14 results about "Metaplasia" patented technology

Pyrvinium and its derivatives for reprogramming precancerous mucosa into a noncancerous state are described herein. Furthermore, pyrvinium and its derivatives for reducing the risk of cancer development in organisms containing metaplastic or dysplastic cells are described herein.

The invention relates to the technical field of biological medicine, provides novel application of IL-17a, and particularly relates to application of an IL-17a inhibitor in preparation of a medicine for treating age-related olfactory dysfunction. The research result shows that the expression increase of the IL-17a can trigger an inflammation signal and damage the olfactory function. Administration of the IL-17a inhibitor Y-320 or a neutralizing antibody promotes sensory neuron regeneration in the olfactory epithelium (OE) and reverses age-related respiratory metaplasia. In addition, conditional knockout of IL-17a in T cells can promote olfactory epithelium regeneration by promoting recruitment and differentiation of horizontal basal cells (HBCs) into globular basal cells (GBCs). In general, the research of the invention determines the previously undetermined effect of the IL-17a in olfactory epithelium regeneration and age-related olfactory function defects, and provides evidence for the IL-17a as a potential therapeutic target for olfaction of the elderly.

The invention relates to the technical field of biology, in particular to application of black phosphorus nanosheet hydrogel to preparation of medicine for treating dry eye syndrome. The black phosphorus nanosheet hydrogel can promote tear film healing, treat dry corneal injury and remove active oxygen and free radicals, has an anti-inflammatory effect, inhibits squamous metaplasia, inhibits expression of IL-1beta, K10 and MMP-9 and the like, and provides a new direction for treatment of the dry eye syndrome.

The invention provides an M2 macrophage exosome loaded canagliflozin nano-drug and application thereof, an M2 macrophage exosome is used as a carrier, and canagliflozin is loaded on the M2 macrophage exosome. The Exo-CANA delivery system is constructed for the first time, the exosomes are small in size, the phagocytosis of mononuclear macrophages can be effectively avoided, the exosomes can freely penetrate through vascular walls and extracellular matrixes, Th2 type airway inflammation, goblet cell metaplasia and pulmonary interstitial collagen deposition can be remarkably improved, and the treatment effect is remarkably superior to that of a CANA single-drug treatment group and an M2-Exos single-drug treatment group.

Recombinant blood group antigen-binding adhesin (BabA) can be used in a composition to raise humoral immune response i.e. antibodies, that target conserved structural epitopes in the fucosylated blood group antigen Lewis b (Leb) antigen binding domain in the blood group antigen-binding adhesin (BabA). Such broadly Leb-blocking antibodies can reduce the gastric mucosal attachment of Helicobacter pylori (H. pylori) to human gastric mucosa. This approach can be used for preventing and / or alleviating gastric disease in a subject diagnosed with H. pylori infection, said gastric disease chosen from gastroesophageal reflux disease, chronic active gastritis, peptic ulcer diseases, gastric ulcer disease, gastric cancer gastritis and gastric cancer, in particular gastric cancer. It also becomes possible to identify subjects that carry BabA positive H. pylori infections and subjects that are at risk of developing severe gastric disease, such as peptic ulcer diseases, gastric ulcer disease, gastritis with metaplasia and gastric cancer.

The invention belongs to the technical field of medical experimental animal models, and particularly relates to a construction method of a spleen and stomach damp-heat syndrome chronic atrophic gastritis animal model. The construction method comprises the following steps: firstly, performing spleen and stomach damp-heat modeling on a tested animal to obtain spleen and stomach damp-heat syndromes, and then performing chronic atrophic gastritis induction. According to the specific three-step atrophic gastritis induction method, the clinical pathological process of inflammation caused by stimulation, gastric mucosa atrophy caused by damp heat and blood stasis for a long time and intestinal metaplasia can be accurately copied, the clinical pathological process is highly matched with the stage progress characteristic of clinical chronic atrophic gastritis, and the model is high in success rate, good in stability and high in repeatability.

The invention relates to the technical field of medicines, in particular to application of polypeptide in prevention and / or treatment of gastrointestinal metaplasia. The polypeptide with the amino acid sequence of KIVFILCAAAAIVTRKT is found and verified for the first time and can target a molecular polypeptide of an intestinal key transcription factor CDX2 and a downstream signal channel of the CDX2, expression of the CDX2 and expression of the downstream signal channel of the CDX2 can be inhibited, expression of a stomach type marker can be promoted, the pathological process of GIM can be effectively reversed, and the GIM can be used for preparing a medicine for treating intestinal diseases. Compared with medicines which can only relieve symptoms or delay progression in the prior art, the medicine can realize pathological reversion of the GIM, so that a new direction can be provided for development of intervention medicines of the GIM.

