54 results about "Cancer incidence" patented technology

The five component composition consisting essentially of: (1) Water soluble antioxidant vitamin C or ascorbic acid, or any of its forms or derivatives, or mixtures thereof. (2) Oil soluble antioxidant vitamin E or Alpha-tocophorol, or any of its forms or derivatives, or mixtures thereof. (3) The element selenium, or a chemical (or composition) containing it, or mixtures thereof. The most preferred chemical containing selenium is dimethyl selenide and mixtures thereof. The words "dimethyl selenide" here and hereinafter mean dimethyl selenide and / or it's oxidation products, including dimethyl selenoxide. (4) A sulfur amino acid, in any form, or a sulfur peptide, or a sulfur protein, or any of their derivatives, or mixtures thereof. The mixture of methionine and cysteine, which contains as impurities some seleno-methionine and some selenocysteine, is preferred,-the tripeptide glutathione containing cysteine is also preferred. (5) Another antioxidant, other than vitamin C and other than vitamin E, which is synthetic or natural and water soluble or oil soluble, or a mixture of such antioxidants, or a combination of such forms thereof. The mixtures of butylated hydroxyanisole and ethoxyquin is preferred.

The present invention relates to a novel class of anti-cancer compounds, which contain a haloacetamide or azide moiety and are, in one embodiment, alkylating agents. These agents, either alone or in a composition, are useful for treating cancer, preventing cancer, delaying the progression of cancer, treating and / or preventing the recurrence of cancer, suppressing, inhibiting or reducing the incidence of cancer, or inducing apoptosis in a cancer cell. Accordingly, the present invention provides a) methods of treating cancer in a subject; b) methods of preventing cancer in a subject; c) methods of delaying the progression of cancer in a subject; d) methods of treating the recurrence of cancer in a subject; e) methods of preventing the recurrence of cancer in a subject; f) methods of suppressing, inhibiting or reducing the incidence of cancer in a subject; and g) methods of inducing apoptosis in a cancer cell; by administering to the subject an anti-cancer compound of the present invention or an analog or metabolite thereof, its N-oxide, ester, pharmaceutically acceptable salt, hydrate, or any combination thereof as described herein.

A method and composition for extending the lifespan of an individual and delaying the onset of age-related disease is provided. The method includes the administration of an effective dose of oxaloacetate, wherein the oxaloacetate acts to mimic the cellular conditions obtained under caloric restriction to provide similar benefits. The invention further includes methods and compositions for reducing the incidence or treatment of cancer. Compositions and methods for reducing body fat by administering an effective amount of oxaloacetate are likewise provided. Compositions for DNA repair in UV damaged cells is provided are also provided. Similarly, a method for treating a hang-over comprising administering an effective amount of oxaloacetate is disclosed.

The present invention belongs to the technical field of food, and discloses a Se-enriched natural nutritional food having a high nutritional value and a preparation method thereof. The Se-enriched natural nutritional food is prepared from the following raw materials: Se-enriched wild lobed kudzuvine root powder, Se-enriched amorphophalms konjac fine flour, common yam rhizome powder, oriental sesame seed, walnut meat and granulated sugar. The Se-enriched natural nutritional food has effects of improving metabolism of human tissues and organs, enhancing cardiovascular function, delaying cellular senescence, and has a better health care function. Furthermore, by the addition of selenium, the Se-enriched natural nutritional food can significantly prevent cancer and reduce the incidence of cancer. The Se-enriched natural nutritional food is a safe, effective, convenient and tasty table food for people.

The present invention relates to a novel class of anti-cancer compounds, which contain a haloacetamide or azide moiety and are, in one embodiment, alkylating agents. These agents, either alone or in a composition, are useful for treating cancer, preventing cancer, delaying the progression of cancer, treating and / or preventing the recurrence of cancer, suppressing, inhibiting or reducing the incidence of cancer, or inducing apoptosis in a cancer cell. Accordingly, the present invention provides a) methods of treating cancer in a subject; b) methods of preventing cancer in a subject; c) methods of delaying the progression of cancer in a subject; d) methods of treating the recurrence of cancer in a subject; e) methods of preventing the recurrence of cancer in a subject; f) methods of suppressing, inhibiting or reducing the incidence of cancer in a subject; and g) methods of inducing apoptosis in a cancer cell; by administering to the subject an anti-cancer compound of the present invention or an analog or metabolite thereof, its N-oxide, ester, pharmaceutically acceptable salt, hydrate, or any combination thereof as described herein.

