4 results about "Disulfide Linkage" patented technology

This invention relates to the field of adhesive technology, and discloses an environmentally friendly biomass-based underwater adhesive, its preparation method, and its applications. The adhesive is prepared by one-step melt copolymerization of three biomass raw materials: lipoic acid, caffeic acid, and cysteine. This system utilizes the ring-opening polymerization of lipoic acid to form a dynamic disulfide bond network providing cohesive force, the catechol groups of caffeic acid to provide various interfacial interactions with the substrate, and the thiol groups of cysteine ​​to simultaneously participate in network construction and inhibit catechol oxidation, thereby synergistically achieving high-strength and durable underwater adhesion. The adhesive achieves an underwater adhesion strength of up to 5.5 MPa on iron sheets, remains stable in various acid, alkali, and salt environments, and can be repeatedly recycled through hot melting. This invention uses entirely bio-based raw materials, employs a simple and non-toxic process, and is suitable for underwater remediation, marine engineering, and other fields.

The invention relates to the technical field of polymer materials, and discloses a thermal response welding type epoxy glass polymer and a green preparation method thereof, the polymer is formed by covalent cross-linking polymerization of liquid epoxy resin and a reaction type eutectic precursor; the reaction type eutectic precursor is formed by combining 4, 4 '-dithiodiphenylamine and a phenolic hydroxyl group-containing hydrogen bond donor with catalytic activity, and the molar ratio of the total equivalent of reactive hydrogen provided by the precursor to an epoxy group of the liquid epoxy resin is (0.9-1.1): 1; the preparation method comprises the following steps: carrying out solvent-free in-situ homogeneous blending and vacuum defoaming on a reaction type eutectic precursor and liquid epoxy resin, pouring into a mold, and carrying out non-isothermal programmed thermocuring and cooling demolding. Through solvent-free in-situ copolymerization, the pore defect generated by conventional solvent volatilization is avoided, and a dynamic reversible cross-linked network formed by disulfide bonds is introduced into a polymer skeleton, so that the material is endowed with phase state uniformity and thermal response welding recovery capability at high temperature.

Provided herein are, inter alia, polypeptides and covalent complexes including the same, with multivalent binding specificity. The polypeptides include an Fc receptor portion / domain (e.g., a CD16 domain, a CD32 domain, a CD64 domain and variants thereof) with a cysteine amino acid substitution capapble of forming a disulfide linkeage with a second cysteine amino acid substitution in an Fc domain (e.g., an Fc domain of IgG1, IgG2, IgG3, IgG4) thereby forming a covalent complex with multivalent binding ability. The compositions provided herein exhibit highly specific binding with reduced or no endogenous Fc receptor binding activity thereby resulting in therapeutics that lack undesirable side effects.

The invention discloses a chimeric antigen receptor targeting HER2 (human epidermal growth factor receptor 2) and application of the chimeric antigen receptor. Wherein the chimeric antigen receptor comprises: an extracellular region, the extracellular region comprises one or more antigen recognition sequences, the antigen recognition sequence is a disulfide-bond-rich polycyclic peptide (DDMP), the chimeric antigen receptor comprises one or more than one polycyclic peptide, the one or more than one polycyclic peptide is one or more than one polycyclic peptide, the one or more than one polycyclic peptide is one or more than one polycyclic peptide, the one or more than one polycyclic peptide is one or more than one polycyclic peptide, and the one or more than one polycyclic peptide is one or more than one polycyclic peptide. The N end of the transmembrane region is connected with the C end of the extracellular region; the N end of the intracellular region is connected with the C end of the transmembrane region; or the HER2-targeting chimeric antigen receptor comprises: an extracellular region, wherein the extracellular region comprises one or more antigen recognition sequences and linkers; the N end of the transmembrane region is connected with the C end of the extracellular region; and the N end of the intracellular region is connected with the C end of the transmembrane region. According to the technical scheme, the chimeric antigen receptor which is excellent in anti-tumor effect and small in toxicity is provided.