929results about How to "Reduce dwell time" patented technology

The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.

Provided herein is a conditioning apparatus that includes a geometrical configuration having an inlet flow deceleration conduit and a cyclonic tube to effectuate both liquid-gas separation and droplet coalescence. The apparatus is typically positioned at the inlet of a separator vessel used for removing water and gas from extracted crude oil containing entrained water and gas. The apparatus promotes droplet coalescence and gas separation for mixed fluids flowing into an existing water and oil separation device.

A method includes determining an operational parameter of a first vehicle traveling with a plurality of vehicles in a transportation network and / or a route in the transportation network, identifying a failure condition of the first vehicle and / or the route based on the operational parameter, obtaining plural different sets of remedial actions that dictate operations to be taken based on the operational parameter, simulating travel of the plurality of vehicles in the transportation network based on implementation of the different sets of remedial actions, determining potential consequences on travel of the plurality of vehicles in the transportation network when the different sets of remedial actions are implemented in the travel that is simulated, and based on the potential consequences, receiving a selection of at least one of the different sets of remedial actions to be implemented in actual travel of the plurality of vehicles in the transportation network.

Disclosed herein are navigational systems for automated robotic floor cleaners. RFID passive tags are positioned at specified areas of a floor to be treated so as to increase or decrease dwell time of the cleaning device adjacent the tags. An RFID interrogator on the robot learns from each tag its nature, and based thereon instructs the device to change the dwell time over specified areas. This permits areas of a carpet or other surface requiring extra or less treatment to be cleaned in an optimal manner.

The present invention concerns a process and an apparatus for thermal conversion of biomass and organic wastes. According to the invention, the feedstock is fed into a fluidized-bed reactor, wherein the feed is converted at an elevated temperature under the influence of particulate matter kept in a fluidized state by a fluidizing gas, the particulate matter is transferred from the reactor to a regenerator for regeneration and then recirculated to the reactor after the regeneration, and the converted hydrocarbon products are recovered from the reactor. Both the reactor and the regenerator comprise risers having an axially annular cross section and being equipped with multi-inlet cyclones for the separation of particulate matter. By means of the invention, it is possible to producer pyrolysis oil, the quality of which is higher than that of oil produced with the processes of the prior art. The incorporation of multi-inlet cyclones into the reactor configuration reduces gas velocities, reduces the physical size of the cyclone and shortens the residence time of gases in the cyclone.

A plasma reactor for processing a workpiece includes a chamber adapted to accept processing gases in an evacuated environment including a workpiece support, a hollow conduit defining a wall of the chamber, and having respective ends opening adjacent opposite sides of the workpiece support, and a chamber wall portion in facing relationship to the workpiece support and defining a workpiece processing zone therebetween, the processing zone and the interior of the conduit forming a torroidal interior path, and an RF energy applicator irradiating gas within the chamber to maintain a plasma within the torroidal interior path.

The instant invention is based, at least in part on the finding that binding molecules which bind to different epitopes within IGF-1R result in improved IGF-1 and / or IGF-2 blocking capabilities when compared to binding molecules that bind to a single IGF-1R epitope. The instant invention provides compositions that bind to multiple epitopes of IGF-1R, for example, combinations of monospecific binding molecules or multispecific binding molecules (e.g., bispecific molecules). Methods of making the subject binding molecules and methods of using the binding molecules of the invention to antagonize IGF-1R signaling are also provided.

A surgical device for localized delivery of beta radiation in surgical procedures, particularly ophthalmic procedures. Preferred surgical devices include a cannula with a beta radiotherapy emitting material at the distal end of the cannula. The surgical device is particularly suitable for use in the treatment of treat Age Related Macular Degeneration (AMD).

A system includes a first controller, a data acquisition device, a friction modification unit, and a friction management controller. The first controller is configured to obtain an operational setting for a vehicle, and to output a first signal relating to the operational setting for controlling the vehicle. The data acquisition device is configured to obtain operational data of the vehicle as the vehicle travels, and to provide the operational data to the first controller. The first controller is configured to obtain a difference between the operational data and the operational setting, and to adjust the first signal based on the difference. The friction modification unit is configured to modify a friction characteristic of a surface of the route. The friction management controller is configured to direct the friction modification unit to modify the friction characteristic of the surface of the route based on the operational setting.

