74 results about "Hyperviscosity" patented technology

The present invention relates to a sustained release microsphere and a sustained release preparation comprising a GLP-1 receptor agonist or a pharmaceutically acceptable salt thereof. The present invention relates to a sustained release formulation, and more specifically, to a sustained release formulation comprising a GLP-1 receptor agonist or a pharmaceutically acceptable salt thereof, the sustained-release microparticles comprise a GLP-1 receptor agonist or a pharmaceutically acceptable salt thereof, one kind of low-viscosity polylactic acid-glycolic acid copolymer (PLGA) having an intrinsic viscosity of 0.14 dL / g to 0.24 dL / g, and two or more kinds of high-viscosity polylactic acid-glycolic acid copolymers having an intrinsic viscosity of 0.32 dL / g to 0.60 dL / g, so that the sustained-release microparticles do not have the problems of excessive release and delayed release in the initial stage of a drug. Long-term sustained release can be realized, and the bioavailability is excellent.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a turbidity-dissolving and lipid-lowering composition and a preparation method thereof.The composition comprises 80-130 parts of polygonum cuspidatum, 50-90 parts of fried semen cassiae, 100-140 parts of hawthorn, 50-90 parts of rhizoma alismatis, 10-60 parts of rhizoma atractylodis macrocephalae fried with bran and 50-90 parts of rhizoma wenyujin concisum. The composition disclosed by the invention has the effects of eliminating phlegm, dissolving turbidity, promoting blood circulation to remove blood stasis, invigorating stomach and promoting diuresis, can be used for treating hyperlipidemia, hyperviscosity and arteriosclerotic cardia-cerebrovascular diseases, and has a very good application prospect.

The breast pad provided by the embodiment of the present application comprises a body, the body comprises a surface layer, a bottom layer and an absorbing core body sandwiched between the surface layer and the bottom layer, the surface layer and the bottom layer are combined along the outer peripheral edge, the absorbing core body comprises a top absorbing layer and a main absorbing layer which are stacked, the main absorbing layer comprises a main absorbing area, the top absorbing layer further comprises a notch part, the notch part forms a containing area, and the main absorbing area is located in the containing area. Through the above arrangement, on the one hand, the gushing milk can be fully absorbed into the fitting area, on the other hand, the back seepage is greatly reduced, on the third hand, the top absorbing layer forms a cushion layer, the compression feeling on the nipple is reduced, the comfort is improved, on the fourth hand, the absorbing capacity for high-viscosity milk is improved, and on the fifth hand, the absorbing capacity of the breast pad is improved.

This invention provides low-viscosity antigen-binding proteins and methods for producing them. [Solution] The present invention relates to a method for reducing the viscosity of an antigen-binding protein by modifying the sequence in the framework region and / or Fc domain, which has been shown to be associated with high viscosity. The present invention provides antigen-binding proteins, particularly antibodies, that have been mutated to reduce viscosity. Preferred antigen-binding proteins according to the present invention include antibodies, as shown in Figure 1B, having one or more, preferably all, of the following: VH1|1-18 germline subfamily substitution; VH3|3-33 germline subfamily substitution; VK3|L16 germline subfamily substitution; VK3|L6 germline subfamily substitution; or Fc substitution.

The invention discloses a child emergency treatment respiratory tract foreign matter rapid removing device, relates to the technical field of respiratory tract foreign matter removing, and aims to solve the technical problem that existing negative pressure suction equipment is too large in negative pressure and prone to directly adsorbing laryngeal mucosa to cause injury. Comprising a hose adaptively communicated with the input end of a negative pressure suction tube, a leakage connector, an annular groove, a removing mechanism, a collecting assembly and an angle adjusting assembly. By means of meshing or non-meshing switching of the transmission rod and the conveying cylinder, the two working states of lower cone rotating collection and upper cone sealing extraction of the guide sealing module can be flexibly adjusted and controlled, in the non-meshing state, the guide sealing module is in a lower cone shape and rotates with a gap reserved, throat mucus can be actively drawn in, and hard extrusion to the delicate throat is avoided; during meshing, the module moves upwards to be in a sealed upper cone shape, negative pressure extraction and spiral groove path optimization are matched, discomfort of the throat of a child caused by too high local negative pressure is prevented, high-viscosity mucus fracture can be avoided, and it is guaranteed that mucus is rapidly and thoroughly discharged.

