Repair medicament for treating epigastric pain and atrophic gastritis with erosion and intestinal metaplasia and preparation method thereof

Abstract

The invention relates to the field of epigastric pain treatment, in particular to a repairing medicament for treating epigastric pain atrophic gastritis with erosion and intestinal metaplasia. Comprising the following components in parts by weight: 10-20 parts of radix bupleuri, 10-20 parts of radix paeoniae alba, 10-20 parts of fructus aurantii immaturus, 8-12 parts of raw liquorice, 10-20 parts of rhizoma atractylodis macrocephalae, 10-20 parts of poria cocos, 10-20 parts of radix pseudostellariae, 10-20 parts of radix angelicae sinensis, 10-20 parts of ligusticum wallichii, 10-20 parts of radix rehmanniae preparata, 10-20 parts of radix aucklandiae, 10-20 parts of pawpaw, 10-20 parts of fructus aurantii, 10-20 parts of radix linderae, 20-40 parts of lily, 15-25 parts of rhizoma corydalis, 15-25 parts of radix salviae miltiorrhizae, 15-25 parts of dandelion, 15-25 parts of white flower herb, 10-20 parts of rhizoma bletillae and 10-20 parts of radix notoginseng. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 20-40 parts of cuttlebone, 20-40 parts of corrugated shells, 15-25 parts of curcuma zedoary, 20-40 parts of endothelium corneum gigeriae galli, 15-25 parts of thunberg fritillary bulb, 15-25 parts of oyster, 10-20 parts of coptis chinensis and 15-20 parts of serissa serissoide. The radix bupleuri and the fructus aurantii immaturus are used for soothing the liver and regulating qi, the rhizoma atractylodis macrocephalae and the poria cocos are matched for strengthening the spleen and eliminating dampness, and improving qi stagnation of the spleen and the stomach, and a plurality of dosage forms are adopted in the preparation mode, so that decoction, oral thick paste, powder, pills and tablets can be provided to meet the requirements of different patients.

Description

Technical Field

[0001] The present invention relates to the field of treating epigastric pain, and particularly to a repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain and a preparation method thereof. Background Art

[0002] Epigastric pain, commonly known as "stomachache", is a common digestive system disease mainly manifested by pain in the epigastric region above the abdomen. The pain location is mostly at the xiphoid process or two transverse fingers above the umbilicus, that is, the epigastric region. Epigastric pain is called "heartache" or "pain below the heart" in traditional Chinese medicine theory, and it has been recorded in detail by ancient physicians. The causes of epigastric pain are complex and diverse, mainly including the following aspects: Improper diet: Overeating, excessive hunger, eating too fast or long-term consumption of spicy, greasy, raw and cold and other irritating foods may damage the spleen and stomach, resulting in epigastric pain; Emotional disorders: Long-term anxiety, tension, depression and other bad emotions will affect gastrointestinal function, leading to epigastric pain. Emotional discomfort and liver qi stagnation, attacking the stomach transversely, are also common causes of epigastric pain; External pathogen invasion: Such as abdominal cold, cold pathogen invading the stomach, cold nature coagulating and contracting, causing disharmony of stomach qi and pain; Disease factors: Acute and chronic gastritis, gastric and duodenal ulcers, gastric neurosis, chronic pancreatitis and other diseases can all cause epigastric pain. In addition, Helicobacter pylori infection is also one of the important causes of epigastric pain. When epigastric pain (erosive gastritis, atrophic gastritis with erosion, atrophic gastritis with intestinal metaplasia) occurs, it is necessary to take traditional Chinese medicine prescriptions with the efficacy of strengthening the spleen and regulating the stomach for treatment.

[0003] Among the existing traditional Chinese medicine preparations for treating epigastric pain, although they are equipped with Baikou Powder, Moluodan and other drugs containing certain spleen-strengthening drugs, they lack special dampness-removing drugs, and it is difficult to effectively treat syndromes such as spleen deficiency with excessive dampness and damp pathogen stagnating the spleen in epigastric pain patients, resulting in poor curative effects. Moreover, the dosage forms are single, and traditional decoctions or pills are difficult to meet the diverse needs of patients for portability, taste and dosage accuracy, affecting medication compliance.

[0004] Therefore, aiming at the problems that the existing traditional Chinese medicine preparations for treating epigastric pain lack the compatibility of drugs such as soothing the liver and regulating qi, strengthening the spleen and removing dampness, the drug compatibility is improper, and the dosage forms are single, a repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain and a preparation method thereof can be designed. Summary of the Invention

[0005] In order to overcome the problems that the existing traditional Chinese medicine preparations for treating epigastric pain lack the compatibility of drugs such as soothing the liver and regulating qi, strengthening the spleen and removing dampness, the drug compatibility is improper, and the dosage forms are single.

[0006] The technical solution of the present invention is as follows: A repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia accompanied by epigastric pain, comprising the following components in parts by weight: 10-20 parts of Bupleurum chinense, 10-20 parts of Paeonia lactiflora, 10-20 parts of Fructus Aurantii Immaturus, 8-12 parts of raw Glycyrrhiza uralensis, 10-20 parts of Atractylodes macrocephala, 10-20 parts of Poria cocos, 10-20 parts of Pseudostellaria heterophylla, 10-20 parts of Angelica sinensis, 10-20 parts of Ligusticum wallichii, 10-20 parts of Rehmannia glutinosa, 10-20 parts of Aucklandia lappa, 10-20 parts of Chaenomeles sinensis, 10-20 parts of Fructus Aurantii, 10-20 parts of Lindera aggregata, 20-40 parts of Lilium brownii, 15-25 parts of Corydalis yanhusuo, 15-25 parts of Salvia miltiorrhiza, 15-25 parts of Taraxacum mongolicum, 15-25 parts of Herba Portulacae, 10-20 parts of Bletilla striata, 10-20 parts of Panax notoginseng, 20-40 parts of Endoconcha Sepiae, 20-40 parts of Concha Arcae, 15-25 parts of Rhizoma Curcumae, 20-40 parts of Endothelium Corneum Gigeriae Galli, 15-25 parts of Fritillaria thunbergii, 15-25 parts of Concha Ostreae, 10-20 parts of Coptis chinensis, and 15-20 parts of Serissa japonica.