The invention provides a co-culture method and application of mouse olfactory organoid and T cells. An age-related olfactory disorder (OD) organ model is constructed by co-culturing mouse olfactory organs and Th17 cells, and is used for exploring the pathogenesis of olfactory disorder, screening pathogenic genes and establishing a new method for treating olfactory disorder. Experimental results show that Tuj1 [+] and OMP [+] cells are significantly reduced after co-culture with Th17 cells; krt19 [+] cells are obviously increased and show strong intracellular staining, which indicates metaplasia and transformation; the contents of Muc5ac [+] mucus cells and secretions are increased; after 14 days of co-culture, both young and aged organs have obvious cystic structures, and the change of the aged organs is more obvious. Importantly, the IL-17a neutralizing antibody can effectively block the pedigree transformation to maintain the olfactory differentiation potential, so that the key effect of the IL-17a in regulating and controlling the cell fate decision is disclosed. It is shown that the inflammation microenvironment in the age-related OD patient can be simulated by co-culturing the olfactory organoid and the Th17 cells.

The disclosure provides methods for identifying genomic loci (e.g., vimentin and / or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and / or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and / or neoplasias.

The invention discloses a stomach intestinal metaplasia grading method and system based on noise robustness and an open set, and belongs to the technical field of medical image processing. Processing the stomach endoscope image based on a pre-trained intestinal metaplasia grading model, and outputting an intestinal metaplasia grading result; the intestinal metaplasia grading model comprises a noise identification module, a comparison learning module, a label correction module and a classification output module; the pre-training process comprises the following steps: obtaining a clean sample set and a noise sample set based on a noise identification module; calculating class prototype similarity based on a comparative learning module, and discriminating valid noise and invalid noise; calculating an effective noise confidence coefficient based on a label correction module, and generating a differentiated pseudo label; and performing multi-module cooperative training based on the joint optimization total loss function, and outputting an intestinal metaplasia classification result through a classification output module. According to the method, the robustness of the model in noise and open set scenes is effectively improved, and the problem of 0-2-level fine-grained classification of intestinal metaplasia is solved.

The invention provides a traditional Chinese medicine composition for treating chronic atrophic gastritis with intestinal metaplasia, which is prepared from 16 medicinal materials, namely ginseng, vinegar turtle shell, curcuma zedoary, astragalus membranaceus, bighead atractylodes rhizome, poria cocos, radix bupleuri, white paeony root, pericarpium citri reticulatae, rhizoma pinelliae preparata, angelica sinensis, moutan bark, fructus amomi, almond, cassia twig and honey-fried licorice root, and a specific process that the vinegar turtle shell is crushed to 3-5mm and then decocted is adopted. According to the treatment principle of tonifying qi, promoting tissue regeneration, dredging collaterals, removing food retention and guiding ascending and descending, astragalus membranaceus and ginseng are matched to tonify qi and promote mucosa regeneration; vinegar turtle shell and curcuma zedoary can enter collaterals to remove blood stasis and remove food retention; the almonds and the cassia twigs are matched to form a Qi movement guide of ventilating and dredging, so that the medicine accurately acts on the gastric submucosa. Through clinical observation of 120 patients with chronic atrophic gastritis accompanied with intestinal metaplasia, the total effective rate is 96.7%, the obvious effective rate is 91.7%, the mucosa improvement rate under a gastroscope is 92.5%, the intestinal metaplasia reversal rate is 68.3%, the recurrence rate is only 3.3% after 6 months, and the occurrence rate of liver and kidney dysfunction of the patients is 0%. The contrast experiment further proves that the intestinal metaplasia reversion rate is only 42.5% after the apricot kernels and the cassia twigs are removed. The traditional Chinese medicine composition can quickly reverse atrophy and intestinal metaplasia, promote mucosa repair, protect healthy qi and reduce relapse, and overcomes the defects that a traditional blood stasis dispersing and tonifying prescription is prone to injuring healthy qi, assists dampness and heat and is low in reversion rate.

The invention provides an asthma susceptibility gene, a medicine thereof and application of the medicine. The susceptibility gene is SGLT2. The medicine is an inhibitor canagliflozin of SGLT2. The potential causal association between the hypoglycemic drug canagliflozin and the asthma risk is found for the first time, the canagliflozin can significantly improve Th2 type airway inflammation, goblet cell metaplasia and pulmonary interstitial collagen deposition, the treatment effect is significant, and the anti-inflammatory protection effect is related to a PI3K / AKT pathway.

The present invention relates to a pharmaceutical composition for use in the treatment of a disease involving undesired migration, proliferation and / or metaplasia of retinal pigment epithelium (RPE) cells in a subject wherein the pharmaceutical composition comprises at least one epidermal growth factor receptor (EGFR) antagonist.

The disclosure provides methods for identifying genomic loci that are differentially methylated in neoplastic cancers, e.g., esophageal cancers. Identification of methylated genomic loci, and optionally in combination with the identification of somatic mutations in TP53, has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal neoplasias.