56 results about "Hyperviscosity" patented technology

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a turbidity-dissolving and lipid-lowering composition and a preparation method thereof.The composition comprises 80-130 parts of polygonum cuspidatum, 50-90 parts of fried semen cassiae, 100-140 parts of hawthorn, 50-90 parts of rhizoma alismatis, 10-60 parts of rhizoma atractylodis macrocephalae fried with bran and 50-90 parts of rhizoma wenyujin concisum. The composition disclosed by the invention has the effects of eliminating phlegm, dissolving turbidity, promoting blood circulation to remove blood stasis, invigorating stomach and promoting diuresis, can be used for treating hyperlipidemia, hyperviscosity and arteriosclerotic cardia-cerebrovascular diseases, and has a very good application prospect.

The breast pad provided by the embodiment of the present application comprises a body, the body comprises a surface layer, a bottom layer and an absorbing core body sandwiched between the surface layer and the bottom layer, the surface layer and the bottom layer are combined along the outer peripheral edge, the absorbing core body comprises a top absorbing layer and a main absorbing layer which are stacked, the main absorbing layer comprises a main absorbing area, the top absorbing layer further comprises a notch part, the notch part forms a containing area, and the main absorbing area is located in the containing area. Through the above arrangement, on the one hand, the gushing milk can be fully absorbed into the fitting area, on the other hand, the back seepage is greatly reduced, on the third hand, the top absorbing layer forms a cushion layer, the compression feeling on the nipple is reduced, the comfort is improved, on the fourth hand, the absorbing capacity for high-viscosity milk is improved, and on the fifth hand, the absorbing capacity of the breast pad is improved.

This invention provides low-viscosity antigen-binding proteins and methods for producing them. [Solution] The present invention relates to a method for reducing the viscosity of an antigen-binding protein by modifying the sequence in the framework region and / or Fc domain, which has been shown to be associated with high viscosity. The present invention provides antigen-binding proteins, particularly antibodies, that have been mutated to reduce viscosity. Preferred antigen-binding proteins according to the present invention include antibodies, as shown in Figure 1B, having one or more, preferably all, of the following: VH1|1-18 germline subfamily substitution; VH3|3-33 germline subfamily substitution; VK3|L16 germline subfamily substitution; VK3|L6 germline subfamily substitution; or Fc substitution.

The invention discloses a child emergency treatment respiratory tract foreign matter rapid removing device, relates to the technical field of respiratory tract foreign matter removing, and aims to solve the technical problem that existing negative pressure suction equipment is too large in negative pressure and prone to directly adsorbing laryngeal mucosa to cause injury. Comprising a hose adaptively communicated with the input end of a negative pressure suction tube, a leakage connector, an annular groove, a removing mechanism, a collecting assembly and an angle adjusting assembly. By means of meshing or non-meshing switching of the transmission rod and the conveying cylinder, the two working states of lower cone rotating collection and upper cone sealing extraction of the guide sealing module can be flexibly adjusted and controlled, in the non-meshing state, the guide sealing module is in a lower cone shape and rotates with a gap reserved, throat mucus can be actively drawn in, and hard extrusion to the delicate throat is avoided; during meshing, the module moves upwards to be in a sealed upper cone shape, negative pressure extraction and spiral groove path optimization are matched, discomfort of the throat of a child caused by too high local negative pressure is prevented, high-viscosity mucus fracture can be avoided, and it is guaranteed that mucus is rapidly and thoroughly discharged.