A method and apparatus for upgrading a petroleum feedstock with supercritical water are provided. The method includes the steps of: (1) heating and pressurizing a petroleum feedstock; (2) heating and pressurizing a water feed to above the supercritical point of water; (3) combining the heated and pressurized petroleum feedstock and the heated and pressurized water feed to produce a combined feed; (4) supplying the combined feed to a hydrothermal reactor to produce a first product stream; (5) supplying the first product stream to a post-treatment process unit to produce a second product stream; and (6) separating the second product stream into a treated and upgraded petroleum stream and a water stream.

Process for the purification of toluenediisocyanate from a crude distillation feed comprising toluenediisocyanate, an organic solvent and less than 2% by weight phosgene by separating the crude distillation feed in a dividing-wall distillation column into at least four product fractions P1-P4. P1 is a phosgene enriched low-boiler product, P2 is a solvent-enriched product, P3 is a high boiler enriched bottoms and P4 is a toluenediisocyanate product stream.

A plasma reactor for processing a workpiece, including an enclosure defining a vacuum chamber, a workpiece support within the enclosure facing an overlying portion of the enclosure, the enclosure having at least first and second pairs of openings therethrough near generally opposite sides of the workpiece support. At least first and second hollow conduits are connected to respective pairs of the openings to provide at least first and second closed torroidal paths through the respective conduits and extending between respective pairs of the openings across the wafer surface. A process gas supply is coupled to the interior of the chamber for supplying process gas to the torroidal paths. Coil antennas are coupled to RF power sources and inductively coupled to the interior of the hollow conduits and capable of maintaining a plasma in the torroidal paths.

The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.

The present invention provides media for inactivating pathogens found within protein-containing biological fluids. The media of the present invention preserve the structural integrity and biological activity of labile proteins while simultaneously exhibiting potent disinfectant activity. The media of the present invention comprise iodinated chromatographic media, particularly ion exchange media. The invention further provides methods for disinfecting biological fluids.

A plasma chamber defining an evacuated interior environment for processing a substrate includes a substrate support, an apertured gas distribution plate in spaced facing relationship to the substrate support, and adapted to flow process gases into the chamber interior environment adjacent the substrate support, the gas distribution plate and substrate support defining a substrate processing region therebetween, a hollow reentrant conduit having respective ends opening into the substrate processing region on opposite sides of the gas distribution plate, with the interior of said conduit sharing the interior environment. The conduit is adapted to accept irradiation of processing gases within the conduit to sustain a plasma in a path extending around the conduit interior and across the substrate processing region within the chamber interior environment.

A petroleum feedstock upgrading method is provided. The method includes supplying a mixed stream that includes hydrocarbon feedstock and water to a hydrothermal reactor where the mixed stream is maintained at a temperature and pressure greater than the critical temperatures and pressure of water in the absence of catalyst for a residence time sufficient to convert the mixed stream into a modified stream having an increased concentration of lighter hydrocarbons and / or concentration of sulfur containing compounds. The modified stream is then supplied to an adsorptive reaction stage charged with a solid adsorbent operable to remove at least a portion of the sulfur present to produce a trimmed. The trimmed stream is then separated into a gas and a liquid streams, and the liquid stream is separated into a water stream and an upgraded hydrocarbon product stream.

One exemplary embodiment can be a fluid catalytic cracking system. The system can include a reaction zone operating at conditions to facilitate olefin production and including at least one riser. The at least one riser can receive a first feed having a boiling point of about 180-about 800° C., and a second feed having more than about 70%, by weight, of one or more C4+ olefins.

The invention discloses a pure electric vehicle hill-start assist control method. When in an uphill assist mode, whether a motor rotates reversely or not is detected, a vehicle slips reversely if the motor rotates reversely, needed additional anti-slip torque of the motor is calculated according to the reverse rotation speed and the accelerated speed of the motor, and the torque of the motor is increased until the motor no longer rotates reversely. When in a flat road assist mode, slip judgment is not performed. When in a downhill assist mode, the highest stable speed of downhill start is set according to a ramp angle, driving force generated by a ramp is calculated according to a vehicle weight sensor, needed parking torque is calculated, and a brake pedal opening value K corresponding to the parking torque is calculated. When the opening of a brake pedal is smaller than K, the start process is divided into a non-accelerator start mode and an accelerator start mode by judging acceleration pedal signals, and different start assist control is performed. Based on multi-sensor information fusion technology, the pure electric vehicle can stably, rapidly and safely start on the ramp by the aid of reasonable pure electric vehicle hill-start assist control strategies.

