176 results about "Biological adhesion" patented technology

The invention discloses a composite multi-frequency marine ultrasonic anti-fouling system and method, relates to the technical field of marine anti-fouling, and aims to change a single-frequency or simple-pulse ultrasonic transmitting mode, transmit composite multi-frequency ultrasonic waves in a wide frequency band, and superpose the ultrasonic waves of multiple frequencies in a transmission medium to generate a cavitation effect so as to achieve the anti-fouling effect. The method is used for avoiding the tolerance of marine organisms, improving the anti-adhesion efficiency and enhancing the effect of a specific area; the wave generating frequency and the working frequency are dynamically adjusted according to the running state and the environment condition of the ship, the energy consumption and the biological adhesion rate of the ship are reduced, and the relation among the biological adhesion rate, low energy consumption and the environment protection requirement is balanced.

The invention discloses a temperature-sensitive hydrogel based on Chinese prickly ash alkaloid. The temperature-sensitive hydrogel is prepared from poloxamer 407, poloxamer 188 and Chinese prickly ash alkaloid powder. The temperature-sensitive hydrogel based on the pepper alkaloid prepared by the invention has three characteristics of biological adhesion, self-healing property and slow release property, and solves the technical problems that the pepper alkaloid is poor in stability and uncontrollable in drug release.

The invention relates to the technical field of oral membranes, in particular to a multilayer oral membrane and a preparation method thereof. The invention provides an oral membrane composition, which comprises semeglutide and pharmaceutically acceptable auxiliary materials, and is characterized in that the composition is formed by combining a drug-containing biological adhesion layer and a backing layer, and the backing layer mainly comprises a membrane forming material, a solvent and a plasticizer; the drug-containing biological adhesion layer mainly comprises semeglutide, a film-forming material, an adhesive, a pH regulator, a flavoring agent and a solvent. By preparing the double-layer oral membrane, the semeglutide is administrated through the oral cavity, and after the insoluble or slowly eroded / dissolved backing layer (preventing saliva from dissolving the medicine) and the adhesive layer containing the main medicine are combined together, the one-way delivery of the main medicine can be realized; through experiments, it is accidentally found that when temperature-sensitive materials such as poloxamer are added to be combined with a conventional adhesive for use, the residence time of the medicine in the oral mucosa can be remarkably prolonged, the curative effect of the medicine is improved, and the main mechanism is that after the medicine is administered, in the oral temperature environment, after the medicine makes contact with mucus on the surface of the oral mucosa, the oral mucosa does not adhere to the oral mucosa. And after the entanglement and piling effects among poloxamer micelles are intensified to form gel, the gel and a conventional adhesive are cooperated to improve the adhesion between the oral membrane and the oral mucosa. Besides, the medicine can be removed at any time, blood sugar can be better controlled, T2DM complications can be better reduced, a more ideal taking mode is provided for weight loss patients, and a new administration mode is provided for reducing blood sugar and reducing weight. The prepared oral cavity membrane is small in size, light in weight, thin, convenient to apply, carry and transport, safe and environmentally friendly to use and capable of meeting the requirements of old people and travelers.

Bioadhesive microparticle formulations and methods for preparation thereof are described. The microparticle formulation comprises cross linked poly-amino acid microparticles and may be delivered alone or may be used for delivery of an agent to a biological surface.

The invention discloses antibacterial gel for female private part nursing and a preparation method of the antibacterial gel, and belongs to the technical field of female nursing gel. The gel provided by the invention has good biocompatibility and biological adhesion, is convenient to form a gel state under the action of body temperature, is tightly adhered to the surface of a mucous membrane to form a protective hydrated film, can physically isolate pathogens, and is used for preventing female genital tract infection and maintaining vagina health. The performance of the chitosan is improved through grafting modification, a plurality of carboxyl, guanidyl and siloxane structural units are introduced to the chitosan at the same time, guanidyl can effectively adsorb and destroy bacteria and fungi usually carrying negative charges, and the water solubility and biocompatibility of molecules are enhanced through the carboxyl and siloxane structure; the siloxane structure can improve the spreadability and adhesion of molecules on the mucous membrane surface and prolong the drug residence time, and the functional monomers are grafted to the chitosan skeleton through amido bonds to ensure the structural stability and function durability of the modified polymer.

