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133 results about "Biological adhesion" patented technology

The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions. [GOC:isa_complete]

Temperature-sensitive hydrogel based on pepper alkaloid and preparation method thereof

The invention discloses a temperature-sensitive hydrogel based on Chinese prickly ash alkaloid. The temperature-sensitive hydrogel is prepared from poloxamer 407, poloxamer 188 and Chinese prickly ash alkaloid powder. The temperature-sensitive hydrogel based on the pepper alkaloid prepared by the invention has three characteristics of biological adhesion, self-healing property and slow release property, and solves the technical problems that the pepper alkaloid is poor in stability and uncontrollable in drug release.
Owner:THE NAVAL MEDICAL UNIV OF PLA

Bioadhesive microparticle formulations

PCT designated stageWO2025262234A1Organic active ingredientsPowder deliveryCross-linkBiological adhesion
Bioadhesive microparticle formulations and methods for preparation thereof are described. The microparticle formulation comprises cross linked poly-amino acid microparticles and may be delivered alone or may be used for delivery of an agent to a biological surface.
Owner:NATIONAL UNIVERSITY OF IRELAND

Bionic self-cleaning anti-fouling culture net cage material as well as preparation method and application thereof

The invention relates to the field of biomimetic materials, in particular to a biomimetic self-cleaning anti-fouling aquaculture net cage material, a preparation method and application of the biomimetic self-cleaning anti-fouling aquaculture net cage material. 0.5 to 2.0 parts by weight of a carboxylated graphene nanosheet; 2.0 to 5.0 parts by weight of nitrogen-doped titanium dioxide nanoparticles; 1.0 to 3.0 parts by weight of silica nanoparticles; 5.0 to 10.0 parts by weight of calcium ion cross-linked modified sodium alginate; 1.0 to 3.0 parts by weight of octadecyl trichlorosilane; 0.5 to 1.5 parts by weight of lauryl sodium sulfate; through the synergistic effect of a double bionic structure and enhanced photocatalysis, the effective inhibition on attachment of various organisms is realized, and the inhibition rate on attachment organisms such as algae, bacteria and barnacles reaches 75% or above.
Owner:WEIFANG UNIV OF SCI & TECH

Marine plankton image segmentation method and system

The invention relates to the technical field of image data processing, in particular to an image segmentation method and system applied to marine plankton. The method comprises the following steps: acquiring an in-situ microscopic image of marine plankton, carrying out binarization processing and connected domain analysis on the in-situ microscopic image, and screening out a biological adhesion block mass to be processed; synchronously extracting the edge contour of the biological adhesion block mass to be processed, and calculating a biological structure integrity score; selecting the candidate segmentation path with the highest biological structure integrity score as an optimal segmentation line; curvature smooth completion is carried out along the optimal segmentation line, and a single biological image is obtained; and inputting the single biological image into a pre-trained classifier to obtain a biological abundance data set. According to the method, high-precision automatic identification and abundance statistics of plankton in a complex marine environment are realized by screening and positioning the adhesion block mass, carrying out adaptive adhesion segmentation and combining multi-dimensional morphological feature classification.
Owner:FIRST INSTITUTE OF OCEANOGRAPHY MNR

Fishway observation window and preparation method thereof

The invention discloses a fishway observation window and a preparation method thereof, belongs to the technical field of ecological monitoring, and can solve the problems that a traditional fishway observation window lacks a long-acting anti-fog function, the biological adhesion problem is serious, and the function integration degree is low. The fishway observation window comprises a transparent composite substrate; the conductive anti-fog layer is embedded in the middle of the transparent composite substrate and is used for raising the temperature to a preset temperature after being electrified, and the preset temperature is higher than the air dew point temperature; the biological corrosion resistant coating is arranged on the surface of one side of the transparent composite substrate; the anti-biological-corrosion coating comprises a plurality of convex structures, and each convex structure is formed by spraying an anti-biological-corrosion material and then curing the anti-biological-corrosion material; the hydrophobic coating is arranged on the surface of the side, away from the transparent composite substrate, of the biological corrosion resistant coating and covers the biological corrosion resistant coating. The invention is used for the fishway observation window.
Owner:NORTHWEST ENGINEERING CORPORATION LIMITED

