18 results about "Cold pain" patented technology

The invention relates to the technical field of traditional Chinese medicine, in particular to a traumatology crymodynia traditional Chinese medicine composition and a preparation method and application thereof. The cold pain traditional Chinese medicine composition for the department of traumatology comprises the following components in parts by weight: 6-10 parts of cortex cercis chinensis, 6-10 parts of fructus viticis, 1-3 parts of radix salviae miltiorrhizae, 1-3 parts of rhizoma wenyujin concisum, 1-2 parts of fructus forsythiae, 1-3 parts of flos caryophylli, 1-3 parts of cortex cinnamomi and 1-3 parts of lamiophlomis rotata. After a mouse with knee osteoarthritis (KOA) is intervened with the traumatology crymodynia patch prepared by the method, mouse synovial inflammation is relieved, serum inflammatory factors and pain media are reduced, crymodynia sensitivity threshold value is increased, up-regulation of relevant indexes of crymodynia sensitivity, fibrosis and nerve germination as well as relevant index protein and gene expression level of training immunity is remarkably reversed, and the traumatology department crymodynia patch can be used for treating knee osteoarthritis (KOA). The traditional Chinese medicine composition can significantly improve synovitis and crymodynia sensitivity of KOA mice, adopts channel-warming and blood-activating medicines, has a significant curative effect in clinical application, and especially has a relatively significant effect on the symptom of crymodynia sensitivity of KOA patients.

The invention relates to a traditional Chinese medicine composition for treating rheumatic bone pain and application thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating rheumatic bone pain is prepared from the following raw materials: radix aconiti, radix aconiti agrestis, alpine yarrow herb, ardisia crenata, akebiaquinata, pawpaw, garden balsam stem, eucommia ulmoides, ligusticum chuanxiong hort, radix saposhnikoviae, radix stephaniae tetrandrae, caulis spatholobi, lycopodium clavatum, radix clematidis and radix bupleuri. The traditional Chinese medicine composition disclosed by the invention has the treatment effects of clearing and activating the channels and collaterals, dispelling wind and eliminating dampness, and warming channels and relieving pain, is mainly used for treating gout, waist and knee crymodynia, rheumatic arthritis, numbness of limbs and the like, and has relatively high effective rate.

The invention provides sinomenine in preparation of a medicine for treating chronic pain of rheumatoid arthritis and application of the sinomenine in preparation of the medicine for treating the chronic pain of the rheumatoid arthritis, and aims at solving the problems that an existing medicine for resisting the rheumatoid arthritis is limited in action target spot and poor in treatment effect. The sinomenine takes a histamine receptor H1R on a nervous system dorsal root ganglion M1 type macrophage as the action target spot; the target spot is intervened to regulate and control polarization of macrophages, reduce expression of histamine H1R in M1 type macrophages and inhibit infiltration of the macrophages, so that chronic pain, including crymodynia, mechanical pain, heat pain and the like, of rheumatoid arthritis is effectively relieved; the sinomenine combined action target can improve pain and arthritis symptoms of a model mouse, reduce the level of inflammatory factors and inhibit LPS-induced macrophage migration and H1R expression, and the sinomenine pharmaceutical composition has various dosage forms, has unique action target and mechanism, has a remarkable treatment effect, and can be used for preparing medicines for treating chronic infectious diseases. The compound is expected to become a novel non-opioid anti-rheumatoid arthritis chronic pain medicine.

The utility model discloses a joint protection device for epilepsy nursing. The joint protection device comprises an upper supporting body, a connecting body, a lower supporting body, a heating pad, a heating pipe and a control connecting line. According to the joint protection device, the flexible connecting body is arranged to serve as a connecting piece for connecting the upper supporting body and the lower supporting body, and is matched with the hard supporting plate and the spring for supporting, so that the joint protection device is not prone to displacement in the using process, can be stably worn and has the stable protection effect on the joint, and the mounting bags are arranged on the two sides of the connecting body, so that the joint protection device is convenient to use. A heating pad and a heating pipe are conveniently placed, so that the two ends of the joint are conveniently subjected to hot compress, the cold pain feeling of the joint is dispelled, and the joint nursing accuracy is improved.

The invention discloses application of isotoosendanin in preparation of a medicine for relieving neuropathic pain and application of TRPV1 and Nav1.7 as medicine targets of the isotoosendanin, and relates to the technical field of biological medicine. The medicine prepared from the isotoosendanin can inhibit the expression of dorsal root ganglion (DRG) neurons TRPV1 and Nav1.7 protein; the medicine prepared from the isotoosendanin can inhibit the reduction of mechanical pain threshold and crymodynia threshold; the neuropathic pain comprises pain after selective injury of sciatic nerve branches; the TRPV1 and Nav1.7 are used as drug targets to be applied to preparation of the neuropathic pain relieving drug taking the isotoosendanin as an effective component. The isotoosendanin plays a role in relieving neuropathic pain, and the isotoosendanin can be used for inhibiting the expression of TRPV1 and Nav1.7; the isotoosendanin can be used for treating neuropathic pain by inhibiting expression of TRPV1 and Nav1.7 channel proteins, and a new thought is provided for preparing the neuropathic pain medicine.