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

The invention relates to the field of biomimetic materials, in particular to a biomimetic self-cleaning anti-fouling aquaculture net cage material, a preparation method and application of the biomimetic self-cleaning anti-fouling aquaculture net cage material. 0.5 to 2.0 parts by weight of a carboxylated graphene nanosheet; 2.0 to 5.0 parts by weight of nitrogen-doped titanium dioxide nanoparticles; 1.0 to 3.0 parts by weight of silica nanoparticles; 5.0 to 10.0 parts by weight of calcium ion cross-linked modified sodium alginate; 1.0 to 3.0 parts by weight of octadecyl trichlorosilane; 0.5 to 1.5 parts by weight of lauryl sodium sulfate; through the synergistic effect of a double bionic structure and enhanced photocatalysis, the effective inhibition on attachment of various organisms is realized, and the inhibition rate on attachment organisms such as algae, bacteria and barnacles reaches 75% or above.

The invention relates to the technical field of image data processing, in particular to an image segmentation method and system applied to marine plankton. The method comprises the following steps: acquiring an in-situ microscopic image of marine plankton, carrying out binarization processing and connected domain analysis on the in-situ microscopic image, and screening out a biological adhesion block mass to be processed; synchronously extracting the edge contour of the biological adhesion block mass to be processed, and calculating a biological structure integrity score; selecting the candidate segmentation path with the highest biological structure integrity score as an optimal segmentation line; curvature smooth completion is carried out along the optimal segmentation line, and a single biological image is obtained; and inputting the single biological image into a pre-trained classifier to obtain a biological abundance data set. According to the method, high-precision automatic identification and abundance statistics of plankton in a complex marine environment are realized by screening and positioning the adhesion block mass, carrying out adaptive adhesion segmentation and combining multi-dimensional morphological feature classification.

An antithrombotic surface-modified biomaterial is provided comprising a biomaterial substrate coated with a polymerizable dopamine-containing bioadhesive to which is attached one or more antithrombotic agents. A method of preparing the surface-modified biomaterial is also provided. The surface-modified biomaterial is beneficial for use in blood-contacting medical devices such as catheters, dialyzers and blood oxygenators to prevent or minimize the occurrence of thrombosis on the surface thereof.

The invention discloses a fishway observation window and a preparation method thereof, belongs to the technical field of ecological monitoring, and can solve the problems that a traditional fishway observation window lacks a long-acting anti-fog function, the biological adhesion problem is serious, and the function integration degree is low. The fishway observation window comprises a transparent composite substrate; the conductive anti-fog layer is embedded in the middle of the transparent composite substrate and is used for raising the temperature to a preset temperature after being electrified, and the preset temperature is higher than the air dew point temperature; the biological corrosion resistant coating is arranged on the surface of one side of the transparent composite substrate; the anti-biological-corrosion coating comprises a plurality of convex structures, and each convex structure is formed by spraying an anti-biological-corrosion material and then curing the anti-biological-corrosion material; the hydrophobic coating is arranged on the surface of the side, away from the transparent composite substrate, of the biological corrosion resistant coating and covers the biological corrosion resistant coating. The invention is used for the fishway observation window.

The present invention belongs to the field of biomedicine technology, and in particular to a preparation method and use of a composite hydrogel based on bioadhesive nanoparticles. The present invention utilizes bioadhesive nanoparticles BNP based on PLA-HPG to react with carboxymethyl chitosan, and a reversible Schiff base bond is formed by the aldehyde group on the surface of BNP and the amino group of carboxymethyl chitosan, so that BNP and the polymer are cross-linked to form a composite hydrogel with a porous network structure and containing bioadhesive nanoparticles. The composite hydrogel has good biocompatibility and injectability, and the BNP and porous structure therein enable the hydrogel to deliver water-insoluble and water-soluble drugs simultaneously, and has a sustained-release effect, can be applied to aspects such as peritoneal drug delivery and skin drug delivery, greatly expanding the application value of BNP, and has huge potential application prospects.