The invention discloses a kit and a primer pair group for detecting expression of cytosine deaminase (Apobec3B / C, Apobec3F / G and AID) and molecular (UNG) genes related to cytosine deaminase in free DNA (deoxyribonucleic acid) in peripheral blood. The primer pair group is shown in SEQ ID No:1-SEQ ID No:8 in a sequence table. The kit containing the primer pair group evaluates the risk of cancer incidence and the treatment effects by detecting methylation modification of Apobec3B / C, Apobec3F / G, AID and UNG gene promoters. A detection method has the characteristics of high sensitivity, specificity, directness, real-time property and stability.

The invention relates to application of paclitaxel in preparation of medicament for treatment of non small cell lung cancer EGFR-TKI (epidermal growth factor receptor-tyrosine kinase inhibitor) resistance. Lung cancer ranks the first in cancer incidence and mortality all over the world. Curative effects of Gefitinib and Erlotinib in NSCLC are often limited by acquired resistance, and currently known main mechanism of acquired resistance is due to mutation of second generation of EGFRT790M and acquired amplification of MET gene. The invention shows that when EGFR-TKI acquired resistance appears, paclitaxel may reverse the resistance. That is to say, non small cell lung cancer patients who generate acquired resistance from Erlotinib / Gefitinib treatment can reconsider the use of Erlotinib / Gefitinib treatment after chemotherapy with paclitaxel, so as to make the erlotinib / gefitinib continue to function; meanwhile, paclitaxel may also inhibit tumor, and thus play rotary resistance and synergism.

The present invention relates to the field of food technology, disclosing a rich-in-Se fresh flower paste with high nutrient value and its preparation method. It's prepared from using seleniferous black soybeans, maize flower pistils, garlics, onions, edible flowers as raw materials, mixed with white sugar and malic acid, and their proportioning is 2.5-3.5:1:0.8-1.3:0.06-0.08. The edible flowers may be loofah flowers, pumpkin flowers, waxgourd flowers, camellias, bombax flowers, pagodatree flowers, pear flowers, plum blossom, peach blossom, China rose ,rose and so on. Malic acid can be replaced by citric acid. It can promote metabolism and delays senility. For adding selenium, it can prevent cancer and reduce incidence of cancer.

The invention relates to the technological field of food and a kind of fresh flower drink containing abundant selenium and its manufacturing method is disclosed. Said drink is prepared from black bean, maize pistil, garlic, onion and edible fresh flowers containing selenium among which fresh flower constitutes more than 25% of the general amount. Said drink contains selenium 1.00-3.00 mg / ml. Edible flowers could be one or several kinds of the following: towel gourd flower, camellia, pagoda tree flower, apple flower, pear flower, plum blossom, plum flower, peach flower, lotus flower, Chinese rose, rose, etc. Said drink also contains corrigent such as sugar, malic acid, citric acid, essence, etc.

The present invention is a vegetable blending oil with a reasonable proportion of fatty acids. The weight percentage of each vegetable oil component is 20%-65% of rapeseed oil, corn germ oil or peanut oil or sunflower oil or safflower oil or their Any combination of 15-71%, soybean oil or linseed oil or any combination thereof 2-42%, sesame oil 0-5%, the percentage by weight of various fatty acids that make up fat in the blended oil product to the total fatty acids is, Saturated fatty acids 7%-17%, monounsaturated fatty acids 41%-47%, n-6 polyunsaturated fatty acids 35%-39%, n-3 polyunsaturated fatty acids 5%-9%, and total polyunsaturated fatty acids 41-47%. The present invention is designed on the basis of the recommended intake and proportion of fat and fatty acid for Chinese residents by the Chinese Nutrition Society. It is very important to reduce the incidence of cardiovascular disease and cancer, and it is cheap and good.