[0007] The preparation method of the traditional Chinese medicine decoction of the repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia accompanied by epigastric pain, which includes the above-mentioned repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia accompanied by epigastric pain, and its preparation steps are as follows:

[0008] Step 1: Raw material preparation, weigh Bupleurum chinense, Paeonia lactiflora, Fructus Aurantii Immaturus, raw Glycyrrhiza uralensis, Atractylodes macrocephala, Poria cocos, Pseudostellaria heterophylla, Angelica sinensis, Ligusticum wallichii, Rehmannia glutinosa, Aucklandia lappa, Chaenomeles sinensis, Fructus Aurantii, Lindera aggregata, Lilium brownii, Corydalis yanhusuo, Salvia miltiorrhiza, Taraxacum mongolicum, Herba Portulacae, Bletilla striata, Panax notoginseng, Endoconcha Sepiae, Concha Arcae, Rhizoma Curcumae, Endothelium Corneum Gigeriae Galli, Fritillaria thunbergii, Concha Ostreae, Coptis chinensis, and Serissa japonica according to the required ratio of the formula and set aside;

[0009] Step 2: Raw material pretreatment, put the weighed medicinal materials into clear water and soak for 30 minutes to 1 hour to make the medicinal materials fully absorb water and expand;

[0010] Step 3: First decoction, add water to the earthenware pot, and the ratio of water to the total weight of the medicinal materials is 8:1. Then add Concha Ostreae and Concha Arcae, which are hard in texture, to the earthenware pot. After boiling, turn to slow fire and decoct for 10-15 minutes. Then add the remaining medicinal materials except Serissa japonica and decoct together. The decoction time is controlled within 40-60 minutes, and add Serissa japonica containing volatile oil 5 minutes before the end of decoction, and filter to obtain the juice;

[0011] Step 4: Second decoction, add water to the earthenware pot again, and the water volume exceeds the medicinal residues surface by 8-10 cm of medicinal residues. Then decoct for 30-40 minutes and filter to obtain the juice;

[0012] Step 5: Cooling and preservation, combine the two filtrates, cool and seal them in bags.

[0013] Preferably, during the administration period, the adult dosage is 100 - 200 ml each time, twice a day, taken warm after breakfast and dinner; the dosage for children (6 - 12 years old) is 50 - 100 ml each time, twice a day; for those under 6 years old, the dosage should be reduced or the medicine should be prohibited according to the doctor's advice.

[0014] The preparation method of a traditional Chinese medicine paste for a repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, which includes the above-mentioned repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, and the preparation steps are as follows:

[0015] Step 1: Raw material preparation, weigh and reserve bupleurum root, white peony root, immature bitter orange, raw licorice root, atractylodes macrocephala, poria cocos, pseudostellaria root, angelica sinensis, chuanxiong rhizome, rehmannia root, costus root, papaya, immature bitter orange, lindera aggregata, lily bulb, Corydalis yanhusuo, salvia miltiorrhiza, dandelion, white flower herb, bletilla striata, notoginseng, sea-ear shell, oyster shell, zedoary, chicken gizzard-membrane, fritillaria thunbergii, oyster, coptis chinensis, and serissa japonica according to the required proportions of the formula.

[0016] Step 2: Raw material pretreatment, put the weighed medicinal materials into clear water and soak for 30 minutes to 1 hour to make the medicinal materials fully absorb water and expand.

[0017] Step 3: First decoction, add water to the earthenware pot, and the ratio of water to the total weight of the medicinal materials is 8:1. Then add the hard-textured oyster shell and oyster shell to the earthenware pot. After boiling, turn to low heat and decoct for 10 - 15 minutes. Then add the remaining medicinal materials except serissa japonica and decoct together. The decoction time is controlled within 40 - 60 minutes, and add serissa japonica containing volatile oil 5 minutes before the end of decoction. Filter to obtain the decoction.

[0018] Step 4: Second decoction, add water to the earthenware pot again, and the water level exceeds the medicinal residues by 8 - 10 cm. Then decoct for 30 - 40 minutes and filter to obtain the decoction.

[0019] Step 5: Standing, combine the two filtrates and let them stand for precipitation, then take the supernatant.

[0020] Step 6: Concentrate and collect the paste, concentrate the clear liquid to a relative density of 1.25 - 1.30, add rock sugar, and the ratio of the medicinal liquid to rock sugar is 1:0.5. Decoct over low heat until it reaches the "flag-hanging" state.

[0021] Step 7: Bottling and storage, quickly pour it into a sterilized glass bottle while it is hot, seal it and store it.

[0022] Preferably, during the administration period, the adult dosage is 10 - 15 g (about 1 tablespoon) each time, twice a day, taken by dissolving in warm water; the dosage for children (6 - 12 years old) is 5 - 8 g (about half a tablespoon) each time, once or twice a day; for those under 6 years old, the dosage should be reduced or the medicine should be prohibited according to the doctor's advice.

[0023] A method for preparing a powdered Chinese medicine for treating epigastric pain, atrophic gastritis with erosion and intestinal metaplasia, comprising the above-mentioned repairing agent for treating epigastric pain, atrophic gastritis with erosion and intestinal metaplasia, and the preparation steps are as follows:

[0024] Step 1: Prepare the raw materials. Weigh radix bupleuri, white peony root, immature bitter orange, raw licorice, atractylodes, poria, pseudoginseng, angelica, ligusticum chuanxiong, prepared rehmannia, costusroot, papaya, fructus aurantii, lindera striata, lily, corydalis, salvia miltiorrhiza, danshen, white flower grass, bletilla striata, notoginseng, cuttlefish, walnut, zedoaria, chicken gizzard lining, thunbergia thunbergii, oyster, coptis chinensis and safflower according to the required proportion of the formula and set aside for use.

