30 results about "Sensory neuron" patented technology

Compositions comprising microalgal extracellular vesicles (MEVs) formulated for intranasal delivery are provided, whereby upon intranasal administration, the MEVs are transported by a specific route, to specific regions in the brain via the olfactory nerve after intranasal administration, and to interconnected brain regions through the lateral olfactory tract (LOT). The MEVs are transported via neuronal axonal transport. The MEVs have the ability to cross synapses including: (i) synapses between olfactory sensory neurons (OSNs) and mitral / tufted neurons; (ii) synapses between mitral / tufted neurons and local neurons in multiple brain regions colonized by the lateral olfactory tract (LOT); and (iii) synapses between neurons in brain regions colonized by the LOT and neurons from the frontal cortex, hippocampus, thalamus, and hypothalamus. The compositions contain extracellular vesicles (MEVs) from microalgae loaded with bioactive cargo for the treatment, detection, diagnosis, or monitoring of diseases, disorders, or conditions of or involving the brain, particularly neuronal delivery of the cargo. The compositions and methods have multiple applications as therapeutic and diagnostic agents for the treatment, diagnosis, and monitoring of diseases, disorders, or conditions of or involving the brain. The compositions can be used in methods and uses for the treatment of cancers involving the brain, and can be used, for example, to deliver therapeutic agents for psychiatric diseases, disorders, conditions, and to deliver therapeutic agents for neurodegenerative diseases, disorders, and conditions.

The invention discloses an application of fenoterol hydrobromide and pharmaceutically acceptable salt thereof in preparation of a medicine for treating diabetic peripheral neuropathy. The fenoterol hydrobromide and the pharmaceutically acceptable salt thereof have obvious effects of promoting growth of peripheral sensory neurite and protecting myelin sheath injury, and can improve symptoms of slow nerve conduction speed and sensory deficiency induced by diabetes mellitus.

The invention relates to the technical field of biological medicine, provides novel application of IL-17a, and particularly relates to application of an IL-17a inhibitor in preparation of a medicine for treating age-related olfactory dysfunction. The research result shows that the expression increase of the IL-17a can trigger an inflammation signal and damage the olfactory function. Administration of the IL-17a inhibitor Y-320 or a neutralizing antibody promotes sensory neuron regeneration in the olfactory epithelium (OE) and reverses age-related respiratory metaplasia. In addition, conditional knockout of IL-17a in T cells can promote olfactory epithelium regeneration by promoting recruitment and differentiation of horizontal basal cells (HBCs) into globular basal cells (GBCs). In general, the research of the invention determines the previously undetermined effect of the IL-17a in olfactory epithelium regeneration and age-related olfactory function defects, and provides evidence for the IL-17a as a potential therapeutic target for olfaction of the elderly.

The present application belongs to the technical field of cosmetics, and relates to a composition for reducing the acid-sensitive irritation of ascorbic acid and / or improving the apparent solubility of ascorbic acid, a preparation method and application thereof. The composition provided by the present application comprises, in parts by weight, 0.05-5 parts of an acid-sensitive inhibitor, 0.25-6 parts of a zwitterionic compound, 0.25-3 parts of a compound containing an amide bond and strong polarity, 0.005-0.5 parts of a surfactant, and 2.5-50 parts of water. The present application also provides a preparation of the composition and ascorbic acid, and application of the preparation in the preparation of skin care cosmetics. The composition of the present application can effectively improve the apparent solubility and stability of ascorbic acid in an aqueous solution, and inhibit the channel activity of ASIC3 of epidermal sensory neuron endings. The composition provided by the present application can effectively improve the apparent solubility of ascorbic acid, and significantly reduce or even block the irritation of ascorbic acid to the skin from the mechanism level, and has a good application prospect.

The present disclosure relates to a tinnitus suppression device, method, system and computer program. In some aspects, a tinnitus suppression device comprises a receiver module configured to receive sound signals, a processing module operably connected to a memory and to the receiver module, and a neurostimulation module operably connected to the processing module. In some aspects, the processing module and the neurostimulation module may be configured to determine a received sound signal that corresponds to a template stored in the memory, that is above a preconfigured threshold, preferably above a preconfigured threshold which is specific for the individual, or both. A multi-channel neurostimulation signal encoding the determined sound signal may be generated and applied to a neurostimulation device of the individual that may be configured to directly stimulate afferent sensory neurons of the central nervous system of the individual and thereby to elicit, for each channel of the neurostimulation signal, one or more non-auditory, preferably somatosensory, perceptions in a cortex area of the individual.

