225 results about "Biomimetic materials" patented technology

The invention discloses a dynamic polymer material. The dynamic polymer material comprises a product obtained through reaction of the following components: at least one polyol compound containing two or more 1,2-diol motifs or 1,3-diol motifs as well as at least one phenylboronic acid compound containing two or more phenylboronic acid motifs provided with aminomethyl groups in ortho-positions. Dynamic reversible phenylborate bonds are formed through the reaction of the components and then constitute a dynamic cross-linked polymer. The polymer material has reusability and recoverability because of the dynamic reversibility of the special phenylborate bonds; besides, when the polymer material adopting a specific formula receives external force, dynamic bonds break preferentially to have energy dissipation and stress elimination functions, so that the material has good toughness. The material has broad application prospect in the fields of military space equipment, functional paint and coatings, biomimetic materials, biomedical materials and the like.

The invention discloses a dynamic polymer having a non-covalent crosslinking structure. The dynamic polymer contains organic boric acid silicon ester bonds on polymer chain backbone; wherein the organic boric acid silicon ester bonds are existed as polymeric chain contacts of the dynamic polymer, and are the necessary condition for forming or maintaining a dynamic polymer structure. The dynamic polymer has energy dissipation performance by means of the organic boric acid silicon ester bonds having strong dynamic reversibility, embodies functional characteristics of stimulation responsiveness and self-repairability, and has a wide application prospect in the fields of sport protection, a functional coating, and a bionic material.

The invention discloses a river channel purification system for processing rural domestic sewage, belonging to the field of rural sewage processing. The system is characterized in that a processing unit is established by utilizing a waste river channel or a swale near-natural type channel; a plant grid sedimentation unit, an artificial biomimetic material contact oxidation unit, a vertical current artificial wetland unit and a floating plant unit are successively arranged from top to bottom according to the direction of water flow; and the rural domestic sewage is processed successively through the four processing units so as to finally achieve the purpose of improving water quality. The system has the advantages that the removing rates of CODcr, SS, NH3-N, TN and TP of the domestic sewage entering the system respectively reach 77.1%, 84.1%, 70%, 68% and 58.8% through the application of the invention; the effect of reducing the pollution load and improving the water quality is realized; and the system provides the guarantee to the improvement of the water environment quality in a downstream river.

The invention relates to calcium carbonate based artificial material and the synthesizing method. It is characterized in that the method comprises following steps: adding low- molecular weight organic matter into system of calcium chloride and sodium carbonate according to a certain proportion, heating, organic molecule absorning selectively on crystal surface to nanocrystal growth along said crystal surface, so it is thin structure for crystal, assembling the crystal thin structure on three-dimensional orientation under interactive action of organic molecule and extension growth of crystal, getting staged layer structure crystal, and that is mentioned final product. The invention is of great importance for understanding biomineralization process and atificial synthesis for biological mineralising material.

The invention discloses an injection-type cartilage bionic matrix for the regenerative repair of cartilage and a method for using the same. The materials, of which the main components are the same as those of the extracellular matrix of the normal articular cartilage, are used as a raw material, and the raw materials undergo dissolution and pH adjustment to form the injection-type cartilage bionic matrix which is in a sol state at the low temperature and at a gel state at the body temperature; and by using the injection-type cartilage bionic matrix as a carrier, the injection-type cartilage bionic matrix is mixed with seed cells at the low temperature and then injected in cartilage deficiency parts, the injected materials undergo phase change by raising the temperature of the deficiency area to turn into the gel, so that the seed cells are fixed in the deficiency parts to conduct the regenerative repair function. The method is simple and easily implemented, the product is conveniently used, the operation injury is small, and the repair effect of the deficiency parts is good; the raw material has high biocompatibility and safety, all components undergo intermolecular bonding under the preparation conditions of the invention, so that the problem that the single bionic material is degraded too fast is solved; and the seed cells are directly mixed with the raw materials, and the culture in vitro is unnecessary so that the detention time in vitro of the seed cells are shortened, and the clinical application is safer.

