29 results about "Hyperviscosity" patented technology

The breast pad provided by the embodiment of the present application comprises a body, the body comprises a surface layer, a bottom layer and an absorbing core body sandwiched between the surface layer and the bottom layer, the surface layer and the bottom layer are combined along the outer peripheral edge, the absorbing core body comprises a top absorbing layer and a main absorbing layer which are stacked, the main absorbing layer comprises a main absorbing area, the top absorbing layer further comprises a notch part, the notch part forms a containing area, and the main absorbing area is located in the containing area. Through the above arrangement, on the one hand, the gushing milk can be fully absorbed into the fitting area, on the other hand, the back seepage is greatly reduced, on the third hand, the top absorbing layer forms a cushion layer, the compression feeling on the nipple is reduced, the comfort is improved, on the fourth hand, the absorbing capacity for high-viscosity milk is improved, and on the fifth hand, the absorbing capacity of the breast pad is improved.

This invention provides low-viscosity antigen-binding proteins and methods for producing them. [Solution] The present invention relates to a method for reducing the viscosity of an antigen-binding protein by modifying the sequence in the framework region and / or Fc domain, which has been shown to be associated with high viscosity. The present invention provides antigen-binding proteins, particularly antibodies, that have been mutated to reduce viscosity. Preferred antigen-binding proteins according to the present invention include antibodies, as shown in Figure 1B, having one or more, preferably all, of the following: VH1|1-18 germline subfamily substitution; VH3|3-33 germline subfamily substitution; VK3|L16 germline subfamily substitution; VK3|L6 germline subfamily substitution; or Fc substitution.

The utility model discloses a stirring device for high viscosity medicine, which relates to the technical field of medicine processing equipment, and comprises a shell, the outer wall of the bottom of the shell is fixedly connected with a base, the inner wall of the shell is provided with a plurality of feed ports, the inner wall of the shell is provided with a stirring mechanism, and the stirring mechanism is connected with the base. The baffle and the knob are arranged, the knob is twisted to drive the baffle to rotate after stirring is completed, and the side, connected with the knob, of the baffle is limited by the positioning block, so that the baffle can only rotate around the positioning block, and medicine falls into a collecting box below along one side; after the collecting box is full, the knob is twisted reversely to enable the baffle to block the bottom of the shell again, the knob is rotated to drive the baffle to rotate, so that the bottom of the shell is opened, and the situation that due to the fact that the viscosity of medicine is too large, part of medicine is prone to adhering to the interior of the device when the medicine is poured out, and the medicine cannot be completely discharged is prevented. And a large amount of medicine is wasted.

The present invention relates to: a liquid formulation comprising an anti-IL-4Rα antibody, a saccharide, and an amino acid and not comprising a buffer; a device comprising same; and a use thereof for treating IL-4Rα-related conditions. The liquid formulation can improve the viscosity of the antibody while ensuring the stability thereof, and thus can be effectively used as a medicine for treating IL-4Rα-related conditions.

The invention provides a bone adhesion solid-phase composition, a bone adhesive as well as a preparation method and application of the bone adhesive, and belongs to the technical field of bone repair materials. The invention provides a bone bonding solid-phase composition which comprises the following components in percentage by mass: 5-60% of phosphoserine, 10-80% of calcium phosphate and 5-50% of polyglutamic acid. According to the invention, by adding the polyglutamic acid and utilizing the chelation of the polyglutamic acid and calcium ions, the polyglutamic acid is adsorbed on the surface of the powder to form steric hindrance, the viscosity is improved, the ion diffusion is delayed, the reaction rate of calcium phosphate and phosphoserine is reduced, and the curing time is prolonged; meanwhile, due to the viscosity, the early-stage viscosity and the overall compressive strength of the material are enhanced. The result of the embodiment shows that the putty time of the bone adhesive prepared from the bone adhesive solid-phase composition provided by the invention can reach 20-70 minutes, and the adhesive strength and compressive strength are remarkably enhanced.

