113 results about "Pain medicine" patented technology

The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl / sufentanil is provided as a water soluble salt (e.g., fentanyl hydrochloride), preferably in a hydrogel formulation, for use in an electrotransport device (10). In accordance with the present invention, a transdermal electrotransport delivered dose of fentanyl / sufentanil is provided which is sufficient to induce analgesia in (e.g., adult) human patients suffering from moderate-to-severe pain associated with major surgical procedures.

A device for pain control or other medical treatments of a patient. The device includes an implantable unit for implantation under the skin of a patient. The implantable unit includes a drug chamber containing a fluid drug, a tube for delivering the fluid drug to a location in the patient's body, an electronic pump for pumping the drug through the tube to the location, a programmable processor for controlling the pump, and an electronic receiver for receiving control signals from outside the patient's body and delivering the control signals to the processor. The device also includes a controller located outside the patient's body for transmitting control signals to said receiver. In preferred embodiments the implantable device also comprises an electrical pulse generator and at least one electrode implanted at a location in said patient's body and connected to said pulse generator wherein said processor is programmed to control said pulse generator to deliver electrical pulsed to said electrode. In a preferred embodiment for the control of pain, the implantable chamber contains a refillable pain-relieving drug that is placed inside the chamber.

The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl / sufentanil is provided as a water soluble salt (eg, fentanyl hydrochloride) dispersed in a hydrogel formulation for use in an electrotransport device (10). In accordance with one aspect of the invention, the concentration of fentanyl / sufentanil in the donor reservoir (26) solution is above a predetermined minimum concentration, whereby the transdermal electrotransport flux of fentanyl / sufentanil is maintained independent of the concentration of fentanyl / sufentanil in solution. In accordance with a second aspect of the present invention, the donor reservoir (26) of the electrotransport delivery device (10) is comprised of silver and the donor reservoir (26) contains a predetermined “excess” loading of fentanyl / sufentanil halide to prevent silver ion migration with attendant skin discoloration. In accordance with a third aspect of the present invention, a transdermal electrotransport delivered dose of fentanyl / sufentanil is provided which is sufficient to induce analgesia in (eg, adult) human patients suffering from moderate-to-severe pain associated with major surgical procedures.

A method for the treatment of pain and / or inflammation in a subject by the administration of N-acetyl-cysteine (NAC) or derivative thereof and a pain and / or anti-inflammatory medication. The pain or anti-inflammatory medication is metabolized by the action of the cytochrome p450 system. The pain medication includes N-methyl-D-aspartate (NMDA) receptor antagonist(s). NAC and the pain medicine can be administered concurrently or sequentially. The joint administration can result in the use of lower dosages than typical dosage of the pain and / or anti-inflammatory medication or in enhanced relief from the treated condition.

The present invention provides a proprietary compositions and systems to modulate genetic and metabolomic contributing factors affecting disease diagnosis, stratification, and prognosis, as well as the metabolism, efficacy and / or toxicity associated with specific vitamins, minerals, herbal supplements, homeopathic ingredients, and other ingredients for the purposes of customizing a subject's nutritional supplement formulation to optimize specific health outcomes. Specific to this invention the utilization of certain known polymorphic genes associated with Substance Use Disorder (SUD) are analyzed to target certain genetic anomalies that lead to a high risk and predisposition to SUD. The genotypic patterns are then utilized to provide certain nutritional customized solutions especially related to the attenuation of aberrant abuse of physician prescribed narcotic pain medication across all pain conditions. A priority GENOPROFILE is measured and directs the customization of a subsequent nutraceutical to act as a therapeutic modality. Specifically the treatment includes slow attenuation of the pain medication by incorporating orals (shakes, liquid beverages, pills, tablets, troche, ointments etc.), Intramuscular, Intravenous, intra-rectal and any form necessary to deliver a sufficient amount of an anti-craving and anti-stress nutraceutical. Moreover, the invention includes examples of novel analgesic ointments coupling Synaptamine and such analgesic and other anesthetic compounds including but not limited to Gabapentin, Ketamine, Baclofen, Ketoprofen, Amitriptyline, Lidocaine, Cyclobenzapine, Diclofenac, Menthol, Camphor and Capsaicin. The GENOPROFILE will be used to determine pain sensitivity Intolerance.

