42 results about "Intractable pain" patented technology

A method for treating female sexual dysfunction by subcutaneous electrical stimulation of a peripheral nerve innervating at least a portion of the vulva is disclosed. A lead is placed subcutaneously over a peripheral nerve that innervates at least a portion of the vulva and clitoris. The peripheral nerve is electrically stimulated to cause paresthesia. The method encompasses subcutaneous placement of an electrical lead near any peripheral nerve innervating at least a portion of the vulva and subsequent electrical stimulation of the nerve to cause paresthesia. Further, a method for treating intractable pain of the vulva using percutaneous and subcutaneous peripheral nerve electrostimulation techniques is disclosed.

Methods are disclosed for increasing the effectiveness of dextromethorphan in treating chronic or intractable pain, for treating tinnitus and for treating sexual dysfunction comprising administering dextromethorphan in combination with a therapeutically effective dosage of a debrisoquin hydroxylase inhibitor. A preferred combination is dextromethorphan and the oxidative inhibitor quinidine.

Novel and advantageous delivery systems for the delivery of analgesic compounds and compositions to patients who are suffering from intractable pain are provided. In some embodiments, these patients already are under the background influence of an opioid agonist. The subject invention also provides methods of managing pain comprising the administration of analgesic compounds via transdermal or transmucosal delivery routes.

The invention relates to a quadruple long-acting medicine composition and application thereof to pain treatment, in particular to the quadruple long-acting medicine composition. The medicine composition contains lappaconitine, tetrahydropalmatine, fumaric acid and succinic acid of the treatment and / or effective quantity as active ingredients. Compared with a composition formed by single ingredients or two ingredients or three ingredients, the quadruple long-acting medicine composition has the characteristics of good water solubility, good curative effect, low toxic and side effects and the like. The quadruple long-acting medicine composition can be used for preventing and / or treating diseases relevant to the pain; the pain includes tumor pain, pain of cancer patients after chemotherapy, joint pain, trauma pain, postoperative pain, inflammatory pain, pain caused by drug detoxification or drug addicition and intractable pain due to unknown reasons. The quadruple long-acting medicine composition can also be used for sedation, hypnosis, collaborative anesthesia, antiarrhythmia and the like.

The disclosed invention is a composition of matter, a process of production thereof, and a method for the treatment of chronic pain, especially to the treatment of heretofore intractable pain as associated with advanced cancer, neurological conditions and rheumatoid arthritis. The treatment of pain associated with viral infections and lesions are also within the contemplation of the present invention. The composition of matter comprises modified alpha-neurotoxins or modified venoms known to contain alpha-neurotoxins in an acceptable carrier for either parenteral, oral or topical administration.

A composition of matter for an analgesia and its method of use is disclosed. The method of use is for the treatment of chronic pain, especially to the treatment of heretofore intractable pain as associated with advanced cancer. The pain associated with neurological conditions, rheumatoid arthritis, viral infections and lesions is also contemplated. The method includes administering to a host an alpha-neurotoxin that is characterized by its ability to blocking of the action of acetylcholine at nicotinic acetylcholine receptors.

The present invention relates to methods of using lactoferrin (LF) to reduce pain in conditions associated with severe or intractable pain by administering a composition of lactoferrin either alone or in combination with other therapy for pain.

The invention discloses an agilawood health care essential oil, which contains the following components: 8-20% of agilawood immersion oil, 0.5-1% of ginseng essential oil, 1-5% of aloe oil, 0.5-3% of cypress essential oil, 0.5-5% of frankincense essential oil, 0.5-3% of tea tree oil and 69-85% of grape seed essential oil. The agilawood health care essential oil provided by the invention employs traditional Chinese medicine extracted essential oil and pure natural plant ingredients, and utilizes the role of guiding drug of eaglewood to quickly act effective components on the pathological position and generate a significant effect. Through massage during usage, the essential oil can relieve intractable pain (cervical spondylosis, rheumatism and rheumatoid), toothache and muscle strain, and can be applied directly to the affected area to achieve the effects of relieving inflammation and swelling, removing acne and scar, killing pain, treating hemorrhoids and promoting wound healing. Through massage or aromatherapy, the agilawood health care essential oil provided by the invention can also relieve dizziness and improve sleep quality.

