Preparation for treating intractable chronic pain and its preparing process

A chronic pain and intractable technology, applied in the direction of non-central analgesics, medical preparations containing active ingredients, anti-inflammatory agents, etc., can solve side effects, can not find pathological anatomical abnormalities of painful parts, and patient addiction, etc. problem, to achieve the effect of improving pain symptoms, easy to promote on a large scale, and reducing side effects

Inactive Publication Date: 2004-12-29
高春平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is a kind of chronic pain that often lasts for months to years, or even decades, and the relationship between the cause of this chronic pain and any acute or chronic disease has not been found, nor can any pathological anatomical abnormalities in the pain site be found, Usually such patients are accompanied by serious emotional abnormalities. If the pain cannot be controlled in time, it will cause severe depression or even suicidal tendencies. If taking morphine, meperidine and other analgesics is effective, the patient will take it for a long time and become addicted. Sometimes the patient Taking psychotropic drugs can also produce some curative effects, but long-term use can also cause serious side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preparation of immunoglobulins from bovine colostrum

[0021] Collect 10 liters of bovine colostrum, centrifuge at 3500 rpm for 20 minutes to defat, adjust the pH value of defatted colostrum to 4.8 with 1N HCL, heat to 40°C for 30 minutes, let stand at 4°C overnight, and use a nylon cloth filter in the next morning Filter out the coagulated casein white, collect the supernatant, and use a vacuum pump to draw the supernatant to the cross section fluid ultrafiltration device. The ultrafiltration membrane used has a molecular weight of 100,000D, the inlet pressure is 3Bar, and the outlet pressure is 2Bar. Collect and concentrate Liquid, spray drying, drying tower temperature is 140 ° F, the preparation of dry powder standby, contains rich immunoglobulin in the prepared dry powder.

Embodiment 2

[0023] Immunization of dairy cows, preparation of specific immunoglobulins

[0024] Purchase Campylobacter jejuni, Helicobacter pylori, human pathogenic coli (Yersinia) bacilli, and Borrelia burgdorferi, inoculate them in conventional bacterial culture medium, cultivate them at 37°C for 48 hours, and heat them to 60°C for 2 hours to kill them. For live bacteria, wash five times with double distilled water, centrifuge and separate the bacteria, freeze-dry them into dry powder, mix the above-mentioned dry powder of bacteria in equal amounts, add normal saline to prepare a concentration of 2.times.10.sup.8cells / ml The polyvalent antigen vaccine of the healthy dairy cow is selected, and 5ml is injected intramuscularly in the buttocks, and the injection is repeated once every two weeks, and the injection is repeated four times. way to prepare immunoglobulins.

Embodiment 3

[0026] clinical validation

[0027] Randomly select 8 patients with chronic pain, 4 males and 4 females, aged from 25 to 35 years old, all have suffered from chronic pain for at least half a year, no local pathological and anatomical lesions in X-ray examination, the pain is mainly manifested in the joints, the patients Oral administration of the immunoglobulin prepared in Example 1 per person 10g / day, taking continuously for 3 months, wherein 6 patients (75%) had significantly improved pain, basically stopped using analgesics, and another 2 patients (25%) had pain There was some improvement, and the dosage of analgesics was reduced by more than half.

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PUM

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Abstract

The present invention relates to one kind of method and preparation for chronic intractable pain, and is especially the preparation process and preparation of one kind of orally taken immune globulin for treating chronic intractable pain. The present invention features that orally taken immune globulin is prepared from ox serum, cow colostrums or milk, or specific immune globulin is prepared from cow colostrums or milk of pregnant cow or dairy cow inoculated with multivalent antigen deactivated bacteria vaccine. The orally taken immune globulin is used in treating chronic intractable pain of patient without local organic pathological changes.

Description

Technical field [0001] The present invention relates to a method and preparation for treating chronic intractable pain, in particular to a method and preparation for preparing oral immunoglobulin for treating chronic intractable pain. technical background [0002] Pain is a physiological reaction of human beings. It is used to warn the human body of attack and injury. Pain generally has a clear cause. Once the cause is removed, the pain often disappears. However, there is a kind of chronic pain that often lasts for months to years, or even decades, and the relationship between the cause of this chronic pain and any acute or chronic disease has not been found, nor can any pathological anatomical abnormalities in the pain site be found, Usually such patients are accompanied by serious emotional abnormalities. If the pain cannot be controlled in time, it will cause severe depression or even suicidal tendencies. If taking morphine, meperidine and other analgesics is effective, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/20A61K39/02A61K39/395A61P25/04A61P29/00
Inventor 高春平
Owner 高春平
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