The invention belongs to the field of pharmaceutical preparations, and provides a medical composition for treating premature delivery and a preparation method thereof. The progesterone nanocrystal (D50 is 250-350 nm) and poloxamer 407 / 188 thermosensitive gel-forming system composite design is adopted, hydroxypropyl methylcellulose or carbomer 974P and a functional adhesion polymer (carbomer-cysteine or carbomer-catechol) are matched, the pH is adjusted to 4.0-4.5 through a lactic acid / sodium lactate buffer system, and the progesterone nanocrystal / poloxamer composite gel-forming agent is prepared. The excellent performance that the sol-gel transition temperature is 30-34 DEG C, the elastic modulus is not smaller than 150 Pa at 37 DEG C, the modulus retention rate is not smaller than 60% after the emulsion is diluted by 5-10 times, the adhesion work is not smaller than 0.60 N.s, and the anti-flushing retention rate is not smaller than 70% after the emulsion is diluted by 5-10 times is achieved. The invention solves the problem of synergy of high-modulus gel strength, rapid self-repairing ability and anti-dilution and anti-flushing stability, realizes unification of long-acting drug release and excellent biological adhesion performance in vagina physiological fluid dilution and mechanical flushing environments, and has wide clinical application value.

Methods for using bioadhesive and stearic interactions specific to copolymers with at least two moieties, to minimize adverse effects mediated by external influences on cell, tissue, organ system, and organism biology. Multifunctional copolymers have bioadhesive properties driven by electrostatic and hydrophobic interactions and passivation though hydrophilic moieties. These copolymers are useful for reducing rates of viral infectivity in target cells, and in reducing host morbidity and can be coforulated. These copolymers are useful for reducing ADC related, oncology therapy related, preservative related, systemic- pharmaceutical-therapy related, and / or topical ophthalmic active-pharmaceutical- ingredient related toxicity which can be manifest as a corneal epithelial toxicity. Methods for enhancing efficacy through coformulations with mucopenetration enhancing technologies and in coformulations with other actives that inhibit macropinocytosis allow for increasing efficacy in patient treatment approaches described herein. Coformulations with other actives ingredient will have therapeutic utility and prove beneficial in various settings. Formulations of these multifunctional copolymers for topical ophthalmic use are safe and well tolerated. Epithelial cells and the ocular surface including limbal stem cell and precursor corneal epithelial cells are treated with these copolymers to confer utility and patient benefit. Corneal nerves are similarly protected and corneal nerve cell damage is mitigated. Contact lenses provide an alternative method for delivering protective copolymers to the eye in these settings.

The invention relates to the technical field of space environment monitoring, and discloses an intelligent intercepting and filtering system with long-acting biological adhesion prevention and self-cleaning functions. Comprising an intelligent net body module, a long-acting super-hydrophobic coating module, an intelligent monitoring module, an automatic spraying and production supporting module, an intelligent operation and maintenance and data management module, an installation and scene adaptation module, a performance detection and verification module, a dynamic weight adjustment module and an environment recovery monitoring module. The intelligent net body module comprises a composite fiber base material and a signal monitoring network unit. Through a dynamic weight adjustment module, based on historical fault data and real-time environment parameters, a risk index is dynamically optimized to calculate a weight, a pain point of insufficient precision of traditional fixed threshold evaluation is solved, a'monitoring-early warning-operation and maintenance-environment recovery 'full-closed loop is constructed, functions of intelligent monitoring, emergency linkage, life prediction, environment recovery confirmation and the like are integrated, and the reliability of the system is improved. And meanwhile, full-process intelligent management and control from risk identification to environmental security recovery are realized.

A film and a method for use thereof such as for the administration of a biologically active agent or for therapy are provided. Specifically, a film, composed of a biodegradable material having a mucoadhesive surface comprising a plurality of mushroom-type structures is provided.

This invention discloses an antibacterial gel for feminine hygiene and its preparation method, belonging to the field of feminine hygiene gel technology. The gel provided by this invention has good biocompatibility and bioadhesion, easily forming a gel state under body temperature, tightly adhering to the mucosal surface to form a protective hydration film, physically isolating pathogens, and is used to prevent female reproductive tract infections and maintain vaginal health. This invention improves the performance of chitosan through graft modification, simultaneously introducing multiple carboxyl, guanidine, and siloxane structural units onto chitosan. Guanidine groups can effectively adsorb and destroy bacteria and fungi that are usually negatively charged. Carboxyl and siloxane structures enhance the water solubility and biocompatibility of the molecule, while the siloxane structure improves the spreadability and adhesion of the molecule on the mucosal surface, prolonging drug residence time. By grafting the above functional monomers onto the chitosan backbone through amide bonds, the structural stability and functional durability of the modified polymer are ensured.

