Methods of reducing the perception of body odors with olfactory adaptation and cross-adapting agents

Abstract

Deodorant compositions are disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of malodor. Deodorant compositions are also disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of gender-specific malodor. The methods feature reducing perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to reduce perception of such odor. Other methods feature blocking perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants. Methods of making deodorant compositions are also provided wherein a cross-adapting agent, alone or in combination with other such agents, are included in an amount effective to reduce perception of malodor.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a divisional of application Ser. No. 10 / 342,626, filed Jan. 15, 2003, and claims benefit of U.S. Provisional Application No. 60 / 349,111, filed Jan. 16, 2002 and U.S. Provisional Application No. 60 / 390,313, filed Jun. 21, 2002, each of which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION [0002] The present invention relates to human olfactory adaptation, including human olfactory cross-adaptation, and to methods, cross-adapting agents and compositions to reduce the perception of body odors, including gender-specific body odors. BACKGROUND OF THE INVENTION [0003] Olfactory adaptation is a phenomenon that is generally understood to include a decrease in sensitivity to an odorant that results from exposure to that odorant. Such adaptation can result, at least in part, from peripheral events, such as fatigue of the receptor. [0004] Cross-adaptation is a phenomenon that is generally understood t...

AI Technical Summary

Benefits of technology

[0057] Data from the cross-adaptation study was compiled and evaluated based on the effect each test material had on the magnitude of the stress-derived axillary odor intensity. Agents that produced the highest reduction in the stress-derived axillary odor intensity were labeled as “best” in Table 2. Agents that showed a moderate reduction were labeled as “good” and agent that had the least effect on reducing the magnitude of the stress-derived axillary odor intensity were labeled as “poor.” A product can be constructed in a way to include as many “best” or “good” materials as desired and provide consumer acceptable hedonics. TABLE 2Magnitude of Reduction of Intensityof Male Stress-Derived Odor (MSDO)MSDOMSDOMalesFemalesAgrumexgoodpoorC14 AldehydegoodpoorAmbrettolidepoorpoorAnisyl Aldehyde——Calone 1951——l-CarvonebestbestCEDRAMBER ®goodpoorCitronellol 950goodgoodCitrylalbestgoodCLARITONE ®bestbestcpd Suprapoorpoorα-DamasconepoorpoorΔ-DamasconebestgoodDatilatpoorpoorDihydromyrcenolbestgoodDynascone 10bestpoorEthyl Vanillin——EugenolbestpoorEvernyl——FARENAL ®poorpoorFloropalgoodpoorGLOBALIDE ®goodpoorGLOBANONE ®——HEDIONE ®poorpoorCis-3-HexenolgoodgoodHexyl SalicylatepoorpoorHexylcinnamic Aldehydegoodgoodα-ionone——β-ionone——ISO E SUPER ®poorpoorIsoananatbestpoorIsoraldeine 70——Lilial——Lyral——MAJANTOL ®——Menthyl Acetate rfbestpoorMugetanolgoodpoorNerolionegoodpoorE-,Z-isomers (3:1) of 3-bestbestmethyl-2-octenoic acid ethylestersH&R odor neutralizer ® (D61012)bestbestOryclone SpecialgoodpoorPatchouli Oil——Phenylethyl AlcoholgoodgoodE-isomer of 3-methyl-2-goodgoodpentenoic acid ethyl esterE-isomer of 3-methyl-2-——octenoic acid ethyl esterZ-isomer of 3-methyl-2-bestpoorpentenoic acid ethyl esterRosaphenbestpoorRose Oxide hcpoorgoodSandelgoodpoorSandolenegoodpoorTetrahydro LinaloolbestpoorTimbranolpoorpoorTonalidegoodpoorVetrocitralgoodbest

[0058] The following examples, 2.1, 2.2, and 2.3, shown in Table 3, illustrate specific embodiments of an exemplary deodorant composition for men. The control is a typical formulation for an underarm antiperspirant stick that contains 1% of a masculine fragrance. The antiperspirant alone with this fragrance is considered a control because it does not contain a...

Problems solved by technology

Such adaptation can result, at least in part, fr...