The present invention comprises a user-friendly, soft and resilient, biomimetic (mimicking biological entities) lower limb support outfits that can be worn externally by people to improve and enhance lower limb, legs and knees performance in sports, daily dynamic activities and medical rehabilitation / physical therapy. More specifically, the present invention relates to an outfit, which allows a portion of the upper limb's quasi-static weight and dynamic weight due to impact forces to be excluded from being transmitted to the lower limb, legs, quadriceps and hamstrings muscles and knees by directly transmitting them to the ankles, footwear and / or the ground, through soft elastic columnar quasi-legs that are equipped with smart biomimetic materials such as shape memory materials and artificial muscles such as synthetic and / or ionic polymeric muscles and provide lower limb support function by buckling and bending in accordance with the dynamic maneuvering of the user. The said lower limb performance enhancing outfit is encapsulated by user-friendly fabric means for easy wear. The upper portion of the outfit can be in the form of a sports short worn by the user and encapsulating the buttocks support plates.

The invention discloses an intrinsic contact angle test apparatus and a test method thereof. A true drop technology or an image fitting technology is adopted to fit the test dynamic contact angle of a Young-Laplace equation, and Wenzel-Casie-Baster stimulation is used to derive an intrinsic contact angle calculating equation. The invention also provides the intrinsic contact angle test apparatus. The apparatus comprises a combination boy controlled by the rotating mechanism of a worm and gear structure and having a lens and a sample bench which rotate together, a XYZ and horizontally-adjustable sample bench combination body, a sample clamp, an injection pump and an XYZ control mechanism combination body thereof, a camera with a telecentric lens, and a parallel light source. The contact angle is obtained by shooting the profile image of a liquid drop and adopting the Young-Laplace equation fitting test. The apparatus and the test method can be used to analyze the chemical anisotropy of a material and the intrinsic contact angle under contact angle hysteresis condition due to surface roughness, and has extremely broad popularization values in fields of new materials and bionic materials.

The present invention comprises a user-friendly, soft and resilient, biomimetic (mimicking biological entities) back pack weight support and mobility enhancement system that can function like a caddie and can be worn externally by people carrying a back pack to improve and enhance shoulder, back, upper body, abdomen, waist, hips, lower limb, legs, knees, calves, quadriceps and hamstrings muscles performance in all dynamic activities while carrying a back pack. The present invention can comprise an outfit, allowing a portion of the back pack's weight to be excluded from being transmitted to the shoulder, back, upper body, abdomen, waist, hips, lower limb, legs, knees, calves, quadriceps and hamstrings muscles; instead directly transmitting the weight to the footwear and / or the ground, through soft elastic columnar quasi-legs equipped with smart biomimetic materials such as shape memory materials and artificial muscles such as synthetic and / or ionic polymeric muscles and provide support function by buckling and bending in accordance with the dynamic maneuvering of the user. The outfit can be encapsulated by user-friendly fabric means for easy wear. The upper portion of the outfit can be in the form of a pouch equipped with fastening portions to be attached to the bottom of the back pack worn by the user while the lower portion of the outfit can be attached to the footwear while transmitting the weight of the back pack to the ground or attached to a ball and socket wheel on the ground right behind the user.

The invention discloses a magnetic molecularly imprinted polymer-fluorescence analysis method, relates to a rapid detection of pesticides, and aims to solve the problem of difficulty in preparation of small molecular natural antibody in the conventional quick detection method. The method comprises the following steps: 1, preparing polyethylene glycol and oleic acid-coated magnetic nanoparticles; 2, preparing a magnetic molecularly imprinted polymer of triazine pesticides; 3, determining a fluorescence signal by using a fluorescence spectrophotometer. The common natural antibody which is difficult to prepare in the normal quick detection method is substituted by using a magnetic molecularly imprinted biomimetric material; quick detection of a non-immune method of the triazinemicromoleuclar pesticides is technically realized through competitive combination of the pesticide molecules and the fluorescence probe on the magnetic imprinting. The method is used for quickly detecting the residue of the triazine pesticides.

The invention belongs to the field of stretchable electronics and relates to a constructing and preparation scheme of a conductive elastic composite material, in particular to a constructing and preparation scheme of a conductive elastic body which keeps high resistance stability when stretches out and draws back. The high-stretching conductive elastic body comprises two main parts including an elastic main body and a conductive layer. The conductive layer adopts graphene, a carbon nano tube and other conductive materials as a basic conductive unit, and the elastic main body serves as a basic structural unit. An experiment result shows that the whole conductivity of the material can reach 10 Scm-1, elastic strain can reach 600-1000%, and the resistance change is smaller than 10% after 10000 times of repeated stretching. The conductive elastic composite material serves as the basic material of a flexible stretchable electronic device, and can be widely used for medical transplanting, intelligent clothes, artificial intelligence, biomimetic materials and the like.