This application discloses a laboratory personnel behavior perception system, including a positioning axis, a sensory neuron module, and a data coupling module. The positioning axis is linked with personnel positioning tags to update personnel positions in real time on an electronic map. Upon receiving a preparation command, when the distance between the personnel's position and at least one area to be prepared in the preparation command is less than a first distance threshold, a personnel behavior perception command is generated and sent to the sensory neuron module. The sensory neuron module creates a personnel movement trajectory and predicts future trajectories. After all personnel behavior perception commands and preparation commands have been received, personnel behavior perception is performed to enable or disable device operation permissions. The data coupling module determines whether there is an intersection between the future trajectory and the experimental area; if so, it identifies the area to be prepared, generates a preparation command, and simultaneously sends it to the positioning axis and the sensory neuron module. This application can achieve efficient and accurate management of laboratory equipment permissions.

Provided are compositions containing microalgae extracellular vesicles (MEVs) formulated for intranasal delivery, whereby, upon intranasal administration the MEVs traffic through specific routes following intranasal administration to specific regions in the brain via the olfactory nerve and throughout the lateral olfactory tract (LOT) to interconnected brain regions. The MEVs traffic via neuronal axonal transport. The MEVs have the ability to cross-over synapses including: (i) the synapses between the olfactory sensory neurons (OSN) and the mitral / tufted neurons; (ii) the synapses between the mitral / tufted neurons and the local neurons in the various brain regions colonized by the lateral olfactory tract (LOT); and (iii) the synapses between the neurons in the brain regions colonized by the LOT and neurons from the frontal cortex, the hippocampus, the thalamus, and the hypothalamus. The compositions contain extracellular vesicles from microalgae (MEVs) that are loaded with bioactive cargo for treating, detecting, diagnosing, or monitoring a disease, disorder, or condition of the brain or involving the brain, particularly providing neuronal delivery of the cargo. The compositions and methods have a variety of applications as therapeutics and diagnostics for treating, diagnosing, and monitoring a disease, disorder, or condition of the brain or involving the brain. The compositions can be used in methods and uses for treating cancers involving the brain, and can be used, for example, to deliver therapeutics for psychiatric diseases, disorders, conditions, and to deliver therapeutics for neurodegenerative diseases, disorders, and conditions.

A modular artificial neural sensing system includes a hierarchical network of neural sensing units including a neuromimetic sensor array of artificial sensory synapses and sensory neurons for receiving physicochemical sensed signals and for outputting sensor output signals. An artificial neural network processor is adapted for processing the sensor output signals and includes processor neurons interconnected by processor synapses forming first connections and second connections. The processor outputs processor output signals. A first sensor interface feeds processed or unprocessed sensed signals into the processor. A second sensor interface receives output predicted signals from other neural sensing units and feeds processed or unprocessed output predicted signals into the processor. A signal decoder decodes the processor output signals and outputs decoder output signals. An error feedback module receives the decoder output signals and teaching signals for generating error signals depending on a difference between teaching signals and decoder output signals.

Disclosed herein are methods of treating spinal muscular atrophy in a subject. A particular method includes applying a therapeutically effective amount of an electrical stimulus to sensory neurons innervating a body region of the subject having motor damage due to the spinal muscular atrophy, where application of the electrical stimulus treats the motor damage due to spinal muscular atrophy in the subject; the method is combined with administration of SMA therapy.

The present disclosure is related to drug delivery compositions containing extracellular vesicles having a therapeutic by utilizing visceral sensory neurons, a method using thereof for delivering the drugs to central nervous system and an organoid on chip model comprising a three-compartment axis-on-a chip for testing delivery of the drug containing EV over BBB, wherein the compositions comprising bacterial extracellular vesicles (EV) and therapeutics, wherein the drug or the therapeutic is encapsulated within the EV or attached or conjugated to EV.

The invention discloses a construction method and application of an hMRGPRX3 humanized mouse model and an atopic dermatitis model, and relates to the technical field of disease model construction. The whole gene sequence of the human MRGPRX3 or a vector containing the gene sequence of the hMRGPRX3 is transferred into mouse genome DNA (Deoxyribonucleic Acid) by utilizing a transgenic technology, and a functional human hMRGPRX3 receptor can be simulated and expressed in a mouse model more truly by transferring upstream and downstream regulatory sequences of the hMRGPRX3 gene. The pruritus signal transduction mediated by the receptor in human dorsal root ganglion sensory neurons can be accurately simulated, and signal deviation caused by species difference of a traditional mouse model is overcome.

