54results about "Measurements using double resonance" patented technology

In a general aspect, a magnetic resonance system performs magnetic resonance measurements. In some examples, a magnetic resonance system includes a data processing device and a superheterodyne spectrometer system. The data processing device generates digital intermediate frequency (IF) signal information based on the pulse profile. The digital IF signal information is configured to suppress a mirror sideband in the magnetic resonance control signal. The superheterodyne spectrometer generates a magnetic resonance control signal based on the digital IF signal information.

The invention relates to a quantum sensor (1), in particular for magnetic field measurement, comprising: a sensor element (4) in the form of a crystal doped with color centers (5), in particular a diamond crystal doped with NV centers, wherein the color centers (5) are designed to generate fluorescent light (7) upon excitation with excitation light (6), a carrier substrate (2) having a surface (2a) to which the sensor element (4) is attached, and a detector (8), in particular a photodiode, for detecting the fluorescent light (7). In the quantum sensor (1), the carrier substrate (2) has a waveguide (3) for supplying the excitation light (6) to the sensor element (4).

In a general aspect, a magnetic resonance system performs a magnetic resonance measurement. In some examples, a magnetic resonance system includes data processing apparatus and a superheterodyne spectrometer system. The data processing apparatus generates digital intermediate frequency (IF) signal information based on a pulse profile. The digital IF signal information is configured to suppress an image sideband in a magnetic resonance control signal. The superheterodyne spectrometer generates the magnetic resonance control signal based on the digital IF signal information.

The present invention describes a method for determining compensated measured values ​​of at least two physical quantities using a sensor system. The sensor system comprises at least one sensor element (SE) with crystals containing color centers. Both the first and the second physical quantity act on the sensor element (SE). A computer system (RSYS) controls the method. First, the sensor element (SE) is irradiated with modulated pump radiation (LB). A program code and configuration parameters for implementing a correction method are provided, with these parameters being stored in a memory of the sensor system or the computer system (RSYS). The fluorescence radiation (FL) of the color centers, which is influenced by the physical quantities, is recorded.Fluorescence parameters are determined from the temporal course of the intensity of the fluorescence radiation (FL) and the pump radiation (LB) and are then expressed as vector components of a fluorescence vector (F. v ). A first measured value of the first physical quantity is determined by mapping the fluorescence vectors to a sensor state vector (S z ) is determined using a neural network model (NNM) using configuration parameters determined by a training program. As a result, the first measured value depends only on the first and not on the second physical quantity, resulting in a compensated measured value. This compensated measured value is ultimately output, stored, transmitted, or reused.

The invention relates to a sensor head (4a-d) for a frequency analyzer (2a-d) comprising a crystal defect resonator (20a-d), an optical pump emitter (14) for exciting the crystal defect resonator (20a-d), a magnetic field unit (30) for generating a magnetic field with a magnetic field gradient along the crystal defect resonator (20a-d), an RF waveguide (22) and a radiation detector (10) for detecting luminescence radiation (42) from the crystal defect resonator (20a-d). To achieve easy manufacturability of the frequency analyzer (2a-d), it is proposed that the crystal defect resonator (20a-d) has a polycrystalline structure.

In a general embodiment, a magnetic resonance system performs magnetic resonance measurements. In some examples, the magnetic resonance system includes a data processing unit and a superheterodyne spectrometer system. The data processing unit generates digital intermediate frequency (IF) signal information based on the pulse profile. The digital IF signal information is configured to suppress image sidebands in the magnetic resonance control signal. The superheterodyne spectrometer generates the magnetic resonance control signal based on the digital IF signal information.

The invention relates to a sensor unit (200) for measuring a magnetic field, comprising at least two sensor media (201, 202, 203) arranged at a fixed distance from each other, at least one excitation light source (220) for shining light (224) into the at least two sensor media (201, 202, 203), at least one microwave source (241, 242, 243) for generating an alternating magnetic field in the at least two sensor media (201, 202, 203), a device for generating a bias magnetic field (B0) having different magnetic field strengths at the locations of the at least two sensor media (201, 202, 203), an optical collecting device for combining fluorescent light (225) emitted from the at least two sensor media (201, 202, 203), and a photodetector (230) for detecting the combined Fluorescence light (225),at least one signal processing unit for determining a gradient of the magnetic field from the detected fluorescence light (225).,

The present invention relates to an apparatus (100) and method for investigating a sample by using nuclear magnetic resonance, particularly zero- to ultra-low- field nuclear magnetic resonance, the apparatus (100) comprising: - a magnetically shielded chamber (20) for magnetically shielding the sample from external static magnetic fields; - magnetic field pulse generation means (30) arranged in the magnetically shielded chamber (20) and configured to manipulate nuclear spins present in the sample, thereby causing the sample to produce a magnetic signal; and - at least one magnetoresistive sensor (40) comprising a ferromagnetic material, wherein the at least one magnetoresistive sensor (40) is arranged in the magnetically shielded chamber (20) and configured to detect the magnetic signal produced by the sample.

A low field MRI instrumental system includes: an electromagnetic Radio Frequency antenna to emit RF pulses for inducing Electron Paramagnetic Resonance; an electromagnetic Low Frequency antenna for measurements, to emit LF pulses for inducing Nuclear Magnetic Resonance, respectively to receive LF signal produce by NMR; a gradient generator, to create a gradient in a static magnetic field generated during measurements; a high field generator to generate a strong pre-polarization magnetic field for magnetic pre-polarization; and, a control / command unit. This low field MRI instrumental system further includes a low field unit to generate a low static magnetic field whose direction is adjustable along the three directions X, Y and Z of a fixed reference frame associated with the low field MRI instrumental system.