The invention relates to an external drug for eliminating cancer tumor bumps and alleviating pains thereof, which belongs to the field of medicine and overcomes the disadvantages that the prior anodyne for terminal cancer has drug addiction and gradually reduced pains alleviating effect. The external drug consists of asafetida, dried lacquer, poison nut, blood clam shell, pangolin, hirudo, gadfly, soil insect, rhizoma corydalis, frankincense, myrrh, rhizoma sparganii, zedoary, rhizoma ligustici wallichii, notoginseng, dragon's blood, hedgehog skin, peach kernel, safflower, radix aconiti, radix aconiti feri, scorpion, centipede, snake skin, oldenlandia diffusa, glabrous greenbrier rhizome, ginseng, radix astragali, american ginseng, angelica, radix salviae miltiorrhizae, muskiness and the like. The external drug has the advantages that the drug can eliminae or obviously alleviate pains of complication of the terminal cancer, has stable analgesic effect, and has no side effects compared with the prior anodyne used for the same disease symptom.

The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl / sufentanil is provided as a water soluble salt (eg, fentanyl hydrochloride) dispersed in a hydrogel formulation for use in an electrotransport device (10). In accordance with one aspect of the invention, the concentration of fentanyl / sufentanil in the donor reservoir (26) solution is above a predetermined minimum concentration, whereby the transdermal electrotransport flux of fentanyl / sufentanil is maintained independent of the concentration of fentanyl / sufentanil in solution. In accordance with a second aspect of the present invention, the donor reservoir (26) of the electrotransport delivery device (10) is comprised of silver and the donor reservoir (26) contains a predetermined “excess” loading of fentanyl / sufentanil halide to prevent silver ion migration with attendant skin discoloration. In accordance with a third aspect of the present invention, a transdermal electrotransport delivered dose of fentanyl / sufentanil is provided which is sufficient to induce analgesia in (eg, adult) human patients suffering from moderate-to-severe pain associated with major surgical procedures.

The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g., uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.

The invention discloses a Chinese medicinal composition for treating hyperosteogeny or hyperosteogeny pain and a preparation method thereof. The Chinese medicinal composition comprises the following components in part by weight: 10 to 30 parts of parsnip, 10 to 30 parts of borneol, 10 to 30 parts of incised notopterygium rhizome, 10 to 30 parts of Szechuan lovage rhizome, 5 to 15 parts of asarum,3 to 6 parts of common monkshood mother root, 3 to 6 parts of kusnezoff monkshood root, 10 to 30 parts of clematis root, 10 to 30 parts of obscured homalomena rhizome, 10 to 30 parts of kudzuvine root, 5 to 15 parts of angelica dahurica, 10 to 30 parts of garden balsam stem, 10 to 30 parts of frankincense, 10 to 30 parts of myrrh, 5 to 15 parts of dragon's blood, and 5 to 15 parts of dried ginger. By using the action mechanism that the internal diseases are treated externally, the Chinese medicinal composition is realized on the aspects of meridian conduction, skin penetration and mucosa absorption. The Chinese medicinal composition provided by the invention is Chinese medicinal plaster for treating hyperosteogeny or hyperosteogeny pain with the advantages of good curative effect, low cost, no side effect and short treatment course.

The invention discloses a traditional Chinese medicine combination for treating bone injury and fracture, which is characterized by comprising oral medicines and external-use medicines, wherein the oral medicines comprise the following active pharmaceutical ingredients: astragalus, angelica sinensis, barrenwort, herba cistanche, pseudo-ginseng, achyranthes root, safflower, cortex eucommiae, salvia miltiorrhiza, rhizomadrynariae, yam, fructus psoralea, sambucus williamsii hance, woodwardia japonica, prepared radix rehmanniae, lumbricus and white peony root; and the external-use medicines comprise various active pharmaceutical ingredients: myrrh, fructus evodiae, teasel, pseudo-ginseng, safflower, rhizoma ligustici wallichii, nux vomica, toad skin, centipede, notopterygium and herba lycopodti. The traditional Chinese medicine combination activates osteoblasts of endosteum and periosteum at the bone injury and fracture site to rapidly calcify, thereby having special efficacy to promote the generation a new bone. The traditional Chinese medicine combination is suitable for treating various bone injuries and fractures, has high cure rate, relieve severe pains of the bone injury and fracture of mass patients without using strong analgesics, can promote bone callus to rapidly form and has the effects of relieving flatulence and pains, eliminating blood stasis and promoting tissue regeneration and growth of the bone callus.