The present invention relates to N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine salts and their pharmaceutically acceptable solvates, for use in the treatment and / or prevention of sensory neuron diseases.

The application discloses application of Neuritin in preparation of a medicine for promoting healing of a diabetic wound. The application proves for the first time through experiments that Neuritin expression in wound edge tissue and surrounding sensory neurons is significantly up-regulated after skin damage, and Neuritin expression is significantly down-regulated under a diabetic condition. By constructing a nervous system conditional knock-out and a sensory neuron specific knock-out Neuritin mouse, it is proved that wound healing is significantly delayed after Neuritin is knocked out. By means of spinal cord site injection of an AAV virus to overexpress Neuritin in a DRG and skin electroporation technology to locally overexpress Neuritin in the skin, it is proved that overexpression of Neuritin can significantly promote wound healing of type 1 and type 2 diabetic mice. The application provides a brand-new target and strategy for treatment of a diabetic refractory wound, and has a good clinical transformation prospect.

A balance prosthesis device for an individual including a sensor module configured to obtain a sensor signal indicative of a balance or equilibrium state of the individual, a processing module configured to determine at least one neurostimulation signal based at least in part on the obtained sensor signal, and a transmitter module configured to transmit the determined neurostimulation signal to a neurostimulation device of the individual. The neurostimulation signal is configured to elicit an artificial sensation in a specific sensory cortex area of the individual via directly stimulating afferent sensory axons of the central or peripheral nervous system of the individual targeting sensory neurons of the sensory cortex area not directly associated with vestibulocortical pathways of the individual. The elicited artificial sensation provides a balance indication to the individual in order to support, mimic, substitute or enhance the natural sense of balance of the individual.

Stapled peptides and mutant BCL-2 family peptides and compositions comprising the same are provided. Also provided are methods of using the stapled peptides and mutant BCL-2 family peptides for selectively protecting sensory neurons from age-related and / or chemotherapy induced axonal degeneration in a human subject in need thereof, treating or preventing chemotherapy induced peripheral neuropathy (CIPN) in a human subject in need thereof, averting neuropathic side effects of chemotherapy and / or other causes of axonal degeneration in a human subject in need thereof, and treating or preventing hearing loss in a human subject in need thereof. The methods involve administering to the human subject a stapled peptide and a mutant BCL-2 family peptide disclosed herein.

The invention relates to the technical field of food, and particularly discloses a composition for promoting auditory sense system development and application. The composition is prepared from the following components in parts by mass: 0.1 part of IGF-1 and 1 to 1500 parts of structural triglyceride. A specific amount of IGF-1 is compounded with structural triglyceride, so that the movement speed and average movement distance of the zebrafish after auditory stimulation can be increased, the content of 5-hydroxytryptamine and acetylcholin esterase in the zebrafish is increased, the expression of GABA receptor genes is promoted, and the yield of the zebrafish is increased. By adding important neurotransmitters in an auditory sense system, auditory sense neuron survival, differentiation and synaptic formation are supported, so that the excitability of an auditory sense nerve pathway is adjusted, and the development of the auditory sense system is promoted. The composition can be used for preparing food such as infant formula milk powder, child formula milk powder, liquid milk, infant complementary food, supplements or dietary supplements.

The invention relates to a phenolic acid-strontium nano-particle and a preparation method and application thereof, the phenolic acid-strontium nano-particle is a nano-structure obtained by self-assembly by using a method of modifying phenolic acid by metal strontium coordination, according to the prepared caffeic acid-strontium nanoparticles, coordination modification of phenolic acid molecules is achieved through coordination of strontium, carboxyl of phenolic acid and catechol groups, and the caffeic acid-strontium nanoparticles are of a spherical structure, small and uniform in particle size, good in dispersity, simple in preparation process, low in cost and easy to produce in batches; after the caffeic acid is subjected to coordination modification by strontium, the capability of targeted inhibition of the caffeic acid on the TRPV1 is remarkably enhanced, so that the problem of calcium overload of a focus is solved, and the problems of inflammatory polarization of macrophages and sensitization of damaged sensory neurons, which are caused by abnormal calcium influx due to high expression of the TRPV1 at the arthritis focus part, are effectively and synchronously solved; and the compound has excellent bone repair performance and extremely high biological safety, and has wide application prospects in preparation of drugs for preventing and / or treating inflammatory bone related diseases and preparation of bone repair drugs.

