113results about "Measurements using double resonance" patented technology

The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising the step of ex vivo polarisation of a high T1 agent and wherein the polarising agent is optionally seperated from the high T1 agent before the high T1 agent is administered to the sample.

A method and apparatus for polarizing nuclear or electronic spins is disclosed. An analyte is passed near a surface that has a plurality of spin defect centers implanted within 10 nm of the surface. The spin defect centers are exposed to a magnetic field and illumination to produce polarized spins. The polarized spins then induce spin polarization in the analyte.

The present invention relates to devices and method for dissolving solid polarised material while retaining a high level of polarisation. In an embodiment of the present invention a material is polarised in a strong magnetic field in a cryostat 2 and then brought into solution while still inside the cryostat 2.

The present invention relates to devices and method for melting solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup (9) in a strong magnetic field in a polarising means (3a, 3b, 3c) in a cryostat (2) and then melted inside the cryostat (2) by melting means such as a laser (8) connected by an optical fibre (4) to the interior of the cryostat.

The invention concerns a method for the hyperpolarisation of ¹³C nuclear spin in a diamond, comprising an optical pumping step, in which colour centre electron spins in the diamond are optically pumped. The method further comprises a transfer step in which the polarisation of a long-lived state of the colour centre electron spins is transferred to ¹³C nuclear spins in the diamond via a long-range interaction.

Apparatus for performing in-vitro DNP-NMR measurements on a sample comprises magnetic field generating apparatus (1a, 1b) located in a cryostat (2) and surrounding a bore defining respective NMR and DNP working regions (90, 92). A system for performing DNP on a suitably prepared sample in the DNP working region. A system for performing a NMR process on a sample in the NMR working region. A sample positioning mechanism (5) which can be inserted in the bore (3) to bring a sample in turn into each of the working regions. The magnetic field generating apparatus is suitably structured so that the magnetic field in the DNP working region has a homogeneity or profile suitable for performing DNP on the sample and the magnetic field in the NMR working region has a homogeneity or profile suitable for performing a NMR process on the sample.

A double-resonance structure for DNP-NMR experiments and/or ENDOR experiments and methods using such a double-resonance structure. The double-resonance structure comprises a microwave resonator for generating electromagnetic fields suitable for EPR and an HF resonator for generating electromagnetic fields suitable for NMR. The HF resonator is formed by a strip resonator, a section of the strip resonator at the same time forming a portion of the microwave resonator.

The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.

A method for the preparation of a sample comprising highly polarized nuclear spins is proposed, comprising at least the following steps:

• • a) provision of molecules with 1,2-dione structural units and/or molecules with 2,5-diene-1,4-dione structural units in the solid state;
  • b) generation of radicals from these molecules by photo induced electron transfer by a first electromagnetic irradiation in the visible or ultraviolet frequency range in the solid state;
  • c) dynamic nuclear polarization in the presence of a magnetic field in the solid state by applying a second electromagnetic irradiation with a frequency adapted to transfer spin polarization from the electrons to the nuclear spins leading to a highly polarized state thereof. Furthermore uses of correspondingly prepared samples for NMR, MRS and MRI experiments are proposed.

An apparatus for DNP-NMR measurement on a sample (P), with a magnet configuration (M) for producing a magnetic field in a first working volume (V1), wherein the magnet configuration (M) produces a stray field in a second working volume (V2) in the direction of an axis (z) with a magnetic field gradient (H1M, H2M, HnM) in the direction of the axis (z), wherein the axis (z) extends through the second working volume (V2), with a device (N) for measuring MR signals, with a DNP excitation device (D), and with a positioning mechanism (T) for transferring the sample (P), is characterized in that, near the second working volume (V2), a compensation configuration (m) made of magnetic material is mounted that, in the operating condition of the magnet configuration (M), produces a magnetic field gradient (H1m, H2m, Hnm) in the direction of the axis (z) in the second working volume (V2) that is between −90% and −110% of the magnetic field gradient of the same order (H1M, H2M, . . . ; HnM) of the stray field of the magnet configuration (M) in the direction of the axis (z) in the second working volume (V2). Thus, homogenization of the magnetic field in the second working volume can be achieved by technically simple means.