The utility model discloses a stirring device for high viscosity medicine, which relates to the technical field of medicine processing equipment, and comprises a shell, the outer wall of the bottom of the shell is fixedly connected with a base, the inner wall of the shell is provided with a plurality of feed ports, the inner wall of the shell is provided with a stirring mechanism, and the stirring mechanism is connected with the base. The baffle and the knob are arranged, the knob is twisted to drive the baffle to rotate after stirring is completed, and the side, connected with the knob, of the baffle is limited by the positioning block, so that the baffle can only rotate around the positioning block, and medicine falls into a collecting box below along one side; after the collecting box is full, the knob is twisted reversely to enable the baffle to block the bottom of the shell again, the knob is rotated to drive the baffle to rotate, so that the bottom of the shell is opened, and the situation that due to the fact that the viscosity of medicine is too large, part of medicine is prone to adhering to the interior of the device when the medicine is poured out, and the medicine cannot be completely discharged is prevented. And a large amount of medicine is wasted.

The present invention relates to: a liquid formulation comprising an anti-IL-4Rα antibody, a saccharide, and an amino acid and not comprising a buffer; a device comprising same; and a use thereof for treating IL-4Rα-related conditions. The liquid formulation can improve the viscosity of the antibody while ensuring the stability thereof, and thus can be effectively used as a medicine for treating IL-4Rα-related conditions.

The invention provides a bone adhesion solid-phase composition, a bone adhesive as well as a preparation method and application of the bone adhesive, and belongs to the technical field of bone repair materials. The invention provides a bone bonding solid-phase composition which comprises the following components in percentage by mass: 5-60% of phosphoserine, 10-80% of calcium phosphate and 5-50% of polyglutamic acid. According to the invention, by adding the polyglutamic acid and utilizing the chelation of the polyglutamic acid and calcium ions, the polyglutamic acid is adsorbed on the surface of the powder to form steric hindrance, the viscosity is improved, the ion diffusion is delayed, the reaction rate of calcium phosphate and phosphoserine is reduced, and the curing time is prolonged; meanwhile, due to the viscosity, the early-stage viscosity and the overall compressive strength of the material are enhanced. The result of the embodiment shows that the putty time of the bone adhesive prepared from the bone adhesive solid-phase composition provided by the invention can reach 20-70 minutes, and the adhesive strength and compressive strength are remarkably enhanced.

This invention discloses a method for preparing biomimetic calcium phosphate particles carrying type III recombinant human collagen, relating to the field of new biomedical materials. The particle formulation, by mass percentage, contains 50%-90% hydroxyapatite and 10%-50% type III recombinant human collagen. The preparation process involves artificially synthesizing hydroxyapatite precipitate, then compounding it with type III recombinant human collagen. The compounded material is then spread, naturally dried, crushed, and sieved to form particles. The resulting particles have a uniform and controllable particle size. When mixed with blood or water, they can quickly form a high-viscosity, malleable, and stable filling material, directly adapting to the site preservation requirements of alveolar sockets after tooth extraction. The advantages are: the degradation rate of these particles precisely matches the bone regeneration rate after site preservation surgery, efficiently guiding bone tissue regeneration while significantly shortening the waiting period for implantation after tooth extraction. This solves the clinical promotion difficulties caused by the long waiting period and complex operation of site preservation surgery, contributing to the widespread application of this technology in oral clinical practice.

The application provides a centrifugal pump impeller design method and a centrifugal pump impeller for conveying high-viscosity non-Newtonian fluid, and aims at the problems of high shear force peak, efficiency attenuation and medium damage when the existing centrifugal pump conveys high-viscosity non-Newtonian fluid. The flow passage outlet section is configured as a three-section type water-drop-shaped section, which is a semi-elliptical section, a Bezier narrowing section and a rounded tip in sequence. The number of flow passages is determined according to the viscosity of the medium, and the higher the viscosity, the fewer the number of flow passages. The inside round corner, the outside round corner and the inlet edge margin in the flow passage are adjusted by using the average shear rate of the outlet surface, and a complete flow passage is constructed by using a gradual transition section. The application can significantly suppress the shear rate peak, reduce the amplitude by more than 86%, and maintain the head and efficiency, and is suitable for efficient and low-damage conveying of high-viscosity non-Newtonian fluid in the fields of petroleum, chemical industry, food and biological medicine.