The invention relates to a biomimetic bone material containing graphene / hydroxyapatite / fibroin and a preparation method of the biomimetic bone material. The biomimetic bone material is prepared by assembling hydroxyapatite which is obtained through coprecipitation on the surface of carboxylation modified graphene through electrostatic adsorption, then blending the graphene assembled with the hydroxyapatite with fibroin solutions different in mass concentration, and freeze-drying layer by layer sequentially from higher mass concentration to lower mass concentration so as to obtain the biomimetic bone material. The graphene / hydroxyapatite / fibroin biomimetic bone material prepared by the invention simulates natural bone in ingredient and structure; the biomimetic bone material is excellent in biocompatibility and biodegradability, and is outstanding in mechanical property and porosity of graded distribution; and the biomimetic bone material, which can be used as a repair or substitute material of bone tissues, is broad in application prospect.

The invention relates to a preparation method and an application of a composite nanometer material for the combined treatment of tumor by optothermal and active oxygen, and belongs to the technical field of medicines used for treatment. Nanometer iron is prepared through an ethylene glycol method, a catechol group on a dopamine molecular is oxidized under the condition of alkaline solution and oxygen, dyhydroxy benzpyrole or a semiquinone free radical is formed to generate rearrangement or coupling crosslinking auto polymerization reaction, a polydopamine layer coats the outer surface of the nanometer iron, the active group of the polydopamine is used for realizing covalent linkage with glucose oxidase to prepare a nanometer iron / polydopamine / glucose oxidase (nanometer iron / PDA(propane diamine) / GOx(gaseous oxygen)) composite nanometer material, and the composite material of the inorganic nanometer material modified by biomacromolecules and biomimetic materials is constructed. The prepared material has the advantages of obvious treatment effect, high biocompatibility, no toxicity and no pollution. The preparation technology has the advantages of simpleness and low cost and is suitable for scale production and clinical medical care.

The invention provides high specific surface area silicon carbide porous ceramic and a preparation method thereof. According to the method, a micro / nano multi-level structure in the nature is used as thought, the novel SiC / C porous composite ceramic is designed from the perspective of biomimetic material designing, a carbon fiber serves as a framework, SiC microspheres are used for simulating microspikes in a living body, SiC nanowires are used for simulating nanometer villus in the living body, and thereby the biomimetic SiC / C porous composite ceramic is constructed. The SiC / C porous composite ceramic has the advantages of being high in specific surface area and strength and easy to form.

The invention relates to a preparation method of a porous tantalum medical implant material. The preparation method comprises the following steps: by adopting pure tantalum powder with the particle size of not more than 10mu m as a raw material, directly performing selective laser sintering formation to form a human bone metal biomimetic material, wherein the thickness of powder spread in each layer during selective laser sintering is 60-80mu m; further sintering and cooling the formed human bone metal biomimetic material to obtain the porous tantalum medical implant material. The porous tantalum medical implant material with complete three-dimensional communication is obtained by sintering and cooling treatment of a formed blank prepared by selective laser sintering, and has a consistent microstructure with a bone tissue of a human body, so that the porous metal implant material has good biocompatibility and biological safety. The method provided by the invention further has the advantages of simple process equipment, low operation cost, no pollution in the whole preparation process, no side effect on a human body, capacity of ensuring the biological safety of the implant material and high forming speed, and is very conductive to industrial production and application.

The invention discloses a method for preparing a porous tantalum medical implant material. The method comprises the following steps of: directly performing selective laser sintering on pure tantalum powder of which the particle size is less than or equal to 10 mu m and which is used as a raw material to form a human bone metal biomimetic material, wherein the thickness of powder paved on each layer during selective laser sintering is 60 to 80 mu m; and sintering and cooling the human bone metal biomimetic material to obtain the porous tantalum medical implant material. Forming blank prepared by selective laser sintering is sintered and cooled so as to obtain the porous tantalum medical implant material of which pores are completely communicated in a three-dimensional way and the structure is consistent with a microstructure of a bone tissue of a human body; the porous medical implant material is high in biocompatibility and biosecurity; and the method also has the advantages that process equipment is simple, operation cost is low, pollution is avoided in the whole preparation process, the toxic and side effects on the human body can be avoided, the biosecurity of the implant material can be guaranteed, the forming speed is high, and the porous tantalum medical implant material can be industrially produced and applied.

