54 results about "Achirality" patented technology

An optically active nanocomposite material is provided that may have a textured substrate and a multilayer optic stack with a plurality of layers comprising nanoplatelets. The nanoplatelets may be achiral and formed of a material such as transition metal chalcogenides, Mxenes, or nanocarbons. The optically active nanocomposite material displays both linear birefringence (LB) and linear dichroism (LD) and optional circular dichroism (CD). The nanocomposite may have an optical asymmetry g-factor of greater than or equal to about 1. Further, the nanocomposite is thermally stable, for example, to a temperature of greater than or equal to about 250° C. Different methods of fabricating such nanocomposites using layer-by-layer (LBL) processes are also provided.

The invention discloses an intrinsic chiral super-structure surface, an angle dispersion regulation and control method and application, and belongs to the field of super-structure surfaces, the intrinsic chiral super-structure surface comprises a plurality of achiral super-atom units, a top resonator comprises two semi-circular rings in mirror symmetry, one ends of opposite sides of the two semi-circular rings are provided with notches, and the other ends of the two semi-circular rings are provided with gaps. The other ends of the opposite sides of the two semicircular rings are bent inwards to form inward protrusions. According to the intrinsic chiral super-structure surface, the angular dispersion regulation and control method and the application, the achiral super-atoms with a single mirror symmetry axis are designed, and multiple interference effects of a metal-insulating medium-metal structure are combined; the ultra-strong circular dichroism (the absolute value is about 0.8, and the single-component absorption efficiency is 98%) of terahertz waves under oblique incidence and dynamic range polarization conversion cooperatively regulated and controlled by the incident angle and the geometric dimension of the super-atom facing and inward protruding are achieved, and a multi-angle and multi-parameter adjustable innovative scheme is provided for efficient reflection type terahertz device design.

The invention provides a fullerene pyrrolidine enantiomer mediated cholesteric liquid crystal with circular polarization luminescence property and nonlinear anti-saturated absorption property, and a preparation method and application thereof. The method comprises the following steps: dissolving C60, paraformaldehyde and (R / S)-(+ / -)-alpha-methylbenzylamine in an organic solvent, and carrying out heating reflux reaction to obtain fullerene pyrrolidine enantiomer molecules; dissolving in carbon disulfide to obtain an enantiomer solution; dissolving achiral dye molecules in a solvent to obtain a dye solution; and dropwise adding the enantiomer solution and the dye solution into thermotropic liquid crystal molecules, and drying to obtain the thermotropic liquid crystal. The method is simple, the obtained cholesteric liquid crystal system shows a characteristic fingerprint texture and has a periodic spiral structure, and the doping proportion of chiral molecules is easy to adjust; the composite system has good time stability and is not prone to phase separation; the liquid crystal platform shows good circular polarization luminescence performance and third-order nonlinear optical property, and is a cholesteric liquid crystal platform with an integrated function.

This case involves a method for temperature-controlled supermolecular chirality of oligoaniline helical nanoribbons in a non-chiral molecule-mediated synthesis system. A mixed solvent of acetone and water is used as the mediating system. Aniline is dissolved in the mixed solvent to obtain a mixed solution. A certain amount of ammonium persulfate aqueous solution is then added, stirred and mixed evenly, and then placed at 0-27°C for a certain period of time. The precipitate that appears in the system is the oligoaniline helical nanoribbon. The present invention successfully achieves the synthesis of helical chiral nanoribbons by mediating the assembly of aniline monomers in a non-chiral acetone / water mixed solvent. The reaction process is simple and easy to operate, the raw materials are readily available, the prepared nanoribbons have obvious helical structures, strong chiral signals, and good environmental stability, and have good application prospects in materials chemistry, especially in chiral recognition and resolution and chiral crystallization. And through the construction method of the present invention, chirality reversal can be achieved simply by regulating the temperature.

The invention relates to the technical field of asymmetric catalysis, and in particular to a chiral bidentate nitrogen ligand based on a cinchona alkaloid skeleton, a preparation method and an application thereof. The compound is used to catalyze an asymmetric hydrogenation reaction of a heterocyclic aromatic ketone. The metal catalytic reaction product co-modified with the chiral ligand and an achiral phosphine ligand has a high conversion rate, and the enantioselectivity can reach 99.9%. The chiral bidentate nitrogen ligand is prepared by using cinchona alkaloid as a raw material, the raw material is cheap and easy to obtain, the preparation reaction process is simple, and the compound is stable in an air environment, and the compound has a very high application value.

