366 results about "Biological adhesion" patented technology

A composition for delivering a tumor therapeutic agent to a patient includes a fast-release formulation of a tumor apoptosis inducing agent, a slow-release formulation of a tumor therapeutic agent, and a pharmaceutically acceptable carrier. An apoptosis-inducing agent in a pharmaceutically acceptable carrier may be administered before or concomitantly therewith. Nanoparticles or microparticles (e.g., cross-linked gelatin) of the therapeutic agent (e.g., paclitaxel) also may be used. The nanoparticles or microparticles may be coated with a bioadhesive coating. Microspheres that agglomerate to block the entrance of the lymphatic ducts of the bladder to retard clearance of the microparticles through the lymphatic system also may be employed. This invention also uses drug-loaded gelatin and poly(lactide-co-glycolide) (PLGA) nanoparticles and microparticles to target drug delivery to tumors in the peritoneal cavity, bladder tissues, and kidneys.

Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and has excellent tissue adhesiveness thanks to modification with/without dopa derivatives. The hydrogel finds a variety of applications in the biomedical field, including bioadhesives or hemostats, implant substances for tissue regeneration and augmentation, carriers for delivering biologically active materials or drugs, etc.

The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection of a liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection. The disclosure also relates to uses of such compositions for forming a matrix on or within the body of a mammal. The compositions have a variety of uses, such as as bioadhesives, as sealants for ruptured tissues, as drug or imaging agent depots, or as mechanical cushions.

The invention belongs to the technical field of medicines and discloses an itraconazole temperature-sensitive type gel preparation as well as a preparation method and application thereof. The itraconazole temperature-sensitive type gel preparation is composed of the following components in percentage by weight: 0.02-3% of medicines, 0.05-15% of solubilizing agent, 5-50% of gel matrix, 0-15% of biological adhesive, 0.001-2% of preservative, 0-10% of other additives and the balance of solvent. The itraconazole temperature-sensitive type gel preparation can regulate gelatinization temperature by adjusting composition and control drug release rate and degree, can effectively inhibit growth of candida in vitro and can be used for drug administration on skins, eyes, nasal cavity, oral cavity, straight intestine or vaginal mucosa. The itraconazole temperature-sensitive type gel preparation has obvious slow release and biological adhesion property and can prolong action time of medicines on an infection part, realize long-acting treatment, reduce dosage and toxic and side effects and improve patient compliance.

The invention relates to a super-hydrophilic and underwater super-oleophobic coating, as well as a preparation method and application thereof. According to the invention, an organic/inorganic hybrid sol preparation method and a surface coating method are adopted, an organic/inorganic hybrid coating containing zwitter-ion groups with a certain thickness is constructed on the material surface, and is prepared through mixing alkoxy silane functionalized glycine betaine type zwitter-ion compound and silicon dioxide particles with other auxiliaries and performing hydrolysis, coating and thermal treatment. The functional coating provided by the invention is super-hydrophilic in air and super-oleophobic underwater; as the glycine betaine type zwitter-ion compound simulating the cell outer membrane molecular structure is introduced in the prepared super-hydrophilic underwater super-oleophobic coating, the prepared functional coating has the self-cleaning function, the antifogging function, the underwater oil resistance function, and the like, and has excellent bioadhesive resistance; the coating, the method and the application thereof have the advantages that the technology is simple, raw materials are easy to obtain, the equipment is simple, the cost is low, and the coating can be large-area prepared.

Formulations and methods for transmucosal delivery of a beneficial agent are described in which a pH-responsive component and a temperature-responsive component are combined and applied to a mucous membrane. The temperature-responsive component is a component that, in aqueous solutions, is capable of undergoing a temperature-dependent sol to gel phase transition. The formulations may be characterized as having bioadhesive properties, and are suitable for delivery of a variety of beneficial agents.

The invention relates to a medicinal composition for treating bacterial vaginitis, which comprises main medicaments, substrates, a bioadhesive material, a release rate regulator and other additives. The medicinal composition for treating bacterial vaginitis has specific biological adhesion, keeps longer time, reduces leakage of the medicaments, prolongs the contact time of the medicaments and the vagina mucosa, and guarantees the curative effect. The composition has specific vagina slow release performance, and can continuously release the medicaments for 2 to 7 days. Compared with the common preparation, the medicinal composition prolongs the releasing time of the medicaments, can reduce the administration times, and is convenient for the patient to take. As simultaneously the medicinal composition has the characteristics of biological adhesion and slowly-released long effect, the medicinal composition has no requirement for the administration time, and the administration can be carried out at any time.