A Chinese medicine in the form of gel for treating vaginitis, cervicities, and cervical erosion is prepared from phellodendron bark, rhubarb, arnebia root and borneol. Its preparing process is also disclosed.

The disclosed invention is a composition of matter, a process of production thereof, and a method for the treatment of chronic pain, especially to the treatment of heretofore intractable pain as associated with advanced cancer, neurological conditions and rheumatoid arthritis. The treatment of pain associated with viral infections and lesions are also within the contemplation of the present invention. The composition of matter comprises modified alpha-neurotoxins or modified venoms known to contain alpha-neurotoxins in an acceptable carrier for either parenteral, oral or topical administration.

A Chinese medicine in the form of infusion for treating oral ulcer, behcet's disease, recurrent oral ulcer, esophagitis, chronic gastritis and peptic ulcer is prepared from 7 Chinese-medicinal materials including coptis root, scutellaria root, dried ginger, jujube, etc. Its preparing process is also disclosed.

The invention relates to the technical field of medical anesthesia, in particular to a medical analgesic and hemostatic dressing for anesthesiology department and a preparation method of the medical analgesic and hemostatic dressing. The dressing comprises a non-woven fabric surface layer, a water absorbing middle layer and a functional bottom layer from top to bottom, wherein the water absorbingmiddle layer is a compressed modified loofah sponge, and pores of the modified loofah sponge are filled with modified sepiolite and modified chitosan; the functional bottom layer is hydrogel doped with an analgesic. The preparation method of the dressing comprises the following steps: the functional bottom layer and the water absorbing middle layer are expanded and overlapped to be placed into a needling machine for needling, and then the non-woven fabric surface layer is placed on the water absorbing middle layer in an overlapping manner for needling. The medical analgesic and hemostatic dressing can stop bleeding rapidly, can also realize sedative and analgesic effects and has good biocompatibility and biodegradability.

A nasal applicator for nasally administering medicinal active pharmaceutical substances and / or ingredients, in particular painkillers or analgetics, includes a dosage device for dosedly discharging the active pharmaceutical substance, dosage determining logic for determining the discharged amount of active pharmaceutical substance as well as a locking device for locking the dosage device, in particular when the determined amount of discharged active pharmaceutical substance reaches a predetermined level. The locking device for locking the discharge dosage device is controlled by an electronic control device with a patient data memory into which an individual patient's control data may be inputted via an input device for individually locking the dosage device for a specific patient.

An antalgic Chinese medicine in the form of exterior-applied spray for treating soft tissue injury and periomethritis without toxic by-effect to liver is prepared from liquor and 16 Chinese-medicinal materials including Sichuan aconite root, myrrh, Chuan-xiong rhizome, rhubarb, etc.

A Chinese medicine for treating the trauma of animal is prepared from primary medicine, secondary medicine and matrix in the ratio of (15-20%): (3-4.4%) and (75.6-82%).

The present invention relates to a TRPV3 (transient receptor potential vanilloid 3) activity inhibitor, more precisely to a method for inhibiting TRPV3 activity including the step of treating isopentenyl pyrophosphate and a method for treating skin disease containing the step of administering isopentenyl pyrophosphate to a subject with skin disease or applying the same on the skin of the subject. Isopentenyl pyrophosphate of the present invention controls increase of sensory cell reactivity to current or migration and proliferation of skin cells induced by TRPV3, so that it can be effectively used for the development of a pain reliever or a therapeutic agent for skin disease.

