Method and apparatus for measuring cancerous changes from reflectance spectral measurements obtained during endoscopic imaging

A reflection spectrum and imaging technology, applied in the field of spectroscopy, can solve the problems of time-consuming and difficult to use endoscopic imaging

Inactive Publication Date: 2008-03-05
维利桑特技术公司 +1
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Problems solved by technology

[0023] Although the use of contact probe geometry gives more controllable diffuse reflectance measurements with less measurement artifacts, such measurements are limited in that they are unwieldy and time-consuming for in vivo endoscopic imaging of internal organs.

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  • Method and apparatus for measuring cancerous changes from reflectance spectral measurements obtained during endoscopic imaging
  • Method and apparatus for measuring cancerous changes from reflectance spectral measurements obtained during endoscopic imaging
  • Method and apparatus for measuring cancerous changes from reflectance spectral measurements obtained during endoscopic imaging

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[0042] While the invention may be embodied in different forms, the particular embodiments shown in the drawings and described in detail herein to facilitate an understanding of the disclosure are considered to be illustrative of the principles of the invention and not to limit the invention thereto. shown and described.

[0043] The method of the present invention is to obtain quantitative information about absorption-related and / or scattering-related properties from diffuse reflectance spectra (DRS) obtained during in vivo endoscopic imaging. Diffuse reflectance depends on the projection of a broadband beam of light into a sample where it is absorbed, reflected, scattered and transmitted or reflected back through the sample material. The reflected (scattered) light is then collected by an accessory (such as an optical fiber) and directed to the detector optics. Only the portion of the beam that scatters within the sample and returns to the surface is considered diffuse.

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Abstract

The present invention provides a new method and device for disease detection, more particularly cancer detection, from the analysis of diffuse reflectance spectra measured in vivo during endoscopic imaging. The measured diffuse reflectance spectra are analyzed using a specially developed light-transport model and numerical method to derive quantitative parameters related to tissue physiology and morphology. The method also corrects the effects of the specular reflection and the varying distance between endoscope tip and tissue surface on the clinical reflectance measurements. The model allows us to obtain the absorption coefficient ([mu]a) and further to derive the tissue micro-vascular blood volume fraction and the tissue blood oxygen saturation parameters. It also allows us to obtain the scattering coefficients ([mu]s and g) and further to derive the tissue micro-particles volume fraction and size distribution parameters.

Description

technical field [0001] The present invention relates to the field of spectroscopy, and more particularly to methods of obtaining information about tissue physiology and morphology using diffuse reflectance spectroscopy. The aim of the present invention is to realize a non-invasive optical method for cancer detection. Background technique [0002] Lung cancer is the leading cause of cancer death in North America, and it has the second most common cancer incidence in both men and women. Medical research indicates that cancer can be treated more effectively when it is detected earlier, when there is less damage, or when the tissue is precancerous. Unfortunately, existing lung endoscopy (bronchoscopic examination) is based on white light reflectance (WLR) imaging, which is commonly used to detect cancerous lesions in the major airways of the lungs, and thus only detects about a percent of Twenty-five lung cancers. Most of these lesions are at an advanced stage, when the cance...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00G01N21/64G01N21/47A61B5/1459A61B5/1455
CPCG01N2021/4742G01J3/02A61B1/043A61B5/0071A61B5/0261G01N21/4795A61B1/2676A61B5/14542G01N21/359A61B5/0084A61B5/1459G01J3/0291A61B5/0066G01J3/0243A61B5/0075G01N21/474
Inventor 曾海山亚瑟·谢里夫·费兹
Owner 维利桑特技术公司
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