The invention discloses a super-hydrophilic and underwater super-lipophobic coating which consists of a substrate and an organic/inorganic hybrid coating, wherein the organic/inorganic hybrid coating containing an ampholytic ionic group is coated on the surface of the substrate. 1, the method disclosed by the invention is simple in process, easy in preparation of raw materials, simple in equipment and low in cost, and the functional coating can be prepared on the surfaces of different substrates in a large area, so as to achieve super hydrophilicity and underwater super lipophobicity; and 2, by introducing a betaine-type ampholytic ionic compound of a cell outer membrane simulating molecular structure to the prepared super-hydrophilic and underwater super-lipophobic coating, the prepared functional coating not only has functions of self-cleaning, anti-fogging, underwater oil resistance and the like, but also has excellent performances of resisting biological adhesion and the like.

A cultured periodontal ligament cell sheet is produced by a process comprising culturing cells on a cell culture support composed of a base material whose surface is coated with a temperature-responsive polymer having an upper limit or lower limit critical dissolution temperature in water of 0 to 80° C. under specified conditions, (1) regulating the temperature of a culture fluid to the upper limit critical dissolution temperature or higher or to the lower limit critical temperature or lower, (2) allowing a cultured periodontal ligament cell sheet resulting from the culturing to adhere to a carrier and (3) detaching the sheet intact together with the carrier. This cultured periodontal ligament cell sheet has a syndesmotic microstructure, exhibits extremely high bioadherence to the dental root surface and realizes high density transplantation of target cells and positive reconstruction of periodontal tissues. Moreover, through lamination of cell sheets to be transplanted and donation of a three-dimensional polarity, highly efficient reconstruction of an adhesion apparatus can be accomplished and clinical application thereof to moderate periodontitis, severe peridontitis, gingival recession and the like is highly promising.

The invention relates to a trans-mucosal component for a dental implant intended to support a prosthetic installation. The trans-mucosal component has been designed for the purpose of improving the quality and stability of the biological adhesion of the junctional epithelium and of the connective tissue and wherein the trans-mucosal component (2) is provided with a waist-shaped or inwardly narrowed part for reducing the necessary height of the trans-mucosal component and creating a volume for generation of a stabilizing and retentive belt of soft tissue. According to the invention the distance in the longitudinal direction along the contact surface of the waist-shaped or narrowed part should at least correspond to the required, biological width of the adjoining soft tissue.

The invention discloses azithromycin gel eye drops and a preparation process thereof. The eye drops are prepared from a main medicine, namely azithromycin and excipients such as an adhesive, a gel matrix, an isotonic regulator, a preservative, an antioxidant, a buffering agent and the like. The adhesive, namely polycarbophil in the eye drops can increase the biological adhesion of the eye drops, so that the detention time of medicines in eyes is further prolonged. The invention provides a practical, convenient and reliable ophthalmic preparation for treating bacterial conjunctivitis, and solves the problems that the detention time of medicines in an eye drop formulation in the eyes is short, the medicines are not easy to absorb, the bioavailability is low and the like.

The invention relates to a resveratrol oral administration drug delivery system prepared through the nanometer technology. The drug delivery system is made of the resveratrol and bearer material of wheat gliadin. By utilizing the characteristic that the nanometer granule is highly dispersed and that of biological adhesion of the bearer material, the contact area and contact time of the resveratrol and absorption region of the intestinal canal is increased, which can promote absorption of the small intestine. In addition, the resveratrol oral administration nanometer drug delivery system is distributed over the suitable auxiliary-material skeletal material to improve the dissolve velocity and degree of the resveratrol.

The invention relates to a graphene catheter composition, a catheter preparation method and an application. The graphene catheter composition comprises the following components by the mass percentages: 90-99.5% of a biodegradable material, and 0.5-10% of graphene. The graphene catheter comprises a catheter and a biological adhesion substance layer, and the biological adhesion substance layer is arranged on the inner wall of the catheter; the catheter is prepared by the graphene catheter composition. The preparation method comprises that the graphene catheter composition is printed in 3D or electrospun to produce a catheter; the interior of the catheter is sprayed with a biological adhesion substance by 3D printing or electrospinning, and the catheter is crosslinked and solidified, so thatthe graphene catheter can be obtained. The catheter can promote regeneration, proliferation and differentiation of nerves, blood vessels and the like. In-vivo experiments show that the repair of animal peripheral nerves such as sciatic nerves is superior to that of autologous nerve transplantation, and practical and clinical value is achieved.

