7 results about "Sensory neuron" patented technology

This application discloses a laboratory personnel behavior perception system, including a positioning axis, a sensory neuron module, and a data coupling module. The positioning axis is linked with personnel positioning tags to update personnel positions in real time on an electronic map. Upon receiving a preparation command, when the distance between the personnel's position and at least one area to be prepared in the preparation command is less than a first distance threshold, a personnel behavior perception command is generated and sent to the sensory neuron module. The sensory neuron module creates a personnel movement trajectory and predicts future trajectories. After all personnel behavior perception commands and preparation commands have been received, personnel behavior perception is performed to enable or disable device operation permissions. The data coupling module determines whether there is an intersection between the future trajectory and the experimental area; if so, it identifies the area to be prepared, generates a preparation command, and simultaneously sends it to the positioning axis and the sensory neuron module. This application can achieve efficient and accurate management of laboratory equipment permissions.

The application discloses application of Neuritin in preparation of a medicine for promoting healing of a diabetic wound. The application proves for the first time through experiments that Neuritin expression in wound edge tissue and surrounding sensory neurons is significantly up-regulated after skin damage, and Neuritin expression is significantly down-regulated under a diabetic condition. By constructing a nervous system conditional knock-out and a sensory neuron specific knock-out Neuritin mouse, it is proved that wound healing is significantly delayed after Neuritin is knocked out. By means of spinal cord site injection of an AAV virus to overexpress Neuritin in a DRG and skin electroporation technology to locally overexpress Neuritin in the skin, it is proved that overexpression of Neuritin can significantly promote wound healing of type 1 and type 2 diabetic mice. The application provides a brand-new target and strategy for treatment of a diabetic refractory wound, and has a good clinical transformation prospect.

Provided herein are methods of producing a population of pluripotent stem cell-derived sensory neurons (PSC-SNs) expressing a target gene associated with pain. In addition, provided herein are compositions and methods comprising populations of pluripotent stems cells for treating pain, osteoarthritis, and osteoarthritis related conditions.

The subject matter provides methods and compositions for preventing or treating chemotherapy-induced peripheral neuropathy (CIPN) by modulating delta-2 tubulin accumulation in sensory neurons. The therapeutic approaches targeting enzymes that regulate delta-2 tubulin formation, such as cytosolic carboxypeptidases (CCP1 and CCP6), or enhancing tubulin re-tyrosination via tubulin tyrosine ligase (TTL).

A system and method of use thereof for inducing colonic motility includes providing stimulations to a rectum of an individual. The stimulations include a plurality of low-frequency stimulations and a plurality high-frequency stimulations. The stimulations can be configured to activate sensory neurons and modulate the recto-colonic reflex pathway without directly activating motor neurons.

This application discloses a laboratory personnel behavior perception system, including a positioning axis, a sensory neuron module, and a data coupling module. The positioning axis is linked with personnel positioning tags to update personnel positions in real time on an electronic map. Upon receiving a preparation command, when the distance between the personnel's position and at least one area to be prepared in the preparation command is less than a first distance threshold, a personnel behavior perception command is generated and sent to the sensory neuron module. The sensory neuron module creates a personnel movement trajectory and predicts future trajectories. After all personnel behavior perception commands and preparation commands have been received, personnel behavior perception is performed to enable or disable device operation permissions. The data coupling module determines whether there is an intersection between the future trajectory and the experimental area; if so, it identifies the area to be prepared, generates a preparation command, and simultaneously sends it to the positioning axis and the sensory neuron module. This application can achieve efficient and accurate management of laboratory equipment permissions.