The invention discloses a new preparation method for an aspirin-containing compound preparation, which is characterized in that: the aspirin-containing compound preparation is an internal and external multi-layer preparation consists of aspirin, and aluminum glycinate and heavy magnesium carbonate which are alkaline medicines; and an insulation layer is formed between the internal and externally-applied medicines to prevent the aspirin from contacting the alkaline medicines directly. The aluminum glycinate can neutralize gastric acid, relieve gastric acid increase, pain in upper abdomen and other clinic symptoms and has effects of astringing and stopping bleeding; and the heavy magnesium carbonate is an antiacid medicine and can reduce the adverse irritation of aspirin to the stomach, obviously reduce rate of gastric mucosal erosion and ulcer, thereby protecting the stomach.

The invention belongs to the technical field of medical apparatus and instruments, and in particular relates to a skin medicine-applying nursing instrument for the skin department. The skin medicine-applying nursing instrument for the skin department comprises a medicine storage barrel, a sucker, a medicine applying module, a resistance module, a medicine plugging module and a medicine injecting module, wherein the medicine storage barrel is a cylinder with a cavity inside, and the medicine storage barrel is used for storing ointment to be applied; the sucker is mounted at the bottom end of the medicine storage barrel, and the medicine storage barrel can be horizontally fixed to the surface of an object through the sucker; the medicine applying module is arranged on the medicine storage barrel, and the medicine applying module applies the ointment to the skin of the back through the extruding of the back; the resistance module is used for avoiding the excessive overflowing amount of the ointment due to the overlarge extrusion force of the back, so that waste can be avoided; the medicine plugging module is positioned in the medicine applying module, and is used for preventing flow-out of the ointment when medicine applying is not needed; the medicine injecting module is mounted on the medicine storage barrel, and the medicine injecting module is used for injecting ointment intothe medicine storage barrel. With the skin medicine-applying nursing instrument for the skin department, ointment applying can be carried out on any part of the back, and the applying process is easy.

The invention relates to a painkiller, which is a medicament prepared by kudzuvine root, hemlock parsley, angelica, ligusticum, white puncturevine caltrop fruit, Chinese magnoliavine fruit, dahurian angelica root, immature orange fruit, incised notopterygium rhizome or root, doubleteeth pubescent angelica root, longstamen onion bulb and giant typhonium rhizome, and is boiled in water for 30 minutes before taking. The invention has the functions of replenishing blood and nourishing yin, activating blood circulation and alleviating pain, relieving dizziness and dredging collaterals, obvious curative effects for treating refractory vascular headache and nervous headache, simple making method, low cost and no toxic side effects.

The invention discloses a formula and a preparation method for an externally-applied medicine capable of rapidly diminishing inflammation and relieving pain. The formula comprises, by mass, 3.5% of sorbitan olivate, 3% of cetearyl alcohol, 2% of squalane, 2% of iso-octyl palmitate, 2% of caprylic / capric triglyceride, 0.5% of xanthan gum, 4% of glycerin, 0.5% of azelaic acid, 2% of aloe, 1% of a honeysuckle flower extract, 1% of a chrysanthemum extract, 0.05% of a freshener (menthol), 0.1% of methyl hydroxybenzoate, 0.1% of propyl hydroxybenzoate, 0.15% of imidazolidinyl urea and 79.1% of water. The medicine is prepared by processing the above-mentioned components. The medicine provided by the invention uses herbaceous plants as raw materials and has small toxic and side effects; the medicine can be directly applied on the surface layer of the skin, targetedly reaches a desired site through rapid absorption by the skin, exerts good anti-inflammation and sterilization effects and has fast action.

A procedure for reducing the pain from orthopedic surgery, such as hip or knee replacement by injecting a mixture of components into the site of trauma (surgical incision or tissue twisting / stretching) before closing the wound. The mixture includes a local anesthetic agent, epinephrine, morphine and a corticosteroid.

The present invention provides compound having the structure and pharmaceutically acceptable salts or derivatives thereof, as well as compositions including such compounds. The invention also provides methods of (1) preventing pain, (2) treating pain, (3) inducing sedation, (4) treating opiate addiction, (5) treating opiate withdrawal (abstinence syndrome) and / or (6) treating cough in a patient in need thereof by administering a compound or composition of the invention.