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

Bioadhesive and biodegradable polymeric nanoparticles can be administered intrathecally, for example, via the cisterna magna, into the spinal column to allow widespread distribution for the treatment of tumors such as leptomeningeal metastases. The nanoparticles rapidly spread to all cerebrospinal fluid (CSF) compartments, including the brain parenchyma and spinal column. The bioadhesive nanoparticles penetrate and are retained for long periods of time, during which time they can continue to release drugs. These nanoparticles can be loaded with different therapeutic, preventive, or diagnostic agents, most preferably DNA repair inhibitors, to enhance the killing of leptomeningeal tumors, such as leptomeningeal metastases, and disseminated tumors, such as medulloblastoma. In a preferred embodiment, patients are treated with a combination of a PARP inhibitor and temozolomide.

This invention discloses a protein composite fiber membrane material with wet adhesion and drug delivery capabilities, and its preparation method. Protein, functional active ingredients, and a volatile conformational stabilizer are mixed and treated with a disulfide reducing agent to obtain a spinning solution. Electrospinning causes the conformational stabilizer to volatilize, while the protein maintains its untransformed conformation. Subsequently, a bioadhesive polymer interlayer is applied to the fiber membrane surface, followed by secondary spinning to form a sandwich-structured composite fiber membrane material. The material obtained by this invention undergoes a controllable conformational transition in a wet environment. The β-sheets and hydrophobic residues at the interface, in conjunction with the interlayer, disrupt the hydration barrier at the interface, achieving strong adhesion through multiple mechanisms and effectively resisting interference from dynamic physiological environments. Simultaneously, the co-spinning technology enables flexible loading and controlled release of functional molecules, providing a scalable technical platform for constructing composite patches with both physical isolation and active therapeutic functions, showing promising applications in tissue repair and drug delivery.

The invention belongs to the technical field of gel preparation, and particularly relates to mussel mucoprotein physical barrier protective gel and a preparation method thereof. The mussel mucin polymer disclosed by the invention can quickly form a compact and flexible isolating membrane with self-repairing capability on the surface of vaginal mucosa. The isolating membrane can be firmly attached to the surface of a mucous membrane based on the strong biological adhesiveness of mussel mucin, can directly block sperm penetration and limit sperm swimming, and also can effectively block pathogenic microorganisms such as viruses and bacteria from contacting the mucous membrane. The acid environment provided by the lactic acid-citric acid buffer system not only can directly inhibit sperm activity, but also can enhance the stability and adhesiveness of the mussel mucin polymer, so that the mussel mucin polymer can be better attached to vaginal mucosa, and the action time of a physical barrier is prolonged. The chitosan quaternary ammonium salt has the effects of killing bacteria and viruses and the like, and the hydroxypropyl methyl cellulose serving as a thickening agent can improve the viscosity and the stability of the gel, so that the gel can be better retained in the vagina, and the action time is prolonged.

The invention relates to a drug delivery system for treating skin injury as well as a preparation method and application of the drug delivery system. The delivery system comprises nanofibers formed by polylactic acid and multi-arm polyglycerol, and nano hydrogel loaded on the nanofibers, the nano hydrogel is prepared from the following raw materials: bioadhesive nanoparticles based on polylactic acid-multi-arm polyglycerol and a high polymer material containing amino groups. The drug delivery system provided by the invention has good wet environment maintenance capability, mechanical strength and moderate fluidity, can improve the antibacterial property and stability of the material, and has a drug sustained release effect.

