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Disinsection composition with synergistic action

A technique for perilla seed oil and injection, which is applied in the field of medicine and achieves the effects of good stability, quality assurance and avoiding side effects

Inactive Publication Date: 2009-03-11
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing preparations, there is no relevant report about making perilla seed oil into fat emulsion injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] prescription:

[0019] Refined Perilla Seed Oil 100g

[0020] Soy Lecithin 20g

[0021] Glycerin 25g

[0022] EDTA-2Na 0.2g

[0023] Anhydrous sodium sulfite 2g

[0024] 0.1% sodium hydroxide solution to adjust pH6.0-8.5

[0025] Add water for injection to 1000ml

[0026] Preparation method: Liquid A: take the prescribed amount of refined perilla seed oil and soybean lecithin for injection, heat to 75°C under nitrogen protection, stir to dissolve and set aside; liquid B: take the prescribed amount of glycerin, EDTA-2Na and anhydrous sodium sulfite Add in 600 ml of water for injection preheated to 75°C and stir to dissolve. Under the protection of nitrogen, slowly add liquid A to liquid B, shear at a high speed of 5000-25000 rpm for 15 minutes, add water for injection preheated to 75°C to the full amount, add sodium hydroxide or hydrochloric acid solution to adjust the pH to 6.0-8.5 , homogenized 8 times under the condition of 90MPa to the particle size range of 1...

Embodiment 2

[0028] prescription:

[0029] Refined Perilla Seed Oil 300g

[0030] Lecithin 20g

[0031] Pluronic F68 2g

[0032] Glycerin 25g

[0033] EDTA-2Na 0.1g

[0034] Thioglycerol 0.3g

[0035] 0.1% sodium hydroxide solution to adjust pH6.0-8.5

[0036] Add water for injection to 1000ml

[0037] Preparation method: Liquid A: take the prescribed amount of refined perilla seed oil for injection, lecithin, Pluronic F68, heat to 75°C under nitrogen protection, stir to dissolve and set aside; Liquid B: take the prescribed amount of glycerin, EDTA- Add 2Na and thioglycerol into 600ml of water for injection preheated to 75°C and stir to dissolve. Under the protection of nitrogen, slowly add liquid A to liquid B, shear at a high speed of 5000-25000 rpm for 15 minutes, add water for injection preheated to 75°C to the full amount, add sodium hydroxide or hydrochloric acid solution to adjust the pH to 6.0-8.5 , homogenized 6 times under the condition of 90MPa to the particle size range...

Embodiment 3

[0039] prescription:

[0040] Refined Perilla Seed Oil 150g

[0041] Lecithin 20g

[0042] Tween-80 3g

[0043] Glycerin 20g

[0044] EDTA-2Na 0.15g

[0045] BHA 0.5g

[0046] 0.1% sodium hydroxide solution to adjust pH6.0-8.5

[0047] Add water for injection to 1000ml

[0048]Preparation method: Liquid A: take the prescribed amount of refined perilla seed oil for injection, lecithin, Tween-80, and BHA, heat to 75°C under nitrogen protection, stir to dissolve and set aside; liquid B: take the prescribed amount of glycerin, Add EDTA-2Na into 600ml of water for injection preheated to 75°C and stir to dissolve. Under the protection of nitrogen, slowly add liquid A to liquid B, shear at a high speed of 5000-25000 rpm for 15 minutes, add water for injection preheated to 75°C to the full amount, add sodium hydroxide or hydrochloric acid solution to adjust the pH to 6.0-8.5 , homogenized 6 times under the condition of 90MPa to the particle size range of 150-350nm, filtered, s...

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Abstract

The invention belongs to the technical field of medicine and relates to purple perilla seed oil fat emulsion injecta being rich in omega-3 fatty acid and a preparation method thereof. The purple perilla seed oil fat emulsion injecta comprises 5 to 30 percent of refined purple perilla seed oil, 0.5 to 7.5 percent of an emulsifying agent, 1.4 to 3.6 percent of glycerin, 0 to 0.5 percent of EDTA-2Na, 0 to 0.5 percent of an antioxidant, 0.1 percent of hydrochloric acid or sodium hydroxide with the pH being 6.0 to 8.5 and the residual amount of water for injection. The purple perilla seed oil fat emulsion injecta has good stability and can avoid side effect caused by the metabolism of fat emulsion which is rich in omega-3 fatty acid. The injecta of the invention is the fat emulsion injecta with natural refined purple perilla seed oil, which can be sent for high-temperature sterilization and provide human bodies with energy to keep the factors needed by brain and nerve functions. The injecta has the functions of anti-thrombus and antiatheroscloresis, canceration prevention, inhabitation of tumour cells transfer and inhabitation of abnormalism symptoms.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a refined perilla seed oil fat emulsion injection rich in omega-3 fatty acids and a preparation method thereof. Background technique [0002] Fat emulsion is an energy supplement with high heat energy. When the human body encounters a disease and energy intake disorder occurs, it needs to supplement the energy needed by the human body from the outside. This energy supplement is to inject fat emulsion into the human body through veins. Fat emulsion is composed of saturated and unsaturated fatty acids and their triglycerides. The fatty acids are divided into short-chain fatty acids (2C-4C), medium-chain fatty acids (6C-12C) and long-chain fatty acids (14C-12C) according to the carbon chain length of fatty acids. 24C). Those containing multiple unsaturated double bonds are called polyunsaturated fatty acids. Polyunsaturated fatty acids can be incorporated directly into the phosphol...

Claims

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Application Information

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IPC IPC(8): A61K36/535A61K9/107A61K47/12A61K47/20A61K47/22A61K47/24A61K47/34A61P3/02A61K47/10A61K47/26
Inventor 王东凯
Owner SHENYANG PHARMA UNIVERSITY
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