A computer aided design method of microfluidic dilution network gradient generator

A computer-aided, design-method technology, applied in the directions of calculation, design optimization/simulation, and instrumentation, which can solve the development of large-scale integration that is not suitable for microfluidic technology, the difficulty of realizing microfluidic dilution network chips, and the doubling of design difficulties. and other problems, to achieve the effect of less design optimization parameters, simple design operation, and improved design process.

Active Publication Date: 2018-12-21
DALIAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And as the complexity of the gradient generator network increases, its design difficulty also doubles
[0004]At present, the design method of microfluidic dilution network is mainly based on the experimental improvement method. Due to the complexity of the fluid characteristics, this method of relying on experience and experimental modifica

Method used

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  • A computer aided design method of microfluidic dilution network gradient generator
  • A computer aided design method of microfluidic dilution network gradient generator
  • A computer aided design method of microfluidic dilution network gradient generator

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Such as Figure 1-3 A computer-aided design method for a microfluidic dilution network gradient generator is shown, comprising the following steps:

[0043] (1) Preliminarily imagine the general configuration of the microfluidic dilution network according to the needs of a certain biochemical principle or according to the special effect of a certain structure on the fluid;

[0044] (2) In the schematic design editor of the circuit design software, the initial fluid network configuration is drawn in the form of an analogous circuit network;

[0045] (3) Enter the total input current value of the power supply and the default value of each resistor in the circuit design editor;

[0046] (4) Select the analysis method as transient analysis, run the simulation, and the output waveform is a straight line;

[0047] (5) Circuit performance analysis, set all input channel currents and output currents as design constraints, set all resistors as variable component parameters, an...

Embodiment 2

[0057] Such as figure 1 , Figure 4-5 A computer-aided design method for a microfluidic dilution network gradient generator is shown, comprising the following steps:

[0058] (1) Preliminarily imagine the general configuration of the microfluidic dilution network according to the needs of a certain biochemical principle or according to the special effect of a certain structure on the fluid;

[0059] (2) In the schematic design editor of the circuit design software, the initial fluid network configuration is drawn in the form of an analogous circuit network;

[0060] (3) Enter the total input current value of the power supply and the default value of each resistor in the circuit design editor;

[0061] (4) Select the analysis method as transient analysis, run the simulation, and the output waveform is a straight line;

[0062] (5) Circuit performance analysis, set all input channel currents and output currents as design constraints, set all resistors as variable component pa...

Embodiment 3

[0072] Such as Figure 6-8 A computer-aided design method for a microfluidic dilution network gradient generator is shown, comprising the following steps:

[0073] (1) Preliminarily imagine the general configuration of the microfluidic dilution network according to the needs of a certain biochemical principle or according to the special effect of a certain structure on the fluid;

[0074] (2) In the schematic design editor of the circuit design software, the initial fluid network configuration is drawn in the form of an analogous circuit network;

[0075] (3) Enter the total input current value of the power supply and the default value of each resistor in the circuit design editor;

[0076] (4) Select the analysis method as transient analysis, run the simulation, and the output waveform is a straight line;

[0077] (5) Circuit performance analysis, set all input channel currents and output currents as design constraints, set all resistors as variable component parameters, an...

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Abstract

The invention provides a computer-aided design method of a microfluidic dilution network gradient generator, which relates to the field of microfluidic dilution network design and comprises the following steps: (1) a preliminary configuration is envisaged; (2) configuration drawing is performed; (3) the input current value and the default value of each resistor are input; (4) transient analysis isperformed; (5) circuit performance analysis is performed; (6) inspection is performed; (7) circuit optimization analysis is performed; (8) the number of variable components that need to be optimizedis reduced; (9) a circuit result diagram is output; (10) the absolute value of the mixing channel length and the flow rate is calculated; (11) the microfluidic network design drawings are obtained; (12) the design accuracy is investigated. The invention solves the problems that the current microfluidic dilution network design method relies on the experience of the designer or the performance of the computer hardware, the experimental design is time-consuming and costly, is not suitable for the large-scale design, the design accuracy is low, the optimized parameters are many, the design difficulty is great and the like.

Description

technical field [0001] The invention relates to the field of microfluidic dilution network design, in particular to a computer-aided design method for a microfluidic dilution network gradient generator. Background technique [0002] Microfluidic technology refers to the technology of controlling and applying flow fluid in micro-scale channels of tens to hundreds of microns. Its initial application is in biochemical analysis and other aspects. Due to the micro-scale relationship, microfluidic technology has many characteristic advantages, such as small size, small flow, low loss, fast response, etc. These characteristics make the application of microfluidics more and more extensive in recent years. In recent years, microfluidic technology has occupied an absolutely important position in many fields, especially in biochemical analysis. [0003] The microfluidic chip realizes the overall function by connecting various functional components through various pipeline networks, an...

Claims

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Application Information

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IPC IPC(8): G06F17/50
CPCG06F30/18G06F30/20
Inventor 郑国侠王云华张倩韩秉旭
Owner DALIAN UNIVERSITY
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