This invention discloses a tandem-responsive self-assembled molecular probe and its applications. The HPO-CYFF-TPP of this invention is converted to HO-CYFF-TPP under the dephosphorylation of overexpressed ALP, restoring the intramolecular charge transfer effect. It then self-assembles into nanoparticles in situ through π-π stacking, exhibiting fluorescence signal quenching and photoacoustic signal enhancement at low viscosity. Upon laser irradiation, the NPs generate a large amount of singlet oxygen in the mitochondria, thereby achieving efficient photodynamic therapy (PDT) and leading to increased viscosity. At high viscosity, due to the suppression of the distorted intramolecular charge transfer effect of HO-CYFF-TPP, the NPs activate the FL signal with a high signal-to-noise ratio and further enhance the PA signal. Therefore, the HPO-CYFF-TPP of this invention can achieve efficient PDT and enable real-time therapeutic effect assessment through FL / PA signals.

The invention relates to the technical field of biosensing, and discloses a pH / viscosity double-lock activated afterglow luminescent small molecule probe as well as a preparation method and application thereof. The structural formula of the afterglow luminescent small-molecule probe is shown in the specification. A rhodamine light-emitting unit and an afterglow light-emitting matrix unit SO are covalently connected through a chemical bond. The luminescent mechanism is as follows: under illumination, molecules generate singlet oxygen to oxidize and activate adjacent SO units, so that active oxygen mediated afterglow luminescence is generated. The afterglow luminescent small-molecule probe has a double-lock activation characteristic, that is, a strong afterglow signal can be generated only when a subacid environment and a high-viscosity condition are met at the same time. And the signal is weak under a single condition or a normal physiological environment. The probe provided by the invention has excellent environmental specificity and high signal-to-noise ratio imaging capability, and provides a powerful tool for realizing accurate imaging in a complex biological system.

Briefly, an injection delivery system is described for subcutaneous or intramuscular injection of a drug, in particular a large volume of a biologic drug, high and low viscosity biologies, or a large volume of a high viscosity and low viscosity chemical drug. The injections may be self-administered or performed by a caregiver. The system uses a pump to move a drug from a vial, thorough an infusion set, and into the patient. A vial of a biological or chemical drug is set into a vial adapter that is associated with the pump, which can be manual or powered. A fluidics subassembly connects the vial adapter, pump, and the infusion set so that a drug pathway is enabled from the vial to the patient. The fluidics subassembly has one or more check valves to assure that the drug pathway is only enabled for a one-way drug flow out of the vial and to the patient. The infusion set has flexible tubing that connects the fluidics subassembly to cannula assembly inside an infuser housing. The cannula assembly has an air evacuation assembly near the tip of the needle. This air evacuation assembly is constructed to safely exhaust air from the cannula assembly at three times: (1) at initial setup to exhaust air while the drug is filling the cannula assembly, which enables the self-priming; (2) during injection to exhaust drug-entrapped air, which increases injection safety; and (3) at the end of drug delivery to exhaust air after the full dose of drug has been delivered to the cannula assembly, including drug that was in the tubing, which reduces wasted drug and minimizes the amount of drug overfill required in the vial.

The invention relates to the technical field of heating devices, in particular to a rapid heating device applied to high-viscosity fluid. The rapid heating device comprises an inner cylinder and an outer cylinder, the inner cylinder and the outer cylinder are not in contact to form a first clearance space, the first clearance space is communicated with a material input channel and a material output channel, the outer cylinder is connected with a rotating mechanism, and the rotating mechanism is connected with the inner cylinder and the outer cylinder. The rotating mechanism is used for driving the outer cylinder to rotate relative to the inner cylinder, and the interior of the inner cylinder is connected with a heat source so as to heat materials in the first gap space. The embodiment of the invention provides a rapid heating device applied to high-viscosity fluid, which can be used for conveniently transporting a mixture consisting of high-molecular hyaluronan and low-molecular hyaluronan and rapidly heating the mixture.