The invention discloses an oil-water separation membrane with a smooth surface, and a preparation method thereof, and belongs to the field of biomimetic material chemistry. The oil-water separation membrane adopts a polymer membrane having a silica rough structure on the surface as a solid substrate, lubricating oil is poured into the silica rough structure on the surface of the polymer membrane as a surface lubricant, and the desired polymer membrane substrate and lubricating oil have diversity; and the oil-water separation membrane has a high separation rate when used to separate an oil-water mixture and a water-in-oil emulsion, can recover the separation rate through pure water washing after being used multiple times, can be repeatedly used, and has good anti-pollution performance and good recyclability.

The invention provides a preparation method for a novel biomimetic matrix type biological wound healing material. According to the method, small intestinal submucosa with a three-dimensional scaffold structure is compounded with platelet-rich blood plasma containing a specific proportion of bioactive factors, and a specific process is adopted to carry out modification to form the novel material containing biological induction factors, wherein the novel material has a three-dimensional biomimetic structure. With the biomimetic matrix type biological wound healing material prepared by the method of the present invention, the healing can be promoted, the physiological repair can be promoted, the pathological repair can be inhibited, and the regeneration repair efficiency and the repair quality of the damaged tissue can be improved. The novel biological wound healing material of the present invention can be used for repairs of various human soft tissues, membranous tissues or cavity walls, and for cavity filling, and can be used as the ideal extracellular matrix biomimetic material and the cell scaffold material for wound repairs of the tissues and the organs, promotion of wound healing, prevention of adhesion and the like.

The present invention pertains to mineral fibers useful as biomimetics of tissue, such as dental enamel and bone, and as filler in paper, paint, coatings, and plastic production. The present invention also concerns methods for producing mineral fibers by contacting an inorganic liquid-phase mineral precursor with a crystalline inorganic substrate under conditions permitting the inorganic liquid-phase mineral precursor to solidify and crystallize, compositions comprising mineral fibers, and methods for treating a tissue defect within a patient by applying mineral fibers to the site of the tissue defect.

The invention discloses a large-aperture bone regeneration bracket material and a preparation method thereof, and belongs to the technical field of medical biomimetic material engineering. A natural porous inorganic biological material (cuttlebone) and ammonium dihydrogen phosphate undergo a full reaction at high temperature under high pressure so as to be transformed into a multi-phase biological ceramic (consisting of calcium carbonate, hydroxyapatite and calcium phosphate). The preparation method for the material is simple in process, the material source is abundant, and the cost is low. In addition, the prepared material has good biological compatibility and high compression strength, and is environmentally-friendly. The bone cell experiment shows that the material has bone conduction activity, can promote and induce bone regeneration self-repair, can be degraded step by step in vivo, is an ideal bone transplant replacement material, and has wide application range and obvious social and economic benefits in bone surgical operation.

The invention discloses a method for preparing composite material of poly-aspartic acid or a derivative thereof, chitosan and a calcium-phosphate compound. The method is as follows: firstly, the poly-aspartic acid with different side chains or the derivative thereof is synthesized, then the poly-aspartic acid with different side chains or the derivative thereof, the chitosan and calcium-containing solution are mixed, reacted and precipitated under certain temperature and pH value. The obtained product has the characteristic of imitating a cell envelope and is environment-friendly biomimetic material. The material has the function of absorbing heavy metals and certain organic substances, can be used to remove the heavy metals, chlorohydrocarbon, organic pigment, dyes and so on, and is widely used for fields such as medicine industry, food engineering, printing and dyeing industry, sewage treatment and so on.