Three new safe pharmaceutical compositions in accordance with the present invention are for treatment and prevention of malignant pleural effusion and increase immune function comprise Lan Xiang Xi (LX) and polysaccharide of Dang Gui. Methods of treating and preventing cancer cells include inhibiting oncogenes, increasing activity of tumor suppressor, inducing differentiation of cancer cells, inhibiting cancer cells proliferation, inducing apoptosis of cancer cells, inhibiting growth of transplanted cancer and inhibiting cancer incidence, etc. In general, anticancer drug always decreases immune function. However, LX and LX+PDG can inhibit cancer also increase immune function at the same time. Also, LX and DG containing soybean-liposomes is safer than LX and DG.

The invention relates to the fields of epidemiology and public health, and provides a tumor registration and follow-up direct reporting information management system. The system includes management, sorting, analysis and quality control of cancer incidence, death and survival information of all the household registration population in the district where the cancer registry is located and comprisesa cancer report card management subsystem, a population data information subsystem, a tumor survival information subsystem and a data analysis subsystem. The tumor registration and follow-up reporting system is established and has the functions of report card management, tumor follow-up, report card reduplication management and the like so that the tumor incidence, death and survival informationof the population in different jurisdictions can be conveniently established and a technical example can be provided for the standardization and the operability of the tumor registration and follow-upnetwork direct reporting work.

A method and composition for extending the lifespan of an individual and delaying the onset of age-related disease is provided. The method includes the administration of an effective dose of oxaloacetate, wherein the oxaloacetate acts to mimic the cellular conditions obtained under caloric restriction to provide similar benefits. The invention further includes methods and compositions for reducing the incidence or treatment of cancer. Compositions and methods for reducing body fat by administering an effective amount of oxaloacetate are likewise provided. Compositions for DNA repair in UV damaged cells is provided are also provided. Similarly, a method for treating a hang-over comprising administering an effective amount of oxaloacetate is disclosed.

The present invention discloses brewing process of vitamin-bifidobacterium vinegar. The brewing process includes the steps of sorting materials, alcoholic fermentation of the materials, vinegar fermentation, ageing, fuming, sterilizing and packing. It features sealed vinegar fermentation at 25-28 deg.c for 15-20 days while monitoring alcohol content; the addition of vitamin C in the amount not less than 0.25% during vinegar fermentation; the addition of table salt in 1-2% during ageing; and the addition of bifidobacterium factor in in the amount not less than 0.7% before packing. The vitamin-bifidobacterium vinegar has the health functions of activating probiotics in intestinal tract, generating vitamins, regulating blood fat, blocking the synthesis of carcinogenic factor, etc.

A method for diagnosing cancer using information on aberrant glycosylation of glycoproteins, which is related with cancer progression. More particularly, the present invention relates to a peptide marker for cancer diagnosis and a method for diagnosing cancer using the peptide marker, wherein glycoproteins aberrantly glycosylated due to cancer incidence and progression is isolated using lectin; and marker peptides generated by hydrolysis or the glycoproteins isolated by the lectin is selected and quantified.

The invention relates to a kit for detecting a gastric cancer. The kit comprises gene mutation primers relative to the gastric cancer: a forward primer shown as SEQ ID NO. 3 and a reverse primer shownas SEQ ID NO. 4. By adopting the kit provided by the invention, a mutation site spectrum and a specific marker relative to gastric cancer incidence are acquired; development and application of the relative diagnostic kit are performed by changing a mutation site sequence, so that diagnosis of the gastric cancer can be more convenient and feasible, the foundations are laid for rapid and accurate grasping of the patient condition for a clinical doctor and clinical treatment effect evaluation, and help is provided to discover a novel micromolecular drug target with potential treatment value.

The present invention discloses a rose-pine needle distillate oral liquid and a preparation method thereof, belongs to a traditional Chinese medicine preparation, and particularly relates to a traditional Chinese medicine preparation adopting a mountain rose distillate and a pine needle distillate as main components, and a preparation method thereof. The rose-pine needle distillate oral liquid is a produce prepared from the following raw materials, by weight: 30-35 parts of a rose distillate, 40-45 parts of a pine needle distillate, 10-15 parts of a rose bee pollen extract, 3-5 parts of rose honey, 7-10 parts of a medlar extraction solution, and 0.5-1 part of vitamin C. According to the present invention, the rose-pine needle distillate oral liquid is a traditional Chinese medicine preparation oral liquid prepared by adopting nature plants as the main components. After constantly taking the rose-pine needle distillate oral liquid, disease symptoms of most of unexplained primary hypertension patients and secondary hypertension patients can be controlled, incidence rates of hyperlipidemia, hyperglycemia, hypercholesterolemia, hyperviscosity, prostatitis and the like can be substantially reduced, symptoms can be reduced, the normal weight of obesity patients can be recovered within a short and medium term, incidence rates of acne and cancer can be substantially reduced, and effects of endocrine regulation, beautifying, face nourishing and the like can be provided.