The invention belongs to the technical field of surgical instruments, and provides a body fluid sample collection device for hydrothorax and ascites and a use method thereof. A pretreatment device is arranged between a body fluid bottle and a suction pipeline and comprises a viscosity control part, the viscosity control part is provided with a conical pipe, the inner diameter of the end, close to the suction pipeline, of the conical pipe is smaller than that of the end, away from the suction pipeline, of the conical pipe, and branch pipe openings capable of being opened and closed are formed in the two ends of the conical pipe. The branch pipe openings comprise the first branch pipe opening and the second branch pipe opening, and the first branch pipe opening is closer to the suction pipeline than the second branch pipe opening. The problems that in the hydrothorax and ascites suction process, due to clots such as fibrin of high-viscosity hydrothorax and ascites, a suction pipeline is blocked, and the microscopic examination accuracy is affected are avoided; the problems that before and after the pleural and ascitic fluid needs to be sucked for multiple times and the pleural and ascitic fluid is indwelled and sucked, the pipeline is blocked due to residual clots in the pipeline, and even indwelling and suction instruments need to be replaced are avoided.

The utility model discloses a stirring device for high viscosity medicine, which relates to the technical field of medicine processing equipment, and comprises a shell, the outer wall of the bottom of the shell is fixedly connected with a base, the inner wall of the shell is provided with a plurality of feed ports, the inner wall of the shell is provided with a stirring mechanism, and the stirring mechanism is connected with the base. The baffle and the knob are arranged, the knob is twisted to drive the baffle to rotate after stirring is completed, and the side, connected with the knob, of the baffle is limited by the positioning block, so that the baffle can only rotate around the positioning block, and medicine falls into a collecting box below along one side; after the collecting box is full, the knob is twisted reversely to enable the baffle to block the bottom of the shell again, the knob is rotated to drive the baffle to rotate, so that the bottom of the shell is opened, and the situation that due to the fact that the viscosity of medicine is too large, part of medicine is prone to adhering to the interior of the device when the medicine is poured out, and the medicine cannot be completely discharged is prevented. And a large amount of medicine is wasted.

The invention discloses an antibacterial blood bag and a preparation method thereof.The antibacterial blood bag comprises a blood bag body, a bionic self-repairing antibacterial surface and an environment adaptability adjusting film, the blood bag body is made of an improved material based on polylactic acid, and quaternary ammonium salt groups of a specific structure and content are introduced through a molecular grafting technology; the invention further discloses a preparation method of the antibacterial blood bag. The preparation method comprises the following steps of S1, material preparation, S2, main body material preparation, S3, bionic surface preparation and S4, adjusting film installation. According to the bionic self-repairing bacteriostatic surface microcapsule innovative design, a unique double-layer microcapsule structure is adopted, when the surface of the blood bag is slightly damaged, the microcapsule can rapidly flow out, the damaged position can be rapidly filled up, the integrity of the surface of the blood bag is recovered, the high-viscosity bacteriostatic repairing liquid packaged on the outer layer can continuously release bacteriostatic components in the follow-up process, and the effect of repairing the surface of the blood bag is achieved. The surface physical damage is repaired, and the antibacterial protection is enhanced.

The present invention relates to: a liquid formulation comprising an anti-IL-4Rα antibody, a saccharide, and an amino acid and not comprising a buffer; a device comprising same; and a use thereof for treating IL-4Rα-related conditions. The liquid formulation can improve the viscosity of the antibody while ensuring the stability thereof, and thus can be effectively used as a medicine for treating IL-4Rα-related conditions.

