9 results about "Disulfide Linkage" patented technology

A non-ASTM low hysteresis carbon black chemically treated, and surface coated with a compound comprising at least one amine group and at least one thiol group, and / or di- and / or polysulfidic linkage is herein disclosed. The surface modified low hysteresis carbon blacks are post treated to remove excess surface modified compound to form refined surface modified low hysteresis carbon blacks.

This invention relates to the field of adhesive technology, and discloses an environmentally friendly biomass-based underwater adhesive, its preparation method, and its applications. The adhesive is prepared by one-step melt copolymerization of three biomass raw materials: lipoic acid, caffeic acid, and cysteine. This system utilizes the ring-opening polymerization of lipoic acid to form a dynamic disulfide bond network providing cohesive force, the catechol groups of caffeic acid to provide various interfacial interactions with the substrate, and the thiol groups of cysteine ​​to simultaneously participate in network construction and inhibit catechol oxidation, thereby synergistically achieving high-strength and durable underwater adhesion. The adhesive achieves an underwater adhesion strength of up to 5.5 MPa on iron sheets, remains stable in various acid, alkali, and salt environments, and can be repeatedly recycled through hot melting. This invention uses entirely bio-based raw materials, employs a simple and non-toxic process, and is suitable for underwater remediation, marine engineering, and other fields.

The invention discloses pole piece slurry for a positive electrode of a lithium ion battery and a preparation method of the pole piece slurry, the pole piece slurry comprises the following raw materials in parts by weight: 90-95 parts of lithium iron phosphate, 2-5 parts of a modified binder, 0.5-1 part of carbon black, 1-1.5 parts of carbon nanotubes and 3-5 parts of deionized water, and the pole piece slurry uses the deionized water to replace an organic solvent. A toxic organic solvent needed by a traditional oily binder is avoided, pollution to the environment is reduced, the modified binder is prepared from a modified cross-linking agent containing disulfide bonds and a pretreatment binder containing furan groups, then a dynamic cross-linked structure is formed, in the charging and discharging process, the positive electrode material is subjected to volume expansion, and therefore the positive electrode material can be charged and discharged, and the service life of the positive electrode material is prolonged. The dynamic crosslinking of the adhesive can buffer stress, ensure the integrity of a pole piece and avoid the falling of active substances, and the molecular chain contains an organic silicon chain segment, so that the high-temperature-resistant effect of the modified adhesive can be improved, the degradation of the modified adhesive at high temperature is inhibited, and the service life of the battery is further prolonged.

This disclosure provides, among other things, a transgenic chicken. In some embodiments, the transgenic chicken comprises B cells in which the endogenous immunoglobulin heavy chain locus comprises: (a) a functional immunoglobulin heavy chain gene comprising a nucleic acid encoding a heavy chain variable domain in which the CDR3 is in the range of 30-60 amino acids in length and comprises at least 2 cysteine residues; and (b) a plurality of pseudogenes that are operably linked to said functional immunoglobulin heavy chain gene and that donate, by gene conversion, nucleotide sequence to the nucleic acid encoding the heavy chain variable domain of (a), wherein the pseudogenes are upstream or downstream of the functional immunoglobulin heavy chain gene.

The invention relates to the technical field of polymer materials, and discloses a thermal response welding type epoxy glass polymer and a green preparation method thereof, the polymer is formed by covalent cross-linking polymerization of liquid epoxy resin and a reaction type eutectic precursor; the reaction type eutectic precursor is formed by combining 4, 4 '-dithiodiphenylamine and a phenolic hydroxyl group-containing hydrogen bond donor with catalytic activity, and the molar ratio of the total equivalent of reactive hydrogen provided by the precursor to an epoxy group of the liquid epoxy resin is (0.9-1.1): 1; the preparation method comprises the following steps: carrying out solvent-free in-situ homogeneous blending and vacuum defoaming on a reaction type eutectic precursor and liquid epoxy resin, pouring into a mold, and carrying out non-isothermal programmed thermocuring and cooling demolding. Through solvent-free in-situ copolymerization, the pore defect generated by conventional solvent volatilization is avoided, and a dynamic reversible cross-linked network formed by disulfide bonds is introduced into a polymer skeleton, so that the material is endowed with phase state uniformity and thermal response welding recovery capability at high temperature.