The invention belongs to the technical field of essential oil and particularly discloses folium artemisiae argyi health-care essential oil and a preparation method thereof. The folium artemisiae argyi health-care essential oil comprises the following raw materials in parts by weight: 0.5-2 parts of folium artemisiae argyi essential oil, 54-60 parts of camellia oil, 30-36 parts of jojoba oil, 10-18 parts of avocado oil and 1-3 parts of vitamin E. The folium artemisiae argyi health-care essential oil has the effects of eliminating swelling and stopping pain, can be directly smeared at the affected part to achieve the purposes of diminishing inflammation and eliminating swelling, can also relieve intractable pain, toothache, muscular strain and the like, and is simple in formula and preparation method, stable in system and long in shelf life.

To provide an amorphous composition for nasal administration or for administration by adhering to oral mucosa in which absorption property and chemical and physical stabilities of (2R)—N-(1-benzylpiperidin-4-yl)-3-cyclohexylmethylthio-2-[(4R)-3-tert-butoxycarbonylthiazolidin-4-ylcarbonylamino]propanamide which is useful as an N type calcium channel inhibitor are improved. A preparation comprising the amorphous composition of the present invention has been found to be excellent in physical stability and chemical stability and to be useful as a nasal preparation or a preparation for adhering to the oral mucosa. As a result, the resulting preparation has a high BA value and is useful for prevention and / or the treatment of a disease mediated by the N type calcium channel including pain (such as neuropathic pain, cancerous pain, intractable pain, postoperative pain, acute pain, chronic pain, neuralgia and infectious pain).

This invention discloses that a combination of two drugs, from two different and previously unrelated categories, provides effective and long-lasting relief from neuropathic pain. Both drugs can be taken orally, in a convenient, painless, non-invasive manner that does not require injections. One drug in this combination is an alpha2 adrenergic agonist, exemplified by clonidine. The other drug in the pain-relieving combination has a tri-cyclo-alkyl-amine (TCAA) structure. At least some TCAA drugs have antagonist (receptor-blocking) activity at two entirely different classes of neuronal receptors: the muscarinic subclass of acetylcholine (ACh) receptors, and the NMDA subclass of glutamate receptors. Such drugs include ethopropazine, normally used as an anti-cholinergic drug, and desipramine, normally used as an anti-depressant. Tests by the Applicants have shown that at least some TCAA drugs can relieve neuropathic pain to a limited extent, but at the doses required to relieve pain, they cause adverse side effects, and any pain relief is relatively brief and short-lived. However, when a TCAA drug such as ethopropazine is administered together with an alpha2 adrenergic agonist such as clonidine, these drugs mutually potentiate one another's neuropathic pain-relieving action, and provide potent and sustained neuropathic pain relief, even when each agent is administered at a low dosage that is below its threshold for causing adverse side effects. Accordingly, this drug combination can provide safe and effective relief of neuropathic pain and possibly other types of chronic and / or intractable pain, at dosages which are so low that they do not pose serious risks of adverse side effects.

A precise transfusion apparatus for antalgic purpose is composed of a protective casing with a three-way supporter in it, an elastic medicine bag, flow regulator, dripping hopper, guide tube, filter, needle jointer and needle. Its advantages are simple structure, uniform transfusion speed, and high antalgic effect.

A composition of matter for an analgesia and its method of use is disclosed. The method of use is for the treatment of chronic pain, especially to the treatment of heretofore intractable pain as associated with advanced cancer. The pain associated with neurological conditions, rheumatoid arthritis, viral infections and lesions is also contemplated. The method includes administering to a host an alpha-neurotoxin that is characterized by its ability to blocking of the action of acetylcholine at nicotinic acetylcholine receptors.

