43 results about "Gradient generator" patented technology

A system for perfusion and diffusion MR imaging of a portion of patient anatomy includes an RF (Radio Frequency) signal generator for generating RF excitation pulses in anatomy and enabling subsequent acquisition of associated RF echo data. A magnetic field gradient generator generates anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition in a three dimensional (3D) anatomical volume. The RF signal generator and the gradient generator acquire within a single MR imaging scan, perfusion image data of the 3D volume, at least partially in the presence of contrast agent, and diffusion image data of the 3D volume.

A system uses multiple RF coils in MR imaging and an RF (Radio Frequency) signal generator generates RF excitation pulses in anatomical regions of interest and enables subsequent acquisition of associated RF echo data. A magnetic field gradient generator generates anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition. The RF signal generator and the gradient generator substantially concurrently acquire first and second volumes of first and second different anatomical regions by providing, a first RF pulse having a first asymmetric shape followed by a successive second RF pulse substantially having the first asymmetric shape but reversed in time, to substantially reduce echo time (TE) differences between acquisition of the first and second volumes and a phase encoding magnetic field gradient prepares for acquisition of data representing the first and second volumes.

The invention relates to a system for fat suppression in obtaining of MR image, comprising: an RF signal generator for generating the RF pulses in an MR pulse sequence, including an RF excitation pulse and an RF re-focusing pulse after the RF excitation pulse, using one or more RF pulses for an echo signal structure. A magnetic field slice selection gradient generator generates two different slice selection magnetic field gradients to be used together with the RF excitation pulse and the RF re-focusing pulse correspondingly, wherein the first and second slice selection magnetic field gradients are substantially different in amplitude. An MR imaging control unit controls the obtaining of MR imaging data substantially suppressed in fat signal using the generated RF signals and the differentslice selection magnetic field gradients.

A system for perfusion and diffusion MR imaging of a portion of patient anatomy includes an RF (Radio Frequency) signal generator for generating RF excitation pulses in anatomy and enabling subsequent acquisition of associated RF echo data. A magnetic field gradient generator generates anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition in a three dimensional (3D) anatomical volume. The RF signal generator and the gradient generator acquire within a single MR imaging scan, perfusion image data of the 3D volume, at least partially in the presence of contrast agent, and diffusion image data of the 3D volume.

The invention discloses a microfluidics cell drug concentration gradient generator. The microfluidics cell drug concentration gradient generator comprises four groups of liquid inlet holes which are communicated through microchannels so as to form drug and culture medium laminar flow combinations of different volume proportions in the microchannels; one group of microchannels with micro-mixing function can ensure that drug and culture medium laminar flow combinations of different volume proportions can be fully mixed to finally form different concentrations which can form nine concentration gradients together with liquid concentrations in two channels led out from a liquid inlet directly; one group of chambers are connected with the micro-mixed channels for cell culturing and drug interaction research, and nine chambers are independent from one another. The concentration gradient generator is hardly influenced by liquid inlet rate during the generation of concentration gradients, good linear concentration gradients can be formed, and the concentration gradient generator has a simple structure and provides a brandnew platform for screening and detection of cell drugs.

A system for fat signal suppression in MR imaging comprises an RF signal generator for generating RF pulses in an MR pulse sequence using one or more RF pulses for echo signal formation including, an RF excitation pulse and an RF refocusing pulse subsequent to said RF excitation pulse. A magnetic field slice select gradient generator generates first and second different slice select magnetic field gradients for corresponding use with the RF excitation pulse and the RF refocusing pulse, respectively, the first and second different slice select magnetic field gradients having substantially different amplitudes. An MR imaging control unit directs acquisition of MR imaging data having fat signal substantially suppressed using the generated RF pulses and different slice select magnetic field gradients.

Low-cost and portable microfluidic systems are needed for cell migration research and Point of Care (POC) testing. This study introduces a low-cost and portable USB Microscope Microfluidic Chemotaxis Analysis System (UMCAS) for rapid analysis of cell chemotaxis studies. A standalone microfluidic gradient generator is also developed for rapid generation of chemical gradient in microfluidic device without need of any peripheral perfusion apparatus. A smart phone based application program was developed for the real-time remote monitoring of the migration data. This system is validated by observing the neutrophil migration in three different conditions: 1) medium control, 2) uniform IL-8 control, and 3) IL-8 gradient. The results show that neutrophils exhibit random migration in both medium and uniform IL-8 control experiments, while they show strong directional migration to the IL-8 gradient. These results successfully validated the developed UMCAS system.