The invention discloses a method for preparing an animal organic selenium-rich additive. The method comprises the following step of: performing ultra-micro crushing and nano treatment on freeze-dried krill serving as a raw material. In the ultra-micro process, the crushing degree can be monitored by using a laser granularity instrument to control the diameter of the granules obtained by crushing. The invention also provides the animal organic selenium-rich additive prepared by the method, wherein the additive can be used for preparing selenium-rich food or selenium-rich feed. Because the selenium in the additive is from natural seafood, namely krill, the additive has the characteristics of safety, non-toxicity and good effect by combining a nano technology. The selenium-rich food prepared by using the organic selenium-rich additive provided by the invention can improve the selenium intake of a common person to 50 to 250 micrograms every day, so the incidence rate of chronic diseases related with heart and brain blood vessels and partial cancers is greatly reduced; and the selenium intake of chronic disease, low-immunity or cancer patients is improved to 200 to 800 micrograms every day.

The invention discloses a cancer screening method and screening system based on face features. According to one embodiment, the cancer screening method based on the human face features comprises the steps that a human face image of a testee is acquired, the position of the human face is detected and aligned through the direction gradient histogram features and the cascade regression technology, and the human face image is zoomed into a unified size through bilinear interpolation; features of the human face are extracted by using a convolutional neural network; and the cancer morbidity is calculated by utilizing a classifier according to the characteristics. According to the technology, no professional medical equipment is needed, and the cancer incidence probability of the testee can be obtained only by taking pictures of the testee.

The invention discloses a system for deducing a cancer risk probability by using multi-modal risk factors, and the system comprises a data collection module which is used for obtaining a risk feature data set of various cancer high-risk groups and a data set of main risk factors affecting the onset of various cancers, and forming a multi-modal data set; a feature extraction module which is used for preprocessing the multi-modal data set and performing risk feature extraction on the preprocessed multi-modal data set; a feature fusion module which is used for determining a multi-modal fusion mode of the normalized mutual information to obtain fusion feature parameters; a model building module which is used for building a risk assessment model by using a Logistic regression analysis method; and a risk assessment module which is used for deducing the risk probabilities of various cancers through the risk assessment model. According to the method, the risk assessment model of the cancer incidence risk factors of the cancer high-risk group is constructed, so the automatic cancer risk assessment and quantitative expression of the early cancer risk based on cross-modal fusion are realized.

The invention discloses piperidinium-2,3-dihydroxy-5-((2R,3R)-3,5,7-trihydroxy-4-oxochroman-2-yl)phenolate (PDTOP) and a preparation method thereof, and applications thereof in treatment or prevention on diseases of a respiratory system. The applications include: a mask with a PDTOP layer attached thereto; a sprayer filled with a PDTOP solution; PDTOP oral tablets; and PDTOP oral liquid. These applications can avoid or greatly reduce damage on health due to haze for people who are exposed to haze, can reduce at least infection on lung and upper respiratory, lung diseases and cancer incidence. In addition, these applications have advantages in all industrial environments with dust. In a high-occurrence season of influenza, a PDTOP preparation can effectively prevent invasion of the influenza to human body and prevent spread of the influenza.

The invention relates to a Chinese medicinal composition for treating malignant tumor, wherein the medicament comprises the following constituents (by weight percent): pine pollen 2.3-2.5%, bamboo leaf essence 0.14-0.2%, and oldenlandia 3-4%, rhizome of Chinese paris 0.67-1.3%, ligustrum japonicum 2% and balancing water.