The invention relates to a Chinese patent medicine for treating climacteric syndrome and a preparation method thereof. The Chinese patent medicine is a pure traditional Chinese medicine capsule preparation, does not have any chemical pharmaceutical ingredient and any toxic or side effect, has the advantages of convenient use, short course of treatment, rapid effect taking and stable curative effect and is a first-choice Chinese patent medicine for treating climacteric syndrome. The Chinese patent medicine is prepared from the Chinese medicinal herbs of epimedium herbs, oyster, rhizoma anemarrhenae, cherokee rose fruits, golden cypress, plantain seeds, ginseng, mulberry, Chinese angelica, walnut kernels, pilos antler, malaytea scurfpea fruits, teasel roots, vine of multiflower knotweed, white paeony roots, fleece-flower roots (prepared), bidentate achyranthes roots, licorice roots, prepared rehmannia roots and the like as raw materials by combining traditional and modern Chinese medicine theories through optimized combination and scientific compatibility. The capsule dosage for treating climacteric syndrome is prepared by using the advanced modern Chinese medicine preparation technology through raw material pretreatment, water extraction, alcohol precipitation, concentration, granulation, capsule packing, inspection, identification and the like. The capsule has the functions of nourishing the heart and the kidney, regulating and supplementing Chong and Ren Channels and is used for treating climacteric syndrome comprising insomnia, palpitation, tinnitus, suspiciousness, sentimentalism, sweating, dysphoria, irritability, backache and the like occurring before and after menopause, and has obvious effect of alleviating intractable pain of patients with climacteric syndrome.

The invention discloses a Chinese herbal medicine capsule for curing chronic refractory pain, which is made through grinding, sieving, sterilizing and canning acanthopanax bark, pittosporumtobira bark, hedgedog skin, wolfberry bark, cassia bark bark, deer bone, dog bone, cat bone, tortoise shell, inkfish bone, whole worm, centipede, earthworm, leech, mole cricket, milettia reticulate, caulis trachelospermi, Japanese sabia, marsdenia officinalis, sargentgloryvine, coix seed, dodder, Buguzi, perilla and nux vomica. The Chinese herbal medicine capsule is used for curing chronic refractory pain such as low back and leg pain, joint pain and various naturopathic pains.

A method for treating intractable pain via electrical stimulation of the spinal cord. Remote, non-contact stimulation of a selected region of spinal cord is achieved by placement of a transceiver patch directly on the surface of that region of spinal cord, with said patch optionally being inductively coupled to a transmitter patch of similar size on either the outer or inner wall of the dura surrounding that region of the spinal cord. By inductively exchanging electrical power and signals between said transmitter and transceiver patches, and by carrying out the necessary electronic and stimulus signal distribution functions on the transceiver patch, the targeted dorsal column axons can be stimulated without the unintended stray stimulation of nearby dorsal rootlets. Novel configurations of a pliable surface-sheath and clamp or dentate ligament attachment features which realize undamaging attachment of the patch to the spinal cord are described.

The invention relates to spinal cord stimulation with interferential current. According to the invention, a stimulator and a method for the treatment of intractable pain syndromes by electrical stimulation of the spinal cord are disclosed. An example method includes positioning a first pair of implantable electrodes to a dura matter in an epidural space proximate to a subject's spinal cord at predetermined locations, positioning a second pair of implantable electrodes to the dura matter in the epidural space proximate to the subject's spinal cord at predetermined locations, and transmitting signals of first and second frequencies through the first and second pairs of implantable electrodes respectively, so that the signals of the first and second frequencies interfere with each other to produce at least one beat signal proximate to the subject's spinal cord. The at least one beat signal has a frequency within a range of more than 250 Hz to about 15,000 Hz.

Disclosed a pharmaceutical composition including one of crotoxin, mojavetoxin or a related toxin and a carrier for use in the treatment of chronic pain, especially to the treatment of heretofore intractable pain such as that associated with advanced cancer wherein the treatment is independent of the reduction of tumors. The crotoxin is preferably obtained from the snake Crotalus durissus terrificus and the mojavetoxin is obtained from the rattlesnake Crotalus scutulatus scutulatus. Preferably the composition further comprises an effective amount of acetylsalicylic acid whereby the toxin and acetylsalicylic acid together produce a synergistic effect providing enhanced pain relief. The composition of the invention may be delivered in parenteral (i.p.) (intravenous, intramuscular or subcutaneous) applications. Alternatively, the composition may be applied as a topical application. The biological activity of the composition is characterized by its ability to bind to presynaptic and postsynapic receptor sites. This results in an inhibition of aceylcholine release and activity.

A method for treating intractable pain via electrical stimulation of the spinal cord. Remote, non-contact stimulation of a selected region of spinal cord is achieved by placement of a transceiver patch directly on the surface of that region of spinal cord, with said patch optionally being inductively coupled to a transmitter patch of similar size on either the outer or inner wall of the dura surrounding that region of the spinal cord. By inductively exchanging electrical power and signals between said transmitter and transceiver patches, and by carrying out the necessary electronic and stimulus signal distribution functions on the transceiver patch, the targeted dorsal column axons can be stimulated without the unintended stray stimulation of nearby dorsal rootlets. Novel configurations of a pliable surface-sheath and clamp or dentate ligament attachment features which realize undamaging attachment of the patch to the spinal cord are described.

