250 results about "Biological adhesion" patented technology

The invention relates to a composite hydrogel dressing for promoting wound healing as well as preparation and application thereof, and belongs to the technical field of biological medicines. The hydrogel disclosed by the invention is prepared by mixing gelatin, oxidized dextran and metal ion modified metal-organic framework compounds (MOF-Ag and MOF-Cu). In the mixed solution, amino groups in the gelatin and aldehyde groups of the oxidized dextran are subjected to a Schiff base cross-linking reaction, and the composite hydrogel is formed after standing. The loaded MOF-Ag has antibacterial and anti-biofilm effects on staphylococcus aureus and escherichia coli, and the loaded MOF-Cu has similar superoxide dismutase activity and similar glutathione peroxidase activity, so that excessive active oxygen can be removed, and inflammatory response can be relieved. The obtained hydrogel has good biocompatibility, proper mechanical properties and biological adhesion, stable rheological properties, excellent antibacterial and anti-inflammatory functions and a certain hemostatic function.

The invention relates to a preparation method of a'microstructure-liquid-like surface 'underwater drag-reduction, noise-reduction and antifouling multifunctional composite coating, and belongs to the field of underwater equipment. The multifunctional composite coating provided by the invention comprises an anti-drag microstructure arranged on the surface of a substrate and a liquid-like surface arranged on the surface of the anti-drag microstructure, and the liquid-like surface retains the original morphology of the anti-drag microstructure. According to the micro-structure, the distance between the wall face and a turbulent vortex can be increased, the frequency and strength of a flow vortex pair can be restrained, and resistance reduction is achieved; and on the liquid-like surface, resistance reduction can be achieved by enabling fluid to generate wall face slippage and reducing the speed gradient of the fluid on the boundary. The two mechanisms of action are different but do not interfere with each other, and a better drag reduction effect can be achieved through the synergistic effect. Meanwhile, the composite coating can achieve the noise reduction effect by reducing the turbulence intensity of the wall face. In addition, the liquid-like surface can resist adhesion of marine organisms, the integrity of the microstructure is guaranteed, and therefore the long-term drag reduction effect is achieved.

The invention discloses a composite multi-frequency marine ultrasonic anti-fouling system and method, relates to the technical field of marine anti-fouling, and aims to change a single-frequency or simple-pulse ultrasonic transmitting mode, transmit composite multi-frequency ultrasonic waves in a wide frequency band, and superpose the ultrasonic waves of multiple frequencies in a transmission medium to generate a cavitation effect so as to achieve the anti-fouling effect. The method is used for avoiding the tolerance of marine organisms, improving the anti-adhesion efficiency and enhancing the effect of a specific area; the wave generating frequency and the working frequency are dynamically adjusted according to the running state and the environment condition of the ship, the energy consumption and the biological adhesion rate of the ship are reduced, and the relation among the biological adhesion rate, low energy consumption and the environment protection requirement is balanced.

The invention discloses a temperature-sensitive hydrogel based on Chinese prickly ash alkaloid. The temperature-sensitive hydrogel is prepared from poloxamer 407, poloxamer 188 and Chinese prickly ash alkaloid powder. The temperature-sensitive hydrogel based on the pepper alkaloid prepared by the invention has three characteristics of biological adhesion, self-healing property and slow release property, and solves the technical problems that the pepper alkaloid is poor in stability and uncontrollable in drug release.

The invention relates to mussel mucin-hyaluronic acid nanogel and a preparation method and application thereof and a pharmaceutical composition, and belongs to the field of biomedical materials, the structural formula of the mussel mucin-hyaluronic acid nanogel is # imgabs0 #, Mussel mucin is a mussel mucin molecule, and n is the number of repetitive units. The mussel mucin-hyaluronic acid nanogel can be swelled in a water-based medium to form a three-dimensional space net-shaped structure, pharmaceutical active molecules are better entrapped, lysine and dopa groups in the structure can be tightly combined with the surface or mucous membrane of an organism through electrostatic interaction, hydrogen-bond interaction and oxidative crosslinking, so that the bioavailability of the mussel mucin-hyaluronic acid nanogel is improved, and the bioavailability of the mussel mucin-hyaluronic acid nanogel is improved. The carrier has good biological adhesion, can prolong the residence time of the carrier on an organism or mucous membrane surface, and promotes drug absorption. The mussel mucin-hyaluronic acid nanogel can also be used as a drug storage cavern, so that the slow release effect of drugs is improved, the action time of the drugs is prolonged, and the administration frequency is reduced.

