Application of ketorolac to preparation of medicine for preventing or treating postoperative recurrence of endometriosis

Abstract

The invention relates to application of ketorolac to preparation of a medicine for preventing or treating postoperative recurrence of endometriosis. According to the invention, by constructing a postoperative recurrent mouse model caused by minimal residual endometriosis and a postoperative recurrent mouse model caused by endometriosis cell overflow and dissemination implantation and preoperatively applying the ketorolac, the ketorolac is proved to be able to effectively reduce the weight of a postoperative recurrent focus, improve pain symptoms caused by endometriosis, and meanwhile, retardsthe lesion progression of postoperative recurrence endometriosis, which is specifically shown as slow-down of epithelial-mesenchymal transition (EMT), fibroblast-myofibroblast transition (FMT) and smooth muscle metaplasia (SMM), reduction of angiogenesis, and reduction of expression of indexes related to recurrence. The ketorolac is convenient and rapid to operate; the ketorolac is used as a clinically common analgesic, has few side effects and is high in safety and low cost; and animal experiments prove that the method has a good curative effect and a good application prospect.

Description

technical field [0001] The invention relates to the application of ketorolac in the preparation of drugs for preventing or treating postoperative recurrence of endometriosis and the technical field of medicinal chemistry. Background technique [0002] Endometriosis (referred to as endometriosis) has the growth function of endometrial tissue (including glands and stroma), which appears in parts other than the uterine cavity and muscle layer, which is invasive, easy to spread, planting, The characteristics of relapse, with dysmenorrhea, chronic pelvic pain, infertility, etc. as the main symptoms. Surgery is recognized as an effective method for the treatment of endometriosis. Surgery can remove the lesion, relieve pain and improve fertility. However, the high recurrence rate after surgery is a very difficult problem at present. It has been reported in the literature that 40-50% of patients relapse within five years after initial surgery, and some patients require further surg...

AI Technical Summary

Problems solved by technology

[0003] At present, clinically, there are mainly the following methods for reducing the recurrence of endometriosis, but all of them have some disadvantages: 1. Surgery combined with drug therapy: such as GnRH-a, oral contraceptives, etc., its curative effect is not optimistic, and it takes a long time Long-term GnRH-a treatment can lead to low estrogen symptoms, osteoporosis, irregular bleeding, etc. Long-term use of oral contraceptives may increase thrombosis, The risk of abnormal liver function, at the same time drug withdrawal is easy to relapse, and long-term drug use also increases the economic burden on individuals, families and society

2. Radical surgery or surgery combined with endometrial resection: it is only applicable to patients who have no childbearing requirements, and may cause a series of psychological problems at the same time

However, there is still no relevant research on the effect of ketorolac on the treatment of endometriosis

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