The invention discloses a moist and regenerative burn liquid, which is prepared by decocting 80-120g of buffalo horn, 80-120g of honeysuckle flower, 80-120g of radix ophiopogonis, 40-80g of gardenla jasminoides Ellis, 80-120g of trichosanthes root, 80-120g of dahurian angelica root, 80-120g of raw rehmannia root, 40-80g of akebia stem and 80-120g of dandelion with water. The burn liquid of the invention has efficacies of clearing heat, detoxifying, diminishing inflammation, easing pain, removing necrosis, promoting granulation, moistening intestines, relaxing bowel and purging fire, and has characteristics of no scar after healing, no disability, no disfigurement, no granulation hyperplasia, no pigmentation, no functional disorder, no anodyne injection or anodyne administration during treatment. Besides, the burn liquid can eliminate pains in 20 minutes in order to rapidly eliminate pains, fantod, anxiety and mitigate mental pressure of a patient. The burn liquid of the invention has a short treatment period and low treatment costs; the wound can be scabbed in 7-12 days and shed automatically; and the patient can keep normal defecation, dietary and mental state during the treatment.

The invention relates to a system of medical supplies for sedation and analgesia, comprising an electronically controlled drug infusion device comprising an IV drug infusion device capable of controlling sedation or analgesia drug flow to the patient, a patient health monitor for collecting and providing the relevant patient physiology condition, and an electrical controller suitable for receiving the mark of the drug infusion device and service mode mark and adjusting infusion speed on the basis of data input by the user input and from the patient health monitor; and a disposable breathing apparatus detachably connected with the drug infusion device and suitable for one-time use and comprising the service mode mark communicated with the electrically controller.

Some embodiments of the present invention relate to a system, kit and method for providing therapy to a portion of a body. The system includes a holder and a therapeutic patch that is held by the holder. The therapeutic patch applies therapy to the portion of the body when the first patch is placed near the portion of the body. The system further includes an oral pain reliever that is held by the holder. The method includes selecting a therapeutic patch from a holder and applying the therapeutic patch near a portion of a body such that the therapeutic patch applies therapy to the portion of the body. The method further includes selecting an oral pain reliever from the holder and ingesting the oral pain reliever.

The invention discloses a Chinese herbal medicine pain-relieving medicinal moxibustion which is prepared from the raw materials of, by weight: 20-30 parts of carbon, 50-60 parts of wormwood, 8-10 parts of Mongolian milkvetch root, 15-20 parts of pilose asiabell root, 8-12 parts of common monkshood mother-root, 8-12 parts of divaricate saposhnikovia, 8-12 parts of ligusticum, 4-6 parts of safflower, 8-15 parts of wild celery, 8-12 parts of ovientvine stem, 8-12 parts of kadsura pepper twig and leaf, 8-10 parts of Chinese pine bark, 4-6 parts of agalloch eaglewood, 8-10 parts of banksian rose, 2-5 parts of borneol, 4-6 parts of Szechwan lovage rhizome, 12-18 parts of sandalwood, 8-10 parts of incised notopterygium rhizome and root, 8-10 parts of Manchurian wildginger herb, 8-10 parts of ligusticum, 8-10 parts of biod magnolia flower bud, and 8-10 parts of salvia miltiorrhiza. The Chinese herbal medicine pain-relieving medicinal moxibustion has the functions of activating blood circulation, removing stasis, dispelling wind evil, dispelling cold, supporting yang, strengthening the foundation, and regulating qi and blood. Through dredging meridians, pain relieving, muscle tone enhancing, muscle function recovering, blood circulation promoting, and nerve conduction promoting effects are provided. The medicinal moxibustion can be used for treating diseases such as common cold, bronchitis, asthma, stroke and sequelae, muscle atrophy, peripheral neuritis, neuronal damage, and the like. The medicinal moxibustion has the advantages of fast skin absorption, good treatment effect, no smoke toxicity, and no toxic or side effect.

The invention provides systems and methods for controlled dispensing of topical analgesics contained in a metered dispensing system. The systems and method are useful for treating signs and symptoms of osteoarthritis. The method includes depressing a hand pump to dispense a dose of a topical pain reliever in a viscous solution from the hand pump, wherein the hand pump is configured to dispense the dose within a tolerance specified by a corresponding label approved by a government regulatory agency; and spreading the topical solution on skin.