet, lumbar muscle degeneration, osteoproliferation, dampness cold pain of tendons and bones, traumatic injury and the like; meanwhile, the rheumatism bone disease plaster is low in cost and convenient in popularization and has high economic value and social value.

The invention provides a device for rehabilitation therapy of lumbar disc herniation and related diseases. The device is a mechanism which at least comprises a lumbar vertebra double-roller rehabilitative device and a lumbar vertebra rehabilitative bed and is additionally provided with an infrared transmitter serving as an auxiliary part. Lumbar vertebra rehabilitative rollers are horizontally placed in the middle of a bed face, the length direction of the rollers is identical to the bed, and an elastic material layer is laid on the upper portion of the bed face. A patient lies on the back flatly on the lumbar vertebra rehabilitative rollers, the two long rollers stride across the two sides of the spine, the two knees are bent, and the two feet step on a transverse support of a bed tail. Through the power of the two hands, the two arms, the two feet and the whole body, the lumbar vertebra rehabilitative rollers roll in a reciprocating mode on the bed face and vibrate. The stroke is controlled, the degree is proper when the two long rollers do not press the spine and the patient feels comfortable. Organism tissue of the back of the patient is irradiated with infrared light emitted from the portion below the lumbar vertebra rehabilitative bed and transmitting a gap of the bed face, with the cooperation of the processes, free traction, massage, acupressure and infrared stimulation of an affected part are achieved in a three-dimensional space, and therefore the device is suitable for treating the diseases such as lumbar disc herniation, ischialgia, lumbar muscle degeneration, lumbar vertebra hyperostosis and spinal curvature and also can be used as measures for height increase and body building.

The invention discloses a traditional Chinese medicine preparation used for treating facial paralysis and an apoplexy sequela, and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises the following components in percentage by mass: 25%-31% of nux vomica preparata, 10.3%-16.6% of ephedra, 8%-11.1% of achyranthis bidentatae, 8.3%-11.1% of stiff silkworms, 5.6%-8.3% of rhizoma atractylodis, 6.9%-8.3% of frankincense, 5.6%-8.3% of scorpio, 6.9%-8.3% of myrrh and 8.3%-11.1% of liquorice. The traditional Chinese medicine preparation has effects of promoting blood circulation, dispersing blood stasis, expelling wind, removing cold, clearing and activating channels and collaterals, counteracting toxic substances, eliminating stagnation, and relieving swelling and pain, is mainly used for treating the apoplexy sequela, the facial paralysis, arthritis, scapulohumeral periarthritis, ischialgia, lumbar muscle degeneration, wind dampness arthralgia, amyotrophia and the like, and is good in healing effect.

The invention discloses an internal medicine nursing exercise device, and solves the problem that a patient is difficult in exercising autonomously in the early stage of rehabilitation. The device comprises a lying plate, a support is fixedly connected to the bottom of the lying plate, an arm exercising frame is rotationally connected to the lying plate, a first gear capable of rotating in a reciprocating mode is fixedly connected to the arm exercising frame, the first gear is engaged with a transmission mechanism, the transmission mechanism is located in the lying plate, a massage box capableof moving in a reciprocating mode is arranged on the lying plate, a driving device is arranged on the left side of the massage box, a telescopic coupler is rotationally connected to the right side ofthe massage box, a reversing gear set is connected among the transmission mechanism, the driving device and the telescopic coupler, the transmission mechanism, the driving device, the telescopic coupler and the reversing gear set form a driving system, and the front side of the lying plate is rotationally connected with an adjustable supporting plate. The problem that autonomous exercise of the patient is difficult due to muscle degeneration and physical strength in the early stage of rehabilitation is solved.

The invention relates to the field of medical instruments, and provides a cervical joint rehabilitation training device. The cervical joint rehabilitation training device comprises a traction helmet,a fixing support and a plurality of traction assemblies. The traction helmet is connected to the fixing support through the traction assemblies. The first ends of the traction assemblies are fixedly connected to different positions of the traction helmet, and the second ends of the traction assemblies are movably connected to the fixing support in a stretching and/or rotating direction of the traction assemblies. The neck joint rehabilitation training device provided by the invention can perform active and passive stretching or rotation in all directions on the cervical joint through the connection and traction of the traction assemblies, so that the cervical joint is corrected to the correct physiological angle. Meanwhile, the device can be used for carrying out strength training on the neck, promoting the recovery of the activity function and strength of the neck, and improving the muscle degeneration of the cervical joint caused by long-term bad postures, so that the purpose of preventing and treating cervical spondylosis is achieved.