The invention relates to the technical field of oral membranes, in particular to a multilayer oral membrane and a preparation method thereof. The invention provides an oral membrane composition, which comprises semeglutide and pharmaceutically acceptable auxiliary materials, and is characterized in that the composition is formed by combining a drug-containing biological adhesion layer and a backing layer, and the backing layer mainly comprises a membrane forming material, a solvent and a plasticizer; the drug-containing biological adhesion layer mainly comprises semeglutide, a film-forming material, an adhesive, a pH regulator, a flavoring agent and a solvent. By preparing the double-layer oral membrane, the semeglutide is administrated through the oral cavity, and after the insoluble or slowly eroded / dissolved backing layer (preventing saliva from dissolving the medicine) and the adhesive layer containing the main medicine are combined together, the one-way delivery of the main medicine can be realized; through experiments, it is accidentally found that when temperature-sensitive materials such as poloxamer are added to be combined with a conventional adhesive for use, the residence time of the medicine in the oral mucosa can be remarkably prolonged, the curative effect of the medicine is improved, and the main mechanism is that after the medicine is administered, in the oral temperature environment, after the medicine makes contact with mucus on the surface of the oral mucosa, the oral mucosa does not adhere to the oral mucosa. And after the entanglement and piling effects among poloxamer micelles are intensified to form gel, the gel and a conventional adhesive are cooperated to improve the adhesion between the oral membrane and the oral mucosa. Besides, the medicine can be removed at any time, blood sugar can be better controlled, T2DM complications can be better reduced, a more ideal taking mode is provided for weight loss patients, and a new administration mode is provided for reducing blood sugar and reducing weight. The prepared oral cavity membrane is small in size, light in weight, thin, convenient to apply, carry and transport, safe and environmentally friendly to use and capable of meeting the requirements of old people and travelers.

The invention discloses a marine environment integrated sensing function net system and a preparation method thereof, a net body is made of antibacterial polyformaldehyde / ultra-high molecular weight polyethylene bi-component composite fibers, and the antibacterial polyformaldehyde / ultra-high molecular weight polyethylene bi-component composite fibers have the characteristics of high strength, corrosion resistance, wear resistance, self-lubrication, biological adhesion resistance, weather resistance and the like, and are suitable for long-term marine deployment. Optical fiber sensing fibers containing single-mode distributed sensing optical fibers, a polytetrafluoroethylene sleeving and packaging layer and a stainless steel alloy wire woven protection layer are integrated in the net, and various sensing fibers such as basalt fiber base, carbon fiber base, carbon nanofiber base and polysulfonamide fiber base are converted into sensing fibers through an integrated sensor, so that a dual-channel multi-parameter sensing system is formed. And various ocean parameters such as temperature, pressure, water quality and biological activity can be monitored, and ocean water quality and biological activity can be accurately mastered. And the stability and reliability of the sensor are ensured through the protection layer. The preparation method ensures the stability of the net body structure and the accuracy of the sensing function. The network not only can stably operate in a marine environment, but also can provide accurate sensing data, and provides powerful support for marine research and monitoring.

The invention belongs to the technical field of sustained-release microcapsules, and particularly discloses a ganoderma triterpenoid sustained-release microcapsule and a preparation method thereof.Bovine serum albumin and octenyl succinic anhydride modified starch are selected to prepare a Maillard product through a carbonyl ammonia condensation method to serve as a wall material, and a core material ganoderma triterpenoid is well wrapped in the wall material; the Maillard reaction product and the ganoderma triterpenoid are crosslinked, the structure of the freeze-dried microcapsule is not damaged, and the prepared granular microcapsule is complete in structure, high in embedding rate and good in stability. The sustained release performance of the ganoderma triterpenoids as an embedding material is improved, the water solubility of the ganoderma triterpenoids is improved, the dissolution speed and the intestinal mucosa permeability of the ganoderma triterpenoids are improved through conjugation change of polymer characteristics, the retention time is prolonged through biological adhesion, the oral bioavailability of the ganoderma triterpenoids is improved, and the bioavailability of the ganoderma triterpenoids is improved. The human body absorption and utilization degree of the ganoderma triterpenoids can be obviously improved.