Medical composition for treating premature delivery and preparation method thereof

The invention belongs to the field of pharmaceutical preparations, and provides a medical composition for treating premature delivery and a preparation method thereof. The progesterone nanocrystal (D50 is 250-350 nm) and poloxamer 407 / 188 thermosensitive gel-forming system composite design is adopted, hydroxypropyl methylcellulose or carbomer 974P and a functional adhesion polymer (carbomer-cysteine or carbomer-catechol) are matched, the pH is adjusted to 4.0-4.5 through a lactic acid / sodium lactate buffer system, and the progesterone nanocrystal / poloxamer composite gel-forming agent is prepared. The excellent performance that the sol-gel transition temperature is 30-34 DEG C, the elastic modulus is not smaller than 150 Pa at 37 DEG C, the modulus retention rate is not smaller than 60% after the emulsion is diluted by 5-10 times, the adhesion work is not smaller than 0.60 N.s, and the anti-flushing retention rate is not smaller than 70% after the emulsion is diluted by 5-10 times is achieved. The invention solves the problem of synergy of high-modulus gel strength, rapid self-repairing ability and anti-dilution and anti-flushing stability, realizes unification of long-acting drug release and excellent biological adhesion performance in vagina physiological fluid dilution and mechanical flushing environments, and has wide clinical application value.
Owner:NANJING COMTRUE MEDICAL TECH CO LTD

Methods for using bioadhesive and steric interactions of copolymers to minimize adverse effects

Methods for using bioadhesive and stearic interactions specific to copolymers with at least two moieties, to minimize adverse effects mediated by external influences on cell, tissue, organ system, and organism biology. Multifunctional copolymers have bioadhesive properties driven by electrostatic and hydrophobic interactions and passivation though hydrophilic moieties. These copolymers are useful for reducing rates of viral infectivity in target cells, and in reducing host morbidity and can be coforulated. These copolymers are useful for reducing ADC related, oncology therapy related, preservative related, systemic- pharmaceutical-therapy related, and / or topical ophthalmic active-pharmaceutical- ingredient related toxicity which can be manifest as a corneal epithelial toxicity. Methods for enhancing efficacy through coformulations with mucopenetration enhancing technologies and in coformulations with other actives that inhibit macropinocytosis allow for increasing efficacy in patient treatment approaches described herein. Coformulations with other actives ingredient will have therapeutic utility and prove beneficial in various settings. Formulations of these multifunctional copolymers for topical ophthalmic use are safe and well tolerated. Epithelial cells and the ocular surface including limbal stem cell and precursor corneal epithelial cells are treated with these copolymers to confer utility and patient benefit. Corneal nerves are similarly protected and corneal nerve cell damage is mitigated. Contact lenses provide an alternative method for delivering protective copolymers to the eye in these settings.
Owner:CALM WATER THERAPEUTICS LLC

Intelligent intercepting and filtering system with long-acting biological adhesion prevention and self-cleaning functions

The invention relates to the technical field of space environment monitoring, and discloses an intelligent intercepting and filtering system with long-acting biological adhesion prevention and self-cleaning functions. Comprising an intelligent net body module, a long-acting super-hydrophobic coating module, an intelligent monitoring module, an automatic spraying and production supporting module, an intelligent operation and maintenance and data management module, an installation and scene adaptation module, a performance detection and verification module, a dynamic weight adjustment module and an environment recovery monitoring module. The intelligent net body module comprises a composite fiber base material and a signal monitoring network unit. Through a dynamic weight adjustment module, based on historical fault data and real-time environment parameters, a risk index is dynamically optimized to calculate a weight, a pain point of insufficient precision of traditional fixed threshold evaluation is solved, a'monitoring-early warning-operation and maintenance-environment recovery 'full-closed loop is constructed, functions of intelligent monitoring, emergency linkage, life prediction, environment recovery confirmation and the like are integrated, and the reliability of the system is improved. And meanwhile, full-process intelligent management and control from risk identification to environmental security recovery are realized.
Owner:SUZHOU QIDONG INTELLIGENT EQUIPMENT CO LTD