The invention discloses a large-scale intelligent precious marine product culture net cage applied to deep and far sea, and belongs to the technical field of marine product culture, the large-scale intelligent precious marine product culture net cage comprises a workbench, a lifting table is arranged on the workbench, a base is arranged on the inner side of the workbench, and a culture box is fixedly mounted at the top of the base. Ocean currents in different directions are converted into driving force through an impeller, a liquid medium is continuously driven to drive a fourth gear to rotate through a liquid supply pipe, and a piston rod periodically reciprocates along the axis while rotating through cooperation of a ball and a sliding groove; automatic cleaning of the circulation holes can be achieved through relative rotation between the circulation holes and the bristles, meanwhile, through cooperation of the piston rod and the piston cavity, seawater is compressed and discharged through the liquid flow pipe, automatic flushing and cleaning of the circulation holes are achieved, the self-cleaning effect is achieved through ocean currents, and through cooperation of the dynamically-designed circulation holes, the cleaning efficiency is improved. Deposition, blockage and biological attachment are reduced, and the internal and external interaction effect of the breeding box is maintained.

The invention provides an anti-storm and anti-organism adhesion seabed observation platform, and relates to the technical field of ocean observation, the anti-storm and anti-organism adhesion seabed observation platform comprises a seabed observation platform main body, a platform shield is arranged above the seabed observation platform main body, four shield columns are arranged below the platform shield, and shield handrails are transversely arranged between adjacent shield columns; marine organisms attached to the outer surface of the metal shield are stripped under the action of the blade structure, so that shield grid blockage caused by excessive marine organisms attached to the outside of the observation platform shield is avoided, and the phenomenon that the observation work progress is affected due to failure of the seabed observation platform caused by internal sealing of the observation platform is avoided; the problems that if shellfish marine organisms such as barnacles are attached to the surface of the protective cover, the liquidity of the protective cover is reduced, seabed seawater is blocked from penetrating through the observation platform, the testing precision of seabed ocean current is influenced, if organisms are seriously attached, the interior of the observation platform is sealed, the seabed observation platform loses efficacy, and the observation work progress is influenced are solved.

The utility model discloses an anti-bioattachment antibacterial ocean rope cable, which comprises a core layer and a surface layer, the core layer is provided with a plurality of strands of aramid fibers and a plurality of strands of antibacterial polyvinyl chloride fibers, the plurality of strands of aramid fibers and the plurality of strands of antibacterial polyvinyl chloride fibers are twisted to form a rope core, the surface layer is a corrosion-resistant layer, and the surface layer is a corrosion-resistant layer. The surface of the surface layer is coated with nano zinc oxide particles and / or cellulose nanocrystalline particles. The aramid fiber rope has excellent corrosion resistance and chemical resistance, the antibacterial and antifouling performance of the aramid fiber rope can be improved, biological adhesion and biological dirt formation are reduced, and the aramid fiber rope is very suitable for the marine environment.

The application relates to a super-hydrophobic surface with a hierarchical fold-back-honeycomb coupling structure and a preparation method and application thereof, the structure of the super-hydrophobic surface comprises a regular hexagonal honeycomb frame structure and a fold-back structure connected with the vertexes of the regular hexagonal honeycomb frame structure; the structure of the fold-back structure comprises a cylinder and a circular chamfered triangular prism connected with the surface of the cylinder. The hierarchical fold-back-honeycomb coupling structure can present excellent super-hydrophobic characteristics; the structure can achieve a physical antibacterial and antifouling function by maximally reducing the actual contact area between liquid drops, microorganisms and the surface. The construction strategy can provide a new design path for the super-hydrophobic surface with antibioadhesion in a marine environment, realizes efficient antifouling, guarantees long-term functional reliability of the surface, and prolongs the service life of marine facilities.

This invention discloses a bone-guided regeneration membrane capable of intraoperative in-situ photocuring, its preparation method, and its applications. The membrane comprises, sequentially from the bone side to the soft tissue side, PDA-Ca²⁺. + The membrane consists of a wetting and adhesion inner layer, a ternary interpenetrating network hydrogel body layer, and a non-crosslinked physical anti-adhesion HA outer layer. The body layer is loaded with VEGF-PLGA fast-release microspheres and BMP-2-PLGA sustained-release microspheres, and contains a LAP photoinitiator. Before photocuring, the membrane is soft and malleable, allowing for intraoperative cutting and shaping to adapt to irregular bone surfaces at nonunion sites. After irradiation with 405 nm visible light for 30–120 seconds, it transforms in situ into a semi-rigid support state, locking the membrane's shape and providing mechanical support. PDA-Ca² + Adhesive coatings enable screwless and sutureless bioadhesive fixation to moistened bone surfaces; PLGA dual microspheres achieve time-controlled release of VEGF and BMP-2 with peak release intervals ≥35 days; Sr-nHA provides sustained release of Sr²⁺. + It synergistically promotes osteogenic effects with BMP-2. This invention is specifically designed to assist in revision surgery of autologous bone grafts for nonunion.