A system for use in MR imaging using tissue mechanical resonance includes an external wave generator for generating mechanical waves for transmission through patient anatomy. An RF pulse generator generates an RF pulse for exciting nuclei magnetic moments at specific spin frequencies in a particular selected anatomical region of interest. A motion encoding gradient generator generates a motion encoding gradient magnetic field within a time duration of a read-out gradient and synchronized with generation of the mechanical waves. A data processor processes data derived from radio frequency signals resulting from nuclei spin frequencies responsive to the motion encoding gradient magnetic field to detect the mechanical waves propagating through the patient anatomy.

Low-cost and portable microfluidic systems are needed for cell migration research and Point of Care (POC) testing. This study introduces a low-cost and portable USB Microscope Microfluidic Chemotaxis Analysis System (UMCAS) for rapid analysis of cell chemotaxis studies. A standalone microfluidic gradient generator is also developed for rapid generation of chemical gradient in microfluidic device without need of any peripheral perfusion apparatus. A smart phone based application program was developed for the real-time remote monitoring of the migration data. This system is validated by observing the neutrophil migration in three different conditions: 1) medium control, 2) uniform IL-8 control, and 3) IL-8 gradient. The results show that neutrophils exhibit random migration in both medium and uniform IL-8 control experiments, while they show strong directional migration to the IL-8 gradient. These results successfully validated the developed UMCAS system.

A system acquires MR image data of a portion of patient anatomy associated with spin lattice relaxation time in a rotating frame using an RF (Radio Frequency) signal generator and a magnetic field gradient generator. The RF (Radio Frequency) signal generator generates RF excitation pulses in anatomy and enables subsequent acquisition of associated RF echo data. The magnetic field gradient generator generates anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition in a three dimensional (3D) anatomical volume. The RF signal generator and the gradient generator use in order, a saturation pulse, a T1 spin lattice relaxation rotating frame preparation pulse sequence and a spoiler gradient, in acquiring image data of the 3D volume showing luminance contrast associated with T1 spin lattice relaxation in a rotating frame.

An apparatus for generating and focusing electrons is provided. The apparatus has an emissive material configured to emit an electron, an electron target, and an electrical potential gradient generator configured to generate an electrical potential gradient within the emissive material. The electrical potential gradient is oriented so as to vary from positive to negative in the general direction toward the electron target. In operation, an electron emitted from the emissive materials is deflected away from the emissive material and generally toward the electron target. The apparatus may be incorporated in scientific analytical equipment such as an electron multiplier.

The invention discloses a 3D printing concentration gradient chip for research of a model for improving HepG2 insulin resistance by pioglitazone. An open-type micro-fluidic chip with a tree-shaped branch structure is designed, diffusion and transportation of fluid are realized by utilizing capillary action of paper-based fibers, the problem that a traditional micro-fluidic gradient generator needs external power is solved, and the gradient generator and a cell three-dimensional culture area are integrated on a same platform, so that high-throughput, repeatable and low-reagent-consumption drug screening experiment operation is realized. An experiment starts with the establishment of an insulin resistance three-dimensional cell model, discusses the reaction degree of human hepatoma carcinoma cell HepG2 insulin resistance induced by different concentrations of insulin and the level of improving HepG2 cell glucose consumption by pioglitazone, and establishes a stable insulin resistance model and a pioglitazone intervention insulin resistance model.

The invention relates to a time difference ranging radar structure with low power consumption and simple structure, and belongs to the technical field of radar structures and radar ranging. The structure comprises a digital gradient generator, a digital control type oscillator, a power amplifier, a transmitting and receiving antenna, a low-noise amplifier, an envelope detector and a time-to-digital converter. The time difference ranging radar structure can solve the problem that the radar resolution of a frequency modulated continuous wave radar is seriously limited by bandwidth, meanwhile, anoscillator in a transmitter part is controlled by an enable signal, and when a multi-bit digital signal is input, the oscillator only works in a half cycle that the multi-bit digital signal is in anupward gradient, so that the power consumption is greatly reduced; in the receiver part, the demodulation and measurement circuit part adopts an envelope detector to detect the envelope of an echo signal, and adopts a time-to-digital converter to measure the time difference, so that compared with a coherent demodulation and frequency difference measurement method of a frequency-modulated continuous wave radar, the structure is simple.