The invention relates to the technical field of coatings, and discloses a deep-sea pressure-resistant shell protective coating and a preparation method thereof.The preparation method comprises the following steps that a base material is treated, epoxy resin modified polyurethane, reinforcing filler, anti-corrosion filler, a curing agent and a solvent are sequentially added according to a preset proportion and mixed to be uniform, primer is prepared, and the base material is sprayed with the primer; and then taking the isoxazole modified polyurea as finish paint, and spraying the finish paint on one side, deviating from the base material, of the primer to obtain the protective coating. The protective coating has excellent waterproof performance, impact resistance, wear resistance and organism adhesion resistance, and can effectively prevent corrosion factors such as moisture and various ions in seawater and various fouling organisms such as barnacles, mussels, oysters and sponges in seawater from being in contact with the surface of a base material.

Bioadhesive microparticle formulations and methods for preparation thereof are described. The microparticle formulation comprises cross linked poly-amino acid microparticles and may be delivered alone or may be used for delivery of an agent to a biological surface.

The invention relates to the technical field of deep-sea ecological restoration, in particular to a deep-sea mining ecological restoration and restoration potential evaluation system based on an efficient substratum, which comprises an environmental data acquisition module, an efficient substratum design and laying module, a deep-sea noise identification and biological adhesion prediction module, a restoration strategy generation module and a restoration effect evaluation module. Wherein; the environment data acquisition module acquires environment data; the high-efficiency substratum design and laying module is used for designing a high-efficiency substratum for a deep sea environment; the deep sea noise identification and biological attachment prediction module predicts attachment behavior characteristics of the surface of an attachment base; the repair strategy generation module is used for generating a targeted repair strategy; and the restoration effect evaluation module quantitatively analyzes the restoration progress of the ecological system. According to the invention, data acquisition precision and processing capability in a complex deep sea environment are enhanced, and reliable guarantee is provided for deep sea substratum laying and ecological restoration.

The invention discloses antibacterial gel for female private part nursing and a preparation method of the antibacterial gel, and belongs to the technical field of female nursing gel. The gel provided by the invention has good biocompatibility and biological adhesion, is convenient to form a gel state under the action of body temperature, is tightly adhered to the surface of a mucous membrane to form a protective hydrated film, can physically isolate pathogens, and is used for preventing female genital tract infection and maintaining vagina health. The performance of the chitosan is improved through grafting modification, a plurality of carboxyl, guanidyl and siloxane structural units are introduced to the chitosan at the same time, guanidyl can effectively adsorb and destroy bacteria and fungi usually carrying negative charges, and the water solubility and biocompatibility of molecules are enhanced through the carboxyl and siloxane structure; the siloxane structure can improve the spreadability and adhesion of molecules on the mucous membrane surface and prolong the drug residence time, and the functional monomers are grafted to the chitosan skeleton through amido bonds to ensure the structural stability and function durability of the modified polymer.

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.

The invention relates to the field of biomimetic materials, in particular to a biomimetic self-cleaning anti-fouling aquaculture net cage material, a preparation method and application of the biomimetic self-cleaning anti-fouling aquaculture net cage material. 0.5 to 2.0 parts by weight of a carboxylated graphene nanosheet; 2.0 to 5.0 parts by weight of nitrogen-doped titanium dioxide nanoparticles; 1.0 to 3.0 parts by weight of silica nanoparticles; 5.0 to 10.0 parts by weight of calcium ion cross-linked modified sodium alginate; 1.0 to 3.0 parts by weight of octadecyl trichlorosilane; 0.5 to 1.5 parts by weight of lauryl sodium sulfate; through the synergistic effect of a double bionic structure and enhanced photocatalysis, the effective inhibition on attachment of various organisms is realized, and the inhibition rate on attachment organisms such as algae, bacteria and barnacles reaches 75% or above.

The invention relates to the technical field of image data processing, in particular to an image segmentation method and system applied to marine plankton. The method comprises the following steps: acquiring an in-situ microscopic image of marine plankton, carrying out binarization processing and connected domain analysis on the in-situ microscopic image, and screening out a biological adhesion block mass to be processed; synchronously extracting the edge contour of the biological adhesion block mass to be processed, and calculating a biological structure integrity score; selecting the candidate segmentation path with the highest biological structure integrity score as an optimal segmentation line; curvature smooth completion is carried out along the optimal segmentation line, and a single biological image is obtained; and inputting the single biological image into a pre-trained classifier to obtain a biological abundance data set. According to the method, high-precision automatic identification and abundance statistics of plankton in a complex marine environment are realized by screening and positioning the adhesion block mass, carrying out adaptive adhesion segmentation and combining multi-dimensional morphological feature classification.

