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8 results about "Floor plate" patented technology

The floor plate is a structure integral to the developing nervous system of vertebrate organisms. Located on the ventral midline of the embryonic neural tube, the floor plate is a specialized glial structure that spans the anteroposterior axis from the midbrain to the tail regions. It has been shown that the floor plate is conserved among vertebrates, such as zebrafish and mice, with homologous structures in invertebrates such as the fruit fly Drosophila and the nematode C. elegans. Functionally, the structure serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube.

Double-hole wind shaft single-side filling condition under the method and structure of mid-partition wall reinforcement

The application provides a method and structure for reinforcing a middle partition wall under the condition of single-side filling of a double-hole air shaft, comprising: installing multiple layers of spaced distribution floor plates along the height direction of the wall; when the wall is filled with water and soil on one side, a multiple-span transverse stress one-way plate structure is formed between the wall and the multiple layers of floor plates; pouring sealing material in each hole to keep each hole sealed; locally thickening the part of the middle partition wall that cannot meet the bearing capacity requirement to form a thickened layer on the side of the wall close to the water and soil; setting a rib plate on the side of the wall away from the water and soil, one end of the rib plate being fixed on a base and the other end being fixed on a floor plate, the rib plate being not lower than the middle of the wall; anchoring the floor plate at the middle of the wall and connecting the rib plate; forming a structure on the side of the wall close to the water and soil, the structure being soil-sealed but water-unsealed; and forming a backfill layer at the bottom of the wall to strengthen the bottom constraint of the middle partition wall. The application can effectively enhance the strength of the middle partition wall and improve the reliability of the middle partition wall.
Owner:CCCC SECOND HIGHWAY CONSULTANTS CO LTD

Floor plate for a manure cellar in a stable, floor plate production method, and system for removing air from a manure cellar

PCT designated stageWO2026049626A1Animal housingAnimal fecesEnvironmental engineering
The invention relates to a floor plate (100) for a manure cellar of a stable, comprising: • - multiple passage openings (110) for the passage of animal feces, • - an embedded channel (120) having a first access opening (221) in a first side wall (104a) of the floor plate (100), and • - distributed over a length of the channel (120) two or more access locations (260) where a thickness between the channel (120) and a bottom surface of the floor plate (100) is smaller than surrounding locations.
Owner:SPAANSEN GROEP BV

METHOD FOR MACHINING PARALLEL GROOVES IN THE UNDERSIDE OF A FLOOR PLATE

ActiveDE602024005021T2Tongue/grooves making apparatusRotary cutting toolsOrganic chemistryFloor plate
Owner:BARLINEK SA

Method for producing nerve cells

PCT designated stageWO2026141672A1Induced pluripotent stem cellLPA Receptors
The present application provides a method for producing, from pluripotent stem cells, neural progenitor cells of the midbrain floor plate region or dopaminergic neural progenitor cells, the method comprising (1) inducing differentiation of pluripotent stem cells into neural progenitor cells of the midbrain floor plate region, and optionally (2) inducing differentiation of the neural progenitor cells of the midbrain floor plate region, which are obtained by the differentiation induced in (1), into dopaminergic neural progenitor cells, wherein all or part of the differentiation induced in (1) includes culturing the cells in a medium containing an agonist for LPA receptor.
Owner:RACTHERA CO LTD +1

Methods of differentiating neural cells and related compositions and methods of use

PendingUS20260166091A1Cell differentiationNervous disorderNeural cellLineage specific
The present disclosure provides methods of lineage specific differentiation of pluripotent stem cells, including induced pluripotent stem cells, into floor plate midbrain progenitor cells, determined dopamine (DA) neuron progenitor cells, and / or DA neurons. Also provided are compositions and uses thereof, such as for treating neurodegenerative diseases and conditions, including Parkinson's disease.
Owner:ASPEN NEUROSCIENCE INC