Microfluidic gradient generators that can create robust platforms that can not only be used for creating co-cultures of cells with various ratios, but also can simultaneously generate gradients of mechanical and chemical stresses. A chip utilizes microchambers embedded within channels to provide space for 3D cell culture and exposes these cells to gradients of mechanical shear stress and a chemical treatment.

A system for use in MR imaging using tissue mechanical resonance includes an external wave generator for generating mechanical waves for transmission through patient anatomy. An RF pulse generator generates an RF pulse for exciting nuclei magnetic moments at specific spin frequencies in a particular selected anatomical region of interest. A motion encoding gradient generator generates a motion encoding gradient magnetic field within a time duration of a read-out gradient and synchronized with generation of the mechanical waves. A data processor processes data derived from radio frequency signals resulting from nuclei spin frequencies responsive to the motion encoding gradient magnetic field to detect the mechanical waves propagating through the patient anatomy.

A system uses multiple RF coils in MR imaging and an RF (Radio Frequency) signal generator generates RF excitation pulses in anatomical regions of interest and enables subsequent acquisition of associated RF echo data. A magnetic field gradient generator generates anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition. The RF signal generator and the gradient generator substantially concurrently acquire first and second volumes of first and second different anatomical regions by providing, a first RF pulse having a first asymmetric shape followed by a successive second RF pulse substantially having the first asymmetric shape but reversed in time, to substantially reduce echo time (TE) differences between acquisition of the first and second volumes and a phase encoding magnetic field gradient prepares for acquisition of data representing the first and second volumes.

The invention relates to the technical field of biomedical material synthesis, in particular to a synthetic method of a bionic gradient mineralized collagen-polycaprolactone composite material, which comprises the following steps: a) activating the surface of PCL (polycaprolactone) through argon plasma to generate carboxyl groups with the density of more than or equal to 5 * 10 / cm; b) carrying out amination modification on nano-hydroxyapatite (nHA) by adopting APTES, wherein the surface potential of the modified nHA is greater than or equal to + 15 mV; c) covalently grafting aminated nHA to the surface of PCL through an amido bond under the conditions that the molar ratio of EDC / NHS is 1: 2 and the pH is 5.5 + / -0.2, and the grafting density is greater than or equal to 3 * 10 particles / mu m; the method has the beneficial effects that the gradient mineralization structure is subjected to bionic optimization: the concentration and the flow velocity (the inner / outer layer flow velocity ratio is 1: 3) of mineralization liquid are accurately controlled through a microfluidic gradient generator, linear gradual change (the gradient slope is 1.5 + / -0.3 wt% / 100 [mu] m, R is equal to 0.97) of the mineralization degree from 20-30 wt% of the inner layer to 50-60 wt% of the outer layer is realized, the mechanical gradient characteristics of the natural bone are simulated, the compression modulus is increased from 0.8 GPa of the inner layer to 3.2 GPa of the outer layer in a gradient manner, and the mechanical property of the natural bone is improved. The mechanical matching property of the material and the host bone is obviously improved.

A method and system of generating electrical power or hydrogen from thermal energy is disclosed. The method includes adding heat to (or removing heat from) a salinity gradient generator configured to generate a more concentrated and a less concentrated saline solution. The method further includes drawing the more concentrated saline solution and the less concentrated saline solution from the salinity gradient generator and feeding the more concentrated saline solution and the less concentrated saline solution into a power generator. Feeding the saline solutions into the power generator causes the power generator to receive the saline solutions and generate power by performing a controlled mixing of the more concentrated saline solution and the less concentrated saline solution. The method further includes drawing, from the power generator, a combined saline solution comprising the mixed saline solutions and feeding the combined saline solution to the salinity gradient generator.

The invention discloses an integrated microfluidic tissue chip and a large-scale stimulant screening analysis method. The chip is composed of a flow layer and a control layer. The flowing layer is provided with a liquid inlet, a chemical concentration gradient generator, a microcavity and an outlet. The chemical concentration gradient generator is provided with a starting end, a non-irritant unit, a flow distribution and mixing unit, an irritant unit and an outlet end, each starting end is correspondingly connected with a single liquid inlet, and each outlet end is correspondingly connected with a single microcavity; and each microcavity is correspondingly connected with a single outlet. And the control layer is provided with an air inlet, a pneumatic microstructure and an air inlet micro pipeline with a closed tail end. And all the pneumatic microstructures are communicated with the air inlet through micro pipelines with closed tail ends. Array cell localization, large-scale three-dimensional tissue-like preparation, large-scale order-of-magnitude concentration gradient type tissue-like stimulation and analysis thereof, and controllable recovery of different stimulated tissue-like samples can be realized in a single chip.