The invention provides a bone adhesion solid-phase composition, a bone adhesive as well as a preparation method and application of the bone adhesive, and belongs to the technical field of bone repair materials. The invention provides a bone bonding solid-phase composition which comprises the following components in percentage by mass: 5-60% of phosphoserine, 10-80% of calcium phosphate and 5-50% of polyglutamic acid. According to the invention, by adding the polyglutamic acid and utilizing the chelation of the polyglutamic acid and calcium ions, the polyglutamic acid is adsorbed on the surface of the powder to form steric hindrance, the viscosity is improved, the ion diffusion is delayed, the reaction rate of calcium phosphate and phosphoserine is reduced, and the curing time is prolonged; meanwhile, due to the viscosity, the early-stage viscosity and the overall compressive strength of the material are enhanced. The result of the embodiment shows that the putty time of the bone adhesive prepared from the bone adhesive solid-phase composition provided by the invention can reach 20-70 minutes, and the adhesive strength and compressive strength are remarkably enhanced.

This invention belongs to the technical field of organic small molecule fluorescent probes and provides a fluorescent probe for viscosity detection. In high-viscosity solutions, the probe exhibits strong fluorescence in the near-infrared region, with high sensitivity, a large Stokes shift, and a high signal-to-noise ratio. This probe can be used not only to detect viscosity changes within mitochondria in living cells but also to measure viscosity in situ gastritis, demonstrating significant advantages in biological analysis and detection.

This invention discloses a method for preparing biomimetic calcium phosphate particles carrying type III recombinant human collagen, relating to the field of new biomedical materials. The particle formulation, by mass percentage, contains 50%-90% hydroxyapatite and 10%-50% type III recombinant human collagen. The preparation process involves artificially synthesizing hydroxyapatite precipitate, then compounding it with type III recombinant human collagen. The compounded material is then spread, naturally dried, crushed, and sieved to form particles. The resulting particles have a uniform and controllable particle size. When mixed with blood or water, they can quickly form a high-viscosity, malleable, and stable filling material, directly adapting to the site preservation requirements of alveolar sockets after tooth extraction. The advantages are: the degradation rate of these particles precisely matches the bone regeneration rate after site preservation surgery, efficiently guiding bone tissue regeneration while significantly shortening the waiting period for implantation after tooth extraction. This solves the clinical promotion difficulties caused by the long waiting period and complex operation of site preservation surgery, contributing to the widespread application of this technology in oral clinical practice.

The application provides a centrifugal pump impeller design method and a centrifugal pump impeller for conveying high-viscosity non-Newtonian fluid, and aims at the problems of high shear force peak, efficiency attenuation and medium damage when the existing centrifugal pump conveys high-viscosity non-Newtonian fluid. The flow passage outlet section is configured as a three-section type water-drop-shaped section, which is a semi-elliptical section, a Bezier narrowing section and a rounded tip in sequence. The number of flow passages is determined according to the viscosity of the medium, and the higher the viscosity, the fewer the number of flow passages. The inside round corner, the outside round corner and the inlet edge margin in the flow passage are adjusted by using the average shear rate of the outlet surface, and a complete flow passage is constructed by using a gradual transition section. The application can significantly suppress the shear rate peak, reduce the amplitude by more than 86%, and maintain the head and efficiency, and is suitable for efficient and low-damage conveying of high-viscosity non-Newtonian fluid in the fields of petroleum, chemical industry, food and biological medicine.

This invention discloses a tandem-responsive self-assembled molecular probe and its applications. The HPO-CYFF-TPP of this invention is converted to HO-CYFF-TPP under the dephosphorylation of overexpressed ALP, restoring the intramolecular charge transfer effect. It then self-assembles into nanoparticles in situ through π-π stacking, exhibiting fluorescence signal quenching and photoacoustic signal enhancement at low viscosity. Upon laser irradiation, the NPs generate a large amount of singlet oxygen in the mitochondria, thereby achieving efficient photodynamic therapy (PDT) and leading to increased viscosity. At high viscosity, due to the suppression of the distorted intramolecular charge transfer effect of HO-CYFF-TPP, the NPs activate the FL signal with a high signal-to-noise ratio and further enhance the PA signal. Therefore, the HPO-CYFF-TPP of this invention can achieve efficient PDT and enable real-time therapeutic effect assessment through FL / PA signals.