The embodiment of the invention provides a scaled laminated tampon based on an inner support, which comprises a main body, and the main body comprises an inner support, an outer support and a plurality of through holes, and the inner support is provided with a hollow space and is provided with a plurality of through holes; the main absorption part is accommodated in the hollow space and is formed by winding a main absorption sheet; the outer absorption part comprises a plurality of outer absorption sheets; wherein one end of each outer absorption piece is fixed on the inner support, the other end of each outer absorption piece extends towards the adjacent outer absorption piece and is stacked on the adjacent outer absorption piece, the main absorption part is in contact with the outer absorption pieces through the through holes, and the main absorption part is limited by the inner support through the arrangement. Therefore, the use discomfort caused by the increase of circumferential volume due to swelling or swelling is prevented; meanwhile, the fish-scale-shaped stacked structure is formed, so that the body fluid can conveniently flow downwards, and the viscous body fluid can be diffused inwards along gaps of the fish-scale-shaped stacked structure, and therefore, the fish-scale-shaped body fluid absorption device is suitable for absorption of high-viscosity or low-viscosity body fluid.

The invention discloses an eye protection external preparation and a preparation method thereof, and belongs to the technical field of ophthalmic preparations. The preparation method comprises the following steps: mixing a main agent solution A containing Ectoine and trehalose with a matrigel solution B containing chitosan quaternary ammonium salt; and then carrying out high-pressure microjet homogenization treatment on the mixed solution at 100-150 MPa so as to construct a supramolecular network structure. Through a specific high-pressure homogenization process, the obtained preparation has an excellent shear thinning characteristic, high viscosity is kept during standing to realize biological adhesion, the viscosity is instantaneously reduced during blinking to ensure comfort, and the problem of blurred vision of traditional gel is solved. Meanwhile, due to the network structure of the preparation, the active ingredients can be instantly released, the hypertonic state of the eyes can be rapidly relieved, and the preparation is adhered to the ocular surface for a long time.

The application discloses a kind of children emergency respiratory tract foreign matter quick removal device, it is related to respiratory tract foreign matter removal technical field, to solve the technical problem that existing negative pressure suction equipment negative pressure is too large, easy to directly absorb throat mucosa and cause damage, including the hose of adaptation and communication in negative pressure suction pipe input end, leakage connector, annular groove, removal mechanism, collection assembly and angle adjusting assembly.The engagement or non-engagement of transmission rod and conveying cylinder is switched, the rotation of the lower cone of the guide sealing module can be flexibly controlled to collect and the upper cone is sealed to separate two working states: when not engaging, the guide sealing module is in the form of a lower cone and leaves a gap to rotate, which can actively roll into the mucus of the throat, avoiding hard extrusion on the delicate throat;when engaging, the module moves up to the form of a sealed upper cone, which, combined with the path optimization of negative pressure separation and spiral groove, can prevent local negative pressure from being too high to cause discomfort in the throat of children, and can also avoid high-viscosity mucus fault, ensuring that the mucus is quickly and completely discharged.

The invention belongs to the technical field of sampling devices, and discloses a sampling device for liquid medicine detection and a method thereof.The sampling device comprises a spherical medicine storage body, the lower portion of the spherical medicine storage body is communicated with a liquid suction pipe, a top pipe is arranged above the spherical medicine storage body, and a limiting plate is rotationally installed between the top pipe and the spherical medicine storage body in a sealed mode; the top pipe and the spherical medicine storage body can be isolated and sealed through the limiting plate, a liquid taking assembly is fixedly installed in the center of the top pipe and vertically extends to the bottom end of the interior of the liquid suction pipe, extraction and discharging of medicine liquid are completed through rotation, and a stirring assembly used for homogenization pretreatment of the medicine liquid is rotationally installed at the upper end of the top pipe. A swing assembly capable of expanding the stirring range is integrated on the stirring assembly, and a driving device used for providing power and achieving function switching is arranged on the top pipe; the liquid medicine stirring device is simple in overall structure, can efficiently and uniformly stir liquid medicine which is easy to layer and high in viscosity, eliminates stirring dead angles, and improves the using effect.