Bioadhesive film and methods of use thereof

ActiveUS12589072B2AntimycoticsOsmotic deliveryActive agentBioadhesive
A film and a method for use thereof such as for the administration of a biologically active agent or for therapy are provided. Specifically, a film, composed of a biodegradable material having a mucoadhesive surface comprising a plurality of mushroom-type structures is provided.
Owner:AZRIELI COLLEGE OF ENG JERUSALEM +1

A bacteriostatic gel for female intimate care and a method for preparing the same

This invention discloses an antibacterial gel for feminine hygiene and its preparation method, belonging to the field of feminine hygiene gel technology. The gel provided by this invention has good biocompatibility and bioadhesion, easily forming a gel state under body temperature, tightly adhering to the mucosal surface to form a protective hydration film, physically isolating pathogens, and is used to prevent female reproductive tract infections and maintain vaginal health. This invention improves the performance of chitosan through graft modification, simultaneously introducing multiple carboxyl, guanidine, and siloxane structural units onto chitosan. Guanidine groups can effectively adsorb and destroy bacteria and fungi that are usually negatively charged. Carboxyl and siloxane structures enhance the water solubility and biocompatibility of the molecule, while the siloxane structure improves the spreadability and adhesion of the molecule on the mucosal surface, prolonging drug residence time. By grafting the above functional monomers onto the chitosan backbone through amide bonds, the structural stability and functional durability of the modified polymer are ensured.
Owner:JILIN YUNFEI PHARMA CO LTD

A protein composite fiber film material having wet adhesion and delivering a drug and a method for preparing the same

PendingCN122272901AFiberTissue repair
This invention discloses a protein composite fiber membrane material with wet adhesion and drug delivery capabilities, and its preparation method. Protein, functional active ingredients, and a volatile conformational stabilizer are mixed and treated with a disulfide reducing agent to obtain a spinning solution. Electrospinning causes the conformational stabilizer to volatilize, while the protein maintains its untransformed conformation. Subsequently, a bioadhesive polymer interlayer is applied to the fiber membrane surface, followed by secondary spinning to form a sandwich-structured composite fiber membrane material. The material obtained by this invention undergoes a controllable conformational transition in a wet environment. The β-sheets and hydrophobic residues at the interface, in conjunction with the interlayer, disrupt the hydration barrier at the interface, achieving strong adhesion through multiple mechanisms and effectively resisting interference from dynamic physiological environments. Simultaneously, the co-spinning technology enables flexible loading and controlled release of functional molecules, providing a scalable technical platform for constructing composite patches with both physical isolation and active therapeutic functions, showing promising applications in tissue repair and drug delivery.
Owner:SHAANXI NORMAL UNIV +1

Mussel mucoprotein physical barrier protective gel and preparation method thereof

The invention belongs to the technical field of gel preparation, and particularly relates to mussel mucoprotein physical barrier protective gel and a preparation method thereof. The mussel mucin polymer disclosed by the invention can quickly form a compact and flexible isolating membrane with self-repairing capability on the surface of vaginal mucosa. The isolating membrane can be firmly attached to the surface of a mucous membrane based on the strong biological adhesiveness of mussel mucin, can directly block sperm penetration and limit sperm swimming, and also can effectively block pathogenic microorganisms such as viruses and bacteria from contacting the mucous membrane. The acid environment provided by the lactic acid-citric acid buffer system not only can directly inhibit sperm activity, but also can enhance the stability and adhesiveness of the mussel mucin polymer, so that the mussel mucin polymer can be better attached to vaginal mucosa, and the action time of a physical barrier is prolonged. The chitosan quaternary ammonium salt has the effects of killing bacteria and viruses and the like, and the hydroxypropyl methyl cellulose serving as a thickening agent can improve the viscosity and the stability of the gel, so that the gel can be better retained in the vagina, and the action time is prolonged.
Owner:HENAN YIWEIYI IND CO LTD

