Fibroin/nylon composite material and preparing method thereof

A technology of nylon composite material and silk fibroin, which is applied in the field of regenerative medicine, can solve problems such as difficulty in obtaining effects, loss of silk flexibility, and limited improvement of mechanical properties, and achieves benefits for the transportation of nutrients, excellent mechanical properties, and excellent mechanical properties. performance effect

Inactive Publication Date: 2017-04-26
吴?基
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although natural silk is a flexible material with high strength and good flexibility, the regenerated silk fibroin film has become a brittle and hard material, which completely loses the original flexibility of silk and can no longer meet the actual needs. application requirements
[0003] At present, many studies have used methods such as grafting and cross-linking to improv

Method used

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  • Fibroin/nylon composite material and preparing method thereof
  • Fibroin/nylon composite material and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Boil mulberry silk with 0.5% sodium bicarbonate solution for 30 minutes to degumming, and obtain silk fibroin fiber after repeating 3 times;

[0025] (2) Silk fibroin fiber is dissolved in 1.1% calcium chloride-98% formic acid solution, and the concentration of silk fiber dispersion is 5%;

[0026] (3) Slowly drop the silk fiber dispersion into the sodium carbonate solution for mineralization reaction, the dropping time is 0.5h; the mass ratio of silk fiber to sodium carbonate is 1:0.1; filter, wash and dry the reacted solution Obtain white appearance, powdery calcium carbonate nanowires; figure 1 It is a scanning electron microscope picture of the above-mentioned calcium carbonate nanowire; it can be seen from the figure that the calcium carbonate wire has a diameter of 80-160nm, a length of about 650nm, and a high aspect ratio;

[0027] (4) Dissolve nylon 6 in the silk fiber dispersion in step (2); then add calcium carbonate nanowires in step (3) to obtain a blen...

Embodiment 2

[0029] (1) Boil mulberry silk with 0.5% sodium bicarbonate solution for 30 minutes to degumming, and obtain silk fibroin fiber after repeating 3 times;

[0030] (2) Silk fibroin fiber is dissolved in 1.6% calcium chloride-90% formic acid solution, and the concentration of silk fiber dispersion is 5%;

[0031] (3) Slowly drop the silk fiber dispersion into the sodium carbonate solution for mineralization reaction, the dropping time is 0.5h; the mass ratio of silk fiber to sodium carbonate is 1:0.1; filter, wash and dry the reacted solution Obtain white, powdery calcium carbonate nanowires; the calcium carbonate wires have a diameter of 90-150nm, a length of about 630nm, and a high aspect ratio;

[0032] (4) Dissolve nylon 66 in the silk fiber dispersion in step (2); then add calcium carbonate nanowires in step (3) to obtain a blended solution; cast on a template and dry naturally; the dried film is placed Soak in deionized water for 0.5h, and then dry at 60°C to obtain silk fi...

Embodiment 3

[0034] (1) Boil mulberry silk with 0.5% sodium bicarbonate solution for 30 minutes to degumming, and obtain silk fibroin fiber after repeating 3 times;

[0035] (2) Silk fibroin fiber is dissolved in 1.5% calcium chloride-98% formic acid solution, and the concentration of silk fiber dispersion is 10%;

[0036] (3) Slowly drop the silk fiber dispersion into the sodium carbonate solution for mineralization reaction, the dropping time is 0.5h; the mass ratio of silk fiber to sodium carbonate is 1:0.5; filter, wash and dry the reacted solution Obtain white, powdery calcium carbonate nanowires; the calcium carbonate wires have a diameter of 100-160nm, a length of about 670nm, and a high aspect ratio;

[0037] (4) Dissolve nylon 6 in the silk fiber dispersion in step (2); then add calcium carbonate nanowires in step (3) to obtain a blended solution; cast on a template and dry naturally; the dried film is placed Soak in deionized water for 1 hour, and then dry at 70°C for infrared t...

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Abstract

The invention relates to a fibroin/nylon composite material and a preparing method thereof. The preparing method comprises the steps of conducting degumming treatment on silk to obtain silk fibroin fiber; dispersing the silk fibroin fiber into mixed liquor of calcium salt/formic acid to obtain silk fibroin fiber dispersion liquid; dropwise adding the silk fibroin fiber dispersion liquid into a carbonate solution to obtain reaction liquid; then filtering the reaction liquid, and conducting washing and drying on a filter cake to obtain calcium carbonate nanowire; dissolving nylon into the silk fibroin fiber dispersion liquid and then adding the calcium carbonate nanowire into the silk fibroin fiber dispersion liquid to obtain a blended solution; adopting a tape-casting method to conduct film-spreading on the blended solution, and conducting drying to obtain dry film; putting the dry film into deionized water to be subjected to washing, and conducting infrared drying at the temperature of 60-60 DEG C to obtain the fibroin/nylon composite material. The internal structure of the obtained fibroin/nylon composite material is mainly composed of fiber, and is composed of the calcium carbonate nanowire at the same time, and thus the fibroin/nylon composite material has a good mechanical property, is very beneficial to transportation of nutrient substances, cell migration, and the growth of tissues, and therefore the fibroin/nylon composite material is an ideal regeneration medical material.

Description

technical field [0001] The invention relates to a silk fibroin / nylon composite material and a preparation method thereof, which can be used in the field of regenerative medicine such as bone repair materials in clinical use. Background technique [0002] Silk protein is a natural polymer biomaterial derived from nature. It has excellent mechanical properties, controllable biodegradability, and easy processing, making it an ideal raw material for regenerative medicine. With the development of modern medicine and surgical techniques, tissue or organ transplantation to repair functional loss has been widely accepted, however, it faces a huge donor gap. The formation of tissues or organs in vivo or in vitro by means of regenerative medicine provides a new treatment option for the repair of damaged functions. According to different uses, silk fibroin is regenerated into powder, gel, porous sponge, nanofiber, non-woven fabric, membrane and other material forms. Regenerated silk ...

Claims

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Application Information

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IPC IPC(8): C08L89/00C08L77/02C08L77/06C08K7/08C08K3/16C08K5/09C08J5/18A61L27/48A61L27/44A61L27/22A61L27/18A61L27/56
CPCA61L27/18A61L27/227A61L27/446A61L27/48A61L27/56C08J5/18C08J2389/00C08J2477/02C08J2477/06C08K5/09C08K7/08C08K2003/162C08L77/02C08L77/06
Inventor 张香会黄继伟
Owner 吴?基
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