The invention discloses beast repelling liquid and application thereof, and belongs to the technical field of security and protection. The beast expelling liquid comprises the following components: a thermal pain agonist, a cold pain agonist, a polar solvent, a non-polar solvent, a thickening adhesive and a surfactant, the expelling liquid disclosed by the invention can generate strong burning and pricking feelings after being inhaled or contacted with the skin for 5-10 seconds, so that the aims of expelling beast and protecting the safety of the beast are fulfilled. The repelling liquid is particularly suitable for being used by related workers in field grazing, construction, hiking, exploration, scientific investigation and the like to protect themselves from being attacked by wild animals.

The traditional Chinese medicine formula is prepared from the following components in parts by mass: 5-9 parts of poria cocos, 5-10 parts of rhizoma alismatis, 6-9 parts of radix rehmanniae, 7-9 parts of Chinese yam, 7-9 parts of cortex moutan, 7-9 parts of sweet potato pulp, 5-9 parts of astragalus membranaceus, 5-10 parts of radix cyathulae, 5-9 parts of radices trichosanthis, 5-8 parts of cistanche, 5-9 parts of cynomorium songaricum, 6-10 parts of medlar, 1-6 parts of American ginseng slices, 2-7 parts of antler slices, 1-4 parts of tussilago farfara, 0.5-2 parts of donkey-hide gelatin, 1-3 parts of scorpion and 1-3 parts of gastrodia elata slices. The traditional Chinese medicine composition is prepared by scientific compatibility of eighteen Chinese herbal medicines, has the core efficacy of consolidating basis, and has significant improvement effects on dizziness, soreness and weakness of waist and knees, hypodynamia, frequent and urgent urination, insomnia and amnesia, slow response, palpitation and shortness of breath, dysphoria and irritability, hidrosis and dreaminess, drooping spirit, cold pain in waist and legs, night sweat and other symptoms caused by kidney deficiency; the problems of impotence and premature ejaculation can be effectively conditioned, and the kidney deficiency state is comprehensively repaired.

The invention relates to a traditional Chinese medicine composition for treating cold evil stomach invading type epigastric pain and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components in parts by weight: 4-8 parts of processed radix aconiti carmichaeli, 6-10 parts of rhizoma zingiberis, 6-10 parts of rhizoma galangae, 3-5 parts of cortex cinnamomi, 3-5 parts of fructus evodiae, 8-12 parts of rhizoma atractylodis, 6-10 parts of cortex magnoliae officinalis, 6-10 parts of pericarpium citri reticulatae, 8-12 parts of rhizoma corydalis, 10-15 parts of radix paeoniae alba, 4-8 parts of flos carthami and 4-8 parts of honey-fried licorice root. Compared with the prior art, the traditional Chinese medicine composition is definite in curative effect, high in safety and free of obvious toxic and side effects, can effectively relieve symptoms such as gastral cavity crymodynia, fullness and belching, sour regurgitation and the like and reduce relapse, and has good clinical application prospects and popularization value.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition and a traditional Chinese medicine preparation for yang deficiency and cold coagulation type osteoporosis, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 4-20 parts of fructus lycii, 10-30 parts of herba epimedii, 2-10 parts of deer-horn glue, 4-15 parts of cortex cinnamomi, 3-12 parts of radix aconiti carmichaeli, 3-12 parts of poria cocos, 10-30 parts of radix astragali and 3-15 parts of rhizoma curculiginis. The traditional Chinese medicine compound disclosed by the invention takes yang warming and cold dispelling, kidney tonifying and bone strengthening, and qi replenishing and spleen strengthening as treatment rules, can comprehensively improve the symptoms of yang deficiency and cold coagulation type osteoporosis, such as intolerance of cold and cold limbs, waist and knee crymodynia, limb numbness and the like, and meanwhile, promotes bone formation, inhibits bone resorption and improves bone density. Compared with an existing treatment scheme, the compound is based on syndrome differentiation and treatment of traditional Chinese medicine, pays attention to overall conditioning, can flexibly add or reduce medicines, realizes individualized treatment and adapts to physiques and symptoms of different patients.