The application provides a 1,5-dicarbonyl compound and a synthesis method and application thereof, wherein the synthesis method of the 1,5-dicarbonyl compound comprises the following steps: under the protection of inert gas, mixing 1,3-dicarbonyl compound and olefin compound in an organic solvent, and under the action of a zirconium-containing catalyst, reacting under the conditions of stirring and light source irradiation to generate the 1,5-dicarbonyl compound. The synthesis method of the 1,5-dicarbonyl compound has the characteristics of mildness, high efficiency and green environmental protection, and can realize catalytic asymmetric process, and the synthesis method is characterized in that under the protection of inert gas, chiral or achiral 1,5-dicarbonyl compound is synthesized by using 1,3-dicarbonyl compound and olefin compound as raw materials, a zirconium-containing catalyst, and the conditions of stirring and light source irradiation. The method can directly react under the condition of inert gas protection and light irradiation, does not need to add an additive, does not generate toxic by-products, and has an atomic economy of 100%.

The application discloses a method for synthesizing chiral 1,3-disubstituted tetrahydroisoquinoline by using a chemical enzyme cascade system and belongs to the technical field of bioengineering. The application establishes a method for preparing chiral 1,3-disubstituted tetrahydroisoquinoline by using an enzyme cascade catalysis. Simple non-chiral ketone is used as a raw material, a transaminase obtained through screening is used to generate a chiral amine, a B-N cyclization reaction is used to obtain a chiral imine, and finally, an imine reductase is used to generate 1,3-disubstituted tetrahydroisoquinoline. The method has a high yield, can be close to 100%, has excellent diastereoselectivity and enantioselectivity, the de value and the ee value are close to 99%, and has good application value and prospect.

The invention discloses a method for obtaining circularly polarized luminescence by covalently anchoring a chiral liquid crystal through light-induced anthraquinone molecules. The method comprises the following steps: S1, adding a solution of a chiral dopant into nematic liquid crystals, stirring until the solution is transparent, and obtaining a binary assembly after a solvent is volatilized; s2, adding a solution of an achiral object into the binary assembly, and volatilizing the solvent to obtain a ternary cholesteric liquid crystal assembly; the achiral guest is a polycyclic conjugated quinone derivative. Under the induction of 365nm ultraviolet light, a diaryl acetylene part and anthraquinone molecules in the ternary cholesteric liquid crystal assembly are covalently bound, so that a new luminous body with a green emission color is formed, and the luminous body generated in situ is well arranged in an original liquid crystal and is beneficial to generating nearly pure circularly polarized light; more importantly, a new method is provided for construction of the circular polarization luminescent material through the non-covalent doping-covalent anchoring mode.

The invention discloses a nano material synthesized based on a chiral metal organic framework material and a chiral molecularly imprinted polymer, which is characterized in that L-glutamic acid is used as a chiral organic ligand, terephthalic acid is used as an achiral organic ligand, and tetrabutyl titanate is used as a metal salt to prepare the chiral metal organic framework material; the preparation method comprises the following steps: uniformly mixing a dispersion liquid of a chiral metal organic framework material with template molecules, a functional monomer, a cross-linking agent and an initiator, reacting at room temperature, filtering after the reaction is finished, washing an eluent to remove the template molecules, and drying to obtain the nano material. The invention discloses a capillary electrochromatography open tubular column. The capillary electrochromatography open tubular column takes a nano material as a stationary phase. The invention discloses an application of the capillary electrochromatography open tubular column in chiral resolution of DL-histidine. Compared with a CEC open tubular column taking L-Glu / MIL-125 (Ti) or CMIPs as a stationary phase, the chiral separation capability of the CEC open tubular column to the histidine enantiomers is greatly improved.

The invention provides a functional current collector and a preparation method and application thereof. The functional current collector sequentially comprises a base film, a hybrid organic-inorganic perovskite coating and a metal layer, the material of the hybrid organic-inorganic perovskite coating comprises a two-dimensional hybrid organic-inorganic perovskite material; the two-dimensional hybrid organic-inorganic perovskite material comprises at least one of an achiral two-dimensional hybrid organic-inorganic perovskite material, a mixed achiral two-dimensional hybrid organic-inorganic perovskite material, a semi-chiral two-dimensional hybrid organic-inorganic perovskite material and a full-chiral two-dimensional hybrid organic-inorganic perovskite material. The functional current collector has relatively low residual stress, and the thermal stability and mechanical strength of the functional current collector are effectively enhanced, so that the stability of the battery in the charge-discharge cycle process is optimized, and the cycle performance and thermal stability of the battery are improved.