A system acquires MR image data of a portion of patient anatomy associated with spin lattice relaxation time in a rotating frame using an RF (Radio Frequency) signal generator and a magnetic field gradient generator. The RF (Radio Frequency) signal generator generates RF excitation pulses in anatomy and enables subsequent acquisition of associated RF echo data. The magnetic field gradient generator generates anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition in a three dimensional (3D) anatomical volume. The RF signal generator and the gradient generator use in order, a saturation pulse, a T1 spin lattice relaxation rotating frame preparation pulse sequence and a spoiler gradient, in acquiring image data of the 3D volume showing luminance contrast associated with T1 spin lattice relaxation in a rotating frame.

The invention discloses a nano-bubble and micron-bubble gradient generator which comprises a nozzle, a first mixing section, a first self-driven rotating impeller, a first diverging section, an air suction chamber, a second mixing section, a second self-driven rotating impeller, a second diverging section and a gas phase inlet pipe. The nozzle, the first mixing section, the first diverging section, the air suction chamber, the second mixing section and the second diverging section are sequentially connected through threads or flanges or in a welding mode. Nano bubbles are separated out at thefront half part of the device by utilizing a reinforced hydrodynamic cavitation effect, micron bubbles are formed at the rear half part of the device by adopting a jet air entraining mode, and the size and the concentration of the separated nano bubbles are adjusted by changing the rotating speed of the first self-driven rotating impeller; the second self-driven rotating impeller can change the turbulence intensity of a gas-liquid two-phase flow field so as to influence the size and dispersion degree of bubbles, and the device is simple in structure, low in energy consumption and beneficial toengineering of the device.

A low field MRI instrumental system includes: an electromagnetic Radio Frequency antenna to emit RF pulses for inducing Electron Paramagnetic Resonance; an electromagnetic Low Frequency antenna for measurements, to emit LF pulses for inducing Nuclear Magnetic Resonance, respectively to receive LF signal produce by NMR; a gradient generator, to create a gradient in a static magnetic field generated during measurements; a high field generator to generate a strong pre-polarization magnetic field for magnetic pre-polarization; and, a control / command unit. This low field MRI instrumental system further includes a low field unit to generate a low static magnetic field whose direction is adjustable along the three directions X, Y and Z of a fixed reference frame associated with the low field MRI instrumental system.

The invention discloses an improved two-inlet concentration gradient generator and a design method thereof. The concentration gradient generator is processed by a soft lithography method, and structurally comprises two inlets, one outlet, a main channel, and a series of splitter plates that are subjected to special structure design and parallel to the main channel. Repeated separation and mixing of a fluid can be realized through the splitter plates, so that a certain concentration gradient is set up at the downstream of the splitter plates. The finally formed concentration gradient is determined by the structural position of the splitter plates, and the concentration gradient resolution of the splitter plate outlets is determined by the series of the splitter plates, the more the series is, the higher the resolution is. The number of the splitter plates contained at each level increases exponentially. The concentration gradient generator can realize concentration gradient establishment of arbitrary monotonic function, and only needs two fluid inlets. The structure is compact, the generated concentration gradient is stable, and the concentration gradient generator can be used for microbial chemotaxis research, drug screening and other biology, pharmacy and medical engineering fields.

The invention relates to the technical field of micro-fluidic chips, in particular to an automatic design method of a concentration gradient generator. Comprising the following steps: S1, establishing a flow resistance calculation model; s2, setting constraint conditions of a flow resistance calculation model, and obtaining flow resistance on the left side of the mixing point on the kth outlet channel and flow resistance on the right side of the mixing point on the (k-1) th outlet channel; s3, iteratively calculating the number of snakelike units in a first non-mixing area pipeline in the kth outlet channel and the length of the snakelike units; s4, calculating the length of the snakelike unit in the mixing area pipeline in the kth outlet pipeline; s5, iteratively calculating the number and the length of the snakelike units in the second non-mixing area pipeline in the kth outlet pipeline; according to the method, simplified and efficient automatic calculation is carried out, personal errors are avoided, and the design verification efficiency is improved.