The invention relates to the technical field of biosensing, and discloses a pH / viscosity double-lock activated afterglow luminescent small molecule probe as well as a preparation method and application thereof. The structural formula of the afterglow luminescent small-molecule probe is shown in the specification. A rhodamine light-emitting unit and an afterglow light-emitting matrix unit SO are covalently connected through a chemical bond. The luminescent mechanism is as follows: under illumination, molecules generate singlet oxygen to oxidize and activate adjacent SO units, so that active oxygen mediated afterglow luminescence is generated. The afterglow luminescent small-molecule probe has a double-lock activation characteristic, that is, a strong afterglow signal can be generated only when a subacid environment and a high-viscosity condition are met at the same time. And the signal is weak under a single condition or a normal physiological environment. The probe provided by the invention has excellent environmental specificity and high signal-to-noise ratio imaging capability, and provides a powerful tool for realizing accurate imaging in a complex biological system.

Briefly, an injection delivery system is described for subcutaneous or intramuscular injection of a drug, in particular a large volume of a biologic drug, high and low viscosity biologies, or a large volume of a high viscosity and low viscosity chemical drug. The injections may be self-administered or performed by a caregiver. The system uses a pump to move a drug from a vial, thorough an infusion set, and into the patient. A vial of a biological or chemical drug is set into a vial adapter that is associated with the pump, which can be manual or powered. A fluidics subassembly connects the vial adapter, pump, and the infusion set so that a drug pathway is enabled from the vial to the patient. The fluidics subassembly has one or more check valves to assure that the drug pathway is only enabled for a one-way drug flow out of the vial and to the patient. The infusion set has flexible tubing that connects the fluidics subassembly to cannula assembly inside an infuser housing. The cannula assembly has an air evacuation assembly near the tip of the needle. This air evacuation assembly is constructed to safely exhaust air from the cannula assembly at three times: (1) at initial setup to exhaust air while the drug is filling the cannula assembly, which enables the self-priming; (2) during injection to exhaust drug-entrapped air, which increases injection safety; and (3) at the end of drug delivery to exhaust air after the full dose of drug has been delivered to the cannula assembly, including drug that was in the tubing, which reduces wasted drug and minimizes the amount of drug overfill required in the vial.

The invention relates to the technical field of heating devices, in particular to a rapid heating device applied to high-viscosity fluid. The rapid heating device comprises an inner cylinder and an outer cylinder, the inner cylinder and the outer cylinder are not in contact to form a first clearance space, the first clearance space is communicated with a material input channel and a material output channel, the outer cylinder is connected with a rotating mechanism, and the rotating mechanism is connected with the inner cylinder and the outer cylinder. The rotating mechanism is used for driving the outer cylinder to rotate relative to the inner cylinder, and the interior of the inner cylinder is connected with a heat source so as to heat materials in the first gap space. The embodiment of the invention provides a rapid heating device applied to high-viscosity fluid, which can be used for conveniently transporting a mixture consisting of high-molecular hyaluronan and low-molecular hyaluronan and rapidly heating the mixture.

The invention belongs to the technical field of medical instruments, and discloses a gastrointestinal decompression device with an anti-blocking function, which comprises a catheter, one end of the catheter is provided with a container, one side of the container is fixedly provided with a pressure reducer, one side of the pressure reducer is fixedly provided with a communicating pipe, the communicating pipe is connected with the container, and the communicating pipe is connected with the container. The pressure reducer can achieve the pressure reduction effect through pressing. The fixed mask is located at the end, away from the container, of the catheter, hook-and-loop fasteners are fixedly installed on the two symmetrical sides of the fixed mask, and the end, close to the fixed mask, of the catheter is used for being inserted into the mouth and nose of a patient; through cooperation of the U-shaped pipe, the supporting block, the pressing assembly and other structures, diversion and blockage prevention of the catheter are conveniently achieved, and the problems that an existing device conducts adsorption through a single catheter, the blockage risk is high, high-viscosity gastric juice or food residues are prone to being accumulated in a single channel, and consequently a pipe cavity is completely blocked are solved.