Disclosed in the present invention are a chiral azobenzene polymer crosslinked thin film and preparation method therefor and application thereof. The present invention relates to a novel super-molecular chiral construction and chiral immobilization method based on an achiral side chain type azobenzene polymer thin film. According to the present invention, limonene steam is utilized to perform chiral induction on a polymer thin film at a high temperature, and then formaldehyde steam is utilized to perform acetal reaction with hydroxyl in an acidic environment to achieve crosslinking; and then differences in the stability of the super-molecular chirality of the polymer thin film before and after crosslinking is studied under the conditions of light, heat and good solvent dissolution, and the self-repairing properties of microcosmic helical chirality is researched. The crosslinked thin film prepared by the present invention has good chiral properties, and excellent solvent resistance, heat resistance, and self-repairing properties.

The invention relates to an artificial synaptic device based on chiral perovskite and a preparation method thereof. The device sequentially comprises a substrate, a comb-shaped bottom electrode, a chiral perovskite functional layer and a comb-shaped top electrode from bottom to top, wherein the projection direction of the bottom electrode comb teeth and the projection direction of the top electrode comb teeth are crossed at an angle of 90 degrees; the chemical general formula of the chiral perovskite functional layer is A < 1-x > A'x PbX3, A is a chiral organic cation, A 'is an achiral organic cation, and X is one or more of Cl <->, Br <-> and I. The device obtained by the invention can respond to a chiral optical signal and complete processing and storage of chiral information, and has an excellent brain synaptic-like function at the same time.

This invention relates to the field of electrocatalyst technology, and in particular to a chiral CoFe-based oxygen evolution electrocatalyst, its preparation method, and its application. Iron salts, cobalt salts, and chiral tartaric acid are dissolved together in N,N-dimethylformamide solvent to form a homogeneous mixed solution. Hydrazine hydrate is added to the mixed solution and thoroughly mixed. The solution is then transferred to a high-pressure reactor and subjected to a solvothermal reaction at a set temperature to obtain a nanocatalyst precursor. The nanocatalyst precursor is then subjected to centrifugation, washing, drying, and vacuum calcination to obtain the product. This method successfully prepares a chiral CoFe-based nanocatalyst through the inductive effect of chiral tartaric acid, combined with a specific solvothermal reaction and subsequent heat treatment process. This chiral CoFe-based electrocatalyst exhibits significantly enhanced catalytic activity and stability in the oxygen evolution electrocatalytic reaction, demonstrating superior electrochemical performance compared to achiral catalysts.

The invention provides a method for preparing chiral amine by catalyzing asymmetric hydrogenation of high-steric-hindrance aromatic imine through an iridium / chiral bidentate phosphoramidite ester ligand. According to the method, the bidentate phosphoramidite ester ligand based on an achiral phosphine-amine skeleton is applied to asymmetric hydrogenation of iridium-catalyzed imine for the first time. The iridium precursor and ligand are easy to obtain, the reaction condition is mild, the operation is simple, the target chiral amine compound can be obtained with high yield and high stereoselectivity, and continuous large-scale preparation can be realized. The catalyst system is high in activity, the molar ratio of imine to the catalyst can reach 600000: 1, and the catalyst has a very good industrial application prospect.

A chiral cyclophane molecule BinapoBox·4PF6 and its preparation method and application belong to the field of macrocyclic molecule research, specifically to a chiral cyclophane molecule and its preparation method and application. The present invention aims to solve the problems of high synthesis cost of existing chiral aromatic dyes and complex process of inducing chirality of achiral compounds. The chiral cyclophane molecule BinapoBox·4PF6 of the present invention has the general structural formula of C 92 H 70 F 24 N4O2P6. The chiral cyclophane molecule BinapoBox·4PF6 exhibits excellent binding ability and unique fluorescent properties with aromatic dyes, making it an ideal chiral host material for preparing chiral host-achiral guest CPL materials. This method avoids tedious synthetic modifications and expensive liquid crystal materials, allowing for large-scale production, significantly reducing costs. This chiral cyclophane molecule is a recyclable and versatile chiral cyclophane product.