The invention discloses a drinking water quality optimization mineralization device, which comprises a water storage tank. The two sides of the water storage tank are respectively provided with a water inlet and a water outlet. The trace element diffusion assembly on the top, the trace element diffusion assembly includes at least one trace element diffuser; the trace element diffuser communicates with the water storage tank through a diffusion pipe or a diffusion hole, and the trace element diffuser is equipped with Trace element compounds beneficial to human health with a solubility of less than 1% in water at room temperature. The present invention releases selenium, calcium, magnesium, silicon and other trace elements beneficial to the human body into the water by means of diffusion, especially after adding selenium, calcium, magnesium, silicon and other trace elements to the water after the water purifier whose water outlet is pure water It not only increases minerals but also changes the water from weakly acidic to weakly alkaline, so drinking the optimized water of the invention can make the body healthier and reduce the incidence of cancer.

The embodiments include methods of treating prostate cancer by administering to a low grade unifocal prostate cancer tumor a composition comprising a therapeutically effective amount of pharmaceutically active ingredient capable of inducing necrosis of a low grade unifocal prostate cancer tumor, wherein administration reduces cancer incidence, cancer grade, and cancer progression (worsening) in the entire hemi-prostate where the initial focus was located and treated.

The present invention discloses bulbus lilii and radix polygonati officinalis fine dried noodles. The bulbus lilii and radix polygonati officinalis fine dried noodles are prepared from the following raw materials in parts by weight: 5-30 parts of bulbus lilii fermented powder, 1.5-10 parts of white sugar, 1-10 parts of radix polygonati officinalis, 80-95 parts of flour, and 0.5-1.0 part of konjacglucomannan. The present invention also discloses a preparation method of the bulbus lilii and radix polygonati officinalis fine dried noodles. The preparation method comprises the following steps: firstly, bulbus lilii is ground into bulbus lilii powder, then the bulbus lilii powder is fermented into the bulbus lilii fermented powder, then the radix polygonati officinalis and konjac glucomannan are used to prepare a mixed solution of the radix polygonati officinalis and konjac glucomannan, finally the bulbus lilii fermented powder, mixed solution of the radix polygonati officinalis and konjacglucomannan, and flour are mixed, and dough kneading, curing, slicing, strip cutting, shaping, drying, cutting and packaging are conducted to obtain a finished product. The bulbus lilii and radix polygonati officinalis fine dried noodles have effects of balancing endocrine, improving body immunity, beautifying features and nourishing skin, lowering blood sugar and blood lipids, and dispelling toxins and relaxing bowels, can effectively reduce incidence of cancers, and have broad application prospects.

The invention discloses an application of pyrimidine derivatives to treatment of thyroid cancer. Thyroid cancer is an endocrine malignant tumor with high incidence. Cancer incidence and mortality datareleased by Chinese center for cancer control and prevention in 2018 show that about 170,000 new cases of thyroid cancer and about 8,000 deaths of thyroid cancer occurred in China in 2014. At present, drugs for effective treatment of thyroid cancer are few and cannot meet clinical needs. It is found that partial pyrimidine derivatives have significant inhibitory effect on human thyroid cancer B-CPAP cells and can be used for preparing drugs for treating the thyroid cancer. Parent nuclei and substituents of the pyrimidine derivatives significantly affect effect of the derivatives on thyroid cancer.

The invention relates to the field of traditional Chinese medicines, and in particular relates to use of madder in preparation of a nitrite scavenging agent. The nitrite scavenging agent has higher scavenging capability on nitrite and can be further developed to reduce the cancer morbidity of people smoking for a long time (smoking promotes a cancerogenic substance, namely tobacco specific N-nitrite, to be secreted into a bile duct) or other crowds having high nitrite intake, and as a food, a health-care food or a medicament aiming at nitrite poisoning; and the nitrite scavenging capability is far beyond that of vitamin C.

The invention relates to the technological field of food and a kind of fresh flower drink containing abundant selenium and its manufacturing method is disclosed. Said drink is prepared from black bean, maize pistil, garlic, onion and edible fresh flowers containing selenium among which fresh flower constitutes more than 25% of the general amount. Said drink contains selenium 1.00-3.00 mg / ml. Edible flowers could be one or several kinds of the following: towel gourd flower, camellia, pagoda tree flower, apple flower, pear flower, plum blossom, plum flower, peach flower, lotus flower, Chinese rose, rose, etc. Said drink also contains corrigent such as sugar, malic acid, citric acid, essence, etc.