The invention discloses a universal method for constructing a chiral organic molecular cage, which comprises the following steps: with a 2,6-dicarbonyl-4-substituted phenol structure as a parent nucleus, carrying out aldehyde ligand synthesis by coupling reaction, methoxy protection and deprotection reaction, Duff reaction and the like; and then introducing polyaldehyde synthons with different structures and functions are constructed by introducing rigid functional groups such as various benzene rings, naphthalene and anthracene, and then efficiently constructing the chiral porous molecular cage by the polyaldehyde synthons and chiral cyclohexanediamine under organic/water/acid conditions. The method has the advantages of simple and efficient ligand design, rich chiral molecular cage configuration, easiness in purification, wide ligand application range, easiness in reaction expansion and the like. By utilizing the modular synthesis method, a series of chiral molecular cages with richand adjustable structures can be prepared on a large scale for the fields of adsorption, separation, catalysis, energy and the like.