The invention discloses a plate cutting machine and relates to the technical field of plate machining. The plate cutting machine comprises a working table; a mounting supporting seat and a guiding rail are fixed to the working table; a sliding plate is in sliding connection to the guiding rail; and a driving mechanism is disposed in the guiding rail. The plate cutting machine is simple in structure, and convenient to operate; by arranging a second upright column, height in a first upright column can be adjusted, height adjustment of the supporting seat can be achieved so as to adapt to operators with the different heights, lumbar muscle degeneration and the like caused by long-time bending of people with the different heights are reduced, and the practicability is high; and the position ofthe sliding plate on the guiding rail is moved, the position of a sleeve rod in an abnormal-shaped sleeve is adjusted, and a small gear drives the abnormal-shaped sleeve to rotate, thus transverse displacement and angle change of a cutter are achieved, the working efficiency is improved, multi-angle cutting can be achieved, and the cutter changing time is shortened.

The invention relates to the field of drugs, in particular to an external-use drug for treating pain in waist and lower extremities, a process and application. The external-use drug is prepared from radix clematidis, rhizoma et radix notopterygii, radix angelicae pubescentis, rhizoma curcumae, radix notoginseng, radix aconiti, radix aconiti kusnezoffii, black pepper, radix angelicae dahuricae, herb of tuberculate speranskia, frankincense, myrrh, unprocessed rhizoma pinelliae, unprocessed arisaema cum bile, herbal asari, rhizoma drynariae, radix dipsaci, semen strychni, sophorra flavescens, cortex dictamni and fructus kochiae. The external-use drug can efficiently and rapidly treat cervical spondylosis, protrusion of lumbar intervertebral disc, lumbar muscle degeneration, chronic injury diseases and multiple kinds of internal and external rheumatic arthritis, and is wide in disease adaptation range.

The invention discloses an externally applied medicine for treating lumbar muscle degeneration and a preparation method. The externally applied medicine comprises thirteen Chinese medicinal plants ofChinese angelica, pubescent angelica root, Japanese honeysuckle stem, suberect spatholobus stem, divaricate saposhnikovia root, clematis root, garden balsam stem, twotooth achyranthes root, tall gastrodia tuber, Chinese taxillus herb, dried ginger, myrrh and frankincense. After the medicine is combined according to the medicaments, the medicinal effect has the efficacy of synergy, and medicine canachieve remarkable curative effect through applying the pharmacology and pharmacodynamics of external application of Chinese medicines in a process of treating the lumbar muscle degeneration.

The invention discloses instant eaglewood leaf tea and a preparation method thereof. The instant eaglewood leaf tea is obtained by adopting a superfine grinding technology to crush leaves, then extracting nutritional ingredients of eaglewood leaves, mixing beautiful millettia roots, chrysanthemum, licorice roots, longan, momordica grosvenori, Pu'er tea and other auxiliary extracting solutions according to certain proportion and performing filtration, concentration, vacuum drying and packaging. The instant eaglewood leaf tea prepared by adopting the method retains effective ingredients of the eaglewood leaves, is also supplemented with the beautiful millettia roots, the chrysanthemum, the licorice roots, the longan, the momordica grosvenori and other ingredients, improves nutritional value, is good in instant effect and meanwhile is supplemented with other tea for reasonable blending, the taste is improved, the tea has the multiple health-care effects of tonifying deficiency, moistening lung, relieving cough, maintaining beauty, keeping young, promoting sleep, clearing away heat, expelling toxin, lowering blood fat and blood sugar and meanwhile has a certain effect on lumbar muscle degeneration and rheumatic arthritis.

The invention discloses an office chair, which comprises a lower chair surface (1) and four chair legs (2) arranged at the four corners of the lower chair surface (1). The upper seat surface (3), the lower part of the upper seat surface (3) is connected with the four corners of the upper part of the lower seat surface (1) through four compression springs (4) located at its four corners, the lower part of the upper seat surface (3) The central area of ​​the seat is fixedly provided with a ball head (5), and the upper part of the lower seat surface (1) corresponding to the position of the ball head (5) is provided with a ball socket (6) suitable for the ball head (5). , the ball head (5) is located in the ball socket (6) to cooperate with the ball socket (6). The seat surface of the office chair can be moved, which can effectively move the waist of the sitting and standing person, and can reduce the risk of lumbar muscle strain for the sitting and standing person.