[0025] Step 2: crushing, putting the above medicinal materials into a special crusher for crushing;

[0026] Step 3: Sieve the crushed mixture through a 80-100 mesh sieve;

[0027] Step 4: Bottle and store the powder in a sealed light-proof container.

[0028] Preferably, the dosage for adults is 3-5 g each time, 3 times a day, taken with warm water or made into a paste; the dosage for children (6-12 years old) is 1-2 g each time, 2 times a day; children under 6 years old should follow the doctor's advice to reduce the dosage or prohibit using it.

[0029] A method for preparing a Chinese herbal medicine powder and pills for a repairing agent for treating epigastric pain, atrophic gastritis with erosion and intestinal metaplasia, comprising the above-mentioned repairing agent for treating epigastric pain, atrophic gastritis with erosion and intestinal metaplasia, and the preparation steps thereof are as follows:

[0030] Step 1: Prepare the raw materials. Weigh radix bupleuri, white peony root, immature bitter orange, raw licorice, atractylodes, poria, pseudoginseng, angelica, ligusticum chuanxiong, prepared rehmannia, costusroot, papaya, fructus aurantii, lindera striata, lily, corydalis, salvia miltiorrhiza, danshen, white flower grass, bletilla striata, notoginseng, cuttlefish, walnut, zedoaria, chicken gizzard lining, thunbergia thunbergii, oyster, coptis chinensis and safflower according to the required proportion of the formula and set aside for use.

[0031] Step 2: crushing, putting the above medicinal materials into a special crusher for crushing;

[0032] Step 3: Sieve the crushed mixture through a 80-100 mesh sieve to obtain fine powder;

[0033] Step 4: Make pills. Add refined honey to the powder, with the ratio of powder to refined honey being 1:1.2. Knead into a soft material, roll into strips and divide into 3-5g pills.

[0034] Step 3: Drying: Place the pellets in a cool and ventilated place and dry them until the moisture content is ≤9%;

[0035] Step 4: Bottle and store the pellets in a sealed light-proof container.

[0036] Preferably, during the period of taking the medicine, the dosage for adults is 1 pill (3 - 5 g) each time, 3 times a day, taken with warm water; the dosage for children (6 - 12 years old) is half a pill each time, 2 times a day; for those under 6 years old, the dosage should be reduced or the medicine should be prohibited according to the doctor's advice.

[0037] The method for tabletting the Chinese herbal pieces of the repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain includes the above-mentioned repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, and its preparation steps are as follows:

[0038] Step 1: Weigh Bupleurum chinense, White Peony Root, Immature Bitter Orange, Raw Licorice Root, Atractylodes macrocephala, Poria cocos, Pseudostellaria heterophylla, Angelica sinensis, Chuanxiong rhizome, Rehmannia glutinosa, Aucklandia lappa, Chaenomeles sinensis, Immature Bitter Orange, Lindera aggregata, Lily brownii, Corydalis yanhusuo, Salvia miltiorrhiza, Taraxacum mongolicum, Herba Saussureae, Bletilla striata, Panax notoginseng, Endoconcha Sepiae, Concha Arcae, Rhizoma Curcumae, Endothelium Corneum Gigeriae Galli, Fritillaria thunbergii, Oyster, Coptis chinensis, and Serissa serissoides according to the required proportions of the formula for standby;

[0039] Step 2: Crushing, putting the above-mentioned medicinal materials into a special crusher in sequence for crushing;

[0040] Step 3: Sieving, sieving the crushed mixture through an 80 - 100 - mesh sieve to obtain fine medicinal powder;

[0041] Step 4: Mixing, putting the fine medicinal powder, microcrystalline cellulose, and starch paste into a special mixer according to the ratio of 1:0.1:0.2, and mixing until "it can be kneaded into a ball by hand and dispersed when lightly pressed" to make soft material;

[0042] Step 5: Granulating, adding the soft material into a special rocking granulator in batches and multiple times to obtain granules;

[0043] Step 6: Drying and sizing, drying the granules in a special dryer, and sizing the dried granules through a 20 - 40 - mesh sieve;

[0044] Step 7: Lubricating, adding magnesium stearate, whose weight is 0.5% of the total weight, and mixing for 10 minutes to reduce the risk of sticking during tabletting;

[0045] Step 8: Tabletting and forming, using a rotary tableting machine, adjusting the pressure to 20 - 40 kN, and tabletting the granules into round or special-shaped tablets of 0.3 - 0.5 g;

[0046] Step 9: Packaging, packaging the tablets by aluminum-plastic blister packaging, and storing them in a cool and dry place.

[0047] Preferably, during the period of taking the medicine, the dosage for adults is 2 - 3 tablets (0.3 - 0.5 g / tablet) each time, 3 times a day, taken after meals; the dosage for children (6 - 12 years old) is 1 tablet each time, 2 times a day; for those under 6 years old, the dosage should be reduced or the medicine should be prohibited according to the doctor's advice.

[0048] Advantages of the present invention:

[0049] The repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain and its preparation method can soothe the liver and regulate qi with Bupleuri Radix and Aurantii Fructus Immaturus, and be combined with Atractylodis Macrocephalae Rhizoma and Poria cocos to strengthen the spleen and remove dampness, improving qi stagnation in the spleen and stomach. With Salviae Miltiorrhizae Radix, Curcumae Rhizoma and Notoginseng Radix et Rhizoma promoting blood circulation to remove blood stasis, it can promote microcirculation of gastric mucosa and reverse the pathological changes of intestinal metaplasia, thus realizing the synergy of soothing the liver and strengthening the spleen and promoting blood circulation to remove blood stasis. With Endoconcha Sepiae and Concha Arcae containing calcium carbonate components to neutralize gastric acid, and Ostreae Concha astringing and repairing the erosive surface, and Coptidis Rhizoma and Serissae Herba clearing heat and detoxifying, inhibiting the activity of Helicobacter pylori, thus realizing the synergy of antacid and protecting the membrane and detoxifying and promoting granulation. With Pseudostellariae Radix, Angelicae Sinensis Radix and Rehmanniae Radix Praeparata nourishing qi and blood, improving anemia and low immune function associated with atrophic gastritis, and with Endoconcha Galli and Thunberg Fritillary Bulb promoting digestion and resolving food stagnation, regulating gastric acid secretion and preventing further mucosal damage, thus realizing the synergy of tonifying qi and blood and promoting digestion and removing stagnation, and the preparation method covers multiple dosage forms, and can provide decoctions, paste extracts, powders, pills and tablets to adapt to the needs of different patients. Compared with traditional treatment medicaments, through formula innovation and dosage form expansion, the present invention takes into account the improvement of drug efficacy, retention of component activity and medication convenience, and provides an efficient, stable and personalized treatment plan for patients with epigastric pain. Detailed implementation mode

[0050] The present invention will be further described below in conjunction with embodiments.