Provided herein are, inter alia, polypeptides and covalent complexes including the same, with multivalent binding specificity. The polypeptides include an Fc receptor portion / domain (e.g., a CD16 domain, a CD32 domain, a CD64 domain and variants thereof) with a cysteine amino acid substitution capapble of forming a disulfide linkeage with a second cysteine amino acid substitution in an Fc domain (e.g., an Fc domain of IgG1, IgG2, IgG3, IgG4) thereby forming a covalent complex with multivalent binding ability. The compositions provided herein exhibit highly specific binding with reduced or no endogenous Fc receptor binding activity thereby resulting in therapeutics that lack undesirable side effects.

The present invention provides a subtractive-additive bioenzyme anti-felting finishing method for wool, which belongs to the technical field of textile dyeing and finishing. The method comprises the following steps: dissolving keratinase and sodium 2-cyclohexylaminoethanesulfonate in water, immersing the wool fiber product in the anti-felting treatment, and obtaining a subtractive anti-felting wool fiber product; dissolving a disulfide bond-containing phenolic small molecule and horseradish peroxidase in water, immersing the subtractive anti-felting wool fiber product in the anti-felting treatment, and obtaining a polyphenol macromolecule grafted wool fiber product; immersing the polyphenol macromolecule grafted wool fiber product in hot water, washing it with water, and drying it to obtain a subtractive-additive anti-felting wool fiber product. The finishing method of the present invention is ecologically safe, low-carbon, and green, significantly reduces the felting rate of the wool fiber product, has low strength loss on the wool fiber, improves the strength of the wool fiber, and has little effect on the hand feel; the subtractive-additive anti-felting wool fiber product obtained has low felting rate, low strength loss, and no deterioration in the hand feel.

The present invention belongs to the field of drug delivery technology, and specifically relates to a multi-responsive colon inflammation targeting hydrogel microsphere and its preparation method and application. The hydrogel microsphere includes calcium ion cross-linked sodium alginate microspheres and HA-Cys / Cur NPs encapsulated in the calcium ion cross-linked sodium alginate microspheres; method: hyaluronic acid modified with cysteine ethyl ester and curcumin are self-assembled to form nanoparticles, and then HA-Cys / Cur NPs are encapsulated into sodium alginate microspheres by emulsification, and calcium ion cross-linking is performed. The hydrogel microspheres have pH and GSH response characteristics and hyaluronic acid-mediated active targeting capabilities, remain stable in the gastric acid environment, accurately release and target macrophages in the inflammatory site in the colon, and NPs break disulfide bonds and release curcumin in the high GSH environment in the cells, achieving synergistic treatment of anti-inflammatory, anti-oxidation and intestinal mucosal repair, and have good application prospects in the treatment of ulcerative colitis.

The invention discloses a chimeric antigen receptor targeting HER2 (human epidermal growth factor receptor 2) and application of the chimeric antigen receptor. Wherein the chimeric antigen receptor comprises: an extracellular region, the extracellular region comprises one or more antigen recognition sequences, the antigen recognition sequence is a disulfide-bond-rich polycyclic peptide (DDMP), the chimeric antigen receptor comprises one or more than one polycyclic peptide, the one or more than one polycyclic peptide is one or more than one polycyclic peptide, the one or more than one polycyclic peptide is one or more than one polycyclic peptide, the one or more than one polycyclic peptide is one or more than one polycyclic peptide, and the one or more than one polycyclic peptide is one or more than one polycyclic peptide. The N end of the transmembrane region is connected with the C end of the extracellular region; the N end of the intracellular region is connected with the C end of the transmembrane region; or the HER2-targeting chimeric antigen receptor comprises: an extracellular region, wherein the extracellular region comprises one or more antigen recognition sequences and linkers; the N end of the transmembrane region is connected with the C end of the extracellular region; and the N end of the intracellular region is connected with the C end of the transmembrane region. According to the technical scheme, the chimeric antigen receptor which is excellent in anti-tumor effect and small in toxicity is provided.