Drug delivery system for treating skin injury and preparation method and application thereof

The invention relates to a drug delivery system for treating skin injury as well as a preparation method and application of the drug delivery system. The delivery system comprises nanofibers formed by polylactic acid and multi-arm polyglycerol, and nano hydrogel loaded on the nanofibers, the nano hydrogel is prepared from the following raw materials: bioadhesive nanoparticles based on polylactic acid-multi-arm polyglycerol and a high polymer material containing amino groups. The drug delivery system provided by the invention has good wet environment maintenance capability, mechanical strength and moderate fluidity, can improve the antibacterial property and stability of the material, and has a drug sustained release effect.
Owner:SHENZHEN AOLI BIOTECHNOLOGY CO LTD

Large-scale intelligent precious marine product culture net cage applied to deep and far sea

The invention discloses a large-scale intelligent precious marine product culture net cage applied to deep and far sea, and belongs to the technical field of marine product culture, the large-scale intelligent precious marine product culture net cage comprises a workbench, a lifting table is arranged on the workbench, a base is arranged on the inner side of the workbench, and a culture box is fixedly mounted at the top of the base. Ocean currents in different directions are converted into driving force through an impeller, a liquid medium is continuously driven to drive a fourth gear to rotate through a liquid supply pipe, and a piston rod periodically reciprocates along the axis while rotating through cooperation of a ball and a sliding groove; automatic cleaning of the circulation holes can be achieved through relative rotation between the circulation holes and the bristles, meanwhile, through cooperation of the piston rod and the piston cavity, seawater is compressed and discharged through the liquid flow pipe, automatic flushing and cleaning of the circulation holes are achieved, the self-cleaning effect is achieved through ocean currents, and through cooperation of the dynamically-designed circulation holes, the cleaning efficiency is improved. Deposition, blockage and biological attachment are reduced, and the internal and external interaction effect of the breeding box is maintained.
Owner:WEIHAI BAIYUN SHIP MFG CO LTD

Seabed observation platform capable of resisting stormy waves and preventing biological adhesion

The invention provides an anti-storm and anti-organism adhesion seabed observation platform, and relates to the technical field of ocean observation, the anti-storm and anti-organism adhesion seabed observation platform comprises a seabed observation platform main body, a platform shield is arranged above the seabed observation platform main body, four shield columns are arranged below the platform shield, and shield handrails are transversely arranged between adjacent shield columns; marine organisms attached to the outer surface of the metal shield are stripped under the action of the blade structure, so that shield grid blockage caused by excessive marine organisms attached to the outside of the observation platform shield is avoided, and the phenomenon that the observation work progress is affected due to failure of the seabed observation platform caused by internal sealing of the observation platform is avoided; the problems that if shellfish marine organisms such as barnacles are attached to the surface of the protective cover, the liquidity of the protective cover is reduced, seabed seawater is blocked from penetrating through the observation platform, the testing precision of seabed ocean current is influenced, if organisms are seriously attached, the interior of the observation platform is sealed, the seabed observation platform loses efficacy, and the observation work progress is influenced are solved.
Owner:QINGDAO HUANHAI OCEAN ENG INVESTIGATION RES INST

A super-hydrophobic surface with hierarchical re-entrant-honeycomb coupling structure and its preparation method and application

The application relates to a super-hydrophobic surface with a hierarchical fold-back-honeycomb coupling structure and a preparation method and application thereof, the structure of the super-hydrophobic surface comprises a regular hexagonal honeycomb frame structure and a fold-back structure connected with the vertexes of the regular hexagonal honeycomb frame structure; the structure of the fold-back structure comprises a cylinder and a circular chamfered triangular prism connected with the surface of the cylinder. The hierarchical fold-back-honeycomb coupling structure can present excellent super-hydrophobic characteristics; the structure can achieve a physical antibacterial and antifouling function by maximally reducing the actual contact area between liquid drops, microorganisms and the surface. The construction strategy can provide a new design path for the super-hydrophobic surface with antibioadhesion in a marine environment, realizes efficient antifouling, guarantees long-term functional reliability of the surface, and prolongs the service life of marine facilities.
Owner:SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI

Bone guided regeneration membrane photocurable in situ and its preparation method and application

PendingCN122399129AMicrosphereBiochemistry
This invention discloses a bone-guided regeneration membrane capable of intraoperative in-situ photocuring, its preparation method, and its applications. The membrane comprises, sequentially from the bone side to the soft tissue side, PDA-Ca²⁺. + The membrane consists of a wetting and adhesion inner layer, a ternary interpenetrating network hydrogel body layer, and a non-crosslinked physical anti-adhesion HA outer layer. The body layer is loaded with VEGF-PLGA fast-release microspheres and BMP-2-PLGA sustained-release microspheres, and contains a LAP photoinitiator. Before photocuring, the membrane is soft and malleable, allowing for intraoperative cutting and shaping to adapt to irregular bone surfaces at nonunion sites. After irradiation with 405 nm visible light for 30–120 seconds, it transforms in situ into a semi-rigid support state, locking the membrane's shape and providing mechanical support. PDA-Ca² + Adhesive coatings enable screwless and sutureless bioadhesive fixation to moistened bone surfaces; PLGA dual microspheres achieve time-controlled release of VEGF and BMP-2 with peak release intervals ≥35 days; Sr-nHA provides sustained release of Sr²⁺. + It synergistically promotes osteogenic effects with BMP-2. This invention is specifically designed to assist in revision surgery of autologous bone grafts for nonunion.
Owner:SHANGHAI SIXTH PEOPLES HOSPITAL

Special composite anti-marine-biological ship coating and preparation method thereof

This invention belongs to the field of marine coating technology, specifically relating to a special composite antifouling marine coating and its preparation method. It uses modified polyurethane as the film-forming matrix, and utilizes polytetrahydrofuran ether soft segments and IPDI hard segments to impart seawater resistance and high toughness to the coating. Imidazole groups can recognize acidic microdomains formed by microbial metabolism, allowing the coating to maintain a low surface energy state in seawater to block initial biological adhesion. Under acidic conditions, charge reversal and hydrophilic switching are achieved through hydrogen bonding, disintegrating the biofilm and forming a physical anti-adhesion barrier. By constructing pH-responsive microcapsules, IPDI is cross-linked with amine monomers to form an anti-swelling wall material. Acidic sensitizing units are grafted onto the surface double bonds, and the interior is encapsulated with a core material composed of modified dehydroabscisic acid and matrine. Under acidic conditions, the sensitizing units protonate, triggering the release of the core material, inhibiting primary microorganisms and large attached organisms. In the weakly alkaline environment of seawater, it can automatically seal pores and stop release, achieving long-lasting antifouling and environmentally friendly performance, suitable for marine protection applications.
Owner:AMBASSADOR PAINT (ANHUI) CO LTD +2

PLGA-based long-acting slow-release anti-parasitic implant for population wildlife

The invention relates to the technical field of anti-parasitic implants, and discloses a population wild animal PLGA-based long-acting slow-release anti-parasitic implant, which is composed of the following components in parts by weight: a PLGA carrier, an anti-parasitic composite drug, an auxiliary agent, a skin penetration enhancer, a biological adhesive, a stabilizer, a pH regulator, a plasticizer and an antioxidant. The implant disclosed by the invention can meet the prevention and treatment requirements of the group-living wild animals through functional synergy of all the components: on one hand, the long-acting slow-release performance greatly reduces the administration frequency, the animals do not need to be frequently captured, the interference on group life of the group-living animals is reduced, meanwhile, the investment of manpower and material resources is reduced, and the implant is suitable for large-scale group prevention and treatment; and on the other hand, the implant has excellent physical properties and biocompatibility, and does not cause obvious inflammation or stress response in vivo.
Owner:长治市园林技术服务中心