Doxycycline injections improve the appearance of cosmetically significant lower eyelid festoons and malar edema, as well as of the jowls. The doxycycline is also useful for reducing edema of turbinates, the nasal concha or conchae shell-shaped networks of bones, vessels, and tissue within the nasal passageways that are responsible for warming, humidifying, and filtering the air as it is inhaled. The doxycline, in a concentration preferably of greater than 10 to 20 mg / ml, preferably in combination with a local anesthetic and optionally with a vasoconstrictor such as epinephrine and a pH buffering agent, is injected into the subcuticular space at the site of swelling. The high viscosity limits the spread of the doxycycline to the area to be treated. The resulting sclerosis prevents fluid accumulation. The doxycline also decreases swelling due to fat, by causing a decrease in lipomas.

The invention belongs to the field of organic molecule fluorescent probes, and relates to a small molecule fluorescent probe HX which realizes the integration of diagnosis and treatment by monitoring related physical properties of a tumor microenvironment and photodynamic therapy of tumors. A tumor microenvironment of a solid tumor generally has the characteristics of low pH, high viscosity, low oxygen and the like, and has important significance on real-time monitoring and effective inhibition of tumor tissues on the basis of characteristic parameters of tumor parts. Therefore, a near-infrared fluorescent probe HX is designed, the probe does not respond to surrounding viscosity change in a high pH value environment, however, in a tumor low pH value microenvironment, a donor-pi-receptor (Donor-pi-acceptor, D-pi-A) structure of the probe is opened, and the sensitive viscosity response characteristic is shown, so that the dynamic monitoring of the tumor microenvironment is realized. Besides, through structural optimization, the probe is proved to be capable of serving as a photosensitizer with I-type reaction and used for tumor tissue photodynamic therapy under the hypoxic condition. By means of a mouse living tumor model, we prove that the probe HX not only has the capability of identifying tumor tissues and normal tissues, but also has an excellent tumor inhibition effect and good biocompatibility under the hypoxic condition, and a new technology is provided for integrated design of diagnosis and treatment of tumor diseases. # imgabs0 #

The embodiment of the invention provides a scaled laminated tampon based on an inner support, which comprises a main body, and the main body comprises an inner support, an outer support and a plurality of through holes, and the inner support is provided with a hollow space and is provided with a plurality of through holes; the main absorption part is accommodated in the hollow space and is formed by winding a main absorption sheet; the outer absorption part comprises a plurality of outer absorption sheets; wherein one end of each outer absorption piece is fixed on the inner support, the other end of each outer absorption piece extends towards the adjacent outer absorption piece and is stacked on the adjacent outer absorption piece, the main absorption part is in contact with the outer absorption pieces through the through holes, and the main absorption part is limited by the inner support through the arrangement. Therefore, the use discomfort caused by the increase of circumferential volume due to swelling or swelling is prevented; meanwhile, the fish-scale-shaped stacked structure is formed, so that the body fluid can conveniently flow downwards, and the viscous body fluid can be diffused inwards along gaps of the fish-scale-shaped stacked structure, and therefore, the fish-scale-shaped body fluid absorption device is suitable for absorption of high-viscosity or low-viscosity body fluid.

The invention discloses a fluorescent probe for distinguishing and simultaneously detecting sulfite and viscosity. The chemical structural formula of the probe is as follows: # imgabs0 #. The probe can utilize different fluorescence channels to realize differentiated detection of sulfite and viscosity, and after the probe and sulfite are subjected to a specific chemical reaction, blue fluorescence of 466 nm is emitted under the excitation wavelength of 400 nm; the probe emits yellow-green fluorescence of 553 nm under the excitation wavelength of 470 nm in a high-viscosity environment. Due to the fluorescence quenching effect of a strong pull electron group nitryl group in a coumarin mother nucleus, the probe does not act with other active substances, and high-selectivity and high-fidelity detection of sulfite and viscosity can be realized. The probe for detecting the sulfite has the advantages of high reaction speed, high sensitivity and the like, and can be used for selectively and differentially detecting the sulfite and the viscosity in an in-vitro environment, and simultaneously differentiating fluorescence imaging analysis when the sulfite and the viscosity in biological systems such as cells and the like are detected. The method has a great application prospect in the technical fields of analytical chemistry, life science, chemical biology and the like.

