28 results about "Achirality" patented technology

The invention provides a fullerene pyrrolidine enantiomer mediated cholesteric liquid crystal with circular polarization luminescence property and nonlinear anti-saturated absorption property, and a preparation method and application thereof. The method comprises the following steps: dissolving C60, paraformaldehyde and (R / S)-(+ / -)-alpha-methylbenzylamine in an organic solvent, and carrying out heating reflux reaction to obtain fullerene pyrrolidine enantiomer molecules; dissolving in carbon disulfide to obtain an enantiomer solution; dissolving achiral dye molecules in a solvent to obtain a dye solution; and dropwise adding the enantiomer solution and the dye solution into thermotropic liquid crystal molecules, and drying to obtain the thermotropic liquid crystal. The method is simple, the obtained cholesteric liquid crystal system shows a characteristic fingerprint texture and has a periodic spiral structure, and the doping proportion of chiral molecules is easy to adjust; the composite system has good time stability and is not prone to phase separation; the liquid crystal platform shows good circular polarization luminescence performance and third-order nonlinear optical property, and is a cholesteric liquid crystal platform with an integrated function.

The application provides a 1,5-dicarbonyl compound and a synthesis method and application thereof, wherein the synthesis method of the 1,5-dicarbonyl compound comprises the following steps: under the protection of inert gas, mixing 1,3-dicarbonyl compound and olefin compound in an organic solvent, and under the action of a zirconium-containing catalyst, reacting under the conditions of stirring and light source irradiation to generate the 1,5-dicarbonyl compound. The synthesis method of the 1,5-dicarbonyl compound has the characteristics of mildness, high efficiency and green environmental protection, and can realize catalytic asymmetric process, and the synthesis method is characterized in that under the protection of inert gas, chiral or achiral 1,5-dicarbonyl compound is synthesized by using 1,3-dicarbonyl compound and olefin compound as raw materials, a zirconium-containing catalyst, and the conditions of stirring and light source irradiation. The method can directly react under the condition of inert gas protection and light irradiation, does not need to add an additive, does not generate toxic by-products, and has an atomic economy of 100%.

The application discloses a method for synthesizing chiral 1,3-disubstituted tetrahydroisoquinoline by using a chemical enzyme cascade system and belongs to the technical field of bioengineering. The application establishes a method for preparing chiral 1,3-disubstituted tetrahydroisoquinoline by using an enzyme cascade catalysis. Simple non-chiral ketone is used as a raw material, a transaminase obtained through screening is used to generate a chiral amine, a B-N cyclization reaction is used to obtain a chiral imine, and finally, an imine reductase is used to generate 1,3-disubstituted tetrahydroisoquinoline. The method has a high yield, can be close to 100%, has excellent diastereoselectivity and enantioselectivity, the de value and the ee value are close to 99%, and has good application value and prospect.

Disclosed in the present invention are a chiral azobenzene polymer crosslinked thin film and preparation method therefor and application thereof. The present invention relates to a novel super-molecular chiral construction and chiral immobilization method based on an achiral side chain type azobenzene polymer thin film. According to the present invention, limonene steam is utilized to perform chiral induction on a polymer thin film at a high temperature, and then formaldehyde steam is utilized to perform acetal reaction with hydroxyl in an acidic environment to achieve crosslinking; and then differences in the stability of the super-molecular chirality of the polymer thin film before and after crosslinking is studied under the conditions of light, heat and good solvent dissolution, and the self-repairing properties of microcosmic helical chirality is researched. The crosslinked thin film prepared by the present invention has good chiral properties, and excellent solvent resistance, heat resistance, and self-repairing properties.

The invention relates to an artificial synaptic device based on chiral perovskite and a preparation method thereof. The device sequentially comprises a substrate, a comb-shaped bottom electrode, a chiral perovskite functional layer and a comb-shaped top electrode from bottom to top, wherein the projection direction of the bottom electrode comb teeth and the projection direction of the top electrode comb teeth are crossed at an angle of 90 degrees; the chemical general formula of the chiral perovskite functional layer is A < 1-x > A'x PbX3, A is a chiral organic cation, A 'is an achiral organic cation, and X is one or more of Cl <->, Br <-> and I. The device obtained by the invention can respond to a chiral optical signal and complete processing and storage of chiral information, and has an excellent brain synaptic-like function at the same time.