The invention provides medicinal liquor for treating intractable wind-cold pain. The medicinal liquor is prepared by adding the following medicines into 5000g of liquor, wherein the medicines include 50g of radix angelicae sinensis, 30g of radix rehmanniae, 30g of stir-baked radix paeonlae alba, 15g of ligusticum wallichii, 10g of cassia twig, 10g of costus root, 15g of frankincense, 15g of myrrh, 15g of prepared aconite wild aconite main root, 15g of radix angelicae tuhuo, 30g of radices cyathulae and 10g of liquorice, and the medicinal liquor can be orally taken after all the above medicines are soaked for 7 days twice each day, once before lunch, once before supper, and 50-80g each time. The medicinal liquor provided by the invention can achieve the effects of regulating qi and blood, warming and activating meridian, eliminating impediment and killing pain, can be applied to treating the intractable wind-cold pain, and can treat both symptoms and root causes.

Intractable pain is a horrific cause of world-wide suffering. Nervous system excitation is a hallmark of intractable pain and lesioning of excited pathways and structures can produce sustained analgesia. This invention shows that red blood cells exposed to changing magnetic fields are disrupted, releasing hemoglobin, and that this effect is related to the dose (conformation, frequency, strength and duration) of the changing magnetic fields. Extrapolating these finding to the nervous system, transcranial magnetic lesioning of select areas of the central nervous system, in particular the anterior cingulate cortex or anterior cingulate cortices, can provide relief for patients who suffer devastating intractable pain. The changing magnetic fields are produced by electrical current through a Helmholtz coil with a soft iron core. Focusing the magnetic fields within a Helmholtz coil has advantages over focusing radiation or ultrasound because the brain can be stimulated before lesioning and the intensity of the magnetic fields can be changed according to the gap distance between the coil. In addition magnetic lesioning of tissues other than that within the nervous system may possibly provide “bloodless” surgery without exposure to radiation.

The invention belongs to the field of medical supplies, and provides an anesthesia dressing and a preparation method thereof. The anesthetic dressing comprises an anesthetic layer and a heating layer, the anesthetic layer is gel containing anesthetic and anesthetic sustained-release microspheres, and the heating layer sequentially comprises an isolating membrane adjacent to the anesthetic layer, a self-heating material and a breathable membrane. The anesthesia dressing provided by the invention is simple and convenient to use and convenient to apply, and does not need to be cleaned after being used; the anesthesia medicine and the anesthesia medicine slow-release micro-capsule are used in cooperation to prolong the duration of the anesthesia effect, the onset time of the anesthesia medicine is shortened in a heating mode, and therefore the anesthesia dressing has the advantages of being fast in onset of the anesthesia effect and long in duration of the anesthesia effect, can be widely applied to various surgeries needing surface anesthesia, and is suitable for various surgeries needing surface anesthesia. And the anesthesia dressing can be conveniently applied to postoperative analgesia and treatment of various intractable pains.

The present invention relates to a magnetic medicine microsphere for directively-destroying dorsal root of spinal nerve and its preparation method. It is formed from magnetic material, skeletno material and nerve destroying agent, and is made up by adopting the processes of physical adsorption or emulsifying, crosslinking and embedding. Said invention can be effectively used for curing obstinacy pain and pain of late cancer. It is a safe and effective nerve destroying agent.

The invention discloses an analgesic and antipruritic pharmaceutical composition and an application method thereof, and belongs to the technical field of medical chemistry. The research of the invention finds that the analgesic effect generated by independently inhibiting the activity of Nav1.7 or Nav1.8 is reduced along with the time history of peripheral nerve injury, and also finds that a neuropathic pain mouse with poor response to the Nav1.7 small-molecule inhibitor has better response to the Nav1.8 small-molecule inhibitor. According to the discovery, the analgesic effect of combined administration of different Nav1.7 inhibitors and Nav1.8 inhibitors is researched, and it is found that the analgesic effect can be remarkably improved and the response rate can be increased to 100% by combined administration of appropriate doses of the Nav1.7 inhibitor PF-05089771 and the Nav1.8 inhibitor PF-04885614. Therefore, the composition of the PF-05089771 and the PF-04885614 can be used for treating diseases caused by too high activity of the Nav1.7 or the Nav1.8, and the diseases include but are not limited to intractable pain and itching.

