64 results about "Cell Migration Process" patented technology

Methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, biocompatible structures formed by three-dimensional fabrication, are described. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and / or as artificial organs. The structures may be three-dimensional and can mimic the shapes and dimensions of tissues and / or organs, including the microarchitecture and porosities of the tissues and organs. Pores in the structure may allow delivery of molecules across the structure, and may facilitate cell migration and / or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal and / or may be used ex vivo as bioartificial assist devices.

The invention relates to a cell migration high-resolution impedance real-time tracking, measurement and control device, and a manufacturing method and an application method thereof, and is particularly suitable for cell impedance measurement, cell migration, cell detection, medicine screening, microfluidics and a nano technology. The tracking, measurement and control device comprise a cavity; a chamber in which liquid is accommodated is formed in the middle of the cavity; the middle of the chamber is divided into an upper chamber and a lower chamber by a microporous membrane; an upper chamber electrode is inserted into the electrode hole of an upper cavity; a lower chamber electrode is inserted into the electrode hole of a lower cavity; the two electrodes are connected with an analysis device respectively; and the lower part of the lower cavity is provided with a liquid inlet and outlet channel which is communicated with the external. The invention has the advantages that: 1, cells are detected in real time, and a transmembrane migration process of cells cultured in vitro is reliably tracked, measured, controlled and analyzed in real time at high resolution in a non-destructive way; 2, detection sensitivity is improved and the transmembrane migration of a single cell is tracked; 3, the effect of a medicine on the cell can be precisely determined through a microflow pipeline; 4, manual measurement and control errors are reduced; 5, the tracking, measurement and control device is easy and convenient to operate and high in accuracy; and 6, the tracking, measurement and control device is easy to manufacture and low in cost.

Systems, including methods, apparatus, compositions, and kits, for multiplexed assay of cell migration with subdivided cell holders and / or microplates.

Disclosed is a root canal filler for non-extracted tooth which causes no internal resorption or external resorption in a tooth with complete root formation, shows no odontoclast, and contributes to the regeneration of a dental tissue in which odontoblasts are smoothly aligned on the dentin wall. After pulpectomy or enlargement / cleaning of an infected root canal, a root canal filler for non-extracted tooth, which comprises tooth pulp stem cells and an extracellular matrix, is inserted into the apical side of the root canal of the non-extracted tooth. The tooth pulp stem cells may be, for example, dental pulp CXCR4-positive cells. It is preferred to attach, to the crown side of the root canal, migration factor(s) including at least one factor selected from among a cell migration factor, a cell proliferation factor, a neurotrophic factor and an angiogenic factor.

The present invention is directed to a modified cell migration assay allowing for improved identification and discrimination of chemokine receptor antagonists from non-specific blockers.