Stapled peptides and mutant BCL-2 family peptides and compositions comprising the same are provided. Also provided are methods of using the stapled peptides and mutant BCL-2 family peptides for selectively protecting sensory neurons from age-related and / or chemotherapy induced axonal degeneration in a human subject in need thereof, treating or preventing chemotherapy induced peripheral neuropathy (CIPN) in a human subject in need thereof, averting neuropathic side effects of chemotherapy and / or other causes of axonal degeneration in a human subject in need thereof, and treating or preventing hearing loss in a human subject in need thereof. The methods involve administering to the human subject a stapled peptide and a mutant BCL-2 family peptide disclosed herein.

The invention provides application of oleic acid in a medicine for treating atopic dermatitis and relates to the technical field of biomedicine, oleic acid is common monounsaturated fatty acid, it is found for the first time through a non-targeted metabonomics technology that after peripheral sensory neurons are stimulated by an itching and inflammatory factor IL-31, the level of oleic acid (OA) in cells is remarkably increased (the VIP score gt; according to the present invention, the specific verification test results show that the oleic acid can significantly improve the symptoms of the pruritus model animal and regulate the related immune response under the specific concentration, and the new low-cost candidate scheme is provided for the treatment of the specific dermatitis;

The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human embryonic stem cells (hESC), somatic stem cells, and induced human pluripotent stem cells (hiPSC) using novel culture conditions. Specifically, methods are provided for obtaining neural tissue, floor plate cells, and placode including induction of neural plate development in hESCs for obtaining midbrain dopamine (DA) neurons, motor neurons, and sensory neurons. Further, neural plate tissue obtained using methods of the present inventions are contemplated for use in co-cultures with other tissues as inducers for shifting differentiation pathways, i.e. patterning.

Systems and methods for stimulating the sensory cortex of an individual by obtaining a neuronal stimulation signal adapted to provide a movement cue for the individual and transmitting the neuronal stimulation signal to an electric contact of a neuronal stimulation electrode that is already implanted into the brain of the individual for a purpose different from providing the movement cue. Proprioceptive information is communicated to the individual by obtaining information about the body posture of the individual and applying a neuronal stimulation signal to an afferent axon targeting a sensory neuron in the cortex of the individual. The neuronal stimulation signal is determined based on the obtained body posture information and corresponds to the proprioceptive information. A first neuronal stimulation signal providing the movement cue and a second neuronal stimulation signal providing the proprioceptive information may be applied together to the cortex of the individual.

The application discloses a preparation method and application of a metformin grafted polycaprolactone nanoscaffold, and the polycaprolactone nanofiber membrane is coated with a layer of polydopamine in a weak alkaline Tri-HCl buffer solution, is blended with metformin in the weak alkaline Tri-HCl buffer solution, and is incubated on a shaking table at 37 DEG C, so that a product is obtained; after washing and freeze-drying, the metformin grafted polycaprolactone nanoscaffold is obtained. The METG-PCLN developed in the application can continuously release MET into the fibrotic microenvironment in sensory neurons and EFs. In vitro cell experiments and animal model experiments prove that the METG-PCLN can significantly slow down the development of EFs by finely adjusting the release of sensory nerve CGRP. Therefore, the application provides a promising proof of concept for the potential clinical treatment of EFs, and shows considerable conversion value.

Provided herein are methods of producing a population of pluripotent stem cell-derived sensory neurons (PSC-SNs) expressing a target gene associated with pain. In addition, provided herein are compositions and methods comprising populations of pluripotent stems cells for treating pain, osteoarthritis, and osteoarthritis related conditions.

The subject matter provides methods and compositions for preventing or treating chemotherapy-induced peripheral neuropathy (CIPN) by modulating delta-2 tubulin accumulation in sensory neurons. The therapeutic approaches targeting enzymes that regulate delta-2 tubulin formation, such as cytosolic carboxypeptidases (CCP1 and CCP6), or enhancing tubulin re-tyrosination via tubulin tyrosine ligase (TTL).