An antithrombotic surface-modified biomaterial is provided comprising a biomaterial substrate coated with a polymerizable dopamine-containing bioadhesive to which is attached one or more antithrombotic agents. A method of preparing the surface-modified biomaterial is also provided. The surface-modified biomaterial is beneficial for use in blood-contacting medical devices such as catheters, dialyzers and blood oxygenators to prevent or minimize the occurrence of thrombosis on the surface thereof.

The invention discloses a fishway observation window and a preparation method thereof, belongs to the technical field of ecological monitoring, and can solve the problems that a traditional fishway observation window lacks a long-acting anti-fog function, the biological adhesion problem is serious, and the function integration degree is low. The fishway observation window comprises a transparent composite substrate; the conductive anti-fog layer is embedded in the middle of the transparent composite substrate and is used for raising the temperature to a preset temperature after being electrified, and the preset temperature is higher than the air dew point temperature; the biological corrosion resistant coating is arranged on the surface of one side of the transparent composite substrate; the anti-biological-corrosion coating comprises a plurality of convex structures, and each convex structure is formed by spraying an anti-biological-corrosion material and then curing the anti-biological-corrosion material; the hydrophobic coating is arranged on the surface of the side, away from the transparent composite substrate, of the biological corrosion resistant coating and covers the biological corrosion resistant coating. The invention is used for the fishway observation window.

The present invention belongs to the field of biomedicine technology, and in particular to a preparation method and use of a composite hydrogel based on bioadhesive nanoparticles. The present invention utilizes bioadhesive nanoparticles BNP based on PLA-HPG to react with carboxymethyl chitosan, and a reversible Schiff base bond is formed by the aldehyde group on the surface of BNP and the amino group of carboxymethyl chitosan, so that BNP and the polymer are cross-linked to form a composite hydrogel with a porous network structure and containing bioadhesive nanoparticles. The composite hydrogel has good biocompatibility and injectability, and the BNP and porous structure therein enable the hydrogel to deliver water-insoluble and water-soluble drugs simultaneously, and has a sustained-release effect, can be applied to aspects such as peritoneal drug delivery and skin drug delivery, greatly expanding the application value of BNP, and has huge potential application prospects.

The present invention provides a magnetically controlled fish pathogenic microorganism microfluidic chip detection platform with an ultra-smooth surface and a method of use, which belongs to the field of microbial detection technology. The microfluidic chip detection platform described in the present invention is an application of the integration of three research direction technologies: super-hydrophobic anti-biological adhesion materials, magnetically controlled separation and sorting, and electrochemical microbial Coulter counting detection sensors. The super-hydrophobic anti-biological adhesion material can increase liquid flux and avoid sample residue. The present invention combines immune nano-magnetic beads with magnetically controlled sorting functions to improve sorting efficiency; the present invention adopts a labeled fish pathogenic microorganism Coulter counting technology, and uses a Coulter counting method that generates instantaneous fluctuation pulses of current due to conductivity changes to achieve quantitative detection of fish pathogenic microorganisms. Compared with traditional laboratory incubation methods, microscope counting methods, etc., it has the advantages of less sample consumption and shorter time consumption.

The invention belongs to the technical field of oral care, and particularly relates to an equivalent remineralized oral care composition which comprises a dosage form A and a dosage form B which are independently stored, wherein the dosage form A comprises the following components in percentage by mass: 0.05-0.15% of fluoride, 0.1-1.5% of a biological adhesive, 40-70% of a humectant, 3-8% of a dispersing agent, 0.1-5% of a sweetening agent, 10-20% of a friction agent, 0.1-1% of a preservative, 1-3% of a foaming agent, 0.5-1.5% of essence, 0-1% of a pH regulator and a certain amount of water; the dosage form B comprises the following components in percentage by mass: 0.1-5% of calcium salt, 0.1-2% of zinc salt, 0.1-1.5% of a biological adhesive, 40-70% of a humectant, 3-8% of a dispersing agent, 0.1-5% of a sweetening agent, 10-20% of a friction agent, 0.1-1% of a preservative, 1-3% of a foaming agent, 0.5-1.5% of essence, 0-1% of a pH regulator and a certain amount of water.

