42 results about "Intractable pain" patented technology

A method for treating female sexual dysfunction by subcutaneous electrical stimulation of a peripheral nerve innervating at least a portion of the vulva is disclosed. A lead is placed subcutaneously over a peripheral nerve that innervates at least a portion of the vulva and clitoris. The peripheral nerve is electrically stimulated to cause paresthesia. The method encompasses subcutaneous placement of an electrical lead near any peripheral nerve innervating at least a portion of the vulva and subsequent electrical stimulation of the nerve to cause paresthesia. Further, a method for treating intractable pain of the vulva using percutaneous and subcutaneous peripheral nerve electrostimulation techniques is disclosed.

Methods are disclosed for increasing the effectiveness of dextromethorphan in treating chronic or intractable pain, for treating tinnitus and for treating sexual dysfunction comprising administering dextromethorphan in combination with a therapeutically effective dosage of a debrisoquin hydroxylase inhibitor. A preferred combination is dextromethorphan and the oxidative inhibitor quinidine.

Novel and advantageous delivery systems for the delivery of analgesic compounds and compositions to patients who are suffering from intractable pain are provided. In some embodiments, these patients already are under the background influence of an opioid agonist. The subject invention also provides methods of managing pain comprising the administration of analgesic compounds via transdermal or transmucosal delivery routes.

The present invention relates to methods of using lactoferrin (LF) to reduce pain in conditions associated with severe or intractable pain by administering a composition of lactoferrin either alone or in combination with other therapy for pain.

The invention discloses an agilawood health care essential oil, which contains the following components: 8-20% of agilawood immersion oil, 0.5-1% of ginseng essential oil, 1-5% of aloe oil, 0.5-3% of cypress essential oil, 0.5-5% of frankincense essential oil, 0.5-3% of tea tree oil and 69-85% of grape seed essential oil. The agilawood health care essential oil provided by the invention employs traditional Chinese medicine extracted essential oil and pure natural plant ingredients, and utilizes the role of guiding drug of eaglewood to quickly act effective components on the pathological position and generate a significant effect. Through massage during usage, the essential oil can relieve intractable pain (cervical spondylosis, rheumatism and rheumatoid), toothache and muscle strain, and can be applied directly to the affected area to achieve the effects of relieving inflammation and swelling, removing acne and scar, killing pain, treating hemorrhoids and promoting wound healing. Through massage or aromatherapy, the agilawood health care essential oil provided by the invention can also relieve dizziness and improve sleep quality.

The invention relates to a Chinese patent medicine for treating climacteric syndrome and a preparation method thereof. The Chinese patent medicine is a pure traditional Chinese medicine capsule preparation, does not have any chemical pharmaceutical ingredient and any toxic or side effect, has the advantages of convenient use, short course of treatment, rapid effect taking and stable curative effect and is a first-choice Chinese patent medicine for treating climacteric syndrome. The Chinese patent medicine is prepared from the Chinese medicinal herbs of epimedium herbs, oyster, rhizoma anemarrhenae, cherokee rose fruits, golden cypress, plantain seeds, ginseng, mulberry, Chinese angelica, walnut kernels, pilos antler, malaytea scurfpea fruits, teasel roots, vine of multiflower knotweed, white paeony roots, fleece-flower roots (prepared), bidentate achyranthes roots, licorice roots, prepared rehmannia roots and the like as raw materials by combining traditional and modern Chinese medicine theories through optimized combination and scientific compatibility. The capsule dosage for treating climacteric syndrome is prepared by using the advanced modern Chinese medicine preparation technology through raw material pretreatment, water extraction, alcohol precipitation, concentration, granulation, capsule packing, inspection, identification and the like. The capsule has the functions of nourishing the heart and the kidney, regulating and supplementing Chong and Ren Channels and is used for treating climacteric syndrome comprising insomnia, palpitation, tinnitus, suspiciousness, sentimentalism, sweating, dysphoria, irritability, backache and the like occurring before and after menopause, and has obvious effect of alleviating intractable pain of patients with climacteric syndrome.