This invention discloses a method for preparing biomimetic calcium phosphate particles carrying type III recombinant human collagen, relating to the field of new biomedical materials. The particle formulation, by mass percentage, contains 50%-90% hydroxyapatite and 10%-50% type III recombinant human collagen. The preparation process involves artificially synthesizing hydroxyapatite precipitate, then compounding it with type III recombinant human collagen. The compounded material is then spread, naturally dried, crushed, and sieved to form particles. The resulting particles have a uniform and controllable particle size. When mixed with blood or water, they can quickly form a high-viscosity, malleable, and stable filling material, directly adapting to the site preservation requirements of alveolar sockets after tooth extraction. The advantages are: the degradation rate of these particles precisely matches the bone regeneration rate after site preservation surgery, efficiently guiding bone tissue regeneration while significantly shortening the waiting period for implantation after tooth extraction. This solves the clinical promotion difficulties caused by the long waiting period and complex operation of site preservation surgery, contributing to the widespread application of this technology in oral clinical practice.

The application provides a centrifugal pump impeller design method and a centrifugal pump impeller for conveying high-viscosity non-Newtonian fluid, and aims at the problems of high shear force peak, efficiency attenuation and medium damage when the existing centrifugal pump conveys high-viscosity non-Newtonian fluid. The flow passage outlet section is configured as a three-section type water-drop-shaped section, which is a semi-elliptical section, a Bezier narrowing section and a rounded tip in sequence. The number of flow passages is determined according to the viscosity of the medium, and the higher the viscosity, the fewer the number of flow passages. The inside round corner, the outside round corner and the inlet edge margin in the flow passage are adjusted by using the average shear rate of the outlet surface, and a complete flow passage is constructed by using a gradual transition section. The application can significantly suppress the shear rate peak, reduce the amplitude by more than 86%, and maintain the head and efficiency, and is suitable for efficient and low-damage conveying of high-viscosity non-Newtonian fluid in the fields of petroleum, chemical industry, food and biological medicine.

This invention discloses a tandem-responsive self-assembled molecular probe and its applications. The HPO-CYFF-TPP of this invention is converted to HO-CYFF-TPP under the dephosphorylation of overexpressed ALP, restoring the intramolecular charge transfer effect. It then self-assembles into nanoparticles in situ through π-π stacking, exhibiting fluorescence signal quenching and photoacoustic signal enhancement at low viscosity. Upon laser irradiation, the NPs generate a large amount of singlet oxygen in the mitochondria, thereby achieving efficient photodynamic therapy (PDT) and leading to increased viscosity. At high viscosity, due to the suppression of the distorted intramolecular charge transfer effect of HO-CYFF-TPP, the NPs activate the FL signal with a high signal-to-noise ratio and further enhance the PA signal. Therefore, the HPO-CYFF-TPP of this invention can achieve efficient PDT and enable real-time therapeutic effect assessment through FL / PA signals.

The invention relates to the technical field of biosensing, and discloses a pH / viscosity double-lock activated afterglow luminescent small molecule probe as well as a preparation method and application thereof. The structural formula of the afterglow luminescent small-molecule probe is shown in the specification. A rhodamine light-emitting unit and an afterglow light-emitting matrix unit SO are covalently connected through a chemical bond. The luminescent mechanism is as follows: under illumination, molecules generate singlet oxygen to oxidize and activate adjacent SO units, so that active oxygen mediated afterglow luminescence is generated. The afterglow luminescent small-molecule probe has a double-lock activation characteristic, that is, a strong afterglow signal can be generated only when a subacid environment and a high-viscosity condition are met at the same time. And the signal is weak under a single condition or a normal physiological environment. The probe provided by the invention has excellent environmental specificity and high signal-to-noise ratio imaging capability, and provides a powerful tool for realizing accurate imaging in a complex biological system.

The application discloses a kind of children emergency respiratory tract foreign matter quick removal device, it is related to respiratory tract foreign matter removal technical field, to solve the technical problem that existing negative pressure suction equipment negative pressure is too large, easy to directly absorb throat mucosa and cause damage, including the hose of adaptation and communication in negative pressure suction pipe input end, leakage connector, annular groove, removal mechanism, collection assembly and angle adjusting assembly.The engagement or non-engagement of transmission rod and conveying cylinder is switched, the rotation of the lower cone of the guide sealing module can be flexibly controlled to collect and the upper cone is sealed to separate two working states: when not engaging, the guide sealing module is in the form of a lower cone and leaves a gap to rotate, which can actively roll into the mucus of the throat, avoiding hard extrusion on the delicate throat;when engaging, the module moves up to the form of a sealed upper cone, which, combined with the path optimization of negative pressure separation and spiral groove, can prevent local negative pressure from being too high to cause discomfort in the throat of children, and can also avoid high-viscosity mucus fault, ensuring that the mucus is quickly and completely discharged.

