Odorant receptor co-receptor

Abstract

The present invention provides an insect odorant receptor co-receptor that exhibits excellent detection sensitivity of odorants when bound with an odorant receptor to form an odorant receptor complex.This odorant receptor co-receptor is provided with the following first amino acid sequence and second amino acid sequence which follows the amino acid residue furthest on the carboxyl-terminal side of the first amino acid sequence: (1) a first amino acid sequence which is a partial amino acid sequence of an odorant receptor co-receptor of a first insect or a variant of the receptor, and which isan amino acid sequence that is continuous from the amino-terminal of the first insect odorant receptor co-receptor or the variant thereof to any amino acid residue positioned in the range of 20 aminoacid residues before and after the amino acid residue furthest on the carboxyl-terminal side in the fourth transmembrane domain; and (2) a second amino acid sequence which is a partial amino acid sequence of an odorant receptor co-receptor of a second insect of a different variety than the first insect or a variant of the receptor, and which, in an alignment analysis of the amino acid sequence ofthe first insect odorant receptor co-receptor or the variant thereof and the amino acid sequence of the second insect odorant receptor co-receptor or the variant thereof, is an amino acid sequence that is continuous from one carboxyl-terminal-side amino acid residue, said residue being in a position in the second insect odorant receptor co-receptor or the variant thereof that corresponds to the amino acid residue furthest on the carboxyl-terminal side of the first amino acid sequence, to the carboxyl-terminal of the second insect odorant receptor co-receptor or the variant thereof.

Description

technical field [0001] The present invention relates to an olfactory receptor co-receptor. In addition, the present invention relates to a polynucleotide encoding an olfactory receptor co-receptor, an expression plasmid introduced with the polynucleotide, and a cell introduced with the expression plasmid. Background technique [0002] In recent years, various techniques for measuring volatile chemical substances (odourous substances) have been known. This technology is expected to be used in diagnostics such as cancer diagnosis, health care, human body search, disaster prevention such as detection of narcotics, security, and environmental fields such as detection of harmful substances. [0003] Organisms such as dogs and nematodes are sometimes used in the detection of odorous substances. However, although the biological method can detect odorous substances with high sensitivity, it lacks stability due to fluctuations depending on the physical state and individual, and the...

AI Technical Summary

Problems solved by technology

However, although the biological method can detect odorous substances with high sensitivity, it lacks stability because it fluctuates depending on the physical state and individual, and there is a limit to the duration of concentration, so there are The side that is difficult to use for a long time

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