A method for treating intractable pain via electrical stimulation of the spinal cord. Remote, non-contact stimulation of a selected region of spinal cord is achieved by placement of a transceiver patch directly on the surface of that region of spinal cord, with said patch optionally being inductively coupled to a transmitter patch of similar size on either the outer or inner wall of the dura surrounding that region of the spinal cord. By inductively exchanging electrical power and signals between said transmitter and transceiver patches, and by carrying out the necessary electronic and stimulus signal distribution functions on the transceiver patch, the targeted dorsal column axons can be stimulated without the unintended stray stimulation of nearby dorsal rootlets. Novel configurations of a pliable surface-sheath and clamp or dentate ligament attachment features which realize undamaging attachment of the patch to the spinal cord are described.

The invention relates to spinal cord stimulation with interferential current. According to the invention, a stimulator and a method for the treatment of intractable pain syndromes by electrical stimulation of the spinal cord are disclosed. An example method includes positioning a first pair of implantable electrodes to a dura matter in an epidural space proximate to a subject's spinal cord at predetermined locations, positioning a second pair of implantable electrodes to the dura matter in the epidural space proximate to the subject's spinal cord at predetermined locations, and transmitting signals of first and second frequencies through the first and second pairs of implantable electrodes respectively, so that the signals of the first and second frequencies interfere with each other to produce at least one beat signal proximate to the subject's spinal cord. The at least one beat signal has a frequency within a range of more than 250 Hz to about 15,000 Hz.

Disclosed a pharmaceutical composition including one of crotoxin, mojavetoxin or a related toxin and a carrier for use in the treatment of chronic pain, especially to the treatment of heretofore intractable pain such as that associated with advanced cancer wherein the treatment is independent of the reduction of tumors. The crotoxin is preferably obtained from the snake Crotalus durissus terrificus and the mojavetoxin is obtained from the rattlesnake Crotalus scutulatus scutulatus. Preferably the composition further comprises an effective amount of acetylsalicylic acid whereby the toxin and acetylsalicylic acid together produce a synergistic effect providing enhanced pain relief. The composition of the invention may be delivered in parenteral (i.p.) (intravenous, intramuscular or subcutaneous) applications. Alternatively, the composition may be applied as a topical application. The biological activity of the composition is characterized by its ability to bind to presynaptic and postsynapic receptor sites. This results in an inhibition of aceylcholine release and activity.

The invention provides medicinal liquor for treating intractable wind-cold pain. The medicinal liquor is prepared by adding the following medicines into 5000g of liquor, wherein the medicines include 50g of radix angelicae sinensis, 30g of radix rehmanniae, 30g of stir-baked radix paeonlae alba, 15g of ligusticum wallichii, 10g of cassia twig, 10g of costus root, 15g of frankincense, 15g of myrrh, 15g of prepared aconite wild aconite main root, 15g of radix angelicae tuhuo, 30g of radices cyathulae and 10g of liquorice, and the medicinal liquor can be orally taken after all the above medicines are soaked for 7 days twice each day, once before lunch, once before supper, and 50-80g each time. The medicinal liquor provided by the invention can achieve the effects of regulating qi and blood, warming and activating meridian, eliminating impediment and killing pain, can be applied to treating the intractable wind-cold pain, and can treat both symptoms and root causes.

Intractable pain is a horrific cause of world-wide suffering. Nervous system excitation is a hallmark of intractable pain and lesioning of excited pathways and structures can produce sustained analgesia. This invention shows that red blood cells exposed to changing magnetic fields are disrupted, releasing hemoglobin, and that this effect is related to the dose (conformation, frequency, strength and duration) of the changing magnetic fields. Extrapolating these finding to the nervous system, transcranial magnetic lesioning of select areas of the central nervous system, in particular the anterior cingulate cortex or anterior cingulate cortices, can provide relief for patients who suffer devastating intractable pain. The changing magnetic fields are produced by electrical current through a Helmholtz coil with a soft iron core. Focusing the magnetic fields within a Helmholtz coil has advantages over focusing radiation or ultrasound because the brain can be stimulated before lesioning and the intensity of the magnetic fields can be changed according to the gap distance between the coil. In addition magnetic lesioning of tissues other than that within the nervous system may possibly provide “bloodless” surgery without exposure to radiation.