The invention provides a circularly polarized light-emitting template material which can be recycled and has a high asymmetry factor, and a preparation method and application of the circularly polarized light-emitting template material. The method comprises the following steps: synthesis of a monomer F6-OH, synthesis of a polymer PF8-OH, preparation of a chiral co-assembled film, and preparation of a chiral PF8-OH ACR (Assessment-Crosslink-Remote) film, and the preparation of the chiral co-assembled film comprises the following steps of: preparing a chiral co-assembled film, and preparing the chiral PF8-OH ACR (Assessment-Crosslink-Remote) film, the method further comprises post-assembly of molecules participating in dyeing. According to the preparation method, an achiral fluorenyl polymer is synthesized through Suzuki coupling reaction, the achiral fluorenyl polymer and 5, 10, 15, 20-tetra (4-bromophenyl) porphyrin (TBPP) are co-assembled in chiral limonene, supramolecular chirality is induced, and the glum (asymmetric factor) value is increased; cross-linking can be carried out through an aldolization reaction of hydroxyl sites so as to realize chiral fixation; limonene and TBPP are removed through the solvent replacement effect of acetone, so that the quantum yield of the film is recovered to the original level, and the film serves as a chiral template to participate in dye molecule post-assembly. The CPL template material which can be recycled and has high asymmetric factors and different color systems is prepared through the steps.

The invention relates to the technical field of chiral self-assembly materials, and discloses a novel achiral fluorescent material which is characterized in that a D-A type conjugated skeleton is constructed by taking a spirofluorene unit as an electron donor (D) and carborane and triazine as electron acceptors (A); carborane has an AIE effect, triazine is an important six-membered heteroaromatic ring, has three nitrogen atoms, generates three regioisomers, and is widely used for preparing thermal delay fluorescent materials due to good thermal stability, light stability and thermal delay performance; a triazine derivative is used as a hub to be respectively connected with spirofluorene-o-carborane; a three-dimensional space structure of an o-carborane molecule and a rigid structure of a triazine molecule are combined, so that unique photoelectric properties are achieved; the invention provides a basis for the design of the boron cluster material in the aspects of photoelectric application and the like; and a new thought is provided for the research of the light-emitting boron cluster in circularly polarized light emission.

The invention provides a novel chiral phosphine-phosphoramidite ester ligand which is based on an achiral open-chain phenol non-cyclic phosphoramidite ester structural unit and only has skeleton single-center chirality, and a preparation method and application thereof. Different from a traditional chiral phosphine-phosphoramidite ligand, a phosphoramidite structural unit in the novel chiral phosphine-phosphoramidite ligand does not contain a chiral element and is of a non-cyclic open-chain structure. The novel ligand is prepared by taking a chiral phosphine / amine intermediate (R)-or (S)-DPPNHMe, a phenol compound and PC13 as raw materials under a mild condition. The novel chiral phosphine-phosphoramidite ligand provided by the invention has the characteristics of cheap and easily available raw materials, simple synthesis, stable properties, adjustable space structure and electronic properties, excellent activity and enantioselectivity in catalysis of asymmetric hydrogenation reaction, and the like.

The invention relates to a method for synthesizing cyclopentenyl ketone under the catalysis of nickel and aluminum, which comprises the following steps: adding a secondary phosphine oxide ligand PO, a metal catalyst Ni (cod) 2, a solvent, cyclopropyl ketone and alkyne into a reaction container in a nitrogen atmosphere, then adding lewis acid, stirring at a specified reaction temperature, adding an ethylene diamine tetraacetic acid aqueous solution after the reaction is completed, washing, separating liquid, and drying to obtain the cyclopentenyl ketone. And carrying out drying and column chromatography separation on the organic phase to obtain chiral or achiral cyclopentenyl ketone. The method has the advantages of wide substrates, strong tolerance of reaction to functional groups of the substrates, no atom loss, high atom economy and step economy, capability of effectively inhibiting side reactions caused by enolation racemization of ketone and Lewis acid through coordinated regulation and control of the ligand and the solvent, and extremely high reaction efficiency and stereo control capability.

The application discloses a circularly polarized luminescent supramolecular assembly, a polymer film and a preparation method and application thereof. The supramolecular assembly comprises an organic small molecule as a single chiral building block, a zinc salt and an achiral fluorescent dye; the organic small molecule, the zinc salt and the achiral fluorescent dye form the supramolecular assembly with the circularly polarized luminescent property through a supramolecular assembly process. The polymer film comprises the supramolecular assembly and an organic high polymer; the supramolecular assembly is mixed with a mother liquor of the organic high polymer to form a precursor of the polymer film. The single chiral building unit is used as a chiral donor to realize construction of the circularly polarized luminescent material with opposite chirality; the product has the performance of chirality amplification and light stability enhancement; the preparation method is simple and convenient to operate and is suitable for large-scale production.