Doxycycline injections improve the appearance of cosmetically significant lower eyelid festoons and malar edema, as well as of the jowls. The doxycycline is also useful for reducing edema of turbinates, the nasal concha or conchae shell-shaped networks of bones, vessels, and tissue within the nasal passageways that are responsible for warming, humidifying, and filtering the air as it is inhaled. The doxycline, in a concentration preferably of greater than 10 to 20 mg / ml, preferably in combination with a local anesthetic and optionally with a vasoconstrictor such as epinephrine and a pH buffering agent, is injected into the subcuticular space at the site of swelling. The high viscosity limits the spread of the doxycycline to the area to be treated. The resulting sclerosis prevents fluid accumulation. The doxycline also decreases swelling due to fat, by causing a decrease in lipomas.

The invention provides multi-effect composite scar repair gel as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention develops a multi-effect composite scar repair gel with barrier protection, anti-inflammatory regeneration and long-acting permeation by integrating a silicone base material, traditional Chinese medicine active ingredients and an ionic liquid permeation promotion technology. Wherein the high-viscosity polydimethylsiloxane is used for reducing skin tension; the low-viscosity polydimethylsiloxane improves the skin comfort level; the traditional Chinese medicine extract inhibits fibroblast proliferation and promotes microcirculation; the Ectoin-allantoin microcapsule is capable of realizing 72-hour slow-release anti-inflammatory repair; the BPC157 polypeptide can promote angiogenesis and accelerate wound healing; the transdermal rate of the active ingredients is increased by more than 3 times by the arginine-malic acid ionic liquid; the zinc hyaluronate can synergistically moisturize and regulate the inflammation microenvironment. Through cooperation of multiple mechanisms, the effects of barrier protection, anti-inflammatory regeneration and long-acting permeation are achieved, and the anti-inflammatory and long-acting anti-inflammatory ointment is suitable for repairing hypertrophic scars, acne scars and postoperative incisions.

One example of a device can deliver fluids having high viscosity, including fluids having a viscosity of 1,000 cP or more, through a channel. The device can be or include a syringe or a syringe. A barrel, a hub, a needle, or a combination thereof can define at least a portion of the channel. Methods of flowing fluids having such high viscosity are also disclosed herein. In certain embodiments, a method includes flowing a first fluid of relatively high viscosity and a lubricant of relatively low viscosity through a channel simultaneously, for example by using the lubricant to separate the first fluid from an inner surface of the channel, as is the case with a core annular flow. By sizing and shaping the channel as disclosed herein, particularly at a constriction, a stable core annular flow can be achieved, which makes it easier to flow a high viscosity fluid at a useful flow rate by manually applying force.

The invention belongs to the technical field of biological electrodes, and particularly relates to a high-viscosity flexible spinal cord electrical stimulation electrode for chronic pain treatment and a preparation method of the high-viscosity flexible spinal cord electrical stimulation electrode. The preparation method comprises the following steps: pre-polymerizing and dispersing dithiothreitol, benzoin dimethyl ether, vinyl-terminated polydimethylsiloxane and boric acid in a proper ratio in a nitrogen atmosphere to obtain a silica gel mixture; performing ultraviolet irradiation to obtain high-viscosity polyborosilane marked as PBS, and coating a silica gel film with the PBS to serve as a flexible substrate of the electrode; and then sputtering a conductive circuit on the PBS, and packaging by using the PBS to only expose electrode sites to obtain the flexible electrode. The preparation method disclosed by the invention is simple, efficient and rapid, and the obtained electrode is good in biocompatibility, has high adhesion and deformability to all biological interfaces, and can be tightly attached to the surfaces of biological tissues with different shapes; wherein sulfydryl and sulfur atom sites in the PBS can interact with gold, so that a surface circuit has in-vivo long-term stability.