The invention relates to a bone cement targeted plugging and secondary injection method for a patient with fracture centrum edge rupture in orthopaedic vertebroplasty. According to the method, the position of a vertebral rupture opening is determined according to image information such as preoperative X-rays and CT, and injection is carried out for several times through preoperative planning and marking of the position of a target spot and the direction of a puncture needle. During first-time injection, the bone cement push rod is located near a fracture opening of the vertebral body, small-amount injection is conducted in the bone cement high-viscosity period to block the fracture opening, after the fracture opening is closed, bone cement is blended for the second time, injection is conducted on the whole vertebral body in the bone cement low-viscosity period, and the bone cement is evenly and densely distributed in the whole fracture area. According to the technology, the risk of bone cement leakage or poor bone cement dispersion caused by one-time injection is avoided, the risk of bone cement leakage is reduced, the surgical effect is improved, and the surgical safety is also ensured.

The invention discloses an eye protection external preparation and a preparation method thereof, and belongs to the technical field of ophthalmic preparations. The preparation method comprises the following steps: mixing a main agent solution A containing Ectoine and trehalose with a matrigel solution B containing chitosan quaternary ammonium salt; and then carrying out high-pressure microjet homogenization treatment on the mixed solution at 100-150 MPa so as to construct a supramolecular network structure. Through a specific high-pressure homogenization process, the obtained preparation has an excellent shear thinning characteristic, high viscosity is kept during standing to realize biological adhesion, the viscosity is instantaneously reduced during blinking to ensure comfort, and the problem of blurred vision of traditional gel is solved. Meanwhile, due to the network structure of the preparation, the active ingredients can be instantly released, the hypertonic state of the eyes can be rapidly relieved, and the preparation is adhered to the ocular surface for a long time.

The application discloses a kind of children emergency respiratory tract foreign matter quick removal device, it is related to respiratory tract foreign matter removal technical field, to solve the technical problem that existing negative pressure suction equipment negative pressure is too large, easy to directly absorb throat mucosa and cause damage, including the hose of adaptation and communication in negative pressure suction pipe input end, leakage connector, annular groove, removal mechanism, collection assembly and angle adjusting assembly.The engagement or non-engagement of transmission rod and conveying cylinder is switched, the rotation of the lower cone of the guide sealing module can be flexibly controlled to collect and the upper cone is sealed to separate two working states: when not engaging, the guide sealing module is in the form of a lower cone and leaves a gap to rotate, which can actively roll into the mucus of the throat, avoiding hard extrusion on the delicate throat;when engaging, the module moves up to the form of a sealed upper cone, which, combined with the path optimization of negative pressure separation and spiral groove, can prevent local negative pressure from being too high to cause discomfort in the throat of children, and can also avoid high-viscosity mucus fault, ensuring that the mucus is quickly and completely discharged.

The invention belongs to the technical field of sampling devices, and discloses a sampling device for liquid medicine detection and a method thereof.The sampling device comprises a spherical medicine storage body, the lower portion of the spherical medicine storage body is communicated with a liquid suction pipe, a top pipe is arranged above the spherical medicine storage body, and a limiting plate is rotationally installed between the top pipe and the spherical medicine storage body in a sealed mode; the top pipe and the spherical medicine storage body can be isolated and sealed through the limiting plate, a liquid taking assembly is fixedly installed in the center of the top pipe and vertically extends to the bottom end of the interior of the liquid suction pipe, extraction and discharging of medicine liquid are completed through rotation, and a stirring assembly used for homogenization pretreatment of the medicine liquid is rotationally installed at the upper end of the top pipe. A swing assembly capable of expanding the stirring range is integrated on the stirring assembly, and a driving device used for providing power and achieving function switching is arranged on the top pipe; the liquid medicine stirring device is simple in overall structure, can efficiently and uniformly stir liquid medicine which is easy to layer and high in viscosity, eliminates stirring dead angles, and improves the using effect.