In a process for the thermal cracking of hydrocarbons in the presence of steam, the charge mixture is passed through externally heated tubes with helical inner fins, and to make the temperature in the tube wall and over the tube cross section more uniform, as well as to reduce the deposition of pyrolysis coke on the tube inner wall, a swirling flow is generated in the gas mixture and is gradually merged into a core zone with a predominantly axial flow at increasing radial distance from the fins.

A reactor comprises a reaction zone, optionally containing a catalyst bed, and heat exchange means inoperative contact with the reaction zone, e.g. embedded in a catalyst bed, and arranged so as to received reactants for heat exchange purposes, wherein the heat exchange means is formed from a plurality of superposed metal plates wherein fluid flow channels have been formed, according t a pre-determined pattern, the channel-bearing plates being aligned during superposition to define discrete heat exchange pathways respectively for reactant and working fluids, and the said plates are diffusion bonded together.

A gas turbine engine that includes: a combustor coupled to a turbine and a downstream injection system that includes two injection stages, a first stage and a second stage, positioned within an interior flowpath, wherein the first stage comprises an axial position that is aft of the primary air and fuel injection system and the second stage comprising an axial position that is aft of the first stage. Each of the first stage and the second stage include a plurality of circumferentially spaced injectors, each injector of which is configured to inject air and fuel into a flow through the interior flowpath. The first stage and the second stage have a configuration that limits a fuel injected at the second stage to less than 50% of a fuel injected at the first stage.

The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-1) and insulin like growth factor 2 (IGF-2) to bind to IGF-1R, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.

The present invention relates to a system and methodology for extending and making more appropriate the interactive decisions made by automated services by taking into consideration estimates of the time required by users for the cognitive processing of problems, visualizations, and content based on several factors, including the competency and familiarity of the user with the output and nature of the sequences of output, the complexity of the output and overall tasks being considered, and the context of the user. The methods allow automated applications to control the rate at which the applications interact with users. Portions of automated services are controlled in view of limited human processor capabilities in design / operation of such services, and / or visualizations / output from the services (e.g., amount of dwell time provided / considered before a next automated sequence is displayed / invoked). Models can be formulated and utilized in conjunction with automated services such as automatically determining and pausing a period of time before a next sequence in a service is enabled or disabled. The models can also be employed to determine multiple dwells for comprehension, as a function of complexity of graphical / conceptual relationships, at different phases of an animation.

Methods and systems are provided for operating an engine in a hybrid vehicle in response to fuel and water dilution of engine lubricating oil. An engine oil dilution counter may be adjusted based on a number of engine hot starts and duration of engine operation above a threshold temperature. In addition, the counter may be adjusted if the engine is started to deplete stale fuel in the fuel tank.

The instant invention describes novel multispecific binding molecules comprising synthetic connecting peptides. The synthetic connecting peptides result in the preferential synthesis of multispecific binding molecules comprising polypeptide chains that are linked via at least one interchain disulfide linkage. In addition, the invention pertains to compositions in which a majority of the multispecific binding molecules comprising polypeptide chain that are linked via at least one interchain disulfide linkage or are not linked via at least one intrachain disulfide linkage. In a specific embodiment, the invention pertains to compositions comprising multispecific dimeric binding molecules said molecules comprising at least a first binding site specific for a tumor necrosis factor (TNF) receptor or a ligand of a TNF receptor family member and at least a second binding site; and at least two polypeptide chains comprising at least one heavy chain portion and a synthetic connecting peptide; wherein greater than about 50% of the dimers comprise polypeptide chains that are linked via at least one interchain disulfide linkage.

A radio frequency signal acquisition and source location system, including a first signal acquisition and source location module comprising an RF transceiver coupled to an antenna, the antenna provided with a electronic steering circuit. The antenna operative to launch an interrogation signal, the interrogation signal steerable by an electronic steering circuit. A processor operatively coupled to the RF transceiver and the electronic steering circuit, the processor provided with a data storage for storing a signal data record for each of at least one response signal(s) received by the RF transceiver(s). The signal data record including a signal identification, a received signal strength indicator and an RF signal direction along which respective signal(s) are received by the antenna, the RF signal direction derived from the electronic steering circuit. A position logic operative upon the data record(s) deriving a three dimensional signal origin location of each response signal.