This invention relates to the field of electrocatalyst technology, and in particular to a chiral CoFe-based oxygen evolution electrocatalyst, its preparation method, and its application. Iron salts, cobalt salts, and chiral tartaric acid are dissolved together in N,N-dimethylformamide solvent to form a homogeneous mixed solution. Hydrazine hydrate is added to the mixed solution and thoroughly mixed. The solution is then transferred to a high-pressure reactor and subjected to a solvothermal reaction at a set temperature to obtain a nanocatalyst precursor. The nanocatalyst precursor is then subjected to centrifugation, washing, drying, and vacuum calcination to obtain the product. This method successfully prepares a chiral CoFe-based nanocatalyst through the inductive effect of chiral tartaric acid, combined with a specific solvothermal reaction and subsequent heat treatment process. This chiral CoFe-based electrocatalyst exhibits significantly enhanced catalytic activity and stability in the oxygen evolution electrocatalytic reaction, demonstrating superior electrochemical performance compared to achiral catalysts.

The invention relates to the technical field of chiral self-assembly materials, and discloses a novel achiral fluorescent material which is characterized in that a D-A type conjugated skeleton is constructed by taking a spirofluorene unit as an electron donor (D) and carborane and triazine as electron acceptors (A); carborane has an AIE effect, triazine is an important six-membered heteroaromatic ring, has three nitrogen atoms, generates three regioisomers, and is widely used for preparing thermal delay fluorescent materials due to good thermal stability, light stability and thermal delay performance; a triazine derivative is used as a hub to be respectively connected with spirofluorene-o-carborane; a three-dimensional space structure of an o-carborane molecule and a rigid structure of a triazine molecule are combined, so that unique photoelectric properties are achieved; the invention provides a basis for the design of the boron cluster material in the aspects of photoelectric application and the like; and a new thought is provided for the research of the light-emitting boron cluster in circularly polarized light emission.

The invention provides a novel chiral phosphine-phosphoramidite ester ligand which is based on an achiral open-chain phenol non-cyclic phosphoramidite ester structural unit and only has skeleton single-center chirality, and a preparation method and application thereof. Different from a traditional chiral phosphine-phosphoramidite ligand, a phosphoramidite structural unit in the novel chiral phosphine-phosphoramidite ligand does not contain a chiral element and is of a non-cyclic open-chain structure. The novel ligand is prepared by taking a chiral phosphine / amine intermediate (R)-or (S)-DPPNHMe, a phenol compound and PC13 as raw materials under a mild condition. The novel chiral phosphine-phosphoramidite ligand provided by the invention has the characteristics of cheap and easily available raw materials, simple synthesis, stable properties, adjustable space structure and electronic properties, excellent activity and enantioselectivity in catalysis of asymmetric hydrogenation reaction, and the like.

The invention relates to a method for synthesizing cyclopentenyl ketone under the catalysis of nickel and aluminum, which comprises the following steps: adding a secondary phosphine oxide ligand PO, a metal catalyst Ni (cod) 2, a solvent, cyclopropyl ketone and alkyne into a reaction container in a nitrogen atmosphere, then adding lewis acid, stirring at a specified reaction temperature, adding an ethylene diamine tetraacetic acid aqueous solution after the reaction is completed, washing, separating liquid, and drying to obtain the cyclopentenyl ketone. And carrying out drying and column chromatography separation on the organic phase to obtain chiral or achiral cyclopentenyl ketone. The method has the advantages of wide substrates, strong tolerance of reaction to functional groups of the substrates, no atom loss, high atom economy and step economy, capability of effectively inhibiting side reactions caused by enolation racemization of ketone and Lewis acid through coordinated regulation and control of the ligand and the solvent, and extremely high reaction efficiency and stereo control capability.