[0051] The present invention provides an embodiment: a repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, comprising the following components in parts by weight: 10 - 20 parts of Bupleuri Radix, 10 - 20 parts of Paeoniae Radix Alba, 10 - 20 parts of Aurantii Fructus Immaturus, 8 - 12 parts of Glycyrrhizae Radix Preparata, 10 - 20 parts of Atractylodis Macrocephalae Rhizoma, 10 - 20 parts of Poria cocos, 10 - 20 parts of Pseudostellariae Radix, 10 - 20 parts of Angelicae Sinensis Radix, 10 - 20 parts of Chuanxiong Rhizoma, 10 - 20 parts of Rehmanniae Radix Praeparata, 10 - 20 parts of Aucklandiae Radix, 10 - 20 parts of Chaenomelis Fructus, 10 - 20 parts of Aurantii Fructus, 10 - 20 parts of Linderae Radix, 20 - 40 parts of Lilii Bulbus, 15 - 25 parts of Corydalis Rhizoma, 15 - 25 parts of Salviae Miltiorrhizae Radix, 15 - 25 parts of Taraxaci Herba, 15 - 25 parts of Herba Saussureae Albae, 10 - 20 parts of Bletillae Rhizoma, 10 - 20 parts of Notoginseng Radix et Rhizoma, 20 - 40 parts of Endoconcha Sepiae, 20 - 40 parts of Concha Arcae, 15 - 25 parts of Curcumae Rhizoma, 20 - 40 parts of Endoconcha Galli, 15 - 25 parts of Thunberg Fritillary Bulb, 15 - 25 parts of Ostreae Concha, 10 - 20 parts of Coptidis Rhizoma and 15 - 20 parts of Serissae Herba.

[0052] The preparation method of the decoction of traditional Chinese medicine pieces of the repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain includes the repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain as described above, and its preparation steps are as follows:

[0053] Step 1: Raw material preparation. Weigh Bupleurum chinense, Paeonia lactiflora, Aurantii fructus immaturus, Glycyrrhiza uralensis Fisch., Atractylodes macrocephala, Poria cocos, Pseudostellaria heterophylla, Angelica sinensis, Ligusticum wallichii, Rehmannia glutinosa, Aucklandia lappa, Chaenomeles sinensis, Aurantii nobilis pericarpium, Lindera aggregata, Lilium brownii, Corydalis yanhusuo, Salvia miltiorrhiza, Taraxacum mongolicum, Herba Saussureae, Bletilla striata, Panax notoginseng, Endoconcha Sepiae, Concha Arcae, Rhizoma Curcumae, Endothelium Corneum Gigeriae Galli, Fritillaria thunbergii, Concha Ostreae, Coptis chinensis, and Serissa serissoides according to the required proportions in the formula and set aside.

[0054] Step 2: Raw material pretreatment. Put the weighed medicinal materials into clear water and soak them for 30 minutes to 1 hour to make the medicinal materials fully absorb water and expand.

[0055] Step 3: First decoction. Add water to the earthenware pot, and the ratio of water to the total weight of the medicinal materials is 8:1. Then add Concha Ostreae and Concha Arcae, which are hard in texture, to the earthenware pot. After boiling, turn to slow fire and decoct for 10 - 15 minutes. Then add the remaining medicinal materials except Serissa serissoides and decoct them together. The decoction time is controlled within 40 - 60 minutes, and add Serissa serissoides containing volatile oil 5 minutes before the end of decoction. Filter to obtain the decoction.

[0056] Step 4: Second decoction. Add water to the earthenware pot again, and the water level should exceed the medicinal residues by 8 - 10 cm. Then decoct for 30 - 40 minutes and filter to obtain the decoction.

[0057] Step 5: Cooling and storage. Combine the two filtrates, cool them, and then seal and bag them.

[0058] Preferably, during the taking period, the adult dosage is 100 - 200 ml each time, twice a day, taken warm after breakfast and dinner; the dosage for children (6 - 12 years old) is 50 - 100 ml each time, twice a day; for those under 6 years old, the dosage should be reduced or prohibited according to the doctor's advice.

[0059] The preparation method of the traditional Chinese medicine extract for the repair agent for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, which includes the repair agent for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain as described above, and its preparation steps are as follows:

[0060] Step 1: Raw material preparation. Weigh Bupleurum chinense, Paeonia lactiflora, Aurantii fructus immaturus, Glycyrrhiza uralensis Fisch., Atractylodes macrocephala, Poria cocos, Pseudostellaria heterophylla, Angelica sinensis, Ligusticum wallichii, Rehmannia glutinosa, Aucklandia lappa, Chaenomeles sinensis, Aurantii nobilis pericarpium, Lindera aggregata, Lilium brownii, Corydalis yanhusuo, Salvia miltiorrhiza, Taraxacum mongolicum, Herba Saussureae, Bletilla striata, Panax notoginseng, Endoconcha Sepiae, Concha Arcae, Rhizoma Curcumae, Endothelium Corneum Gigeriae Galli, Fritillaria thunbergii, Concha Ostreae, Coptis chinensis, and Serissa serissoides according to the required proportions in the formula and set aside.

[0061] Step 2: Raw material pretreatment. Put the weighed medicinal materials into clear water and soak them for 30 minutes to 1 hour to make the medicinal materials fully absorb water and expand.