The application discloses a method for regulating the chirality of helical polymers by using achiral small molecules and application thereof. The method comprises the following steps: dissolving or dispersing helical polymers with dynamic helical conformation in an aqueous medium; adding achiral aromatic small molecules as an additive; adjusting the molar ratio of the additive and the repeating units of the polymer, so that the circular dichroism signal of the polymer changes, and the helical conformation of the main chain of the helical polymer is reversed, enhanced or stabilized. The application can effectively regulate the helical chirality of helical polymers such as dendritic temperature-sensitive polyphenylacetylene in an aqueous phase by using achiral aromatic small molecules without introducing exogenous chiral substances. The chiral optical response can be further synergistically controlled by adjusting conditions such as pH and temperature. The method is simple in operation and mild in conditions, and can be used for preparing stimulus-responsive chiral optical materials, chiral recognition materials, chiral separation materials and biomimetic supramolecular assembly materials.

The invention relates to achiral and chiral aza-biaryl-oxazoline type ligands and a preparation method thereof, and belongs to the technical field of organic chemistry. The preparation method comprises an aromatic cyanidation reaction and a condensation reaction, according to the present invention, the multi-site substituted achiral and chiral aza-biaryl nitrile compound can be efficiently prepared, and the rapid construction of the aza-biaryl-oxazoline type ligand can be further achieved through the one-step reaction. The ligand belongs to a novel pyridine-oxazoline type ligand, the preparation method has the advantages of greenness, environmental protection, high efficiency, rapidness, low cost and the like, and the variety of N, N-bidentate ligand libraries is expanded.

The invention discloses a chiral gold nanorod with a core-shell structure, a preparation method of the chiral gold nanorod and application of the chiral gold nanorod to preparation of drugs, the chiral gold nanorod takes an achiral gold nanorod as a core, takes one or more of 1, 1 '-co-2-naphthylamine, 1, 1'-co-2-naphthol and 2, 2 '-binaphthalene as chiral ligands, and takes one or more of 1, 1'-co-2-naphthylamine, 1, 1 '-co-2-naphthol and 2, 2'-binaphthalene as the core to prepare the chiral gold nanorod with the core-shell structure. And forming chiral micelles with hexadecyl trimethyl ammonium chloride, and inducing secondary growth of gold to synthesize the chiral gold nanorod with a core-shell structure. The chiral gold nanorod is used for preparing a medicine for treating mouse in-situ glioblastoma, and the transfer of glioblastoma cells in the brain can be inhibited by performing tail intravenous injection administration on the chiral gold nanorod, so that diseases are improved.

The invention discloses a circularly polarized light detection method based on an achiral medium micro-nano structure and a photoelectric detector. As an antisymmetric mode and a symmetric mode excited by x polarized light and y polarized light in the micro-nano structure interfere with each other, light intensities of near-field modes excited by left-handed light and right-handed light can be respectively concentrated on two sides of the micro-nano structure. The electrodes are arranged on the two sides of the micro-nano structure, and a chiral dependent near-field mode can be converted into photoelectric signals in different directions by utilizing photoelectric mechanisms such as a photo-thermoelectric effect or a photovoltaic effect, so that circularly polarized light photoelectric detection is realized. The circularly polarized light detection method and the photoelectric detector are high in chiral resolution capability, large in working bandwidth, free of light intensity calibration and independent of specific materials, structures or photoelectric response mechanisms, and can be popularized to photoelectric detectors based on different materials or mechanisms.

The invention belongs to the technical field of nano photonics and chiral materials, and discloses a preparation method of a chiral gold nano helical structure particle and achiral molecule complex, which comprises the following steps: after centrifugally concentrating gold octahedral nanoparticles prepared by a seed growth method, dispersing the gold octahedral nanoparticles into a hexadecyl trimethyl ammonium bromide solution; dropwise adding the gold octahedral nanoparticles into the gold nano helical structure growth solution, standing in a water bath at 30 DEG C for 2 hours, centrifuging to obtain chiral gold nano helical structure particles, and dispersing the gold nano helical structure particles into a CTAB (Cetyltrimethyl Ammonium Bromide) solution; the achiral molecules are dissolved in ultrapure water, ultrasonic mixing is conducted on the achiral molecules and the gold nano spiral structure particle solution, standing is conducted for 10-12 h at the temperature of 4 DEG C, and the gold nano spiral structure particle and achiral molecule complex is obtained. According to the invention, reverse transfer of chirality from nanoparticles to achiral molecules is realized, an unprecedented CD resonance phenomenon is generated, and a brand new thought is provided for development of near-infrared response chiral devices.