The invention belongs to the field of biomimetic materials, and particularly relates to a preparation method for a soft and hard alternated morphology biomimetic material based on friction performance. The method comprises the following steps that: S1: determining the proportion of two materials with different elasticity moduli; S2: determining the basic element dimension of the material with a large elasticity modulus; and S3: according to the proportion, which is obtained in the S1, of two materials with different elasticity moduli and the basic element dimension obtained in the S2, adopting the method of laser processing, 3D printing and physical blending to prepare the soft and hard alternated morphology biomimetic material. The soft and hard alternated morphology biomimetic material prepared with the invention has the advantages of simple method and excellent abrasive resistance, stretchability and impact resistance, wherein the body surfaces of soil animals including dung beetles, earthworms and the like are taken as archetypes, the biomimetic material of a biomimetic coupling cell cube with a certain rule is distributed on the surface of the biomimetic material, outstanding drag reduction and wear-proof characteristics are shown, and the preparation method is used in engineering practicality to obtain good economic benefits and social benefits.

The invention discloses a self-reinforced bionic material, comprising a reinforced phase prepared from a biodegradable polymer A with high molecular weight and high crystallinity, and a matrix resin phase prepared from a biodegradable polymer B with molecular weight and crystallinity lower than those of the biodegradable polymer A; the reinforced phase and the matrix resin phase are stacked by a guide die; and the stacking percentage of the reinforced phase is 30-90%, and the stacking percentage of the matrix resin phase is 5-60%. The invention also provides a manufacturing method of the self-reinforced bionic material. The invention employs ultrasonic transient heating and interface mechanism with controllable strength to solve a problem for keeping melting fiber morphology when the difference of melting temperature between matrix and the reinforced phase is small; and fiber distribution gradient is constructed to prepare a biodegradable self-reinforced biomimetic material with bamboo imitation structure, high strength and high toughness.

The invention belongs to the technical field of biological materials, and particularly relates to a degradable high polymer material with a patterned surface as well as a preparation method and application thereof. According to the degradable high polymer material, biodegradable hydrogel is used as a matrix, and the surface of the matrix is modified with a pattern composed of active substances; the patterned surface means that the matrix material surface is modified to form a pattern array. The patterned shape constructed on the hydrogel surface is stable in structure, and compositions can beindependent from the matrix material component. The obtained material has good biocompatibility and controllable degradability, and the patterned shape can be used for further modifying sites which have the responsiveness and biological activity; by introducing the dynamic degradability, the material has functions which confirm to the real physiological environment more; the material can be applied to the fields of stem cell culture, tissue engineering, biological diagnosis, biological recognition, biomimetic material design and the like.

The invention relates to a preparation method of flaky nano-hydroxyapatite. The method is characterized by comprising the steps of: dissolving amino-dextran in ultrapure water under 4DEG C to prepare a polysaccharide solution; adding a calcium salt solution into the polysaccharide solution prepared in step (1), slowly heating the solution to 40DEG C, and conducting stirring for 20min; adding a phosphate solution into the mixed solution prepared in step (2) slowly according to a Ca / P ratio of 1.67, and simultaneously adjusting the pH value with sodium hydroxide till the pH value becomes 7 and a white suspension liquid comes into being, keeping the pH value of the current solution at 7.0 for 24h; subjecting the precipitate generated in step (3) to cleaning, centrifugation and drying, thus obtaining flaky nano-hydroxyapatite powder. The flaky nano-hydroxyapatite prepared by the method is applicable to dentin and enamel biomimetic materials. The whole preparation process is simple, the adopted agents are safe and non-toxic, and the biocompatibility is good.

The invention discloses a material adhesion / desorption performance testing system based on gecko bionic legs and a self-regulation method, and belongs to the field of bionic material adhesion performance testing. The system includes a fixed support frame, the gecko bionic legs, a force sensor system and a data acquisition and motion control system. The material adhesion / desorption performance testing system can be applied to biomimetic material adhesion / desorption performance testing and can obtain an expected adhesion / desorption track of the gecko bionic legs, so that three-dimensional obstacle-free movement of a gecko-imitated robot can be achieved.