Medical hemostatic sponge material and preparation method thereof

The invention discloses a medical hemostatic sponge material and a preparation method thereof, and relates to the field of hemostatic materials. According to the medical hemostatic sponge material, silk fibroin and sodium carboxymethyl starch are adopted as main matrixes, a small amount of quaternized chitosan is compounded, the problem of acidic degradation of a traditional chitosan system is solved, and meanwhile the hemostatic activity of polysaccharide is reserved; the mussel mucin provides super-strong biological adhesion, so that the problem that the material falls off at a dynamic bleeding part is solved; the RADA16 polypeptide is self-assembled to form a nanofiber network, an extracellular matrix structure is simulated, platelet anchoring and tissue repair are promoted, and meanwhile, foreign matter reaction is reduced; diatom biomineralized silicon DBS activates an endogenous blood coagulation pathway through a surface silanol group, DMSN-loaded thrombin accurately activates exogenous blood coagulation, calcium glycerophosphate provides calcium ions to strengthen a blood coagulation cascade reaction, and the three parts cooperate to realize blood coagulation activation.
Owner:THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIV

Composite protective structure adapting to porous characteristics of cement alkali and preparation method thereof

The application discloses a composite protection structure suitable for cement alkaline porous characteristics and a preparation method, and belongs to the technical field of cement product marine protection. The application aims to solve the technical problems of weak combination of the existing coating and the cement base material, poor alkali resistance, insufficient synergy of corrosion resistance and biological adhesion resistance. The protection structure is a four-layer gradient structure from inside to outside, which is a silane modified cement base layer, a composite rust prevention layer, a composite bonding layer and a wear-resistant biological surface layer, and precisely adapts to the characteristics of the cement base material. The preparation method integrates cold spraying and induction heating processes, and takes into account the coating density and the feasibility of on-site construction. The bonding strength of the protection structure and the cement base material is greater than or equal to 4.5 MPa, the salt spray corrosion resistance is more than 2200h, the marine biological adhesion area is less than or equal to 1.0%, the mass loss after freeze-thaw cycles (100 times) is less than or equal to 1.0%, and the wear resistance is less than or equal to 0.03g / cm 2 , and the cement alkaline environment serves for 18 months without powdering and cracking, and can be widely applied to cement products such as marine piles, fenders and breakwaters.
Owner:DALIAN PROD QUALITY INSPECTION & TESTING RES INST CO LTD

Biological adhesion prevention coating as well as preparation method and application thereof

The invention relates to a biological adhesion prevention coating as well as a preparation method and application thereof, and belongs to the technical field of biological adhesion prevention coatings. The technical problem that the service life and the effect of an existing anti-biological-adhesion coating cannot be effectively guaranteed is solved. The coating comprises a bottom treatment agent and a composite resin coating, the bottom treating agent comprises epoxy film-forming resin, an active monomer, an initiator, an epoxy curing agent, an organic solvent, a flatting agent, a defoaming agent and a thickening agent; the composite resin coating comprises non-epoxy film-forming resin, epoxy film-forming resin, an active monomer, an initiator, an epoxy curing agent, an organic solvent, a dispersing agent, a flatting agent, a defoaming agent, a thickening agent, conductive filler and zinc oxide. The coating is good in construction performance, high in construction flexibility and suitable for various application scenes, and can also serve as a coating repairing material to conduct on-site repairing on a local anti-biological-adhesion coating, and the prepared coating is good in anti-microbial adhesion, good in corrosion resistance, high in adhesive force and good in barrier property and weather resistance.
Owner:HUAINAN LINGFEI TECH CO LTD

Injectable hydrogel for treating periodontitis as well as preparation method and application of injectable hydrogel

The invention discloses injectable hydrogel for treating periodontitis as well as a preparation method and application of the injectable hydrogel. The injectable hydrogel is prepared from the following raw materials: chitosan and derivatives thereof, oxidative modified natural polysaccharide and modified hydroxyapatite, the modified hydroxyapatite comprises hydroxyapatite, and the surface of the hydroxyapatite is modified with a metal polyphenol network. The modified hydroxyapatite has multiple functions of oxidation resistance, immunoregulation, osteogenesis promotion, migration promotion, tube formation promotion, antibiosis and the like, and can be combined with the injectable hydrogel with biological adhesion and self-healing performance to realize better in-vivo tissue healing. The injectable hydrogel of the composite functional hydroxyapatite nanoparticles synthesized by the invention has biocompatibility, oxidation resistance, immunoregulation performance, osteogenesis promotion performance and antibacterial performance, and can realize better alveolar bone regeneration and repair in a rat periodontitis model, and the effect of the injectable hydrogel is superior to that of clinically common minocycline.
Owner:SHUNDE HOSPITAL SOUTHERN MEDICAL UNIV (THE FIRST PEOPLES HOSPITAL OF SHUNDE FOSHAN)