An integrated high-frequency generator system utilizing the magnetic field of the target application including a magnetic resonance magnet having an application zone and a high-frequency (microwave/terahertz) generator zone in the magnetic field of the magnetic resonance magnet; and a high-frequency (microwave/terahertz) generator disposed in the high-frequency (microwave/terahertz) generator zone and utilizing the magnet field of the magnetic resonance magnet to generate the high-frequency (microwave/terahertz) radiation. The magnetic resonance magnet may have an auxiliary magnetic field source for modifying the magnetic field profile in the high-frequency (microwave/terahertz) generator zone. The high-frequency (microwave/terahertz) generator may include an electron gun for generating an electron beam adapted to be focused by a magnetic field source having a spatially rising region, a homogenous region and a decaying region, an interaction structure for generating high-frequency (microwave/terahertz) radiation, an internal mode converter in the homogenous region for extracting the high-frequency (microwave/terahertz) radiation through a window, and a reduced collector disposed substantially in the homogenous region before the electron beam spreads in the decaying region.

A magnet assembly for use in carrying out nuclear magnetic resonance experiments on a body or sample. The assembly comprises a set of superconducting coils (12) within a cryostat, located about a bore, and arranged to generate a substantially uniform magnetic field in a primary working volume (101) within the bore, and to generate a substantially uniform magnetic field in a secondary working volume (100) within the coil structure and separate from the bore. At least part of a hyperpolarisation system intersects the at least one secondary working volume (101) so as to hold a sample to be hyperpolarised in the secondary working volume.

NMR probe coils designed to operate at two different frequencies, producing a strong and homogenous magnetic field at both the frequencies. This single coil, placed close to the sample, provides a method to optimize the NMR detection sensitivity of two different channels. In addition, the present invention describes a coil that generates a magnetic field that is parallel to the substrate of the coil as opposed to perpendicular as seen in the prior art. The present invention isolates coils from each other even when placed in close proximity to each other. A method to reduce the presence of electric field within the sample region is also considered. Further, the invention describes a method to adjust the radio-frequency tuning and coupling of the MAR probe coils.

Provided is an apparatus and method for automated hyperpolarization of samples for use as an imaging agent comprising a sample box, an airlock chamber configured to receive a sample from the sample box, a cryogenic chamber, a guide channel to transport samples from the airlock chamber to the cryogenic chamber, a heater and pressure module coupled to the sample box, an insertion and retraction device to transport samples through the guide channel to and from the cryogenic chamber, a dissolution module coupled to the sample box, and a controller to regulate hyperpolarization of the samples by controlling one or more of position, sequencing, temperature, pressure, and dissolution of the samples within the apparatus. Also provided is a machine-readable medium comprising instruction which, when executed by a controller, causes a hyperpolarization apparatus to perform the steps of hyperpolarization of a sample.

A rapid cycle dynamic nuclear polarization (DNP) NMR apparatus comprises (i) a cooling unit, configured to cool a sample in a capillary, (b) a DNP polarization unit configured to polarize the sample in the capillary, (c) a stripline-based NMR detector comprising a stripline for NMR analysis of the sample in the capillary, (d) a transport unit configured to guide the capillary from the DNP polarization unit to the stripline of stripline-based NMR detector; and (e) a heating unit configured to heat the sample in the capillary before analysis of the sample by the stripline-based NMR detector. Fast (1D-3D) NMR measurements with high resolution may be obtained.

DNP polarizer comprising a housing receiving a free end of a tubular fluid conduit positioned in fluid communication with a nozzle supported by said housing, said nozzle including an input port, a dispense port and a tapering inner surface or a stepped inner surface defining a nozzle flowpath extending in fluid communication between said input port and said dispense port.

An apparatus and method is discussed for characterizing a fluid sample downhole of aliphatic hydrocarbon compounds, aromatic hydrocarbon compound, or connate mud filtrates containing carbon-13 isotopes using an enhanced nuclear magnetic resonance (NMR) signal on a measurement-while-drilling device. To enhance the carbon-13 NMR signal these nuclei are being hyperpolarized. Either the Overhauser Effect (OE) or the Nuclear Overhauser Effect or optical pumping and the Spin Polarization Induced Nuclear Overhauser Effect (SPINOE) can serve as a mechanism for hyperpolarization of the carbon-13 nuclei.