28results about "Organic compound libraries" patented technology

The present disclosure relates to a novel class of bifunctional molecules that are useful in a targeted or selective degradation of a protein.

One embodiment provides a neurorerestoration compound implementing multiple neuroplasticity inducing mechanisms of action including pharmacologically effective amounts of Cilostazol and Metformin and Telmisartan. A second embodiment provides a neurorestoration compound implementing multiple neuroplasticity inducing mechanisms of action including pharmacologically effective amounts of Cilostazol and Metformin and Duloxetine. The neurorestoration compound implementing multiple neuroplasticity inducing mechanisms of action is believed to be particularly well suited for stroke rehabilitation.

The invention discloses a method for catalytically synthesizing alpha-disubstituted ester, amide, malonic acid monoester or monoamide from disubstituted Meldrum's acid. By developing a new strategy for promoting the ring-opening reaction of the disubstituted Meldrum's acid by alkali, the disubstituted malonic acid monoester or monoamide can be efficiently prepared, and compared with the previous method, the strategy can obtain the target product at the room temperature at the yield of 99%. The method successfully breaks through the limitation of the existing disubstituted malonic acid monoester synthesis method, and enriches the types of target compounds. Besides, a series of novel disubstituted malonic acid monoesters are obtained, and simple chemical conversion is applied to obtain a series of disubstituted malonic acid derivatives with quaternary carbon centers. Then, under the action of a chiral organic catalyst, chiral disubstituted malonic acid monoester is obtained with high yield and high enantioselectivity. And a solid foundation is laid for subsequent application of the compounds in subjects of materials, medicines and the like.

The invention relates to a CPT1A agonist and a construction method and application thereof, the structural formula of the CPT1A agonist is # imgabs0 #, the invention provides an efficient and controllable CPT1A agonist development strategy, the CPT1A agonist is expected to be applied to treatment of metabolic diseases, immune diseases and other diseases, and the obtained CPT1A agonist is proved to have functional activity on CPT1A and has a good application prospect.

The present disclosure relates to methods and kits for analyzing a macromolecule. In some embodiments, the present disclosure relates to macromolecule analysis methods which employ barcoding and nucleic acid encoding of molecular recognition events. Also provided herein is a method and related kits for transferring information using a plurality of enzymes, including for performing a ligation, extension, and cleavage reaction with nucleic acid molecules associated with the macromolecule for analysis. In some embodiments, the macromolecule for analysis comprises a peptide, a polypeptide, or a protein.

The present invention relates to a multivalent molecular glue compound, and a preparation method therefor and the use thereof. Specifically, the compound of the present invention has a structure as represented by formula I, wherein the definition of each group and substituent is as described in the description. Further disclosed in the present invention are a method for preparing the compound and the use thereof in the prevention and / or treatment of cancers.

The invention generally relates to performing sandwich assays in droplets. In certain embodiments, the invention provides methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte, separating the complexes, and detecting the complexes, thereby detecting the target analyte.

Described herein are olfactory receptor proteins having a modified C-terminal domain comprising a specific amino acid sequence motif, as well as related nucleic acid molecules, expression vectors, recombinant host cells, libraries, and methods and uses.

The present disclosure relates to a novel class of bifunctional molecules useful for the targeted or selective degradation of proteins.

The present invention concerns an automated substance preparation method comprising: - providing a first substance container containing a first substance; - a step of sampling to extract at least one portion of the first substance; - determination of a mass of the extracted at least one portion of the first substance; - encapsulating, in a first capsule, the extracted at least one portion of the first substance; and - repeating the step of sampling, mass determination and encapsulating to form a plurality of first capsules of the first substance having randomly distributed different masses of the first substance.

Organic compounds for target identification, drug discovery, chemical library production, high-throughput screening, fluorophore conjugation, chemiluminescent compound conjugation, creation of proximity induced modulators (e.g., protein degraders) / chimeric molecules, or a combination thereof are described. The compounds can contain small molecule moieties for identification of their potential targets; an isocyanate, photoactivatable groups; chemical moieties for enrichment and detection of target-small molecule moiety interactions; proximity induced modulator element; fluorophores; chemiluminescent groups; or combinations thereof.

Disclosed herein is a method of generating a combinatorial library of products having a diverse array of properties. In particular, the method comprises: (a) selecting one or more pairs of reactants comprising complementary functional groups; (b) mapping all possible bond arrangements between the complementary functional groups of each pair to provide a library of possible products; (c) analyzing one or more properties of each possible product to select one or more products with desired properties (desired products); and (d) synthesizing the one or more desired products. Further disclosed herein is a method that involves the retrosynthetic reduction of a complex molecule into simple starting materials.

The invention relates to a modularized molecular gel compound library as well as a construction method and application thereof. Specifically, the compound disclosed by the invention has a structure as shown in a formula I, and the definitions of all groups and substituent groups are described in the specification. The invention also discloses a preparation method of the compound and application of the compound in prevention and / or treatment of cancers and the like.

The application discloses an anti-cTnI antibody and a detection kit, and relates to the technical field of antibodies.The anti-cTnI antibody disclosed by the application comprises a heavy chain complementarity determining region and a light chain complementarity determining region, the antibody provides an important raw material source for detection of cTnI, and can be used for qualitative or quantitative detection of cTnI.