Surface treatment structure of special alloy plate for preventing organisms from being attached

ActiveCN224253183U
The utility model provides a surface treatment structure for preventing organisms from adhering to a special alloy plate. The surface treatment structure for the biological adhesion prevention special alloy plate comprises a conveying assembly, the conveying assembly is connected with a supporting assembly, a rotating assembly and a plate, the supporting assembly is connected with a medicine applying assembly, the conveying assembly is used for conveying the plate to the rotating assembly, and the medicine applying assembly is used for spraying a medicine onto the plate; the rotating assembly is used for conveying the sprayed plates to the conveying assembly. According to the surface treatment structure for preventing organisms from adhering to the special alloy plate, through interaction of the clamping plates, the first conveying device, the groove, the plate, the motor, the transmission rod, the connecting rod, the spray head, the second conveying device and other assemblies, automatic feeding and discharging, automatic shedding agent spraying and automatic conveying to a next cleaning area can be achieved, and the whole process is simple and efficient.
Owner:JIANGSU FUTONGDE METAL PRODUCTS CO LTD

Eye-protecting external preparation and preparation method thereof

PendingCN121177205AOrganic active ingredientsSenses disorderMatrigelBlurred vision
The invention discloses an eye protection external preparation and a preparation method thereof, and belongs to the technical field of ophthalmic preparations. The preparation method comprises the following steps: mixing a main agent solution A containing Ectoine and trehalose with a matrigel solution B containing chitosan quaternary ammonium salt; and then carrying out high-pressure microjet homogenization treatment on the mixed solution at 100-150 MPa so as to construct a supramolecular network structure. Through a specific high-pressure homogenization process, the obtained preparation has an excellent shear thinning characteristic, high viscosity is kept during standing to realize biological adhesion, the viscosity is instantaneously reduced during blinking to ensure comfort, and the problem of blurred vision of traditional gel is solved. Meanwhile, due to the network structure of the preparation, the active ingredients can be instantly released, the hypertonic state of the eyes can be rapidly relieved, and the preparation is adhered to the ocular surface for a long time.
Owner:ZHEJIANG CHENYI STORY ECOLOGICAL TECHNOLOGY DEVELOPMENT CO LTD

Biochemical pool waste gas collection and treatment device

The utility model relates to the technical field of waste gas treatment, in particular to a biochemical pool waste gas collecting and treating device which comprises a main body, the top of the main body is fixedly connected with a waste gas pretreatment component, and the side surface of the main body is provided with a biological attachment gas filtering component; according to the utility model, the gas collecting hood adopts a negative pressure type design, so that waste gas generated by the biochemical pool can be effectively collected, the waste gas is conveyed to a follow-up treatment system through the waste gas conveying pipeline, and the waste gas is firstly cooled by the condenser, so that water vapor in the waste gas is condensed into liquid water; the temperature and humidity of the waste gas are reduced, fog drops in the waste gas are removed through the demister, the influence of the fog drops on subsequent treatment equipment is prevented, the tank body is filled with the volcanic biological filler, and when the waste gas is in contact with the volcanic biological filler, microorganisms on the volcanic biological filler degrade and absorb harmful gas in the waste gas, so that the harmful gas in the waste gas is degraded and absorbed; the waste gas treatment device is simple in structure, high in treatment efficiency and capable of effectively removing harmful gas in waste gas of the biochemical pool.
Owner:江苏聚凯环保科技有限公司

