The invention discloses a method for manufacturing a medium-strength aluminum alloy wire with the electric conductivity of 59 percent (International Annealed Copper Standard, IACS), and relates to a method for manufacturing a medium-strength aluminum alloy wire with high conductivity. The method is characterized by comprising the following steps of: (1) selecting an aluminum matrix and an aluminum intermediate alloy ingot; (2) performing on-the-spot sample analysis and adjustment, namely putting the selected aluminum ingot into a shaft furnace, melting to form molten aluminum, and refining by using a refining agent; (3) casting and crystallizing, namely allowing molten aluminum alloy in a kettle furnace to pass through a runner and filtering by using a ceramic filtering plate, adding rare earth to ensure that the content of the rare earth is 0.05 to 0.15 percent, feeding into an aluminum alloy continuous casting machine, performing continuous casting to form an aluminum alloy cast ingot, and rolling a medium-strength alloy rod by using an aluminum alloy continuous mill; (4) performing solid solution treatment and quenching, namely performing thermal homogenization treatment on the aluminum alloy rod; and (5) drawing, aging and twisting, namely drawing the aluminum alloy rod treated in the previous working procedure into an aluminum alloy wire with the required diameter on an aluminum alloy wire drawing machine, and twisting on a frame type wire twisting machine to obtain the medium-strength aluminum alloy wire with the electric conductivity of 59 percent IACS.