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Fluorescent polymeric vesicle assembled by program control and preparation method thereof

A vesicle and fluorescence technology, which is applied in the field of program-controlled assembly of fluorescent polymerized vesicles and their preparation, can solve problems such as rare occurrence, and achieve the effect of great application value.

Inactive Publication Date: 2016-03-23
NANKAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The concept of logic gates has been widely used in sensing, but rarely in the field of building self-assembling materials

Method used

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  • Fluorescent polymeric vesicle assembled by program control and preparation method thereof
  • Fluorescent polymeric vesicle assembled by program control and preparation method thereof
  • Fluorescent polymeric vesicle assembled by program control and preparation method thereof

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Embodiment

[0020] Its preparation method steps are as follows:

[0021] 1) Mix choline diyne and polyethylene glycol diyne at a molar ratio of 9:1, add 4-hydroxyethylpiperazineethanesulfonic acid buffer solution with a pH of 7.2 to the above mixture to make the solution The didiyne structural unit concentration is 0.2mM, and the solution is sonicated at 60°C for 30 minutes to obtain a uniform colorless and clear solution, and a dynamic compound co-constructed by choline diyne and polyethylene glycol didiyne is obtained. micellar solution;

[0022] 2) Add 5 U / ml butyrylcholinesterase to the dynamic micelle solution jointly constructed by choline diyne and polyethylene glycol diyne, and incubate at 37°C for 2 days to ensure that the enzyme reaction is complete , and then kept at 4°C for 8-10 hours and then stored for later use;

[0023] 3) Put the above hatched dynamic vesicle solution under the ultraviolet light, and irradiate at room temperature for 5 minutes to obtain the blue polyd...

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PUM

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Abstract

The invention discloses a fluorescent polymeric vesicle assembled by program control. A dynamic micelle is constructed by taking choline co-diyne and polyethylene glycol co-diyne as starting raw materials, then butyrycholine and choline co-diyne are subjected to an enzyme reaction, and a co-diyne acid generated by the enzyme reaction and polyethylene glycol co-diyne can form dynamic vesicles; and the dynamic vesicles are polymerized under the condition of 254 nm illumination so as to generate blue crosslinked vesicles, and then the blue crosslinked vesicles are heated for 15 minutes at a temperature of 37 DEG C, so that red polymer fluorescent vesicles can be obtained. The vesicle disclosed by the invention has the advantages that the constructing idea of the fluorescent polymeric vesicle assembled by program control and the concept of logic gates are different in approach but equally satisfactory in result, the concept of logic gates is widely used in the sensing field, but rarely seen in the field of the construction of self-assembled materials, and the assembling process in life entities is always implemented under the combined action of multiple external stimuli, therefore, the fluorescent polymeric vesicle assembled by program control has a great application value in the field of biomimetic material construction.

Description

technical field [0001] The invention belongs to the technical field of nano supramolecular materials, in particular to a program-controlled assembled fluorescent polymeric vesicle and a preparation method thereof. Background technique [0002] Controlled self-assembly is a common phenomenon in living organisms, and it is a necessary process for living organisms to construct advanced functional modules. 【1) G.M.Whitesides, J.P.MathiasandC.T.Seto, Science, 1991, 254, 1312-1319; 2) R.M.Capito, H.S.Azevedo, Y.S.Velichko, A.MataandS.I.Stupp, Science, 2008, 319, 1812- 1816.] In the past ten years, inspired by the complex self-assembly process of proteins and DNA in organisms, scientists have conducted in-depth research on the stimulus-responsive self-assembly process in the laboratory. 【1) E. Gazit, Nat. Chem., 2010, 2, 1010-1011; 2) E. Mattia and S. Otto, Nat. Nanotechnol., 2015, 10, 111-119; 3) J.F. Stoddart, Nat. Chem., 2009 , 1, 14-15; 4) J.M.Lehn, Proc. Natl. Acad. Sci. U.S...

Claims

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Application Information

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IPC IPC(8): C08J3/28C08J3/24C08J3/00C08L71/02
CPCC08J3/00C08J3/24C08J3/28C08J2371/02
Inventor 郭东升彭姝潘雨辰
Owner NANKAI UNIV
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