577 results about "Carcinogenesis" patented technology

The invention discloses an image-guided lung interventional operation system which comprises an image acquiring module, a lung region reconstruction module, a lung respiratory movement model construction module, an operative instrument and operative region image space mapping module, a dynamic focus space-positioning and guide module and an another image acquiring module. The image acquiring module is connected with the lung region reconstruction module which is connected with the lung respiratory movement model construction module, the lung respiratory movement model construction module is connected with the dynamic focus space-positioning and guide module, and the another image acquiring module is connected with the operative instrument and operative region image space-mapping module which is connected with the dynamic focus space-positioning and guide module. Real-time space positioning of dynamic focuses is achieved, early diagnosis of carcinogenesis of lung nodule can be achieved, and error of space positioning precision is within 2mm.

A medical composition is provided which is advantageous as a sealant for wound openings as well as have a function promoting healing of intractable wound or incision wound, and which accelerate tissue regeneration but does not cause any side effect such as canceration. The present invention relates to a medical composition comprising a photo-crosslinkable chitosan derivative and a wound healing promoter. The photo-crosslinkable chitosan derivative is preferably a polymer obtainable by incorporating a carbohydrate chain containing a reducing terminal to at least one portion of amino groups of chitosan back bone and incorporating a photoreactive group to at least another part of the amino groups. The wound healing promoter is preferably a growth factor.

It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the growth of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a chemo-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a chemo-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and chemo-preventive activity can be synthesized.

Methods and apparatus are provided for determining the condition of selected regions of epithelial and stromal tissue. A plurality of electrodes are used to measure surface and transepithelial electropotential of tissue, especially breast tissue, as well as surface electropotential and impedance at one or more locations and at several defined frequencies, particularly low frequencies. An agent may be introduced into the region of tissue to enhance electrophysiological response characteristics. Measured and derived electrical properties facilitating diagnosis include DC potential, impedance, subepithelial resistance, epithelial resistance, capacitance, characteristic frequency, depression angle and transepithelial potential. Ambient and varying pressure measurements applied to epithelial tissue are also used for diagnosis. Improved diagnosis of tissue condition can be made based on the electrical properties and tissue electrophysiological response to altered ion transport and pressure. Devices for practicing the disclosed methods are also provided.

A method of treating a cancerous region in a breast of a patient comprising (i) imaging the breast in a three-dimensional coordinate system, (ii) stereotactically determining the location of the cancerous region in the breast, (iii) optionally determining the volume of the entire cancerous region to be treated, and (iv) while maintaining the breast in a three-dimensional coordinate system that is identical to or corresponds with the three-dimensional coordinate system used in (i), noninvasively exposing the cancerous region of the breast of the patient to a cancer-treatment effective dose of radiation; and equipment for use in such a method.

The invention relates to a cosmetic especially for a cream with 0. 65%-1. 8% turmeric extract and 8%-10% flax seed extract and making method, which is characterized by the following: extracting form natural plants; utilizing the extract of the turmeric and flax seed to be human body's forerunner substance effectively; improving autoregulation hormone secretion of human body; having much security in treating menopause symptom; avoiding the risk of inducing canceration to galactophore and endometrium through supplementing estrogen; improving appearance surface skin of human and adjusting and balancing internal secretion for women in menopausal period. The invention can improve chronic fatigue syndrome to improve metabolism and quality of life, which can treat acne and avoid liver primacy effect of oral medication with a simple making method.

The invention relates to a preparation method of a hair dye, especially to a preparation method for a botanical hair dye, and specifically relates to a preparation method for a hair dye based on a walnut green husk pigment. The preparation method comprises the following steps: striping walnut green husk, air drying in a shady place; crushing, sieving through a sieve of 70-90 meshes; adding green husk powder and acetone into a container with a solid-liquid mass ratio of 1:25-35 and an acetone concentration of 70-90%, oscillation processing the solution at a constant temperature of 40-50 DEG C for 10-14 h; centrifuging the solution for 2-4 times, filtering off impurities and collecting the supernatant; decompressing concentrating the solution at a temperature of 50-65 DEG C to obtain an ointment; and preparing the hair dye according to the following material ratios: 5-7% of the ointment, 85-87% of water, 0.5-1.5% of silicone oil, 0.5-1.5% of oil-solubility VE, 0.5-1.5% of VB, 3-5% of olive oil and 0.5-1.5% of white vaseline. The preparation method is simple, easy to operate and high in recovery rate. The prepared green husk pigment is granular, shows yellow under the developing effect of methyl red, has no escherichia coli, is suitable for exploitation of the hair dye, and helps to solve the problems that the conventional hair dye contains carcinogenesis substances and the natural hair dye is not exploited fully.

The present invention relates to the detection of malignant melanoma. In particular, the present invention relates to systems and methods for the early detection of cancerous lesions.

Inositol hexaphosphate (IP-6) is a polyphosphorylated carbohydrate with potent antioxidant activity to prevent active oxygen species-mediated mutagenesis, cell injury and carcinogenesis. IP-6 also activates DNA repair mechanisms. Sublethal radiation causes DNA damage through the formation of free radicals, reactive oxygen species, and pyrimidine crosslinks leading to cellular proliferation, cell cycle arrest and apoptosis. In the skin it results in the induction of skin cancer, premature skin aging, immuno-suppression, inflammation, and cell death. Likewise sublethal exposure to ionizing radiation as in nuclear blasts (war-time, accidental, terrorist-induced etc), cosmic radiation, etc. also causes the same spectrum of damage to the cells and the organisms with acute symptoms and eventual high risk of many cancers. IP-6 and/or inositol and their pharmaceutically acceptable salts and derivatives, including pyrophosphates and citrate derivatives, significantly counteract the harmful effects of radiation, affecting cell cycle progression in a protective manner (more cells in the protective GI phase) as well as decreasing apoptosis and caspase-3 activation. Various salts of IP-6 are used with comparable efficacy and the combination of IP-6+inositol affords the best protection against radiation-induced cell injury. Thus IP-6 and inositol are effective agents for protection against nuclear, solar and other radiation injuries.