The invention provides a computer-aided design method of a microfluidic dilution network gradient generator, which relates to the field of microfluidic dilution network design and comprises the following steps: (1) a preliminary configuration is envisaged; (2) configuration drawing is performed; (3) the input current value and the default value of each resistor are input; (4) transient analysis isperformed; (5) circuit performance analysis is performed; (6) inspection is performed; (7) circuit optimization analysis is performed; (8) the number of variable components that need to be optimizedis reduced; (9) a circuit result diagram is output; (10) the absolute value of the mixing channel length and the flow rate is calculated; (11) the microfluidic network design drawings are obtained; (12) the design accuracy is investigated. The invention solves the problems that the current microfluidic dilution network design method relies on the experience of the designer or the performance of the computer hardware, the experimental design is time-consuming and costly, is not suitable for the large-scale design, the design accuracy is low, the optimized parameters are many, the design difficulty is great and the like.

The invention discloses a micro-fluidic chip and a particulate matter toxicity gradient analysis method based on the micro-fluidic chip, and belongs to the technical field of particulate matter toxicity analysis. By arranging the gradient generator and the cell culture chamber, particulate matter concentration can be diluted into various different concentration gradients, the cell culture chamber ensures that enough single cells can be captured in the cell culture chamber of each concentration gradient, sufficient conditions are provided for high-resolution single cell analysis, and the device is simple in design, low in cost and easy to popularize. The single-cell dynamic response data can be obtained while the particulate matter toxicity gradient is analyzed, a plurality of gradient generator-cell culture chambers can be integrated into the same chip device, repeated cell experiments or synchronous analysis of a plurality of samples can be met, the requirement for high-throughput screening is met, and the application prospect is wide. The technical problem that the existing chip is difficult to analyze the toxicity gradient of particulate matters and can also obtain single cell dynamic response data is solved.

The utility model discloses food enzyme preparation purification equipment. The food enzyme preparation purification equipment comprises a pretreatment unit, a membrane separation unit and a chromatographic purification unit, the pretreatment unit adopts a double-layer screen vibrating screen and air flotation centrifugal linkage structure, and efficient preliminary impurity removal is achieved in cooperation with a pH adjusting system. And the membrane separation unit is combined with the tubular ceramic module and the hollow fiber module, so that the membrane separation unit has excellent anti-pollution performance and online monitoring capability. The chromatographic purification unit adopts a modular chromatographic column array and carries a buffer solution gradient generator and a multi-parameter detection system, so that the extraction precision and efficiency of target components are improved. The device is high in structural integration level, high in automation level and suitable for efficient and stable purification of the food enzyme preparation.

The invention discloses a nanobubble and micron bubble gradient generator, comprising a nozzle, a first mixing section, a first self-driven rotating impeller, a first gradually expanding section, an air suction chamber, a second mixing section, a second self-driven rotating impeller, a second gradually expanding section and a gas phase inlet pipe, wherein the nozzle, the first mixing section, the first gradually expanding section, the air suction chamber, the second mixing section and the second gradually expanding section are connected in sequence by means of threads, flanges or welding. The invention precipitates nanobubbles by means of enhanced hydraulic cavitation effect in the front half of the device, forms micron bubbles by means of jet entrainment in the back half of the device, adjusts the size and concentration of the precipitated nanobubbles by changing the rotation speed of the first self-driven rotating impeller, and the second self-driven rotating impeller can change the turbulence intensity of the gas-liquid two-phase flow field, thereby affecting the size and dispersion of the bubbles, and the device has a simple structure and low energy consumption, which is conducive to the engineering of the device.

A method and system of generating electrical power or hydrogen from thermal energy is disclosed. The method includes adding heat to (or removing heat from) a salinity gradient generator configured to generate a more concentrated and a less concentrated saline solution. The method further includes drawing the more concentrated saline solution and the less concentrated saline solution from the salinity gradient generator and feeding the more concentrated saline solution and the less concentrated saline solution into a power generator. Feeding the saline solutions into the power generator causes the power generator to receive the saline solutions and generate power by performing a controlled mixing of the more concentrated saline solution and the less concentrated saline solution. The method further includes drawing, from the power generator, a combined saline solution comprising the mixed saline solutions and feeding the combined saline solution to the salinity gradient generator.