Degradable high polymer material with patterned surface as well as preparation method and application thereof

A patterned surface and polymer material technology, applied in the field of degradable polymer materials and their preparation, can solve the problems of insufficient research on the degradation of biomaterials, and achieve strong controllability, good biocompatibility, and strong operability Effect

Inactive Publication Date: 2018-09-04
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there have been many studies on the law of material degradation, but the research on how the degradation of biomaterials simulates the dynamic changes of the environment and affects the behavior of large and small units in the organism, such as the adhesion and differentiation of stem cells, is far from enough.

Method used

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  • Degradable high polymer material with patterned surface as well as preparation method and application thereof
  • Degradable high polymer material with patterned surface as well as preparation method and application thereof
  • Degradable high polymer material with patterned surface as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Natural polymer derivative monomer synthesis

[0041] Take 50 g of hyaluronic acid (HA) with a molecular weight of 50 kDa and dissolve it in Milli-Q to prepare a 1 wt% solution, adjust the pH of the solution to 8 with 1 M sodium hydroxide solution, and add 50% to the solution system in a dropwise manner. equivalent of methacrylic anhydride, the system was reacted in an ice bath for 24 hours. After the reaction, use a dialysis membrane with a molecular weight cut-off of 5-8 kDa for dialysis. During the first 12 hours, the water is changed every hour, and the replacement time of the dialysis solution can be appropriately extended to 2 to 3 hours. The total dialysis time is 48 hours. Hour. After dialysis, the water was removed with a freeze dryer, and white powdery solid MeHA was taken out after 48 hours, and sealed and stored in a -20°C refrigerator.

Embodiment 2

[0043] Weigh the polyethylene glycol with dihydroxy ( M n = 2000) 50g (25 mmol), transferred into a three-necked reaction flask. The system was sealed, protected by argon gas, connected to a water-cooled pump for heat dissipation; the system was heated to 120 °C, and stirring was started at the same time, and vacuumed for 3 h to remove water. After the water removal was completed, the system was cooled to 80 °C, the argon ventilation was increased, and 14.4 g (100 mmol) of racemic lactide (DL-LA) and octanoic acid with a reactant ratio of 0.1 wt% were sequentially added to the three-necked flask. The stannous catalyst was used, and the system was heated to 140°C for the reaction. After 12 h of reaction, the reaction system was lowered to 120 °C, vacuumed for 2-3 h, and then the system was lowered to room temperature. Dilute the reaction product liquid with an appropriate amount of chloroform, and slowly transfer it into 1:10 volume ratio of glacial ether for sedimentation u...

Embodiment 3

[0045] Weigh the polyethylene glycol with dihydroxy ( M n = 2000) 50g (25 mmol), transferred into a three-necked reaction flask. The system was sealed, protected by argon gas, connected to a water-cooled pump for heat dissipation; the system was heated to 120 °C, and stirring was started at the same time, and vacuumed for 3 h to remove water. After the water removal was completed, the temperature of the system was lowered to 80 °C, the argon ventilation was increased, and 20.4 g (200 mmol) of trimethylene carbonate and a stannous octoate catalyst with a reactant ratio of 0.1 wt% were added to the three-necked flask in turn. The temperature of the system was raised to 140°C to carry out the reaction. After 12 h of reaction, the reaction system was lowered to 120 °C, vacuumed for 2-3 h, and then the system was lowered to room temperature. Dilute the reaction product liquid with an appropriate amount of chloroform, and slowly transfer it into 1:10 volume ratio of glacial ether...

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Abstract

The invention belongs to the technical field of biological materials, and particularly relates to a degradable high polymer material with a patterned surface as well as a preparation method and application thereof. According to the degradable high polymer material, biodegradable hydrogel is used as a matrix, and the surface of the matrix is modified with a pattern composed of active substances; the patterned surface means that the matrix material surface is modified to form a pattern array. The patterned shape constructed on the hydrogel surface is stable in structure, and compositions can beindependent from the matrix material component. The obtained material has good biocompatibility and controllable degradability, and the patterned shape can be used for further modifying sites which have the responsiveness and biological activity; by introducing the dynamic degradability, the material has functions which confirm to the real physiological environment more; the material can be applied to the fields of stem cell culture, tissue engineering, biological diagnosis, biological recognition, biomimetic material design and the like.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and particularly relates to a degradable polymer material and a preparation method and application thereof. Background technique [0002] The degradability of biomaterials is an extremely important property to consider when designing new biomedical materials. Biomaterials should meet the requirements of modulus and strength required for tissue repair and replacement in the early stage after implantation; once degraded, many properties of the material are involved, such as modulus and strength decrease, mass loss, chemical composition changes, etc. At present, there have been many studies on the laws of material degradation, but the research on how the degradation of biomaterials simulates the dynamic changes of the environment and affects the behavior of large and small units in organisms, such as the adhesion and differentiation of stem cells, is far from enough. The in-depth deve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08J3/075C08G63/664C08G63/91C08G64/18C08G64/42C08L69/00C08L67/04
CPCC08G63/664C08G63/912C08G64/183C08G64/42C08J3/075C08J7/12C08J2367/04C08J2369/00
Inventor 丁建东彭媛梦
Owner FUDAN UNIV
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