The invention belongs to the technical field of sampling devices, and discloses a sampling device for liquid medicine detection and a method thereof.The sampling device comprises a spherical medicine storage body, the lower portion of the spherical medicine storage body is communicated with a liquid suction pipe, a top pipe is arranged above the spherical medicine storage body, and a limiting plate is rotationally installed between the top pipe and the spherical medicine storage body in a sealed mode; the top pipe and the spherical medicine storage body can be isolated and sealed through the limiting plate, a liquid taking assembly is fixedly installed in the center of the top pipe and vertically extends to the bottom end of the interior of the liquid suction pipe, extraction and discharging of medicine liquid are completed through rotation, and a stirring assembly used for homogenization pretreatment of the medicine liquid is rotationally installed at the upper end of the top pipe. A swing assembly capable of expanding the stirring range is integrated on the stirring assembly, and a driving device used for providing power and achieving function switching is arranged on the top pipe; the liquid medicine stirring device is simple in overall structure, can efficiently and uniformly stir liquid medicine which is easy to layer and high in viscosity, eliminates stirring dead angles, and improves the using effect.

The invention provides multi-effect composite scar repair gel as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention develops a multi-effect composite scar repair gel with barrier protection, anti-inflammatory regeneration and long-acting permeation by integrating a silicone base material, traditional Chinese medicine active ingredients and an ionic liquid permeation promotion technology. Wherein the high-viscosity polydimethylsiloxane is used for reducing skin tension; the low-viscosity polydimethylsiloxane improves the skin comfort level; the traditional Chinese medicine extract inhibits fibroblast proliferation and promotes microcirculation; the Ectoin-allantoin microcapsule is capable of realizing 72-hour slow-release anti-inflammatory repair; the BPC157 polypeptide can promote angiogenesis and accelerate wound healing; the transdermal rate of the active ingredients is increased by more than 3 times by the arginine-malic acid ionic liquid; the zinc hyaluronate can synergistically moisturize and regulate the inflammation microenvironment. Through cooperation of multiple mechanisms, the effects of barrier protection, anti-inflammatory regeneration and long-acting permeation are achieved, and the anti-inflammatory and long-acting anti-inflammatory ointment is suitable for repairing hypertrophic scars, acne scars and postoperative incisions.

One example of a device can deliver fluids having high viscosity, including fluids having a viscosity of 1,000 cP or more, through a channel. The device can be or include a syringe or a syringe. A barrel, a hub, a needle, or a combination thereof can define at least a portion of the channel. Methods of flowing fluids having such high viscosity are also disclosed herein. In certain embodiments, a method includes flowing a first fluid of relatively high viscosity and a lubricant of relatively low viscosity through a channel simultaneously, for example by using the lubricant to separate the first fluid from an inner surface of the channel, as is the case with a core annular flow. By sizing and shaping the channel as disclosed herein, particularly at a constriction, a stable core annular flow can be achieved, which makes it easier to flow a high viscosity fluid at a useful flow rate by manually applying force.

The application belongs to the field of organic molecule fluorescent probe, and a small molecule fluorescent probe HX is rationally designed, and the integration of diagnosis and treatment is realized by monitoring the related physical properties of tumor microenvironment and the photodynamic therapy of tumor. The tumor microenvironment of solid tumor usually has the characteristics of low pH, high viscosity, low oxygen and the like, and it is of great significance to carry out real-time monitoring and effective inhibition on tumor tissue based on the characteristic parameters of tumor site. Herein, a near-infrared fluorescent probe HX is designed, the probe does not respond to the change of surrounding viscosity in a high pH environment, however, in a low pH microenvironment of tumor, the "Donor-π-Acceptor (D-π-A)" structure thereof is opened, and sensitive viscosity response characteristics are exhibited, so that the dynamic monitoring of the tumor microenvironment is realized. In addition, through structure optimization, it is also confirmed that the probe can be used as a photosensitizer with type I reaction for photodynamic therapy of tumor tissue under hypoxic conditions. With the help of a mouse tumor model in vivo, it is confirmed that the probe HX not only has the ability to identify tumor tissue and normal tissue, but also has excellent tumor inhibition effect and good biocompatibility under hypoxic conditions, thereby providing a new technology for the diagnosis and treatment integration design of tumor diseases.