This invention belongs to the field of medical auxiliary device technology and discloses a chemotherapy support device for oncology. It includes a seat body, a respiratory status detection device, and a controller. The seat body is connected to armrests, a Neiguan acupoint massage component, a Zusanli acupoint massage component, an abdominal heat therapy component, a headrest, and a speaker. The Neiguan acupoint massage component includes a base, a motor, a fixed gear ring, a sun gear, planetary gears, and massage balls. The Zusanli acupoint massage component includes an air pump and an airbag. The abdominal heat therapy component includes a strap, a medicine storage box, a heat therapy bag, and an electric heating wire. The respiratory status detection device includes a pressure sensor. This invention utilizes the Neiguan acupoint massage component to stimulate and massage the Neiguan acupoint, the Zusanli acupoint massage component to compress the Zusanli acupoint, and the abdominal heat therapy component to provide heat therapy to the abdomen, effectively relieving symptoms such as nausea and vomiting, numbness in the hands and feet, and abdominal cold pain after chemotherapy.

The invention belongs to the technical field of biological medicines, and relates to a spiro polypeptide with a single disulfide bond and a mutant and application thereof. The amino acid sequence of the conotoxin polypeptide is shown as SEQ ID NO.1 in a sequence table. One or more amino acid site-directed mutagenesis is carried out on the amino acid sequence of the conotoxin polypeptide to obtain a series of mutants. A plurality of mutants have better inhibitory activity and selectivity on an alpha9alpha10 acetylcholine receptor; wherein the IC50 of the M16R is 28.2 nM, and the IC50 of the F19R is 17.5 nM. In addition, M16R and F19R show in-vivo analgesic activity in a chemotherapeutic drug oxaliplatin induced rat crymodynia model, and have the potential of being developed into a neuropathic pain treatment drug targeting alpha9alpha10nAChR.

The invention relates to a yang warming and governor meridian dredging pill which is prepared by the following steps: 1) weighing raw materials: (1) centipede and gecko; (2) cynomorium songaricum, flastem milkvetch seed (fried), gordon euryale seed (steamed), dragon bone (calcined), oyster (calcined) and lotus seed; (3) amur corktree bark and rhizoma atractylodis (fried); (4) mantis egg-case, prepared rehmannia root, morinda officinalis, cistanche, spina date seed (fried), cornu cervi degelatinatum, poria cocos, bighead atractylodes rhizome (fried), salted eucommia ulmoides, pulp of dogwood fruit, herba epimedii, Chinese yam, raw liquorice, white paeony root (fried) and angelica sinensis; (5) schisandra chinensis, semen plantaginis, semen cuscutae, fructus lycii and (2) grinding (1) into fine powder, putting into pills, decocting (2), (4) and (5), concentrating, and refining with (1) to obtain pills as large as phoenix tree seeds. The traditional Chinese medicine has the advantages that the raw materials are reasonable, the preparation is convenient, and the traditional Chinese medicine can treat soreness, cold and pain of waist, dyspepsia and lumbago caused by liver and kidney deficiency, kidney deficiency and essence deficiency; sciatic nerve numbness and pain; and the traditional Chinese medicine composition has the advantages of good popularization prospect and economic value, and can be used for treating symptoms such as joint soreness, cold pain, fatigue, impotence, sterility, spermatorrhea, premature ejaculation and residual urination.

The invention relates to the technical field of moxibustion physiotherapy, in particular to a medicinal moxa stick and a preparation method thereof. The moxa stick comprises the following components in parts by weight: 80-100 parts of Chinese mugwort, 10-20 parts of sandalwood, 5-10 parts of mint, 5-10 parts of cacumen biotae, 5-10 parts of borneol, 10-20 parts of agilawood, 10-20 parts of safflower and 10-20 parts of auxiliary materials, the auxiliary materials comprise the following raw materials in parts by weight: 5-10 parts of bamboo fibers, 5-10 parts of elm powder and 1-5 parts of starch. The traditional Chinese medicine composition has the effects of soothing the nerves, helping sleep, clearing and activating the channels and collaterals, warming channels, dispelling cold and soothing the nerves; the traditional Chinese medicine is suitable for symptoms such as insomnia and dreaminess, wind-cold-dampness arthralgia, soreness and numbness of muscles, arthralgia of joints and limbs, abdominal cavity and cold pain, cold uterus and dysmenorrhea. And the moxa stick is moderate in hardness, can be fully burnt, and is less in smoke, and ash is not easy to fall off.

