38 results about "Odorant Receptor" patented technology

The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine receptor M3) capable of enhancing odorant receptor activation. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for polypeptide polymorphisms and mutations associated with odorant receptor activation (e.g., polymorphisms and mutations associated with muscarinic actetylcholine receptor polypeptides (e.g., M1, M2 M3, M4, M5)), as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.

The present invention relates to the characterization of odorant receptors. In particular, the present invention relates to the OR7D4 proteins and nucleic acids encoding OR7D4 proteins and cell systems for screening for modulators of OR7D4 receptors. The present invention further provides assays for the detection of OR7D4 polymorphisms and mutations associated with altered olfactory sensation states, as well as methods of screening for therapeutic agents, ligands, and modulators of OR7D4 receptors.

The present invention provides an insect odorant receptor co-receptor that exhibits excellent detection sensitivity of odorants when bound with an odorant receptor to form an odorant receptor complex.This odorant receptor co-receptor is provided with the following first amino acid sequence and second amino acid sequence which follows the amino acid residue furthest on the carboxyl-terminal side of the first amino acid sequence: (1) a first amino acid sequence which is a partial amino acid sequence of an odorant receptor co-receptor of a first insect or a variant of the receptor, and which isan amino acid sequence that is continuous from the amino-terminal of the first insect odorant receptor co-receptor or the variant thereof to any amino acid residue positioned in the range of 20 aminoacid residues before and after the amino acid residue furthest on the carboxyl-terminal side in the fourth transmembrane domain; and (2) a second amino acid sequence which is a partial amino acid sequence of an odorant receptor co-receptor of a second insect of a different variety than the first insect or a variant of the receptor, and which, in an alignment analysis of the amino acid sequence ofthe first insect odorant receptor co-receptor or the variant thereof and the amino acid sequence of the second insect odorant receptor co-receptor or the variant thereof, is an amino acid sequence that is continuous from one carboxyl-terminal-side amino acid residue, said residue being in a position in the second insect odorant receptor co-receptor or the variant thereof that corresponds to the amino acid residue furthest on the carboxyl-terminal side of the first amino acid sequence, to the carboxyl-terminal of the second insect odorant receptor co-receptor or the variant thereof.

The invention provides a sensor device comprising an insect odorant receptor complex, comprising an OrX and an Orco, in electrical communication with a substrate, wherein the sensor device is configured to detect a change in an electrical characteristic of the substrate. The invention also provides sensor device component comprising an insect odorant receptor complex, comprising an OrX and an Orco, in electrical communication with a substrate. The invention also provides methods for manufacture and use of the sensor device and sensor device component. The invention also provides methods of useof the sensor to detect an analyte.

The invention provides a sensor device comprising an insect odorant receptor (OrX) in electrical communication with a substrate, wherein the sensor device is configured to detect a change in an electrical characteristic of the substrate. The invention also provides sensor device component comprising an insect odorant receptor (OrX) in electrical communication with a substrate. The invention also provides methods for manufacture and use of the sensor device and sensor device component. The invention also provides methods of use of the sensor to detect an analyte.

The present invention relates to a diagnostic kit for metabolic diseases selected from the group consisting of obesity, dyslipidemia, fatty liver, and insulin resistance syndrome, and a method for screening a therapeutic composition for said diseases. The invention provides a large number of new gene targets for metabolic diseases such as obesity and the like, thereby enabling a more reliable diagnosis of genes such as obesity and the like and the use in the screening of a therapeutic candidate material based on the new gene targets.

The present invention relates to an odorant receptor based odorant sensor system and related methods. In particular, systems and methods are provided permitting detection and discrimination of an odorant molecule in a vapor / gaseous phase using a panel of odorant receptors expressed in heterologous cells.