The invention provides a near-infrared fluorescent viscosity probe as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The near-infrared fluorescence viscosity probe has a structure as shown in a formula I; the invention also provides a preparation method and application of the near-infrared fluorescence viscosity probe. The near-infrared fluorescence viscosity probe disclosed by the invention has the characteristics of aggregation-induced emission, high viscosity sensitivity, pH stability and good biocompatibility, can realize rapid and accurate imaging of rheumatoid arthritis and osteoarthritis, and provides a novel tool for arthritis diagnosis and pathological research.

Syringe attachments and syringes have particular suitability to the precision dispensing of small amounts of high viscosity materials, such as dermal fillers. An attachment may include a main body having an assist feature that includes a wheel and pinion gears on each side of the wheel which engage respective racks on the syringe body. A mechanical advantage may be provided to the user as the wheel is rotated relative to the syringe body and racks. Syringes and attachments may include precision position indicators viewed from multiple positions to enable a user to determine plunger position and the amount of dispensed contents with precision. An alternative configuration attachment may be slidably secured to a syringe to permit a user to operation the syringe from a lateral position using sliding movement of the thumb and fingers of one hand, for example. This configuration may be particularly suitable for self-administered insulin injections.

Provided are a sustained-release pharmaceutical composition of a GLP-1 receptor agonist and a preparation method therefor. The composition contains 0.05 wt% to 0.5 wt% of an active ingredient, 45 wt% to 85 wt% of a sustained-release agent, and 15 wt% to 55 wt% of a viscosity-reducing agent, or contains 0.05 wt% to 0.5 wt% of an active ingredient, and 45 wt% to 99.95 wt% of a thermal sensitive sustained-release agent, wherein the active ingredient is a GLP-1 receptor agonist, the sustained-release agent is a polyorthoester, and the viscosity-reducing agent is preferably a glyceryl ester compound. Further provided are a drug-medical device combination product containing the sustained-release pharmaceutical composition, wherein the drug is the above-described sustained-release drug, and the medical device is a jet microneedle capable of injecting high-viscosity substances, and the use of the composition in the treatment of metabolism-related diseases. The sustained-release pharmaceutical composition has significantly improved pharmacokinetic characteristics, can realize long-acting administration, improves patient compliance, and exhibits good effects in improving blood glucose control, promoting weight loss, improving blood lipid levels, etc.

The present application relates to a kind of double detection nitric oxide and viscosity accurate diagnosis of liver fibrosis ratio type fluorescent probe, belong to fluorescent probe field.Its molecular structure is as follows: the fluorescent probe molecule presents red fluorescence, and after complete response with NO, the red fluorescence at 715nm is weakened until disappear, emits intense orange fluorescence, the fluorescence intensity ratio (I 625nm / I 715nm ) of probe BDP with NO concentration has good linear relationship;High viscosity leads to the significant fluorescence enhancement of probe before and after response NO, realizes the effect of simultaneous response.The probe molecule described in the present application can not only qualitatively analyze NO and viscosity, but also can realize rapid, quantitative detection NO and viscosity, has important application value in the field of biochemistry molecular analysis.

The invention relates to a spiral propelling type intelligent dosing device for a high-viscosity concentrated solution, and belongs to the technical field of fluid conveying. The device comprises a dosing tank and further comprises a supporting frame and a medicine outlet pipe, the medicine outlet pipe is composed of a large ring, a small ring and a connecting plate, the dosing tank is installed in the large ring of the supporting frame, the medicine outlet pipe is installed in the small ring of the supporting frame, the dosing tank is communicated with the medicine outlet pipe, and a stirring assembly is arranged in the dosing tank. And a pushing assembly is mounted in the medicine outlet pipe. According to the device, the rotating shaft and the scraper assembly are driven by the driving motor to continuously rotate, so that the scraper is tightly attached to the inner wall of the dosing tank to operate, high-viscosity liquid medicine adhered to the tank wall due to long-term standing is scraped, materials are prevented from being hung on the wall and remaining, and therefore it is guaranteed that components of the liquid medicine are uniform; the screw continuously rotates to extrude liquid medicine downwards, the hollow column is pushed to overcome the resistance of the spring to move downwards so as to communicate and seal the conveying channel, the electric push rod drives the piston to quantitatively extract the liquid medicine, and directional conveying of the high-viscosity liquid medicine is achieved.