The application discloses a circularly polarized luminescent supramolecular assembly, a polymer film and a preparation method and application thereof. The supramolecular assembly comprises an organic small molecule as a single chiral building block, a zinc salt and an achiral fluorescent dye; the organic small molecule, the zinc salt and the achiral fluorescent dye form the supramolecular assembly with the circularly polarized luminescent property through a supramolecular assembly process. The polymer film comprises the supramolecular assembly and an organic high polymer; the supramolecular assembly is mixed with a mother liquor of the organic high polymer to form a precursor of the polymer film. The single chiral building unit is used as a chiral donor to realize construction of the circularly polarized luminescent material with opposite chirality; the product has the performance of chirality amplification and light stability enhancement; the preparation method is simple and convenient to operate and is suitable for large-scale production.

The application discloses a method for regulating the chirality of helical polymers by using achiral small molecules and application thereof. The method comprises the following steps: dissolving or dispersing helical polymers with dynamic helical conformation in an aqueous medium; adding achiral aromatic small molecules as an additive; adjusting the molar ratio of the additive and the repeating units of the polymer, so that the circular dichroism signal of the polymer changes, and the helical conformation of the main chain of the helical polymer is reversed, enhanced or stabilized. The application can effectively regulate the helical chirality of helical polymers such as dendritic temperature-sensitive polyphenylacetylene in an aqueous phase by using achiral aromatic small molecules without introducing exogenous chiral substances. The chiral optical response can be further synergistically controlled by adjusting conditions such as pH and temperature. The method is simple in operation and mild in conditions, and can be used for preparing stimulus-responsive chiral optical materials, chiral recognition materials, chiral separation materials and biomimetic supramolecular assembly materials.

The invention relates to achiral and chiral aza-biaryl-oxazoline type ligands and a preparation method thereof, and belongs to the technical field of organic chemistry. The preparation method comprises an aromatic cyanidation reaction and a condensation reaction, according to the present invention, the multi-site substituted achiral and chiral aza-biaryl nitrile compound can be efficiently prepared, and the rapid construction of the aza-biaryl-oxazoline type ligand can be further achieved through the one-step reaction. The ligand belongs to a novel pyridine-oxazoline type ligand, the preparation method has the advantages of greenness, environmental protection, high efficiency, rapidness, low cost and the like, and the variety of N, N-bidentate ligand libraries is expanded.

The invention discloses a chiral gold nanorod with a core-shell structure, a preparation method of the chiral gold nanorod and application of the chiral gold nanorod to preparation of drugs, the chiral gold nanorod takes an achiral gold nanorod as a core, takes one or more of 1, 1 '-co-2-naphthylamine, 1, 1'-co-2-naphthol and 2, 2 '-binaphthalene as chiral ligands, and takes one or more of 1, 1'-co-2-naphthylamine, 1, 1 '-co-2-naphthol and 2, 2'-binaphthalene as the core to prepare the chiral gold nanorod with the core-shell structure. And forming chiral micelles with hexadecyl trimethyl ammonium chloride, and inducing secondary growth of gold to synthesize the chiral gold nanorod with a core-shell structure. The chiral gold nanorod is used for preparing a medicine for treating mouse in-situ glioblastoma, and the transfer of glioblastoma cells in the brain can be inhibited by performing tail intravenous injection administration on the chiral gold nanorod, so that diseases are improved.

The invention discloses a circularly polarized light detection method based on an achiral medium micro-nano structure and a photoelectric detector. As an antisymmetric mode and a symmetric mode excited by x polarized light and y polarized light in the micro-nano structure interfere with each other, light intensities of near-field modes excited by left-handed light and right-handed light can be respectively concentrated on two sides of the micro-nano structure. The electrodes are arranged on the two sides of the micro-nano structure, and a chiral dependent near-field mode can be converted into photoelectric signals in different directions by utilizing photoelectric mechanisms such as a photo-thermoelectric effect or a photovoltaic effect, so that circularly polarized light photoelectric detection is realized. The circularly polarized light detection method and the photoelectric detector are high in chiral resolution capability, large in working bandwidth, free of light intensity calibration and independent of specific materials, structures or photoelectric response mechanisms, and can be popularized to photoelectric detectors based on different materials or mechanisms.