Doxycycline injections improve the appearance of cosmetically significant lower eyelid festoons and malar edema, as well as of the jowls. The doxycycline is also useful for reducing edema of turbinates, the nasal concha or conchae shell-shaped networks of bones, vessels, and tissue within the nasal passageways that are responsible for warming, humidifying, and filtering the air as it is inhaled. The doxycline, in a concentration preferably of greater than 10 to 20 mg / ml, preferably in combination with a local anesthetic and optionally with a vasoconstrictor such as epinephrine and a pH buffering agent, is injected into the subcuticular space at the site of swelling. The high viscosity limits the spread of the doxycycline to the area to be treated. The resulting sclerosis prevents fluid accumulation. The doxycline also decreases swelling due to fat, by causing a decrease in lipomas.

The invention provides multi-effect composite scar repair gel as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention develops a multi-effect composite scar repair gel with barrier protection, anti-inflammatory regeneration and long-acting permeation by integrating a silicone base material, traditional Chinese medicine active ingredients and an ionic liquid permeation promotion technology. Wherein the high-viscosity polydimethylsiloxane is used for reducing skin tension; the low-viscosity polydimethylsiloxane improves the skin comfort level; the traditional Chinese medicine extract inhibits fibroblast proliferation and promotes microcirculation; the Ectoin-allantoin microcapsule is capable of realizing 72-hour slow-release anti-inflammatory repair; the BPC157 polypeptide can promote angiogenesis and accelerate wound healing; the transdermal rate of the active ingredients is increased by more than 3 times by the arginine-malic acid ionic liquid; the zinc hyaluronate can synergistically moisturize and regulate the inflammation microenvironment. Through cooperation of multiple mechanisms, the effects of barrier protection, anti-inflammatory regeneration and long-acting permeation are achieved, and the anti-inflammatory and long-acting anti-inflammatory ointment is suitable for repairing hypertrophic scars, acne scars and postoperative incisions.

One example of a device can deliver fluids having high viscosity, including fluids having a viscosity of 1,000 cP or more, through a channel. The device can be or include a syringe or a syringe. A barrel, a hub, a needle, or a combination thereof can define at least a portion of the channel. Methods of flowing fluids having such high viscosity are also disclosed herein. In certain embodiments, a method includes flowing a first fluid of relatively high viscosity and a lubricant of relatively low viscosity through a channel simultaneously, for example by using the lubricant to separate the first fluid from an inner surface of the channel, as is the case with a core annular flow. By sizing and shaping the channel as disclosed herein, particularly at a constriction, a stable core annular flow can be achieved, which makes it easier to flow a high viscosity fluid at a useful flow rate by manually applying force.

The invention belongs to the technical field of biological electrodes, and particularly relates to a high-viscosity flexible spinal cord electrical stimulation electrode for chronic pain treatment and a preparation method of the high-viscosity flexible spinal cord electrical stimulation electrode. The preparation method comprises the following steps: pre-polymerizing and dispersing dithiothreitol, benzoin dimethyl ether, vinyl-terminated polydimethylsiloxane and boric acid in a proper ratio in a nitrogen atmosphere to obtain a silica gel mixture; performing ultraviolet irradiation to obtain high-viscosity polyborosilane marked as PBS, and coating a silica gel film with the PBS to serve as a flexible substrate of the electrode; and then sputtering a conductive circuit on the PBS, and packaging by using the PBS to only expose electrode sites to obtain the flexible electrode. The preparation method disclosed by the invention is simple, efficient and rapid, and the obtained electrode is good in biocompatibility, has high adhesion and deformability to all biological interfaces, and can be tightly attached to the surfaces of biological tissues with different shapes; wherein sulfydryl and sulfur atom sites in the PBS can interact with gold, so that a surface circuit has in-vivo long-term stability.