The invention belongs to the field of pharmaceutical preparations, and provides a medical composition for treating premature delivery and a preparation method thereof. The progesterone nanocrystal (D50 is 250-350 nm) and poloxamer 407 / 188 thermosensitive gel-forming system composite design is adopted, hydroxypropyl methylcellulose or carbomer 974P and a functional adhesion polymer (carbomer-cysteine or carbomer-catechol) are matched, the pH is adjusted to 4.0-4.5 through a lactic acid / sodium lactate buffer system, and the progesterone nanocrystal / poloxamer composite gel-forming agent is prepared. The excellent performance that the sol-gel transition temperature is 30-34 DEG C, the elastic modulus is not smaller than 150 Pa at 37 DEG C, the modulus retention rate is not smaller than 60% after the emulsion is diluted by 5-10 times, the adhesion work is not smaller than 0.60 N.s, and the anti-flushing retention rate is not smaller than 70% after the emulsion is diluted by 5-10 times is achieved. The invention solves the problem of synergy of high-modulus gel strength, rapid self-repairing ability and anti-dilution and anti-flushing stability, realizes unification of long-acting drug release and excellent biological adhesion performance in vagina physiological fluid dilution and mechanical flushing environments, and has wide clinical application value.

The invention discloses a tooth-cushion-free oral tracheal intubation system, and particularly relates to a portable integrated bag which comprises a catheter, a fixing device and a guide wire, and the portable integrated bag can be used immediately after being opened and is efficient and convenient. Wherein the catheter comprises an oral cavity anti-biting section, a pharynx transition section and a trachea flexible section which are sequentially arranged, the section of the oral cavity anti-biting section is oval and can prevent biting deformation, the section of the pharynx transition section is gradually changed to be round from oval and can prevent collapse, and the trachea flexible section is an ultra-thin silica gel corrugated pipe and can reduce damage to airway mucosa; the fixing device comprises a fixator, a biological bonding fin and an anti-slip fixing band, the fixator is connected with the catheter in a buckled mode, the biological bonding fin can be bonded to the skin of the upper jaw of the human body, and the anti-slip fixing band can be fixedly arranged on the head of the human body in a sleeving mode, so that the catheter can be fixed without a tooth pad, operation steps are simplified, and the use experience of a patient is improved.

Methods for using bioadhesive and stearic interactions specific to copolymers with at least two moieties, to minimize adverse effects mediated by external influences on cell, tissue, organ system, and organism biology. Multifunctional copolymers have bioadhesive properties driven by electrostatic and hydrophobic interactions and passivation though hydrophilic moieties. These copolymers are useful for reducing rates of viral infectivity in target cells, and in reducing host morbidity and can be coforulated. These copolymers are useful for reducing ADC related, oncology therapy related, preservative related, systemic- pharmaceutical-therapy related, and / or topical ophthalmic active-pharmaceutical- ingredient related toxicity which can be manifest as a corneal epithelial toxicity. Methods for enhancing efficacy through coformulations with mucopenetration enhancing technologies and in coformulations with other actives that inhibit macropinocytosis allow for increasing efficacy in patient treatment approaches described herein. Coformulations with other actives ingredient will have therapeutic utility and prove beneficial in various settings. Formulations of these multifunctional copolymers for topical ophthalmic use are safe and well tolerated. Epithelial cells and the ocular surface including limbal stem cell and precursor corneal epithelial cells are treated with these copolymers to confer utility and patient benefit. Corneal nerves are similarly protected and corneal nerve cell damage is mitigated. Contact lenses provide an alternative method for delivering protective copolymers to the eye in these settings.

The purpose of the present invention is to provide a material that has higher strength and / or bioadhesion after self-repair and is obtained by using an elastin-like polypeptide.　Provided is a composition comprising: a polypeptide that has an amino group and comprises an elastin-like block peptide sequence including a G sequence block comprising (SEQ ID NO: 1:X1GGX2G)n (wherein: X1's are the same as or different from each other and each independently represent V or L; X2's are the same as or different from each other and each independently represent V or L; and n represents an integer of 4 or more) and a P sequence block comprising (SEQ ID NO: 2:VPGX3G)m (wherein X3's are the same as or different from each other and each independently represent an arbitrary amino acid residue, and m represents an integer of 5 or more); and a water-soluble polymer having an aldehyde group.