The invention belongs to the technical field of organic synthesis, and discloses a synthesis method of a chiral 1, 5-dihydro-3H-pyrano [3, 4, 5-cd] indole derivative. According to the synthesis method, a simple achiral substrate 4-indolyl carbinol and a compound containing an aldehyde group structure serve as raw materials, the chiral 1, 5-dihydro-3H-pyrano [3, 4, 5-cd] indole derivative is synthesized through chiral phosphoric acid catalysis, the synthesis process is simple, efficient and high in enantioselectivity, and the synthesized chiral 1, 5-dihydro-3H-pyrano [3, 4, 5-cd] indole derivative has the advantages of being high in yield and high in yield. The 2, 5-cd] indole derivative disclosed by the invention has relatively high yield and ee (enantiomeric excess) value.

The invention belongs to the technical field of high polymer materials, and discloses a method for regulating and controlling a chiral structure and chiral transfer of a triblock copolymer by a middle block, the chiral triblock copolymer and application. The method comprises the steps that firstly, a chiral triblock copolymer is selected, the structural general formula of the triblock copolymer is PS-b-B-b-PLLA, B is a middle block, and B is selected from one of the following polymer chain segments: PLA, PEO, PCL, P4VP, P4CS and PMMA; then regulating and controlling the self-assembly behavior of the triblock copolymer through B, so that the copolymer is self-assembled to form a chiral structure or an achiral structure; the regulation comprises the steps of 1) determining chi between the middle block B and the PLLA, and 2) determining the chain length of the middle block B. According to the chiral triblock copolymer, chiral transmission of the triblock copolymer is realized, and a chiral spiral phase structure is formed through self-assembly, and the chiral triblock copolymer is used for preparing advanced functional materials such as chiral photonic crystals, circular polarization luminescent materials and chiral separation membranes.

The invention belongs to the technical field of organic synthetic chemistry, and particularly discloses a preparation method of S-4-chloro-3-hydroxybutyronitrile. According to the method, 1, 3-dichloropropanol is used as a raw material and reacts with a chiral catalyst 9-trimethylsilylquinine to generate quaternary ammonium salt, the quaternary ammonium salt and hydrocyanic acid are subjected to a substitution reaction, and then heating is performed to remove the chiral catalyst, so that the S-4-chloro-3-hydroxybutyronitrile is prepared with high yield and high enantioselectivity. The method is simple and convenient to operate, the yield of the product S-4-chloro-3-hydroxybutyronitrile is high, the chiral catalyst is adopted instead of a chiral raw material, the chiral catalyst can be repeatedly used, and the cost is low.

The invention belongs to the technical field of fine chemical engineering, and particularly relates to a method for preparing diphosphine monooxide through selective single reduction of diphosphine dioxide. According to the preparation method, trimethylsilyl trifluoromethanesulfonate (TMSOTf), trimethylchlorosilane (TMSCl) or trifluoroacetic acid is used as a catalyst (TfOH), silane ([Si-H]) is used as a reducing agent, efficient selective single reduction of diphosphine dioxide I is achieved at the temperature of 50-80 DEG C, and BPMOs with potential axial chirality, spiral chirality or planar chirality are generated. The method has the advantages of mild reaction conditions, high selectivity, wide substrate range, no need of metal catalysts and excessive additives and the like, is suitable for synthesizing various chiral or achiral diphosphine monooxygen ligands, and can be used in different types of catalytic reactions, so that the selective reduction method is a diphosphine monooxygen preparation method with practical value.