The invention relates to the technical field of medical technology assistance, in particular to an artificial intelligence diagnosis method for gastric cancer under a narrow-band imaging amplificationgastroscope, which comprises the following steps: S1, constructing a mini-UNet neural network model; S2, constructing a UNet + + image segmentation neural network model, and obtaining an area ratio Rabnormal of an image feature difference region; S3, adopting a generative adversarial network (GAN) technology to obtain a microvascular morphological diagram and a microstructure morphological diagram of the feature abnormal region; S4, identifying the microvessel form dissimilarity degree and the microstructure form dissimilarity degree in the microvessel form diagram and the microstructure formdiagram by the neural network model ResNet50; and S5, carrying out identification and judgment by using the random forest model obtained by training to obtain final judgment of cancer or non-cancer,and identifying the canceration position range of the image, which is judged to be cancer, as the identified image feature difference region Pabnormal. The sensitivity and specificity of the kit to cancer and non-cancer recognition reach about 93.4% and 90.7% respectively, a clinician can be effectively assisted in discriminating and diagnosing cancer and non-cancer, and a canceration position range is given.

The invention relates to the technical field of medical image processing, in particular to a gastric early cancer auxiliary diagnosis method based on a deep learning multi-model fusion technology, which comprises the following steps: S1, constructing multiple models; s2, collecting gastroscope images, forming continuous serialized image frames, identifying the light source mode of the current image frame by utilizing the image classification model 1, entering the step S3 to mark the position of a focus by the target detection model 2 when the current image frame is identified as a white lightmode, and marking the high-risk focus by utilizing the image classification model 3; and when the image frame is identified as the dyeing amplification mode, entering the step S4 in which a segment model group can extract the boundary range, the microvessel form and the micro-tissue structure feature map in the image frame in real time, and outputting whether canceration occurs or not, the credibility and the differentiation type by the decision-making model 7. A plurality of deep learning models are constructed according to different tasks, a parallel cascade model fusion technology is adopted, and a full-process intelligent auxiliary diagnosis function is provided in the stomach early cancer screening process of endoscopists.

The invention belongs to the technical field of medicine and relates to purple perilla seed oil fat emulsion injecta being rich in omega-3 fatty acid and a preparation method thereof. The purple perilla seed oil fat emulsion injecta comprises 5 to 30 percent of refined purple perilla seed oil, 0.5 to 7.5 percent of an emulsifying agent, 1.4 to 3.6 percent of glycerin, 0 to 0.5 percent of EDTA-2Na, 0 to 0.5 percent of an antioxidant, 0.1 percent of hydrochloric acid or sodium hydroxide with the pH being 6.0 to 8.5 and the residual amount of water for injection. The purple perilla seed oil fat emulsion injecta has good stability and can avoid side effect caused by the metabolism of fat emulsion which is rich in omega-3 fatty acid. The injecta of the invention is the fat emulsion injecta with natural refined purple perilla seed oil, which can be sent for high-temperature sterilization and provide human bodies with energy to keep the factors needed by brain and nerve functions. The injecta has the functions of anti-thrombus and antiatheroscloresis, canceration prevention, inhabitation of tumour cells transfer and inhabitation of abnormalism symptoms.

Medicinal compositions for treating or preventing diabetes, rheumatoid, diseases wherein inflammation should be inhibited, diseases wherein alpha-glycosidase should be inhibited, diseases wherein the synthesis of prostaglandin should be inhibited, diseases wherein endotoxin shock should be inhibited, diseases wherein the production of interleukin should be inhibited, diseases wherein the production of heme oxygenase should be induced, and diseases wherein the production of tumor necrosis factor or carcinogenesis should be inhibited, which contain as the active ingredient at least one compound selected from the group consisting of 3,6-anhydrogalactopyranose represented by formula (I), its aldehyde, its hydrate and 2-O-methylated derivatives and 2-O-sulfated derivatives thereof.

The invention provides a monoclonal rabbit antibody for identifying HPV16 positive cervical tissues. The antibody can be used for specifically detecting a biomarker HPV16E7 protein in tissues including cervical cancer and cervical lesions, so that HPV persistent infection related cervical cancer tissues from abnormal or noncancerous cervical epithelial tissues, cervical cancer caused by high-risk HPV infection can be accurately diagnosed, and risk early-warning can be especially performed for whether early cervical lesions cancerate or not, so that the misdiagnosed rate of cervical lesions can be effectively reduced, and injuries and resource waste caused by over treatment for patients can be improved.

The invention discloses a method for screening new internal reference molecules suitable for cervical tissue micro RNA real-time fluorescence quantitative PCR research. The method comprises the following technical steps: screening human Micro RNA probes by using a Micro RNA chip, and selecting Micro RNAs with constant normal tissue expression and high expression abundance of cervical cancer and cervix as candidate internal references; selecting a normal cervical epithelial tissue and a cancerous cervical tissue as clinical cervical tissue specimens respectively, and verifying the specimens by using fluorescence quantitative PCR; and analyzing data by using two special internal reference analysis software comprising geNorm software and Norm Finder so as to discover the internal reference molecules suitable for cervical tissue Micro RNA research. The internal reference molecules screened and verified by using the method of the invention can avoid possible differences of different cervical tissue specimens on the yield, quality and reverse transcription efficiency of the RNA, well correct and standardize the data for real-time fluorescence quantitative PCR detection, and improve the accuracy and the reliability of the search.