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A substance with a structure similar to a nucleoside molecule that is capable of occupying the active catalytic site of a reverse transcriptase resulting in inhibition of enzyme function, chain termination, and inhibition of viral replication. These compounds are converted to their active phosphorylated forms by cellular kinases.
Crystal form of an HIV nucleoside reverse transcriptase inhibitor
PCT designated stageWO2026136102A1Organic active ingredientsSugar derivativesNucleoside Reverse Transcriptase InhibitorMedicine
This disclosure provides crystalline forms of a compound of Formula (A), and pharmaceutical compositions thereof. This disclosure further provides methods for their preparation and use in methods of treatment, prophylaxis, or delay in onset or progression of HIV infection or AIDS in a subject. This disclosure further provides dosage forms, such as oral tablets, of a compound of Formula (A) and its crystalline forms.
Owner:MERCK SHARP & DOHME LLC