The invention relates to the technical field of space environment monitoring, and discloses an intelligent intercepting and filtering system with long-acting biological adhesion prevention and self-cleaning functions. Comprising an intelligent net body module, a long-acting super-hydrophobic coating module, an intelligent monitoring module, an automatic spraying and production supporting module, an intelligent operation and maintenance and data management module, an installation and scene adaptation module, a performance detection and verification module, a dynamic weight adjustment module and an environment recovery monitoring module. The intelligent net body module comprises a composite fiber base material and a signal monitoring network unit. Through a dynamic weight adjustment module, based on historical fault data and real-time environment parameters, a risk index is dynamically optimized to calculate a weight, a pain point of insufficient precision of traditional fixed threshold evaluation is solved, a'monitoring-early warning-operation and maintenance-environment recovery 'full-closed loop is constructed, functions of intelligent monitoring, emergency linkage, life prediction, environment recovery confirmation and the like are integrated, and the reliability of the system is improved. And meanwhile, full-process intelligent management and control from risk identification to environmental security recovery are realized.

A film and a method for use thereof such as for the administration of a biologically active agent or for therapy are provided. Specifically, a film, composed of a biodegradable material having a mucoadhesive surface comprising a plurality of mushroom-type structures is provided.

The invention discloses a buffering and energy-absorbing rope capable of preventing organisms from being attached, and belongs to the technical field of offshore and underwater components. The rope comprises a rope body, and an auxiliary assembly and a wear-resistant assembly are arranged on the outer surface of the rope body; according to the invention, the magnetic dielectric rods and the spiral coils are arranged, the magnetic dielectric rods are sequentially arranged in each strand of cable, and the multiple turns of spiral coils are wound on the magnetic dielectric rods, so that when current passes through the spiral coils, a magnetic field is formed, and then a strong local magnetic field is formed around the cable under the condition that the magnetic field is further amplified through mediation of the magnetic dielectric rods; in the process, a spiral coil and a similar spring which are arranged between the rope core and the outer protection layer can buffer impact of seawater on the rope and play roles in absorbing energy and protecting the inner rope core, the rope can stop as soon as possible through an inner energy dissipation mechanism, the abrasion resistance of the rope is improved, and the service life of the rope is prolonged. Therefore, the effect of preventing biological adhesion is improved while the simple structure of the rope is ensured.

This invention discloses an antibacterial gel for feminine hygiene and its preparation method, belonging to the field of feminine hygiene gel technology. The gel provided by this invention has good biocompatibility and bioadhesion, easily forming a gel state under body temperature, tightly adhering to the mucosal surface to form a protective hydration film, physically isolating pathogens, and is used to prevent female reproductive tract infections and maintain vaginal health. This invention improves the performance of chitosan through graft modification, simultaneously introducing multiple carboxyl, guanidine, and siloxane structural units onto chitosan. Guanidine groups can effectively adsorb and destroy bacteria and fungi that are usually negatively charged. Carboxyl and siloxane structures enhance the water solubility and biocompatibility of the molecule, while the siloxane structure improves the spreadability and adhesion of the molecule on the mucosal surface, prolonging drug residence time. By grafting the above functional monomers onto the chitosan backbone through amide bonds, the structural stability and functional durability of the modified polymer are ensured.

The invention discloses uranium adsorption resin as well as a preparation method and application thereof. The preparation method of the uranium adsorption resin comprises the following steps: 1) mixing acrylonitrile, alkyl acrylate, divinylbenzene, a pore-foaming agent and an initiator for reaction to prepare ternary polymerization microspheres; 2) mixing the ternary copolymerized microspheres with ethidene diamine for reaction to prepare aminated microspheres; (3) mixing and reacting the aminated microspheres with 2-bromobenzimidazole, so as to prepare functionalized microspheres; and 4) reacting the functionalized microspheres with an amidoximation reagent to prepare the uranium adsorption resin. The biological adhesion resistance of the resin is improved, the ball milling rate of the prepared resin is high, and the resin has good uranium adsorption capacity.

A patch to be placed over an injury or defect in tissue in a biological structure having a lumen and preventing migration of contents of the biological structure through the injury or the defect. The patch includes an adhesive layer configured to adhere to the biological tissue via formation of hydrogen or covalent bonds with chemical groups present in the biological tissue and a backing layer coupled to and coextensive with the adhesive layer, the backing layer configured to be impervious to the contents.