This invention belongs to the field of marine coating technology, specifically relating to a special composite antifouling marine coating and its preparation method. It uses modified polyurethane as the film-forming matrix, and utilizes polytetrahydrofuran ether soft segments and IPDI hard segments to impart seawater resistance and high toughness to the coating. Imidazole groups can recognize acidic microdomains formed by microbial metabolism, allowing the coating to maintain a low surface energy state in seawater to block initial biological adhesion. Under acidic conditions, charge reversal and hydrophilic switching are achieved through hydrogen bonding, disintegrating the biofilm and forming a physical anti-adhesion barrier. By constructing pH-responsive microcapsules, IPDI is cross-linked with amine monomers to form an anti-swelling wall material. Acidic sensitizing units are grafted onto the surface double bonds, and the interior is encapsulated with a core material composed of modified dehydroabscisic acid and matrine. Under acidic conditions, the sensitizing units protonate, triggering the release of the core material, inhibiting primary microorganisms and large attached organisms. In the weakly alkaline environment of seawater, it can automatically seal pores and stop release, achieving long-lasting antifouling and environmentally friendly performance, suitable for marine protection applications.

The application belongs to the field of oral medical drugs, and provides an oral ulcer gel dressing, a preparation method and application thereof; the characteristics of high cross-linking particle type sodium hyaluronate are used to reduce the water absorption and swelling of the product, and the synergistic effect of micro-nano level hyaluronic acid particles and high molecules endows the gel with the shear thinning characteristics of non-Newtonian fluid; in the static state, the gel shows high adhesion and can firmly cover the oral mucosa wound surface; when being applied or external force being applied, the viscosity is significantly reduced, so that more convenient operability and distribution uniformity are realized; the high molecular material further enhances the thickening performance and biological adhesion of the gel, so that the gel can be closely combined with the oral mucosa surface, and also provides multiple functions such as antibiosis, moisturizing and healing promotion, and is suitable for the treatment and nursing of oral ulcer and other mucosa injuries.

The invention provides injectable, tough hydrogels that can be crosslinked in situ on demand using minimally-invasive methods, such as visible light exposure is an unmet medical challenge. Among the emerging biopolymers for tissue sealing, gelatin methacryloyl (GelMA), a naturally-derived biopolymer obtained from denatured collagen, has secured a promising role as a result of its excellent bioadhesion, biodegradation, and biocompatibility. To overcome one of the main shortcomings of GelMA, i.e., brittleness, we hybridized it using methacrylate-modified alginate (AlgMA) to impart ion-induced reversible crosslinking that can dissipate energy under strain. The hybrid GelMA-AlgMA hydrogels provide a photocrosslinkable, injectable, and adhesive platform with an excellent toughness that can be engineered using divalent cations, such as calcium. This class of novel hybrid biopolymers with more than 600% improved toughness may set the stage for durable, mechanically-resilient, and cost-effective tissue sealants in minimally invasive procedure, especially for stretchable tissues.

Existing clinically adopted epicardial pacing leads mostly rely on surgical suturing or insertion of electrodes to the heart tissue. However, these approaches can cause tissue trauma during application and / or retrieval of the implants, potentially causing detrimental complications such as bleeding, tissue damage, and / or device failure. The present invention provides a bioadhesive epicardial pacing lead for atraumatic epicardial monitoring and stimulation of the heart in vivo to overcome the limitations of existing bioelectronic implants. The bioadhesive pacing lead is composed of an insulation layer, a conductive bioadhesive interface, a built-in reservoir, an electrode lead wire, and a fluidic channel. The bioadhesive pacing lead shows robust mechanical and electrical properties, biocompatibility, continuous epicardial monitoring and pacing capability, and rapid on-demand atraumatic employment and removal.