The invention belongs to the field of medical supplies, and provides an anesthesia dressing and a preparation method thereof. The anesthetic dressing comprises an anesthetic layer and a heating layer, the anesthetic layer is gel containing anesthetic and anesthetic sustained-release microspheres, and the heating layer sequentially comprises an isolating membrane adjacent to the anesthetic layer, a self-heating material and a breathable membrane. The anesthesia dressing provided by the invention is simple and convenient to use and convenient to apply, and does not need to be cleaned after being used; the anesthesia medicine and the anesthesia medicine slow-release micro-capsule are used in cooperation to prolong the duration of the anesthesia effect, the onset time of the anesthesia medicine is shortened in a heating mode, and therefore the anesthesia dressing has the advantages of being fast in onset of the anesthesia effect and long in duration of the anesthesia effect, can be widely applied to various surgeries needing surface anesthesia, and is suitable for various surgeries needing surface anesthesia. And the anesthesia dressing can be conveniently applied to postoperative analgesia and treatment of various intractable pains.

The present invention relates to a magnetic medicine microsphere for directively-destroying dorsal root of spinal nerve and its preparation method. It is formed from magnetic material, skeletno material and nerve destroying agent, and is made up by adopting the processes of physical adsorption or emulsifying, crosslinking and embedding. Said invention can be effectively used for curing obstinacy pain and pain of late cancer. It is a safe and effective nerve destroying agent.

The invention discloses an analgesic and antipruritic pharmaceutical composition and an application method thereof, and belongs to the technical field of medical chemistry. The research of the invention finds that the analgesic effect generated by independently inhibiting the activity of Nav1.7 or Nav1.8 is reduced along with the time history of peripheral nerve injury, and also finds that a neuropathic pain mouse with poor response to the Nav1.7 small-molecule inhibitor has better response to the Nav1.8 small-molecule inhibitor. According to the discovery, the analgesic effect of combined administration of different Nav1.7 inhibitors and Nav1.8 inhibitors is researched, and it is found that the analgesic effect can be remarkably improved and the response rate can be increased to 100% by combined administration of appropriate doses of the Nav1.7 inhibitor PF-05089771 and the Nav1.8 inhibitor PF-04885614. Therefore, the composition of the PF-05089771 and the PF-04885614 can be used for treating diseases caused by too high activity of the Nav1.7 or the Nav1.8, and the diseases include but are not limited to intractable pain and itching.

The invention discloses a Chinese herbal ointment and a preparation method thereof. Raw materials include 8 to 15 parts of each of various flower herbs, 120 to 180 parts of each of various branch herbs, 120 to 180 parts of each of various disperse drugs, and other types: 280 to 320 parts of rheum officinale, 80 to 120 parts of centipedes, 80 to 120 parts of pillis ophidiae, 280 to 320 parts of male hair, 7,000 to 8,000 parts of sesame oil, 7,0000 to 8,0000 parts of rosin and 2,000 to 3,000 parts of plant soot. All the drugs are added in the sesame oil to dip; all the drugs are placed in a container to decoct until the drugs are dried up and the oil turns black and forms beads when being dripped into water; dregs are filtered out, the medicinal oil is weighed, and 400 parts of medicinal oil and 2,500 parts of rosin are decocted until the oil does not disperse when being dripped into water; and 50 to 100 parts of plant soot are added. The Chinese herbal ointment can soften hard lumps, clear and activate the channels and collaterals, manage Qi and activate blood, relieve pain, diminish inflammation and swelling, clear heat and remove toxicity, remove thyroid and tumors, prevent corrosion and ulceration and promote granulation. In addition, the Chinese herbal ointment can eliminate pathogen, strengthen vital qi and treat all pains from rheumatism, and the cure rate reaches 85% or more than 85%. The Chinese herbal ointment is mainly used for treating various cervical vertebra pains and various scabies, sores, deep-rooted ulcers, malignant pyogenic infections and intractable pains.

The invention discloses a medicine formula for treating aseptic inflammation and a use method thereof. The medicine formula comprises a basic formula and improved formulas of the medicine, wherein thebasic formula comprises 2.5ml of 2% lidocaine injection, 1-2mg of Vitb12 injection, 100-200mg of Vitb1 injection, 1-1.5mg of dexamethasone injection and 10-20mg of normal saline; the first improved formula comprises the following steps: adding 4ml of ilongshu injection into the basic formula; the second improved formula comprises the following steps: removing 100-200mg of Vitb1 injection in the basic formula and replacing with 4ml of bone peptide injection; the third improved formula comprises the following steps: adding 4ml of ligustrazine injection into the basic formula; the fourth improved formula comprises the following steps: combining the basic formula with 4ml of betahistine injection and performing local acupoint injection. According to the invention, the intractable pain of thepatient in clinic can be solved, the happening speed of senile degeneration can be delayed and the life quality of the patient can be promoted.