The invention relates to a biomimetic material technology, and in particular relates to a carbon nanotube-based biomimetic material with a micro-nano branch structure and a preparation method for the same. The material comprises a carbon nanotube array formed by combining carbon nanotubes with a high-molecular material, wherein the top end of the array is the nanoscale carbon nanotubes, the root of the array is the carbon nanotubes surrounded by the high-molecular material, a microscale composite structure formed by the interpenetration of the high-molecular material and the carbon nanotubes is arranged between the root and the top end, and the diameter of the microscale composite structure is gradually reduced to nanoscale from microscale; and the high-molecular material is a high-molecular polymer with a thermocuring characteristic or a photocuring characteristic. The preparation method comprises the following steps of preparing a carbon nanotube array on a monocrystal Si substrate, then covering a high-molecular material liquid on the top end of the carbon nanotube array, and then completely curing the high-molecular material by virtue of heating or illumination; and finally removing the high-molecular material to obtain the carbon nanotube-based biomimetic material with the micro-nano branch structure. The material is capable of effectively overcoming a structural damage problem caused by the bending deformation of the carbon nanotubes during an adhesion process.

The present invention relates to the production of cell cultures and tissues from undifferentiated pluripotent stem cells using three-dimensional biomimetic materials. The resultant cell cultures or tissues can be used in any of a number of protocols including testing chemicals, compounds, and drugs. Further, the methods and compositions of the present invention further provide viable cell sources and novel cell delivery platforms that allow for replacement of diseased tissue and engraftment of new cardiomyocytes from a readily available in vitro source. The present invention includes novel methods required for the successful production of cell cultures and tissues, systems and components used for the same, and methods of using the resultant cell and tissue compositions.

The invention discloses an infrared stealth biomimetic material and a preparation method thereof. The infrared stealth biomimetic material has a three-layer composite structure, namely a porous air-permeable surface layer, a water-absorbing / water-retaining and moisture transmission intermediate layer and a waterproof base layer. The preparation method comprises the following steps: firstly commonly foaming polyisocyanate emulsion, polyurethane emulsion, super absorbent and retention resin, fibers, a hygroscopic agent, a hydrophilic agent and auxiliaries on the waterproof base layer to generate the water-absorbing / water-retaining and moisture transmission layer; then combining solvent polyurethane slurry with a pore-foaming agent, soft segment and hard segment materials to form the porous air-permeable layer emulsion, and spraying to the intermediate layer at high pressure to form the porous air-permeable surface layer; and drying and curing to obtain the infrared stealth biomimetic material. The infrared stealth biominmetic material has a great number of micron-scale micropores which are communicated one another, and has good mechanical performance, reasonable porosity, bidirectional heat and moisture migration characteristic and surface automatic temperature adjustment characteristic.

The invention discloses a fluorescent polymeric vesicle assembled by program control. A dynamic micelle is constructed by taking choline co-diyne and polyethylene glycol co-diyne as starting raw materials, then butyrycholine and choline co-diyne are subjected to an enzyme reaction, and a co-diyne acid generated by the enzyme reaction and polyethylene glycol co-diyne can form dynamic vesicles; and the dynamic vesicles are polymerized under the condition of 254 nm illumination so as to generate blue crosslinked vesicles, and then the blue crosslinked vesicles are heated for 15 minutes at a temperature of 37 DEG C, so that red polymer fluorescent vesicles can be obtained. The vesicle disclosed by the invention has the advantages that the constructing idea of the fluorescent polymeric vesicle assembled by program control and the concept of logic gates are different in approach but equally satisfactory in result, the concept of logic gates is widely used in the sensing field, but rarely seen in the field of the construction of self-assembled materials, and the assembling process in life entities is always implemented under the combined action of multiple external stimuli, therefore, the fluorescent polymeric vesicle assembled by program control has a great application value in the field of biomimetic material construction.

The invention discloses a preparation method of a biomimetic material, in particular relates to a method for preparing the composition material of poly-aspartic acid or the derivatives, chitosan, lecithin and calcium-phosphate compound. The method first compounds poly-aspartic acid or the derivatives with different side chains, and then makes the poly-aspartic acid or the derivatives with different side chains, chitosan, lecithin, calciferous solution and crosslinking agent mix, react and settle down under a certain temperature and pH value. The obtained product has the properties of biomimetic membrane materials and is an environment-friendly biomimetic material. The material has the function of absorbing heavy metals and some organics, can be used for removing heavy metals, chlorinated hydrocarbon, organic pigment and dye, and can be widely applied to pharmaceutical industry, food industry, printing and dyeing industry, waste water treatment and other fields.