The invention discloses a production method of novel super-comfortable moisture-absorption strong-toughness blended yarns of mucilage glue and polyethylene fibers with high molecular weight. The production method comprises the following technical steps: firstly, preprocessing polyethylene fibers with ultra-high molecular weight, namely pre-adding an antistatic agent of silicone oil; matching with different fiber proportions according to requirements for the degree of comfort and toughness; sequentially performing blowing-carding, breaker-drawing, secondary drawing, coarse spinning, fine spinning and automatic spooling so as to prepare the novel super-comfortable moisture-absorption strong-toughness yarns. Compared with the prior art, the novel super-comfortable moisture-absorption strong-toughness blended yarns of mucilage glue and polyethylene fibers with high molecular weight, which are prepared according to the production method disclosed by the invention, have the advantages that the mucilage glue has the properties of softness, moisture absorption and light weight, which are superior to natural cotton fibers, and the polyethylene fibers with high molecular weight have the properties of wear resistance, high strength, corrosion resistance, and the like, which are superior to cotton fibers. The cost of overall raw materials and the processing cost of the blended yarns of two kinds of fibers are lower than those of conventional yarns, so that the prepared blended yarns can be used in the civilian field completely instead of conventional fabrics of cotton yarns.