This invention discloses a method for producing high-purity (1R,2S,5R)-WS-3, comprising the following steps: using a mixture of menthol containing eight stereoisomers or naturally extracted menthol as raw material, and reacting it with diethylamine and phosgene under solvent-free conditions at 55-65°C; using a non-chiral adsorbent to separate six diastereomers of (1R,2S,5R)-WS-3 from the obtained WS-3 mixture, and then using a chiral adsorbent to separate the remaining two enantiomers, thus obtaining high-purity (1R,2S,5R)-WS-3. This invention achieves the production of high optical purity (1R,2S,5R)-WS-3 menthol amide cooling agent under mild operating conditions, and has significant industrial application value for the efficient production and quality upgrading of cooling agents.

This invention belongs to the field of chemical energy storage battery technology, specifically providing a chiral hydrogel electrolyte based on supramolecular assembly and its preparation method, to solve the problems of disordered ion channels and insufficient free water binding in traditional achiral gel electrolytes. This invention introduces a single, pure-configuration chiral guest molecule into an achiral polymer substrate, forming a supramolecular chiral membrane based on stereo-oriented supramolecular assembly. After swelling and saturation in an aqueous electrolyte, a chiral hydrogel electrolyte is obtained. The chiral guest molecule, acting as a topological guest, reshapes the polymer topology network, forming a stereo-oriented network, causing a sudden leap in the gel's energy storage modulus, thus providing resistance to dendrite penetration. Simultaneously, the chiral guest molecule can achieve interfacial stability at the negative electrode, further suppressing dendrite formation at the negative electrode. Furthermore, the stereo-oriented network can significantly limit the activity of free water molecules, eliminating the erosion of the vanadium cathode by free water molecules and vanadium dissolution.

An optically active nanocomposite material is provided that may have a textured substrate and a multilayer optic stack with a plurality of layers comprising nanoplatelets. The nanoplatelets may be achiral and formed of a material such as transition metal chalcogenides, Mxenes, or nanocarbons. The optically active nanocomposite material displays both linear birefringence (LB) and linear dichroism (LD) and optional circular dichroism (CD). The nanocomposite may have an optical asymmetry g-factor of greater than or equal to about 1. Further, the nanocomposite is thermally stable, for example, to a temperature of greater than or equal to about 250° C. Different methods of fabricating such nanocomposites using layer-by-layer (LBL) processes are also provided.

This invention discloses a method for detecting 99 achiral / chiral endocrine disruptors in urine based on a dual-column coupled analysis system, belonging to the field of pollutant monitoring and analysis technology. The method involves a single pretreatment of the urine sample, including formic acid-acetonitrile extraction and ethylenediamine-N-propyl silica gel purification. A dual-column coupled analysis mode is then used, with a C18 column simultaneously quantifying the total concentration of 93 achiral endocrine disruptors (EDCs) and 6 chiral pesticides. The chiral column yields the R / S enantiomer signal intensity ratio, and the content of each enantiomer is calculated using a "total-proportional conversion" model. This invention achieves, for the first time, a unified detection system for achiral and chiral substances, eliminating the need for a single enantiomer standard; accurate quantification can be achieved using only racemic mixtures, effectively avoiding the direct quantitative bias of chiral columns. The method has a limit of quantification as low as 0.25 μg / L, is simple to operate, low in cost, and has good reproducibility, providing an efficient and reliable analytical tool for population exposure monitoring and chiral selective metabolism research.

The application discloses a water-soluble achiral rare earth tetrahedral cage CPL probe for recognition of mercapto amino acids and a preparation method thereof, and relates to a CPL probe for recognition of mercapto amino acids and a preparation method thereof. The application is aimed at solving the problems that water solubility and functional cavities are difficult to balance, and specific recognition ability is limited in the detection of mercapto amino acids by using existing supramolecular cage optical probes. The water-soluble achiral rare earth tetrahedral cage CPL probe for recognition of mercapto amino acids has high water solubility, strong CPL signal and high selective rare earth tetrahedral cage probe, realizes efficient recognition and quantitative detection of mercapto amino acids such as D-penicillamine, and has the advantages that Eu4L4 is an achiral rare earth tetrahedral cage, the number of aldehyde groups is multiplied due to the tetrahedral structure, excellent circularly polarized luminescence performance is exhibited, high-precision distinction between mercapto amino acids and non-mercapto amino acids is successfully realized, and the selectivity of detection is remarkably improved.