[0062] Step 3: For the first decoction, add water to the casserole, with the ratio of water to total weight of medicinal materials being 8:1, then add hard oysters and oyster shells to the casserole, boil and then simmer for 10-15 minutes, then add the remaining medicinal materials except for the Chinese hibiscus, and decoct for 40-60 minutes, and add the Chinese hibiscus containing volatile oil 5 minutes before the end of decoction, and filter to obtain the juice;

[0063] Step 4: Second decoction, add water to the casserole again, the water level should be 8-10cm above the medicinal residue, then decoct for 30-40 minutes, filter and take the juice;

[0064] Step 5: Let stand, combine the two filtrates and let them settle, and take the supernatant;

[0065] Step 6: Concentrate the clear liquid to a relative density of 1.25-1.30, add crystal sugar, the ratio of liquid medicine to crystal sugar is 1:0.5, and simmer over low heat until it becomes a "hanging flag" shape;

[0066] Step 7: Bottle and store. While hot, bottle into sterilized glass bottles and seal them for storage.

[0067] Preferably, the dosage for adults is 10-15 g (about 1 tablespoon) each time, twice a day, dissolved in warm water; the dosage for children (6-12 years old) is 5-8 g (about half a tablespoon) each time, 1-2 times a day; children under 6 years old should follow the doctor's advice to reduce the dosage or prohibit use.

[0068] A method for preparing a powdered Chinese medicine for treating epigastric pain, atrophic gastritis with erosion and intestinal metaplasia, comprising the above-mentioned repairing agent for treating epigastric pain, atrophic gastritis with erosion and intestinal metaplasia, and the preparation steps are as follows:

[0069] Step 1: Prepare the raw materials. Weigh radix bupleuri, white peony root, immature bitter orange, raw licorice, atractylodes, poria, pseudoginseng, angelica, ligusticum chuanxiong, prepared rehmannia, costusroot, papaya, fructus aurantii, lindera striata, lily, corydalis, salvia miltiorrhiza, danshen, white flower grass, bletilla striata, notoginseng, cuttlefish, walnut, zedoaria, chicken gizzard lining, thunbergia thunbergii, oyster, coptis chinensis and safflower according to the required proportion of the formula and set aside for use.

[0070] Step 2: crushing, putting the above medicinal materials into a special crusher for crushing;

[0071] Step 3: Sieve the crushed mixture through a 80-100 mesh sieve;

[0072] Step 4: Bottle and store the powder in a sealed light-proof container.

[0073] Preferably, the dosage for adults is 3-5 g each time, 3 times a day, taken with warm water or made into a paste; the dosage for children (6-12 years old) is 1-2 g each time, 2 times a day; children under 6 years old should follow the doctor's advice to reduce the dosage or prohibit using it.

[0074] The method for making pills by powdering traditional Chinese medicine pieces of a repair medicament for treating gastric pain, atrophic gastritis with erosion and intestinal metaplasia, which includes the repair medicament for treating gastric pain, atrophic gastritis with erosion and intestinal metaplasia as described above, and its preparation steps are as follows:

[0075] Step 1: Raw material preparation, weigh and reserve bupleurum root, white peony root, immature bitter orange, raw licorice root, largehead atractylodes rhizome, poria cocos, heterophylly falsestarwort root, Chinese angelica, chuanxiong rhizome, rehmannia root, costusroot, papaya, immature bitter orange, combined spicebush root, lily bulb, Corydalis yanhusuo, salvia miltiorrhiza, dandelion, white flower herb, bletilla striata, notoginseng, sea-ear shell, oyster shell, zedoary, chicken gizzard-membrane, thunberg fritillary bulb, oyster, coptis root and serissa japonica according to the required proportions of the formula;

[0076] Step 2: Crushing, successively put the above-mentioned medicinal materials into a special crusher for crushing;

[0077] Step 3: Sieving, sieve the crushed mixture through an 80 - 100 mesh sieve to obtain fine medicinal powder;

[0078] Step 4: Pill making, add refined honey to the medicinal powder, the ratio of the medicinal powder to the refined honey is 1:1.2, knead it into a soft material, roll it into strips and then divide it into pill grains of 3 - 5 g;

[0079] Step 3: Drying, place the pill grains in a cool and ventilated place to dry until the water content ≤ 9%;

[0080] Step 4: Bottling and storage, seal the pill grains in a light-proof container for storage.

[0081] Preferably, during the taking period, the adult dosage is 1 pill (3 - 5 g) each time, 3 times a day, taken with warm water; the dosage for children (6 - 12 years old) is half a pill each time, 2 times a day; those under 6 years old need to follow the doctor's advice to reduce the dosage or avoid using it.

[0082] The method for tabletting after powdering traditional Chinese medicine pieces of a repair medicament for treating gastric pain, atrophic gastritis with erosion and intestinal metaplasia, which includes the repair medicament for treating gastric pain, atrophic gastritis with erosion and intestinal metaplasia as described above, and its preparation steps are as follows:

[0083] Step 1: Weigh and reserve bupleurum root, white peony root, immature bitter orange, raw licorice root, largehead atractylodes rhizome, poria cocos, heterophylly falsestarwort root, Chinese angelica, chuanxiong rhizome, rehmannia root, costusroot, papaya, immature bitter orange, combined spicebush root, lily bulb, Corydalis yanhusuo, salvia miltiorrhiza, dandelion, white flower herb, bletilla striata, notoginseng, sea-ear shell, oyster shell, zedoary, chicken gizzard-membrane, thunberg fritillary bulb, oyster, coptis root and serissa japonica according to the required proportions of the formula;

[0084] Step 2: Crushing, successively put the above-mentioned medicinal materials into a special crusher for crushing;

[0085] Step 3: Sieving, sieve the crushed mixture through an 80 - 100 mesh sieve to obtain fine medicinal powder;

[0086] Step 4: Mixing. The fine medicinal powder, microcrystalline cellulose, and starch paste are put into a dedicated mixer in a ratio of 1:0.1:0.2 and mixed until "it can be kneaded into a ball by hand and dispersed when gently pressed", to make soft materials.