The invention belongs to the technical field of medical instruments, particularly relates to a visual emergency radial artery compression hemostat and a use method thereof, and aims to solve the problems that an existing hemostat is prone to slipping off, difficult to position and constant in pressure to cause ischemia. The technical scheme includes that the visual emergency radial artery compression hemostat comprises a fixing plate, a bottom receding groove and a protective cover are arranged at the bottom of the fixing plate, and a pressure head is arranged below the protective cover; a driving mechanism is arranged in the fixing plate and the protective cover and comprises a piston disc I which slides in the protective cover in a sealing manner and an air bag fixed in the pressure head, a receding mechanism is further arranged and is used for keeping the protective cover relatively static when the fixing plate moves, and a plurality of throttling holes are formed in the piston disc I to form a pressure reducing mechanism, so that high-viscosity silicone oil below can slowly flow upwards; the bottom of the pressure head is provided with a V-shaped groove and a suction cup, the hemostat can keep the compression position stable when limbs of a patient shake or transfer jolts, the compression force is automatically decreased along with time, and the hemostat is mainly applied to radial artery compression hemostasis in emergency treatment.

The application relates to the technical field of biomedical engineering, and discloses a method for constructing an ex vivo normal-temperature perfusion repair model based on a discarded liver. The method constructs a double-path closed-loop perfusion system, applies a shear stress flow field with low-frequency fluctuation characteristics to a portal vein loop to maintain endothelial function, loads a composite flow field obtained by superimposing low-frequency pulsation and high-frequency micro-shaking on a hepatic artery loop, and significantly reduces microcirculation flow resistance by using the thixotropy and shear thinning characteristics of oxygen-containing perfusion liquid. The system further realizes physical layering of red blood cells and lipids by using acoustic radiation force of a standing wave acoustic flow control layered cavity, and automatically guides a high-viscosity fat-rich flow layer into an adsorption module for specific purification by cooperating with a thixotropic passive shunt valve based on fluid viscosity feedback. Temperature-gas coupling adjustment based on a metabolic temperature coefficient is performed in a rewarming stage. The application solves the problems of microcirculation non-recurrent flow and hyperlipidemia clearance by coupling of multi-dimensional physical fields, and realizes effective repair of the discarded liver.

The application discloses a kind of fluorescent probe of cascade response and its application in inflammatory bowel disease, belong to medical field.The fluorescent probe of cascade response of the application is simply recorded as P-Cy-RGD, its structural formula is as shown in following formula: The hydroxyl group of the fluorescent probe of the application is protected by phosphate group, and the intramolecular charge transfer (ICT) that it occurs to positively charged nitrogen heterocyclic fragment is effectively inhibited, so that fluorescence signal is in quenching state.When P-Cy-RGD is specifically recognized by the dephosphorylation of ALP overexpressed on the surface of inflammatory cell membrane, Cy of free hydroxyl group is released, and the fluorescence signal is activated by restoring ICT effect;Meanwhile, the high viscosity of inflammatory microenvironment inhibits the twisted intramolecular charge transfer (TICT) of Cy, so that its fluorescence signal is further amplified.

This application relates to a high-viscosity liquid aseptic filling system with end-to-end constant temperature control, including a liquid transfer assembly, an end-to-end heating assembly, a frame, and a clearance mechanism. The end-to-end heating assembly provides continuous heating and insulation for the liquid transfer assembly and is mounted on the frame via the clearance mechanism. The clearance mechanism can switch between an assembly position and a working position. In the assembly position, it drives the heating assembly out of a predetermined space, providing a sterile, isolated operating space for tubing connection and solving the technical problem of heating structures interfering with assembly within a confined sterile chamber. The pump unit adopts a U-shaped groove design with heat-conducting blocks, achieving efficient heat conduction and convenient lateral snap-fit ​​installation. For the reciprocating filling needle holder, a fixed heating chamber provides a constant temperature environment for the moving flexible infusion tubing, avoiding mechanical interference.

The present invention concerns a method for preparing antigen binding proteins specific for PCSK9 with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.