The invention is a device comprising a substrate and a material provided on at least a portion of the substrate and having an exposed surface. The exposed surface of the material is non bio-adhesive. The invention further includes a non bio-adhesive material composition and a method of making a device having the same non bio-adhesive surface. The invention further provides a device having a coating of a hydrophobic material. In particular, the hydrophobic material coated portion of the device is resistant to bio-adhesion.

The invention discloses a diamond-based electrode material of a seawater salinity sensor. A diamond thin film material and a diamond composite thin film material are used as the electrode material of the seawater salinity sensor. The diamond thin film material comprises a boron-doped polycrystalline diamond thin film material body and a boron-doped nano diamond thin film material body. The diamond composite thin film material comprises a diamond and graphite composite thin film material body, a diamond and carbide composite thin film material body, boron-doped diamond and amorphous carbon composite thin film material body and a diamond thin film material body with the surface being decorated or modified through metal, or organic matters or inorganic molecules. The electrode material has the advantages of wide electrochemical window, low background current, high corrosion resistance, strong biological adhesion prevention capacity, high mechanical strength, high stability of chemical performance, more functional ways, good reprocessability, high biocompatibility and the like. The measurement precision and reliability of the seawater salinity sensor are further improved, and the service life of the seawater salinity sensor is prolonged.

The invention describes new synthetic medical adhesives and antifouling coatings which exploit the key components of natural marine mussel adhesive proteins.

The invention relates to a composite gel film agent, which is characterized in that sodium carboxymethyl cellulose and other gels are compounded into film agent matrix. The composite gel film agent has the following advantages that the film agent has hemostasis function, has the function of inhibiting bacteria growth, is more stable, can slowly and durably release components of drug so as to improve curative effect, is convenient to use because the gel film agent can quickly absorb water (tissue fluid) in the anus, vagina or uterus, nasal cavity and auditory meatus to expand and dissolve to generate biological adhesion so that the gel film agent is adhered to the cavity and the film agent drug solution is not easy to flow out and a barrier does not need to be placed at the vagina or the anus due to no outflow, has no stimulation, can be biodegradable in vivo, has no residue or toxic and side effects, and is accepted more easily by a patient under the condition of enhancing curative effect.

A mucosal bioadhesive slow release carrier comprising an active principle and devoid of starch, lactose, which can release the active principal for a duration of longer than 20 hours. This bioadhesive carrier contains a diluent, an alkali metal alkylsulfate, a binding agent, at least one bioadhesive polymer and at least one sustained release polymer, as well as a method for its preparation.

The invention provides an anti-bioadhesive material, which is a copolymer formed by copolymerization of a zwitterionic monomer and a phosphonic acid or phosphonate monomer. On the other hand, the invention also provides a preparation method of the anti-bioadhesive material. The method includes: directly mixing the zwitterionic monomer with the phosphonic acid or phosphonate monomer for copolymerization, or firstly preparing a homopolymer of one of the two monomers, then adopting the prepared homopolymer as the macroinitiator or chain transfer agent, and taking the other monomer of the two monomers as the polymerization monomer to prepare a copolymer of the zwitterionic monomer and the phosphonic acid or phosphonate monomer. The invention also provides an anti-bioadhesive metal instrument,the surface of which is provided with a coating of the anti-bioadhesive material. The anti-bioadhesive material has high stability, and by means of a simple coating process, a stable polymer coating can form on the metal surface, an anti-bioadhesive material surface modified metal surface protein has significantly reduced nonspecific adsorption performance, and the anti-bioadhesive performance issignificantly improved.

The invention relates to an oral enteric-coated preparation of total flavonoids of herba epimedii and an application thereof, belonging to the technical field of medicines. The oral enteric-coated preparation is an enteric capsule, an enteric pill or an enteric tablet and the like capable of being orally taken, which can be prepared from total flavonoids of herba epimedii, hydrolytic enzyme, a biological adhesion agent and other common auxiliary materials in pharmaceutics. According to a bionic enzymolysis oral administration system of the total flavonoids of herba epimedii developed by the technical scheme, the total flavonoids of herba epimedii can be subjected to complete enzymolysis to form a secondary glycoside or aglycone form before intestinal emptying under an in-vivo intestinal environment (37 DEG C and pH 5.2-7.4); the retention time of the administration system on the intestinal absorption site is prolonged by adding the biological adhesion agent, and thus 'real-time enzymolysis and real-time absorption' of medicines are achieved, full enzymolysis of herba epimedii flavonoid glycoside can be further guaranteed, the bioavailability is improved, and more effective and more stable treatment means are provided for osteoporosis and the like.