[0087] Step 5: Granulation. The soft materials are added to a dedicated rocking granulator in batches multiple times to obtain granules.

[0088] Step 6: Drying and sizing. The granules are placed in a dedicated dryer for drying, and the dried granules are sized through a 20 - 40 mesh sieve.

[0089] Step 7: Lubrication. Magnesium stearate is added, and its weight is 0.5% of the total weight, and mixed for 10 minutes to reduce the risk of sticking during tablet pressing.

[0090] Step 8: Tablet pressing and forming. A rotary tablet press is used, the pressure is adjusted to 20 - 40 kN, and the granules are pressed into round or shaped tablets of 0.3 - 0.5 g.

[0091] Step 9: Packaging. The tablets are packaged by aluminum - plastic blister packaging and stored in a cool and dry place.

[0092] Preferably, during the taking period, the adult dosage is 2 - 3 tablets (0.3 - 0.5 g / tablet) each time, 3 times a day, swallowed after meals; the dosage for children (6 - 12 years old) is 1 tablet each time, 2 times a day; for those under 6 years old, the dosage needs to be reduced or prohibited according to the doctor's advice.

[0093] Example 1

[0094] The present invention provides an example: a repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, comprising the following components in parts by weight: 10 parts of Bupleuri Radix, 10 parts of Paeoniae Radix Alba, 10 parts of Aurantii Fructus Immaturus, 8 parts of Glycyrrhizae Radix Preparata, 10 parts of Atractylodis Macrocephalae Rhizoma, 10 parts of Poria, 10 parts of Pseudostellariae Radix, 10 parts of Angelicae Sinensis Radix, 10 parts of Chuanxiong Rhizoma, 10 parts of Rehmanniae Radix, 10 parts of Aucklandiae Radix, 10 parts of Chaenomelis Fructus, 10 parts of Aurantii Fructus, 10 parts of Linderae Radix, 20 parts of Lilium Brownii Bulbus, 15 parts of Corydalis Rhizoma, 15 parts of Salviae Miltiorrhizae Radix, 15 parts of Taraxaci Herba, 15 parts of Herba Siphonostegiae, 10 parts of Bletillae Rhizoma, 10 parts of Notoginseng Radix, 20 parts of Endoconcha Sepiae, 20 parts of Concha Arcae, 15 parts of Curcumae Rhizoma, 20 parts of Endothelium Corneum Gigeriae Galli, 15 parts of Thunbergii Fritillariae Bulbus, 15 parts of Ostreae Concha, 10 parts of Coptidis Rhizoma, and 15 parts of Serissae Herba.

[0095] Example 2

[0096] The present invention provides an embodiment: a repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, comprising the following components in parts by weight: 15 parts of Bupleurum chinense, 15 parts of Paeonia lactiflora, 15 parts of Aurantii Fructus Immaturus, 10 parts of raw Glycyrrhiza uralensis, 15 parts of Atractylodes macrocephala, 15 parts of Poria cocos, 15 parts of Pseudostellaria heterophylla, 15 parts of Angelica sinensis, 15 parts of Ligusticum wallichii, 15 parts of Rehmannia glutinosa, 15 parts of Aucklandia lappa, 15 parts of Chaenomeles sinensis, 15 parts of Aurantii Fructus, 15 parts of Lindera aggregata, 30 parts of Lilium brownii, 20 parts of Corydalis yanhusuo, 20 parts of Salvia miltiorrhiza, 20 parts of Taraxacum mongolicum, 20 parts of Herba Portulacae, 15 parts of Bletilla striata, 15 parts of Panax notoginseng, 30 parts of Endoconcha Sepiae, 30 parts of Concha Arcae, 20 parts of Curcuma zedoaria, 30 parts of Endothelium Corneum Gigeriae Galli, 20 parts of Fritillaria thunbergii, 20 parts of Concha Ostreae, 15 parts of Coptis chinensis, and 18 parts of Serissa japonica.

[0097] Example 3

[0098] The present invention provides an embodiment: a repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, comprising the following components in parts by weight: 20 parts of Bupleurum chinense, 20 parts of Paeonia lactiflora, 20 parts of Aurantii Fructus Immaturus, 8 - 12 parts of raw Glycyrrhiza uralensis, 20 parts of Atractylodes macrocephala, 20 parts of Poria cocos, 20 parts of Pseudostellaria heterophylla, 20 parts of Angelica sinensis, 20 parts of Ligusticum wallichii, 20 parts of Rehmannia glutinosa, 20 parts of Aucklandia lappa, 20 parts of Chaenomeles sinensis, 20 parts of Aurantii Fructus, 20 parts of Lindera aggregata, 40 parts of Lilium brownii, 25 parts of Corydalis yanhusuo, 25 parts of Salvia miltiorrhiza, 25 parts of Taraxacum mongolicum, 25 parts of Herba Portulacae, 20 parts of Bletilla striata, 20 parts of Panax notoginseng, 40 parts of Endoconcha Sepiae, 40 parts of Concha Arcae, 25 parts of Curcuma zedoaria, 40 parts of Endothelium Corneum Gigeriae Galli, 25 parts of Fritillaria thunbergii, 25 parts of Concha Ostreae, 20 parts of Coptis chinensis, and 20 parts of Serissa japonica.

[0099] The above has described the embodiments of the present invention in detail. However, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.