The invention discloses a Chinese herbal ointment and a preparation method thereof. Raw materials include 8 to 15 parts of each of various flower herbs, 120 to 180 parts of each of various branch herbs, 120 to 180 parts of each of various disperse drugs, and other types: 280 to 320 parts of rheum officinale, 80 to 120 parts of centipedes, 80 to 120 parts of pillis ophidiae, 280 to 320 parts of male hair, 7,000 to 8,000 parts of sesame oil, 7,0000 to 8,0000 parts of rosin and 2,000 to 3,000 parts of plant soot. All the drugs are added in the sesame oil to dip; all the drugs are placed in a container to decoct until the drugs are dried up and the oil turns black and forms beads when being dripped into water; dregs are filtered out, the medicinal oil is weighed, and 400 parts of medicinal oil and 2,500 parts of rosin are decocted until the oil does not disperse when being dripped into water; and 50 to 100 parts of plant soot are added. The Chinese herbal ointment can soften hard lumps, clear and activate the channels and collaterals, manage Qi and activate blood, relieve pain, diminish inflammation and swelling, clear heat and remove toxicity, remove thyroid and tumors, prevent corrosion and ulceration and promote granulation. In addition, the Chinese herbal ointment can eliminate pathogen, strengthen vital qi and treat all pains from rheumatism, and the cure rate reaches 85% or more than 85%. The Chinese herbal ointment is mainly used for treating various cervical vertebra pains and various scabies, sores, deep-rooted ulcers, malignant pyogenic infections and intractable pains.

A precise transfusion apparatus for antalgic purpose is composed of a protective casing with a three-way supporter in it, an elastic medicine bag, flow regulator, dripping hopper, guide tube, filter, needle jointer and needle. Its advantages are simple structure, uniform transfusion speed, and high antalgic effect.

The invention provides a GST fusion expression of the conotoxin MVII A gene and its application. The GST-CTX MVII A recombinant fusion protein is cloned and expressed in Escherichia coli, and purified by GST affinity chromatography to obtain purified GST-CTX MVII A fusion protein. The fusion protein obtained by the present invention can be used in the preparation of intractable pain medicines for treating advanced cancer and AIDS patients, and can also be used in the preparation of analgesics for treating acute pain after surgery, burns, biliary colic patients, refractory neuralgia, etc. Because of its neuroprotective effect, it can also be used in the preparation of therapeutic drugs for cerebral ischemia and brain damage. The technique of the present invention is simple, stable in quality, and cost is lower, and the fusion protein molecular weight that obtains is larger, and the half-life (t 1 / 2 ) is longer and can be used as an intermediate to obtain active ω-conotoxin MVII A small peptide through enzyme digestion, which can be directly used for drug development.

The invention discloses a medicine formula for treating aseptic inflammation and a use method thereof. The medicine formula comprises a basic formula and improved formulas of the medicine, wherein thebasic formula comprises 2.5ml of 2% lidocaine injection, 1-2mg of Vitb12 injection, 100-200mg of Vitb1 injection, 1-1.5mg of dexamethasone injection and 10-20mg of normal saline; the first improved formula comprises the following steps: adding 4ml of ilongshu injection into the basic formula; the second improved formula comprises the following steps: removing 100-200mg of Vitb1 injection in the basic formula and replacing with 4ml of bone peptide injection; the third improved formula comprises the following steps: adding 4ml of ligustrazine injection into the basic formula; the fourth improved formula comprises the following steps: combining the basic formula with 4ml of betahistine injection and performing local acupoint injection. According to the invention, the intractable pain of thepatient in clinic can be solved, the happening speed of senile degeneration can be delayed and the life quality of the patient can be promoted.

The present invention relates to one kind of method and preparation for chronic intractable pain, and is especially the preparation process and preparation of one kind of orally taken immune globulin for treating chronic intractable pain. The present invention features that orally taken immune globulin is prepared from ox serum, cow colostrums or milk, or specific immune globulin is prepared from cow colostrums or milk of pregnant cow or dairy cow inoculated with multivalent antigen deactivated bacteria vaccine. The orally taken immune globulin is used in treating chronic intractable pain of patient without local organic pathological changes.