The invention belongs to the technical field of organic synthesis, and discloses a synthesis method of a chiral 1, 5-dihydro-3H-pyrano [3, 4, 5-cd] indole derivative. According to the synthesis method, a simple achiral substrate 4-indolyl carbinol and a compound containing an aldehyde group structure serve as raw materials, the chiral 1, 5-dihydro-3H-pyrano [3, 4, 5-cd] indole derivative is synthesized through chiral phosphoric acid catalysis, the synthesis process is simple, efficient and high in enantioselectivity, and the synthesized chiral 1, 5-dihydro-3H-pyrano [3, 4, 5-cd] indole derivative has the advantages of being high in yield and high in yield. The 2, 5-cd] indole derivative disclosed by the invention has relatively high yield and ee (enantiomeric excess) value.

The invention discloses a preparation method and application of a chiral conductive polymer / sulfide composite material, and relates to a preparation method and application of a conductive polymer composite material. The invention aims to solve the problems of high cost and strong scarcity of the existing noble metal-based catalyst, and low catalytic efficiency and lack of electron spin regulation ability of an achiral transition metal catalyst. The method comprises the following steps: 1, preparing an NLLA solution; 2, preparing an An solution; 3, preparing a CSA solution; 4, preparing an APS solution; 5, generating a chiral polyaniline nanofiber membrane on an air-water interface; 6, preparing a Ni (NO3) 2 solution; 7, preparing a diluted hydrochloric acid solution; 8, preparing a Na2S solution; and 9, growing a nickel sulfide catalyst membrane on the chiral polyaniline nanofiber membrane. The catalyst is used for electrocatalytic oxidation of glucose.

The invention belongs to the technical field of high polymer materials, and discloses a method for regulating and controlling a chiral structure and chiral transfer of a triblock copolymer by a middle block, the chiral triblock copolymer and application. The method comprises the steps that firstly, a chiral triblock copolymer is selected, the structural general formula of the triblock copolymer is PS-b-B-b-PLLA, B is a middle block, and B is selected from one of the following polymer chain segments: PLA, PEO, PCL, P4VP, P4CS and PMMA; then regulating and controlling the self-assembly behavior of the triblock copolymer through B, so that the copolymer is self-assembled to form a chiral structure or an achiral structure; the regulation comprises the steps of 1) determining chi between the middle block B and the PLLA, and 2) determining the chain length of the middle block B. According to the chiral triblock copolymer, chiral transmission of the triblock copolymer is realized, and a chiral spiral phase structure is formed through self-assembly, and the chiral triblock copolymer is used for preparing advanced functional materials such as chiral photonic crystals, circular polarization luminescent materials and chiral separation membranes.

The invention belongs to the technical field of asymmetric catalysis, and particularly relates to a chiral nitrogen-nitrogen-phosphine compound as well as a preparation method and application thereof. The chiral nitrogen-nitrogen-phosphine-phosphine compound contains two achiral phosphine atoms and two chiral nitrogen atoms, and when the chiral nitrogen-nitrogen-phosphine-phosphine compound is adopted as a ligand to catalyze an asymmetric hydrogenation reaction of o-amino diaryl ketone, the conversion rate is high, the capability of stabilizing a catalytic active center is achieved, and the enantiomer selectivity reaches 96% or above.

The invention belongs to the technical field of organic synthetic chemistry, and particularly discloses a preparation method of S-4-chloro-3-hydroxybutyronitrile. According to the method, 1, 3-dichloropropanol is used as a raw material and reacts with a chiral catalyst 9-trimethylsilylquinine to generate quaternary ammonium salt, the quaternary ammonium salt and hydrocyanic acid are subjected to a substitution reaction, and then heating is performed to remove the chiral catalyst, so that the S-4-chloro-3-hydroxybutyronitrile is prepared with high yield and high enantioselectivity. The method is simple and convenient to operate, the yield of the product S-4-chloro-3-hydroxybutyronitrile is high, the chiral catalyst is adopted instead of a chiral raw material, the chiral catalyst can be repeatedly used, and the cost is low.