A system (100) for synthesizing copolymerized molecules on a substrate (10) includes: a light source (20) emitting exposure light; a programmable light direction unit (30) for redirecting the light in specific patterns; a substrate holder (40); a reagent delivery system (50) for dispensing reagents; and a lateral movement mechanism (60) for generating relative movement between the light direction unit and the substrate holder. A controller (70) controls: i) reagent dispensing; ii) light exposure in a first pattern; iii) relative movement and adjustment of the light direction unit to a second pattern; and iv) subsequent exposure in the second pattern.

The invention provides a high-throughput PROTAC combined synthesis method based on a cellulose solid-phase carrier and a photolysis method, which specifically comprises the following steps: taking cellulose filter paper as a solid-phase carrier, carrying out amination modification on the solid-phase carrier, loading a photolysis chemical group, and carrying out combined connection of a PROTAC connecting chain, an E3 ubiquitin ligase ligand and a target head step by step to obtain the high-throughput PROTAC combined synthesis method based on the cellulose solid-phase carrier and the photolysis method. And finally, the array PROTAC molecular library is obtained through light splitting release. According to the method, the problems of strong acid cutting, poor stability, complex purification and the like in a traditional chemical cracking mode are solved, the synthesis flux and efficiency are remarkably improved, the operation is simple and convenient, the cost is low, and the rapid development of the PROTAC molecule discovery field is effectively promoted.

The present disclosure relates to a novel class of bifunctional molecules useful for targeted or selective degradation of proteins.

The invention(s) cover a composition, where units of the composition are configured to interact with each other (e.g., as neighbors) in order enable decoding of positions of captured target material relative to neighboring units of the composition. In embodiments, the composition includes: a body; and a set of molecules coupled to the body, the set of molecules comprising a first subset and a second subset, wherein the first subset is structured for target analyte capture, and wherein the second subset is structured for interactions with one or more neighboring objects. The invention(s) also cover systems incorporating one or more units of the composition and methods implementing units of the composition.

The present invention relates to a modular molecular glue compound library, a construction method therefor and the use thereof. Specifically, a compound of the present invention has a structure represented by formula I, the definitions of each group and substituent being as described in the description. Also disclosed in the present invention are a preparation method for the compound and the use thereof in preventing and / or treating cancers and the like.

A system (100) for synthesizing copolymerized molecules on a substrate (10) includes: a light source (20) emitting exposure light; a programmable light direction unit (30) for redirecting the light in specific patterns; a substrate holder (40); a reagent delivery system (50) for dispensing reagents; and a lateral movement mechanism (60) for generating relative movement between the light direction unit and the substrate holder. A controller (70) controls: i) reagent dispensing; ii) light exposure in a first pattern; iii) relative movement and adjustment of the light direction unit to a second pattern; and iv) subsequent exposure in the second pattern.

Described herein are olfactory receptor proteins having modified C-terminal domains comprising specific amino acid sequence motifs, as well as related nucleic acid molecules, expression vectors, recombinant host cells, libraries, and methods and uses.

The application discloses application of glycoside compounds in prevention and treatment of plant pathogenic viruses and belongs to the technical field of pesticide antiviral agents.Taking a tobacco mosaic virus coat protein as an example, small molecules including sugar rings, such as Swertiamarin I (A0) and ZINC85593196 (B0), are screened through virtual screening, molecular dynamics simulation, molecular mechanics and MM / GBSA free energy calculation. Based on this, further optimization is carried out, and six compounds similar to the structure of A0, such as 4-methylumbelliferone-beta-D-xyloside (A1), gardenoside (A2), 4-methylumbelliferone-beta-D-pyranoside (A3), 4-methylumbelliferone-beta-D-pyranoglucoside (A4), catalpol (A5) and esculin (hemihydrate) (A6), are obtained, and in-vivo and in-vitro biological activity evaluation is carried out. The active ingredients screened by the above method have good inhibitory effect on plant viruses.

The present disclosure relates to methods and kits for analyzing a macromolecule. In some embodiments, the present disclosure relates to macromolecule analysis methods which employ barcoding and nucleic acid encoding of molecular recognition events. Also provided herein is a method and related kits for transferring information using a plurality of enzymes, including for performing a ligation, extension, and cleavage reaction with nucleic acid molecules associated with the macromolecule for analysis. In some embodiments, the macromolecule for analysis comprises a peptide, a polypeptide, or a protein.

The invention(s) cover a composition, where units of the composition are configured to interact with each other (e.g., as neighbors) in order enable decoding of positions of captured target material relative to neighboring units of the composition. In embodiments, the composition includes: a body; and a set of molecules coupled to the body, the set of molecules comprising a first subset and a second subset, wherein the first subset is structured for target analyte capture, and wherein the second subset is structured for interactions with one or more neighboring objects. The invention(s) also cover systems incorporating one or more units of the composition and methods implementing units of the composition.

One embodiment provides a neurorerestoration compound implementing multiple neuroplasticity inducing mechanisms of action including pharmacologically effective amounts of Cilostazol and Metformin and Telmisartan. A second embodiment provides a neurorestoration compound implementing multiple neuroplasticity inducing mechanisms of action including pharmacologically effective amounts of Cilostazol and Metformin and Duloxetine. The neurorestoration compound implementing multiple neuroplasticity inducing mechanisms of action is believed to be particularly well suited for stroke rehabilitation.

The invention relates to multivalent molecular glue compounds as well as preparation and application thereof. Specifically, the compound disclosed by the invention has a structure as shown in a formula I, and the definitions of all groups and substituent groups are described in the specification. The invention also discloses a preparation method of the compound and application of the compound in prevention and / or treatment of cancers.