The invention provides a high-viscosity anti-swelling tissue adhesive based on a dual-acceptor deep eutectic solvent as well as a preparation method and application of the high-viscosity anti-swelling tissue adhesive. The high-viscosity anti-swelling tissue adhesive is prepared from a part a and a part b, the part a comprises a cycloenone acetal monomer (CKA), an initiator and a cross-linking agent; and the part b comprises an olefin monomer, choline chloride and arginine. The adhesive provided by the invention is an injectable adhesive taking cycloenone acetal, an olefin monomer and a dihydrogen bond acceptor deep eutectic solvent (DES) as cores, choline chloride and arginine are synergistically used as a hydrogen bond acceptor, and the olefin monomer is used as a hydrogen bond donor to construct a high-viscosity DES pre-polymerized solution, so that the in-vivo anti-scouring property is remarkably improved, and the in-vivo anti-scouring property is improved; a hydrophobic network is formed through CKA ring opening polymerization, and long-term swelling resistance and stability are achieved; the adhesive is suitable for closing and bonding wounds in wet environments such as massive hemorrhage wounds, in-vivo wounds, bone tissues and the like. The adhesive also has excellent swelling resistance and tensile property.

The application belongs to the field of organic molecule fluorescent probe, and a small molecule fluorescent probe HX is rationally designed, and the integration of diagnosis and treatment is realized by monitoring the related physical properties of tumor microenvironment and the photodynamic therapy of tumor. The tumor microenvironment of solid tumor usually has the characteristics of low pH, high viscosity, low oxygen and the like, and it is of great significance to carry out real-time monitoring and effective inhibition on tumor tissue based on the characteristic parameters of tumor site. Herein, a near-infrared fluorescent probe HX is designed, the probe does not respond to the change of surrounding viscosity in a high pH environment, however, in a low pH microenvironment of tumor, the "Donor-π-Acceptor (D-π-A)" structure thereof is opened, and sensitive viscosity response characteristics are exhibited, so that the dynamic monitoring of the tumor microenvironment is realized. In addition, through structure optimization, it is also confirmed that the probe can be used as a photosensitizer with type I reaction for photodynamic therapy of tumor tissue under hypoxic conditions. With the help of a mouse tumor model in vivo, it is confirmed that the probe HX not only has the ability to identify tumor tissue and normal tissue, but also has excellent tumor inhibition effect and good biocompatibility under hypoxic conditions, thereby providing a new technology for the diagnosis and treatment integration design of tumor diseases.

The application relates to the technical field of medical devices, and provides an automatically drivable injection device, which comprises a shell, a containing cavity and a medicine cavity which are arranged along the axial direction of the shell and are communicated with each other, a first limiting piece and a second limiting piece are arranged in the containing cavity, an adjusting mechanism is rotatably arranged in the containing cavity, the adjusting mechanism is provided with an adjusting station and an injection station along the axial direction of the containing cavity, a torsion spring is connected with the adjusting mechanism and the shell at two ends, and an injection mechanism is arranged in the containing cavity and the medicine cavity, one end of the injection mechanism is provided with a threaded rod arranged along the axial direction of the containing cavity, and the other end of the injection mechanism is connected with the shell. Through the improvement of the transmission mode and the spring structure, the injection strength during injection is improved, the injection device is suitable for larger scenes, and is especially suitable for high-viscosity injection drugs. Meanwhile, the injection time is shortened, and the experience of a user is optimized.

The invention provides a near-infrared fluorescent viscosity probe as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The near-infrared fluorescence viscosity probe has a structure as shown in a formula I; the invention also provides a preparation method and application of the near-infrared fluorescence viscosity probe. The near-infrared fluorescence viscosity probe disclosed by the invention has the characteristics of aggregation-induced emission, high viscosity sensitivity, pH stability and good biocompatibility, can realize rapid and accurate imaging of rheumatoid arthritis and osteoarthritis, and provides a novel tool for arthritis diagnosis and pathological research.