Claims

1. A repair agent for treating atrophic gastritis with erosion and intestinal metaplasia in epigastric pain, characterized in that, It comprises the following components in parts by weight: Bupleuri Radix 10 - 20 parts, Paeoniae Radix Alba 10 - 20 parts, Aurantii Fructus Immaturus 10 - 20 parts, Glycyrrhizae Radix Preparata 8 - 12 parts, Atractylodis Macrocephalae Rhizoma 10 - 20 parts, Poria 10 - 20 parts, Pseudostellariae Radix 10 - 20 parts, Angelicae Sinensis Radix 10 - 20 parts, Chuanxiong Rhizoma 10 - 20 parts, Rehmanniae Radix Preparata 10 - 20 parts, Aucklandiae Radix 10 - 20 parts, Chaenomelis Fructus 10 - 20 parts, Aurantii Fructus 10 - 20 parts, Linderae Radix 10 - 20 parts, Lilii Bulbus 20 - 40 parts, Corydalis Rhizoma 15 - 25 parts, Salviae Miltiorrhizae Radix 15 - 25 parts, Taraxaci Herba 15 - 25 parts, Herba Herbae Chrysanthemi Indici 15 - 25 parts, Bletillae Rhizoma 10 - 20 parts, Notoginseng Radix et Rhizoma 10 - 20 parts, Endoconcha Sepiae 20 - 40 parts, Concha Arcae 20 - 40 parts, Curcumae Rhizoma 15 - 25 parts, Galli Gigeriae Endothelium Corneum 20 - 40 parts, Thunbergii Fritillariae Bulbus 15 - 25 parts, Ostreae Concha 15 - 25 parts, Coptidis Rhizoma 10 - 20 parts, and Serissae Herba 15 - 20 parts.

2. Preparation method of decoction of traditional Chinese medicine pieces for a repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, characterized in that It includes the repair medicament for treating gastric pain, atrophic gastritis with erosion and intestinal metaplasia according to claim 1, and its preparation steps are as follows: Step 1: Raw material preparation, weigh Bupleuri Radix, Paeoniae Radix Alba, Aurantii Fructus Immaturus, Glycyrrhizae Radix Preparata, Atractylodis Macrocephalae Rhizoma, Poria, Pseudostellariae Radix, Angelicae Sinensis Radix, Chuanxiong Rhizoma, Rehmanniae Radix Preparata, Aucklandiae Radix, Chaenomelis Fructus, Aurantii Fructus, Linderae Radix, Lilii Bulbus, Corydalis Rhizoma, Salviae Miltiorrhizae Radix, Taraxaci Herba, Herba Herbae Chrysanthemi Indici, Bletillae Rhizoma, Notoginseng Radix et Rhizoma, Endoconcha Sepiae, Concha Arcae, Curcumae Rhizoma, Galli Gigeriae Endothelium Corneum, Thunbergii Fritillariae Bulbus, Ostreae Concha, Coptidis Rhizoma, and Serissae Herba according to the required proportions of the formula and set aside. Step 2: Raw material pretreatment, put the weighed medicinal materials into clear water and soak for 30 minutes to 1 hour to make the medicinal materials fully absorb water and expand. Step 3: First decoction, add water to the casserole, and the ratio of water to the total weight of the medicinal materials is 8:

1. Then add the hard-textured Ostreae Concha and Concha Arcae to the casserole, bring to a boil and then turn to slow fire and decoct for 10 - 15 minutes. Then add the remaining medicinal materials except Serissae Herba and decoct together. The decoction time is controlled within 40 - 60 minutes, and add Serissae Herba containing volatile oil 5 minutes before the end of decoction, and filter to obtain the decoction. Step 4: Second decoction, add water to the casserole again, and the water level exceeds the medicinal residues by 8 - 10 cm. Then decoct for 30 - 40 minutes and filter to obtain the decoction. Step 5: Cooling and storage, combine the two filtrates, cool and seal them in bags.

3. The preparation method of the traditional Chinese medicine decoction for treating atrophic gastritis with erosion and intestinal metaplasia according to claim 2, wherein: During the period of taking, the adult dosage is 100 - 200 ml each time, twice a day, and it is taken warm after breakfast and dinner; the dosage for children (6 - 12 years old) is 50 - 100 ml each time, twice a day; for those under 6 years old, the dosage should be reduced or prohibited according to the doctor's advice.

4. Preparation method of traditional Chinese medicine paste for repairing agent for treating gastric pain, atrophic gastritis with erosion and intestinal metaplasia, characterized in that It includes the repair medicament for treating gastric pain, atrophic gastritis with erosion and intestinal metaplasia according to claim 1, and its preparation steps are as follows: Step 1: Raw material preparation, weigh Bupleuri Radix, Paeoniae Radix Alba, Aurantii Fructus Immaturus, Glycyrrhizae Radix Preparata, Atractylodis Macrocephalae Rhizoma, Poria, Pseudostellariae Radix, Angelicae Sinensis Radix, Chuanxiong Rhizoma, Rehmanniae Radix Preparata, Aucklandiae Radix, Chaenomelis Fructus, Aurantii Fructus, Linderae Radix, Lilii Bulbus, Corydalis Rhizoma, Salviae Miltiorrhizae Radix, Taraxaci Herba, Herba Herbae Chrysanthemi Indici, Bletillae Rhizoma, Notoginseng Radix et Rhizoma, Endoconcha Sepiae, Concha Arcae, Curcumae Rhizoma, Galli Gigeriae Endothelium Corneum, Thunbergii Fritillariae Bulbus, Ostreae Concha, Coptidis Rhizoma, and Serissae Herba according to the required proportions of the formula and set aside. Step 2: Raw material pretreatment, put the weighed medicinal materials into clear water and soak for 30 minutes to 1 hour to make the medicinal materials fully absorb water and expand. Step 3: For the first decoction, add water to the casserole, with the ratio of water to total weight of medicinal materials being 8:1, then add hard oysters and oyster shells to the casserole, boil and then simmer for 10-15 minutes, then add the remaining medicinal materials except for the Chinese hibiscus, and decoct for 40-60 minutes, and add the Chinese hibiscus containing volatile oil 5 minutes before the end of decoction, and filter to obtain the juice; Step 4: Second decoction, add water to the casserole again, the water level should be 8-10cm above the medicinal residue, then decoct for 30-40 minutes, filter and take the juice; Step 5: Let stand, combine the two filtrates and let them settle, and take the supernatant; Step 6: Concentrate the clear liquid to a relative density of 1.25-1.30, add crystal sugar, the ratio of liquid medicine to crystal sugar is 1:0.5, and simmer over low heat until it becomes a "hanging flag" shape; Step 7: Bottle and store. While hot, bottle into sterilized glass bottles and seal them for storage.