A detection system and a method for detecting chiral compounds, wherein the multi-mode analytical system is suitable for separating non-chiral and chiral components and for resolving and detecting enantiomers, and the analytical system includes an injection system, a liquid chromatography system as a first dimension chromatograph, a supercritical chromatography system as a second dimension chromatograph, a trap system, a connection system, and a detector, the liquid chromatography system includes a reversed-phase liquid column, the supercritical chromatography system includes one or more chiral columns, the connection system includes a first multi-port valve and a second multi-port valve, and the detector is a mass spectrometry detector.

The application aims to provide an organic-inorganic hybrid chiral film and a preparation method thereof. The organic-inorganic hybrid chiral film comprises at least two hybrid orientation films, the hybrid orientation film comprises a flexible polymer film and one-dimensional metal nanomaterials distributed on the surface of the flexible polymer film and arranged in an orientation manner, and the flexible polymer film is an achiral polymer film; and each layer of the hybrid orientation film is arranged in a preset deflection angle along the orientation axis direction of the one-dimensional metal nanomaterials. The obtained chiral film is not dependent on a chiral template, has high CD intensity, high g-factor and covers ultraviolet-visible-near infrared super wide wave bands, and the preparation method has low cost and strong universality.

The application provides an optically active polydiacetylene film and a preparation method and application thereof. The preparation method comprises the following steps: forming a nanowire array on a substrate, which comprises a first nanowire layer and a second nanowire layer arranged in sequence in a direction away from the substrate, and the nanowires contained in the first and second nanowire layers have a non-zero torsion angle; depositing an achiral diacetylene monomer on the nanowire array, removing the nanowire array to obtain a diacetylene monomer crystal layer; and irradiating the diacetylene monomer crystal layer with ultraviolet light to make it polymerize to form a helical polydiacetylene chain, thereby obtaining the optically active polydiacetylene film. The method provided by the application forms stereoregulated diacetylene crystals through the heteroepitaxy effect of the twisted stacked nanowire array, and only needs to be irradiated with ultraviolet light to initiate the asymmetric polymerization of diacetylene, thereby solving the problems that the crystal structure is difficult to be regulated as required and an exogenous chirality needs to be introduced in the prior art.

The invention discloses a wavelength-controlled circular dichroism achiral metasurface and a design method thereof, and belongs to the technical field of electromagnetic wave phase and amplitude regulation and control. The wavelength-controlled circular dichroism achiral metasurface comprises a bottom-layer metal reflecting layer, a substrate dielectric layer, a middle structural layer, a top-layer dielectric layer and a top-layer structural layer which are sequentially stacked from bottom to top, each of the middle structure layer and the top structure layer is composed of a plurality of metastructure units which are periodically arranged, the period length of each metastructure unit is sub-wavelength, and each metastructure unit is of a triple rotational symmetry structure; an achiral structure is adopted by the super-structure surface, the structure is symmetrical, geometric parameters needing to be optimized are fewer, the regulation and control mechanism is more visual, the machining tolerance is high, and the working bandwidth is wider; a triple rotational symmetry structure is adopted as a super-structure unit, and the same surface unit structure of a super-structure plane comprises two triple rotational symmetry structures, so that the circular dichroism can be regulated and controlled by switching the wavelength of incident light.

The invention provides a chiral inorganic bismuth oxyhalide material and a preparation method thereof, and the chiral inorganic bismuth oxyhalide material is finally prepared by carrying out hydrothermal reaction on achiral Bi4O5Br2 nanosheets, Yb2O3, Er2O3 and a chiral inducer and annealing. The chiral inorganic bismuth oxyhalide material prepared by the invention has an intrinsic chiral structure and a strong CD signal, can directly generate circularly polarized light, and does not need an additional polarization device. By regulating and controlling the pH value and the concentration of the chiral agent, controllable regulation of chiral signals and luminescence performance can be realized, and the preparation method is simple, controllable in condition and suitable for batch preparation and morphology regulation and control.