System and method for optogenetic therapy

A technology of nervous system and light source, applied in the field of systems and methods for optogenetic therapy, capable of solving problems such as limitations

Inactive Publication Date: 2017-08-29
CIRCUIT THERAPEUTICS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

We also demonstrated in an animal model that direct DRG injection of iC1C2-expressing AAV5 can result i

Method used

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  • System and method for optogenetic therapy
  • System and method for optogenetic therapy
  • System and method for optogenetic therapy

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Experimental program
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Embodiment Construction

[0053] refer to figure 1 , from a high-level perspective, optogenetic-based neuromodulatory interventions involve: identifying the desired modulation of nervous system function that can be facilitated by optogenetic excitation and / or inhibition (2); followed by selecting the source of neuroanatomical structures within the patient to provide such results (4); deliver an effective amount of a polynucleotide encoding a light-responsive opsin that can be expressed in neurons of the target neuroanatomical structure (6); wait for a period of time to ensure sufficient Portions of the target neural anatomy can indeed express this light-responsive opsin that drives an electrical current when exposed to light (8); controlled, specific excitation and / or inhibition of the above neuroanatomical structures (10).

[0054] As noted above, optogenetics-based neuromodulatory interventions involve: determining the desired modulation of nervous system function that can be facilitated by optogene...

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Abstract

One embodiment is directed to a system for controllably managing pain in the afferent nervous system of a patient having a targeted tissue structure that has been genetically modified to have light sensitive protein, comprising a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure; a light source configured to provide light to the light delivery element; and a controller operatively coupled to light source; wherein the targeted tissue structure comprises a sensory neuron of the patient; and wherein the controller is configured to be automatically operated to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation.

Description

[0001] relevant application data [0002] This application claims priority to US Provisional Application Serial No. 62 / 030,467, filed July 29, 2014. The foregoing applications are hereby incorporated by reference in their entirety into the present application. [0003] Incorporation by Reference of Electronic Submissions [0004] The nucleotide / amino acid sequence listing in computer-readable form submitted at the same time as this application is fully incorporated by reference, and the sequence listing is determined as follows: a 156 Kilobyte ASCII (text) file. field of invention [0005] The present invention relates generally to systems, devices and methods that facilitate various levels of cellular and tissue control in vivo, and more particularly to systems and methods for physiological intervention in which light can be used as an input to cells that have been modified to become photosensitized organize. Background of the invention [0006] An estimated 70 million ...

Claims

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Application Information

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IPC IPC(8): A61N5/06
CPCA61N5/0622A61N5/0601A61N2005/0626A61N2005/0651A61N2005/0662A61K38/177A61P25/04A61P29/02A61B18/18A61K48/0075A61M37/0015A61M2037/0023A61M2037/0046A61M2037/0061A61N5/0613A61N5/062
Inventor C·L·汤M·卡普里特S·德尔普K·戴瑟罗斯D·安吉蕾G·斯塔勒D·安德森D·C·伦德马克
Owner CIRCUIT THERAPEUTICS
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