The invention discloses a verification method of a rat neuropathic pain model, and relates to the field of clinical medicine. Comprising the following steps: animal preparation: selecting healthy adult rats, and putting the rats in a laboratory environment for adaptive feeding; model construction: constructing a sciatic nerve branch selective injury model; the pain behavioral test comprises a foot sole hot stabbing pain experiment, a mechanical pain sense test and a cold pain sense test; data analysis: performing data analysis according to a behavioral test result; and model verification: verifying whether the construction of the model is successful or not by observing the behavioral performance of the rat, comparing the symptoms of the model rat with the symptoms of a human neuropathic pain patient, and evaluating the clinical similarity of the model. According to the method, the neuropathic pain model is successfully induced and verified through SNI model surgical operation and hot plate testing, and the method has high reliability and repeatability and provides powerful support for research of neuropathic pain.

The invention provides a composition for relieving stomach cold pain as well as a preparation method and application thereof, and the composition for relieving stomach cold pain is prepared from the following raw materials: pomegranate powder, galangal, black pepper, nutmeg, cinnamon, calcium lactate, sorbitol and magnesium stearate. According to the composition for relieving the stomach cold pain, the galangal, the pomegranate powder, the black pepper, the nutmeg and the cinnamon in a specific proportion are adopted, the effects of invigorating the stomach, removing cold, warming the stomach and nourishing the stomach can be achieved, the stomach cold pain can be well relieved, and therefore the body function of a patient suffering from the stomach cold pain can be conditioned.

The invention provides an external traditional Chinese medicine composition with a dysmenorrhea treatment effect, a preparation and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine compositions. The external traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 25 to 35 parts of radix aconiti preparata, 12 to 20 parts of fructus evodiae, 25 to 35 parts of radix linderae, 25 to 35 parts of rhizoma cyperi, 15 to 25 parts of radix aucklandiae, 25 to 35 parts of rhizoma corydalis, 15 to 25 parts of rhizoma chuanxiong, 15 to 25 parts of trogopterus dung, 15 to 25 parts of myrrh, 3 to 8 parts of cortex cinnamomi and 1 to 3 parts of camphor. According to the invention, the medicine effect directly reaches the local part through the specific matching of the medicines, the discomfort symptoms such as abdominal crymodynia and the like caused by dysmenorrhea of a patient can be quickly relieved, and clinical test results prove that the pain symptom of dysmenorrhea can be obviously improved by singly using the dysmenorrhea patch for one menstrual cycle, and the remission rate can be further improved and the pain duration can be further reduced by using the dysmenorrhea patch for two or more menstrual cycles; the pain relieving time is prolonged; and the use amount of the pain-relieving medicine is reduced.

The invention discloses a cold-dispelling and dampness-eliminating patch, and belongs to the technical field of traditional Chinese medicines. The cold-dispelling and moisture-eliminating patch is composed of spunlace cloth, a medicine core layer, a medicine core rubber ring and gum, the medicine core layer is formed by compounding traditional Chinese medicine active ingredients and physical synergistic ingredients according to a specific mass ratio, and the medicine core layer comprises radix angelicae pubescentis, herba taxilli, ligusticum wallichii, fried pepper, wormwood, ginger powder, tourmaline and wood vinegar powder. The preparation process comprises the following steps: preferably selecting the medicinal materials, finely grinding, drying and dehumidifying, mixing to prepare a core, gluing and compounding, and sealing and packaging. According to the product, the pharmacological effects of warming channels, dispelling cold, dispelling wind, eliminating dampness, promoting blood circulation, dredging collaterals, relieving pain and strengthening tendons are achieved through transdermal absorption of the traditional Chinese medicine components, meanwhile, a physical-chemical dual warming effect is formed by means of far infrared rays released by tourmaline and chemical thermal stimulation generated by ginger, pepper and the like, and local blood circulation and medicine permeation are promoted. The patch is suitable for joint crymodynia, muscle soreness, epigastric and abdominal crymodynia and other symptoms caused by wind-cold-dampness arthralgia, and has the advantages of being definite in curative effect, safe to use, convenient to carry and suitable for home conditioning.

The utility model discloses a cold and hot plate pain detector based on small animals, which belongs to the technical field of medical engineering and comprises a base, a touch display screen is arranged on the front side of the base, and a heat conducting plate is arranged at the upper end of the base; the heat-conducting plate is covered by a barrel, and an openable top cover is arranged at the top end of the barrel; temperature sensors are distributed at the bottom of the heat-conducting plate; a control circuit, a power supply module and a semiconductor chilling plate are arranged in the base; the semiconductor chilling plate is connected with the bottom of the heat-conducting plate; a heat dissipation module is arranged at the lower end of the semiconductor chilling plate; an exhaust fan is arranged on the side edge of the heat dissipation module; the side edge of the base is provided with a heat dissipation window corresponding to the exhaust fan in position. The small animal cold and hot pain detection device is used for realizing cold and hot pain detection experiments of small animals, the experiments are convenient, the labor intensity of workers is reduced, the experiment cost is reduced, and the experiment efficiency and the experiment accuracy are improved.