The application provides a fluorescent probe for detecting cell microenvironment viscosity change and a preparation method thereof, and the fluorescent probe is 2-((E)-2-(6-((Z)-(4-(dimethylamino)phenyl)azo)-2,3-dihydro-1H-thioxanthene-4-yl)vinyl)-1,3,3-trimethyl-3H-indol-1-ium. The fluorescent probe can make the electron donor and the electron acceptor freely run around the N=N double bond in a low viscosity environment. When being stimulated by light, the energy of the excited state is released in a non-radiation mode through a TICT mechanism, so that weak fluorescence is displayed. In a high viscosity environment, intramolecular rotation is limited, the energy of the excited state is emitted in a light radiation mode, so that strong fluorescence is generated. The probe has high sensitivity for microenvironment viscosity detection and does not interfere with other common active oxygen, amino acid and enzyme species.

The invention discloses a red / near-infrared two-region dual-response fluorescent probe based on a hemicyanine skeleton and application of the fluorescent probe in detection of NAD (P) H and viscosity. The probe is designed based on an extended pi conjugated skeleton and an A-pi-A structure, and dual-channel detection of NAD (P) H and viscosity is realized through a unique response mechanism. 3-methylquinoline is used as a response site of NAD (P) H, active hydrogen in the NAD (P) H attacks an aromatic pi bond of a quinoline ring, structural rearrangement is initiated, the quinoline ring is converted into Cy-NH with a D-pi-A structure, and fluorescence enhancement of an NIR-II region is triggered through an enhanced intramolecular charge transfer (ICT) effect. The response to viscosity depends on a benzo [c, d] indole molecular rotor, in a high-viscosity environment, intramolecular rotation is limited, a distorted intramolecular charge transfer (TICT) non-radiative decay pathway is inhibited, a system is converted from a TICT state to an ICT state, and fluorescence is remarkably recovered. According to the mechanism, the Cy-N can realize high-selectivity and high-sensitivity detection on two target objects under the condition of no spectral crosstalk.

Syringe attachments and syringes have particular suitability to the precision dispensing of small amounts of high viscosity materials, such as dermal fillers. An attachment may include a main body having an assist feature that includes a wheel and pinion gears on each side of the wheel which engage respective racks on the syringe body. A mechanical advantage may be provided to the user as the wheel is rotated relative to the syringe body and racks. Syringes and attachments may include precision position indicators viewed from multiple positions to enable a user to determine plunger position and the amount of dispensed contents with precision. An alternative configuration attachment may be slidably secured to a syringe to permit a user to operation the syringe from a lateral position using sliding movement of the thumb and fingers of one hand, for example. This configuration may be particularly suitable for self-administered insulin injections.

Provided are a sustained-release pharmaceutical composition of a GLP-1 receptor agonist and a preparation method therefor. The composition contains 0.05 wt% to 0.5 wt% of an active ingredient, 45 wt% to 85 wt% of a sustained-release agent, and 15 wt% to 55 wt% of a viscosity-reducing agent, or contains 0.05 wt% to 0.5 wt% of an active ingredient, and 45 wt% to 99.95 wt% of a thermal sensitive sustained-release agent, wherein the active ingredient is a GLP-1 receptor agonist, the sustained-release agent is a polyorthoester, and the viscosity-reducing agent is preferably a glyceryl ester compound. Further provided are a drug-medical device combination product containing the sustained-release pharmaceutical composition, wherein the drug is the above-described sustained-release drug, and the medical device is a jet microneedle capable of injecting high-viscosity substances, and the use of the composition in the treatment of metabolism-related diseases. The sustained-release pharmaceutical composition has significantly improved pharmacokinetic characteristics, can realize long-acting administration, improves patient compliance, and exhibits good effects in improving blood glucose control, promoting weight loss, improving blood lipid levels, etc.

This oil for an oily phase of a W / O emulsion has a refractive index of 1.303 or more and a viscosity of 20 mPa∙s or less.