5. The preparation method of the traditional Chinese medicine paste for the repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, characterized in that: During the period of use, the dosage for adults is 10-15g (about 1 tablespoon) each time, twice a day, dissolved in warm water; the dosage for children (6-12 years old) is 5-8g (about half a tablespoon) each time, 1-2 times a day; Children under 6 years old should follow doctor's advice to reduce dosage or prohibit use.

6. Preparation method of traditional Chinese medicine decoction powder for repair agent for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, characterized in that The repair agent for treating epigastric pain, atrophic gastritis with erosion and intestinal metaplasia according to claim 1 is prepared in the following steps: Step 1: Prepare the raw materials. Weigh radix bupleuri, white peony root, immature bitter orange, raw licorice, atractylodes, poria, pseudoginseng, angelica, ligusticum chuanxiong, prepared rehmannia, costusroot, papaya, fructus aurantii, lindera striata, lily, corydalis, salvia miltiorrhiza, danshen, white flower grass, bletilla striata, notoginseng, cuttlefish, walnut, zedoaria, chicken gizzard lining, thunbergia thunbergii, oyster, coptis chinensis and safflower according to the required proportion of the formula and set aside for use. Step 2: crushing, putting the above medicinal materials into a special crusher for crushing; Step 3: Sieve the crushed mixture through a 80-100 mesh sieve; Step 4: Bottle and store the powder in a sealed light-proof container.

7. The preparation method of the traditional Chinese medicine decoction powder for the repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, characterized in that: During the period of use, the dosage for adults is 3-5g each time, 3 times a day, taken with warm water or made into paste; the dosage for children (6-12 years old) is 1-2g each time, 2 times a day; Children under 6 years old should follow doctor's advice to reduce dosage or prohibit use.

8. Method for making pills by powdering traditional Chinese medicine pieces of a repair agent for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, characterized in that The repair agent for treating epigastric pain, atrophic gastritis with erosion and intestinal metaplasia according to claim 1 is prepared in the following steps: Step 1: Prepare the raw materials. Weigh radix bupleuri, white peony root, immature bitter orange, raw licorice, atractylodes, poria, pseudoginseng, angelica, ligusticum chuanxiong, prepared rehmannia, costusroot, papaya, fructus aurantii, lindera striata, lily, corydalis, salvia miltiorrhiza, danshen, white flower grass, bletilla striata, notoginseng, cuttlefish, walnut, zedoaria, chicken gizzard lining, thunbergia thunbergii, oyster, coptis chinensis and safflower according to the required proportion of the formula and set aside for use. Step 2: crushing, putting the above medicinal materials into a special crusher for crushing; Step 3: Sieve the crushed mixture through a 80-100 mesh sieve to obtain fine powder; Step 4: Make pills. Add refined honey to the powder, with the ratio of powder to refined honey being 1:1.

2. Knead into a soft material, roll into strips and divide into 3-5g pills. Step 3: Drying: Place the pellets in a cool and ventilated place and dry them until the moisture content is ≤9%; Step 4: Bottle and store the pellets in a sealed light-proof container.

9. The method for making powder into pills of the traditional Chinese medicine decoction pieces of the repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, which is characterized in that: During the period of taking, the dosage for adults is 1 pill (3 - 5 g) each time, 3 times a day, taken with warm water; the dosage for children (6 - 12 years old) is half a pill each time, 2 times a day; For those under 6 years old, the dosage should be reduced or the medicine should be prohibited according to doctor's advice.

10. Method for tabletting the traditional Chinese medicine decoction pieces of the repair agent for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain, characterized in that Including the repair medicine for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain according to claim 1, the preparation steps are as follows: Step 1: Weigh Bupleurum chinense, White Peony Root, Immature Bitter Orange, Raw Licorice Root, Atractylodes macrocephala, Poria cocos, Pseudostellaria heterophylla, Angelica sinensis, Ligusticum wallichii, Rehmannia glutinosa, Aucklandia lappa, Chaenomeles sinensis, Fructus Aurantii, Lindera aggregata, Lilium brownii, Corydalis yanhusuo, Salvia miltiorrhiza, Taraxacum mongolicum, Herba Saussureae, Bletilla striata, Panax notoginseng, Endoconcha Sepiae, Concha Arcae, Rhizoma Curcumae, Endothelium Corneum Gigeriae Galli, Fritillaria thunbergii, Oyster, Coptis chinensis, and Serissa serissoides according to the required proportions of the formula and set aside; Step 2: Crushing, sequentially putting the above - mentioned medicinal materials into a special crusher for crushing; Step 3: Sieving, passing the crushed mixture through an 80 - 100 - mesh sieve to obtain fine medicinal powder; Step 4: Mixing, putting the fine medicinal powder, microcrystalline cellulose, and starch paste into a special mixer according to the ratio of 1:0.1:0.2 and mixing until "it can be kneaded into a ball by hand and dispersed when gently pressed" to make soft materials; Step 5: Granulating, adding the soft materials into a special swing granulator in batches multiple times to obtain granules; Step 6: Drying and sizing, drying the granules in a special dryer, and sizing the dried granules through a 20 - 40 - mesh sieve; Step 7: Lubricating, adding magnesium stearate, with its weight being 0.5% of the total weight, and mixing for 10 minutes to reduce the risk of sticking during tableting; Step 8: Tableting and forming, using a rotary tablet press, adjusting the pressure to 20 - 40 kN, and pressing the granules into round or irregular tablets of 0.3 - 0.5 g; Step 9: Packaging, packaging the tablets with aluminum - plastic blister packaging and storing them in a cool and dry place.

11. The method for tabletting the traditional Chinese medicine decoction pieces of the repair medicament for treating atrophic gastritis with erosion and intestinal metaplasia of epigastric pain according to claim 10, characterized in that: During the period of taking, the dosage for adults is 2 - 3 tablets (0.3 - 0.5 g / tablet) each time, 3 times a day, swallowed after meals; the dosage for children (6 - 12 years old) is 1 tablet each time, 2 times a day; For those under 6 years old, the dosage should be reduced or the medicine should be prohibited according to doctor's advice.