A method of producing a population of mature human pluripotent stem cell-derived sensory neurons (hPSC-SNs) expressing a target gene associated with at least one of nociceptive pain, chronic pain, pruriception and a nociceptive- or pruriceptive- mediated condition, the method comprising introducing into a population of human pluripotent stem cells (hPSCs) a composition comprising at least one site-directed nuclease targeting a site within the target gene, and at least one nucleic acid comprising a nucleotide sequence encoding at least one screenable, selectable marker that is flanked by (i) a nucleotide sequence homologous with a region located upstream of the target site within the target gene and (ii) a nucleotide sequence homologous with a region located downstream of the target site within the target gene, wherein the target site is located downstream of the open reading frame of the target gene, and wherein the site-directed nuclease cleaves the target site of the target gene and the nucleic acid encoding the screenable, selectable marker is inserted at the target site; covering said population of hPSCs under an extracellular matrix comprising at least one neuronal differentiation driver to produce a sensory committed neural crest population; contacting said sensory committed neural crest population with at least one neuronal differentiation driver and at least one neurotrophic factor to produce a population of early sensory neurons (SNs); and contacting said population of early SNs with at least one neurotrophic factor to produce a population of mature hPSC-SNs expressing at least one of SN marker or one pan neuronal marker; isolating the cells expressing the at least one screenable, selectable marker, wherein said population of mature hPSC-SNs expressed said one target gene associated with nociceptive pain, chronic pain, pruriception a nociceptive- or pruriceptive- mediated condition, and wherein said population of mature hPSC-SNs responds to a nociceptive and pruriceptive stimulus.

A system and method of use thereof for inducing colonic motility includes providing stimulations to a rectum of an individual. The stimulations include a plurality of low-frequency stimulations and a plurality high-frequency stimulations. The stimulations can be configured to activate sensory neurons and modulate the recto-colonic reflex pathway without directly activating motor neurons.

The invention relates to a stretching-pain perception system based on a multi-gate synaptic transistor and a preparation method and application thereof, and belongs to the technical field of artificial sensory neuron and neuromorphic calculation. The system comprises a crack type strain sensor and a multi-gate synaptic transistor, the strain sensor adopts a metal / elastic composite material double-layer conductive structure, and has high sensitivity and a continuous conductive path; the multi-gate synaptic transistor takes an electrolyte material as a gate medium, takes a metal oxide as an electrode and a channel, and is provided with a bottom gate and a side gate. The strain sensor is connected with the bottom grid and the side grid through a voltage division circuit, and dynamic integration and processing of stretching signals are achieved by regulating and controlling different grid voltages. According to the invention, multi-stage mode conversion from conventional stretching perception to pain early warning is realized, the method is suitable for biological nerve simulation systems such as electronic skin, intelligent artificial limbs and bionic robots, and the bottleneck problem that an existing pain perception system is difficult to realize multi-signal fusion and dynamic regulation and control is solved.

This application discloses a laboratory personnel behavior perception system, including a positioning axis, a sensory neuron module, and a data coupling module. The positioning axis is linked with personnel positioning tags to update personnel positions in real time on an electronic map. Upon receiving a preparation command, when the distance between the personnel's position and at least one area to be prepared in the preparation command is less than a first distance threshold, a personnel behavior perception command is generated and sent to the sensory neuron module. The sensory neuron module creates a personnel movement trajectory and predicts future trajectories. After all personnel behavior perception commands and preparation commands have been received, personnel behavior perception is performed to enable or disable device operation permissions. The data coupling module determines whether there is an intersection between the future trajectory and the experimental area; if so, it identifies the area to be prepared, generates a preparation command, and simultaneously sends it to the positioning axis and the sensory neuron module. This application can achieve efficient and accurate management of laboratory equipment permissions.

Disclosed herein are methods for treating spinal muscular atrophy in a subject. Particular methods comprise applying a therapeutically effective amount of an electrical stimulus to sensory neurons innervating a body region of the subject with a motor impairment due to the spinal muscle atrophy, wherein application of the electrical stimulus treats the motor impairment due to spinal muscular atrophy in the subject; in conjunction with administering an SMA therapy.

A compound represented by formula (I) and a preparation method thereof, and a pharmaceutically acceptable salt thereof, a metabolic precursor thereof, a metabolite thereof, an isomer thereof or a prodrug thereof; experiments show that the indole alkaloid not only promotes axon growth of peripheral sensory neurons, improves the nerve conduction velocity and anesthesia symptom of diabetic rats, but also promotes healing of foot ulcer wounds of diabetic rats, thus having good therapeutic effects on diabetic complication peripheral neuropathy and diabetic feet; they also show that the indole alkaloid also obviously reduces a degree of pulmonary fibrosis induced by bleomycin in mice, and plays a role in protecting lung tissues.