Ibuprofen suppositories, process for their preparation and use

PendingCN122097237AOrganic active ingredientsAntipyreticAnalgesics drugsRectal mucous membrane
The application provides a ibuprofen suppository, a preparation method and application thereof, and belongs to the technical field of medicines. The application overcomes the defects of slow effect, easy leakage and low bioavailability of traditional suppositories. The suppository is a hollow suppository, which comprises a shell layer and content filled in a hollow cavity of the shell layer; the shell layer is composed of a water-soluble base and a bioadhesive material, the water-soluble base is a mixture of PEG 400 and PEG 1000 ; the content contains ibuprofen active ingredients and an absorption promoter; the content is in the form of a solid powder, when the suppository enters the rectum, the shell layer dissolves and adheres to the rectal mucosa, and the content is directly exposed to the rectal body fluid in the form of a solid powder and is quickly dissolved. The application is particularly suitable for children's antipyretic and analgesic drug preparation, and has the advantages of rapid effect, accurate dosage and good compliance.
Owner:SHANDONG DYNE FINANCIAL HLDG CHILDRENS PHARM CO LTD

Bionic polypeptide nano-composite skin permeation carrier and preparation method thereof

The invention discloses a bionic polypeptide nano-composite skin permeation carrier and a preparation method thereof. According to the carrier, a biodegradable high polymer material is used as a nano core, hydrophobic active ingredients are loaded, and a nano composite system with a bifunctional bionic shell is formed through covalent immobilization of bionic cell-penetrating peptide and biological adhesion peptide. The preparation method comprises three steps of oil / water emulsification volatilization nucleation, peptide coupling modification and freeze drying. The obtained carrier has the characteristics of actively penetrating a skin barrier and long-acting residence, the encapsulation efficiency reaches 85% or above, the steady-state transdermal rate is increased to 3.7 micrograms / cm < 3 > / h, and the drug leakage rate is lower than 7% after the carrier is stored for 30 days. By simulating the natural mechanism of skin permeation and adhesion, efficient encapsulation, steady-state release and deep delivery of active ingredients are realized, and the preparation method is suitable for the fields of transdermal drug delivery, skin repair, beauty and the like, and has good application prospects and industrialization potential.
Owner:SUZHOU SHUSHU MEDICAL TECH CO LTD

Carbon capture adsorbent with composite carrier loaded with organic amine as well as preparation method and application of carbon capture adsorbent

The invention discloses a carbon capture adsorbent with a composite carrier loaded with organic amine as well as a preparation method and application thereof. The carbon capture adsorbent comprises the composite carrier and a modified active layer loaded on the surface of the composite carrier, the composite carrier comprises magnesium oxide and silicon oxide; and the modified active layer is a polydopamine-polyethyleneimine co-deposition layer. The adopted magnesium oxide has high specific surface area and chemical activity, the adopted silicon oxide has excellent thermal stability and structural stability, the magnesium oxide and the silicon oxide are compounded to prepare the carrier, guarantee can be provided for stable loading and efficient effects of functional groups, and the polydopamine has the characteristics of high biological adhesion and easy functionalization; the polyethyleneimine contains a large number of amino active sites, and the CO2 chemical adsorption capacity and hydrophobicity of the adsorbent can be synchronously enhanced through composite loading of the polyethyleneimine and the amino active sites. The technical bottlenecks that an existing adsorbent is poor in stability, insufficient in moisture resistance and limited in trapping efficiency are solved.
Owner:SICHUAN HONGHU SCI & TECH GRP

Biological adhesion suppression device and biological adhesion suppression method

A biological adhesion suppression device and a biological adhesion suppression method switch a direct current flowing between a biological adhesion suppression target member immersed in water and an anode member constituting a counter electrode of the biological adhesion suppression target member between a first current and a second current. In this case, when the power supply causes the first current to flow, an electrolytic reaction that consumes oxygen occurs on the surface of the member to be inhibited from adhering organisms, and the density of the direct current is less than the current density at the start of electrolysis of water, and when the power supply causes the second current to flow, the density of the direct current is equal to or greater than the current density at the start of electrolysis of water.
Owner:IHI CORP