A microchannel structure for high-viscosity liquid immunoreaction includes a microchannel with an inlet at one end and an outlet at the other end. Several tortuous turbulence structures are spaced apart along the flow direction on both the bottom and top surfaces of the microchannel. The height of each tortuous turbulence structure increases sequentially along the flow direction. Each tortuous turbulence structure includes several interconnected baffles, each baffle tilted towards the substrate where the inlet is located, and each baffle forming an angle of 25°–60° with either the bottom or top surface of the microchannel. Several secondary baffles are spaced apart on the sides of each tortuous turbulence structure. The unequal angles of the baffles on the bottom and top surfaces of the microchannel create an asymmetric turbulence structure, breaking the symmetrical flow field, enhancing local vortices, and the secondary baffles forming turbulence branches, increasing the fluid contact area and improving the diffusion efficiency of the high-viscosity fluid.

The objective of the present invention is to provide an inexpensive artificial blood that has high viscosity and properties similar to actual menstrual blood in terms of color and stain removal behavior. [Solution] The artificial blood according to the present invention is an artificial blood comprising a thickening agent and hemoglobin, characterized in that the content of the thickening agent is 0.30% by mass or more of 100% by mass of the artificial blood.

This invention belongs to the field of biological detection and discloses a polarity and viscosity synergistic response fluorescent probe, its preparation method, and its application. The structural formula of the probe involved in this invention is as follows: This probe exhibits keto form D-A and enol form D in different polar solvents. + -A − The probe undergoes a structural transformation and is influenced by the photoinduced electron transfer (PET) effect. It exhibits no fluorescence in polar solvents and under low-polarity, high-viscosity conditions, but fluorescence is activated under high-polarity, high-viscosity conditions. In PBS buffer, the probe fluorescence is quenched due to the PET effect. Upon binding to HSA, the high steric hindrance microenvironment of HSA restricts probe molecule movement and inhibits the PET process, resulting in specific fluorescence activation at 578 nm. Furthermore, the fluorescence intensity shows a good linear relationship with HSA concentration over a wide range. This probe can rapidly and accurately detect albumin and can be used for detecting albumin levels in cerebrospinal fluid, applying it to the rapid screening of diseases related to blood-brain barrier damage.

The utility model belongs to the field of instruments for inputting a medium into a human body or onto the human body, and particularly discloses a labor-saving injector for high-viscosity medicine, which comprises a main shell, a piston, a mandrel screw, a sleeve screw and a sectioning nut assembly, a liquid storage cavity is arranged in the main shell, the piston is limited to only perform translational motion along the axial direction relative to the main shell, and the mandrel screw and the sleeve screw are arranged in the liquid storage cavity. The sleeve screw wraps the mandrel screw, and the sleeve screw and the mandrel screw are matched through equidirectional threads with small lead difference to form a differential transmission mechanism; the sleeve screw rod is formed by splicing two semicircular cylinder screw rods tensioned by an elastic connecting piece, and is spirally connected with an openable split nut assembly at the near end of the main shell. According to the differential screw principle, rotary input is converted into trace axial propulsion, and the mechanical gain is high; meanwhile, the design of the split nut and the split type sleeve is combined, rapid decoupling and resetting of a thread pair are achieved, and the clinical surgery operation efficiency and the injection precision are remarkably improved.

The invention discloses a double-shaft screw press for solid-liquid separation of a high-viscosity material, and belongs to the technical field of solid-liquid separation equipment. Comprising a rack, a driving device, a feeding box body, a discharging box body, a screen, a spiral extrusion system and a back pressure adjusting mechanism. The screen is of a butt-joint assembly type structure, and two independent cavities are formed. The spiral extrusion system comprises two spiral shafts which are arranged in parallel and rotate reversely, and spiral blades of the spiral shafts have phase difference and are variable in diameter and pitch. The back pressure adjusting mechanism comprises a reverse pushing air cylinder and a main pushing plate, settable constant back pressure is provided through the air cylinder, the main pushing plate can automatically seek dynamic balance between material pushing force and the back pressure, and therefore the size of a discharging gap is adjusted in real time. The problem of shaft sticking of high-viscosity materials is thoroughly solved, self-adaptive dynamic adjustment of pressure and stable and efficient dehydration are achieved, the water content of discharged slag is greatly reduced, meanwhile, the screen is convenient to disassemble, clean and maintain, and the continuous treatment device is suitable for continuous treatment of the high-temperature and high-viscosity materials such as intestinal mucosa salt hydrolysate.