The invention relates to a position sensor with several separate sensor elements (SE), each of which is individually optically queried and read out separately. Each sensor element is connected to an associated detector via an individual optical transmission path, in particular a high-temperature-resistant optical waveguide. This makes the sensor particularly suitable for applications at elevated temperatures. The sensor elements can comprise various paramagnetic centers, including those other than classic NV centers, and different host materials. Each sensor element can be individually irradiated with time-modulated pump light, thus enabling separate evaluation of the intensity and / or phase shift of the fluorescence. The detected signals are optionally evaluated using computer-implemented methods, such as machine learning.The sensor elements are also assigned to specific coded magnetic areas, enabling error detection, error correction or unambiguous position determination.

The present invention relates to an apparatus (100) and method for investigating a sample by using nuclear magnetic resonance, particularly zero- to ultra-low-field nuclear magnetic resonance, the apparatus (100) comprising: —a magnetically shielded chamber (20) for magnetically shielding the sample from external static magnetic fields; —magnetic field pulse generation means (30) arranged in the magnetically shielded chamber (20) and configured to manipulate nuclear spins present in the sample, thereby causing the sample to produce a magnetic signal; and—at least one magnetoresistive sensor (40) comprising a ferromagnetic material, wherein the at least one magnetoresistive sensor (40) is arranged in the magnetically shielded chamber (20) and configured to detect the magnetic signal produced by the sample.

The invention relates to an NMR-DNP probe comprising a sample holder, a temperature control device, a microwave guide and an illumination device, characterized in that the temperature control device comprises a VT channel through which a temperature control fluid can be supplied to the sample container for temperature control of the sample substance in NMR measurement mode, a sample-side end of the light guide is arranged in the VT channel, and a deflection mirror is arranged in the VT channel between the sample-side end of the light guide and the sample container, which directs the light exiting the light guide onto the sample substance in the sample volume of the sample container. This allows additional light excitation with adjustable beam width to illuminate the NMR test sample within the probe without negatively affecting the magnetic field or RF. Furthermore, optical excitation in the UV range can also be realized. The optical fiber is integrated into the probe with a very small bending radius. The invention also relates to a bearing bushing for use in an NMR-MAS probe and to an NMR spectrometer.

In a general aspect, a microwave resonator device for electron spin resonance is described. In some aspects, a microwave resonator device for electron spin resonance includes a substrate, a ground plane on the substrate; and a plurality of conductors that support a plurality of microwave resonant modes in a sample region of the microwave resonator device. The plurality of conductors are disposed on the substrate and include a first transmission line resonator; and a second transmission line resonator, which is coupled to the first transmission line resonator.

A system and method for increasing the nuclear spin polarization of a target compound are disclosed. [Solution] According to this system and method, a first non-thermal equilibrium nuclear spin polarization may be conferred to a source atom of at least one source compound, the source atom having a nuclear gyromagnetic ratio of at least 12 megahertz (MHz / T) per tesla. A first solution containing the source compound and the target compound can be obtained. At least one source atom can be present in the first solution at a source concentration of at least 0.1 moles (M). At least 0.01% of a second non-thermal equilibrium nuclear spin polarization can be conferred to at least one target atom of the target compound via nuclear Overhauser effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to at least one target atom.

In a general aspect, a split-planar microwave resonator device for electron spin resonance is described. In some aspects, a microwave resonator device for electron spin resonance includes parallel first and second substrates that are spaced apart from each other by a separation distance. The microwave resonator device includes a first ground plane disposed on the first substrate; a second ground plane disposed on the second substrate; a first transmission line resonator patterned on the first substrate; and a second transmission line resonator patterned on the second substrate. The first transmission line resonator is configured to produce a first microwave field in a sample region between the first and second substrates; and the second transmission line resonator is configured to produce a second microwave field in the sample region. In some examples, the first and second microwave transmission line resonators are made of superconducting material.

The invention relates to a magnetic field sensor (1) with an NV diamond (2), an excitation light source (3) configured to emit an excitation beam (4) for exciting electronic states of the NV diamond (2), and arranged such that the excitation beam (4) emitted by it can generate an electric field within the NV diamond (2), a detector (5) arranged and configured to detect fluorescence radiation that the NV diamond (2) can emit as a result of irradiation with the excitation radiation (4), a microwave structure (6) arranged and configured to generate a microwave field within the NV diamond (2) for manipulating spin states of the NV diamond (2), a magnetic field generating device (7) configured to generate an internal, static magnetic field within the NV diamond (2), and comprising at least one permanent magnet (8), and a hood (10). and a base plate (11),which are arranged to form a closed chamber (12). The NV diamond (2), the excitation light source (3), the detector (5), and the microwave structure (6) are arranged within the closed chamber (12). The hood (10) has at least one recess (13) for receiving the at least one permanent magnet (8, 9).

In a general aspect, a magnetic resonance system performs a magnetic resonance measurement. In some examples, a magnetic resonance system includes data processing apparatus and a superheterodyne spectrometer system. The data processing apparatus generates digital intermediate frequency (IF) signal information based on a pulse profile. The digital IF signal information is configured to suppress an image sideband in a magnetic resonance control signal. The superheterodyne spectrometer generates the magnetic resonance control signal based on the digital IF signal information.

The invention relates to a method and a device for evaluating a measurement signal (5') emanating from a spin-based quantum system (4), comprising exciting the spin-based quantum system (4) by a pulsed excitation light (13; 220), alternately exposing the spin-based quantum system (4) to a first and a second series of magnetic field pulses (211; 212), wherein one of the first and second series of magnetic field pulses (211; 212) consists of two π 2 − Pulse contains, and the other of the first and second magnetic field pulse sequence (211; 212) a π 2 − Puls 2 and one − π 2 − Puls includes, a detection of the measurement signal (5') emanating from the spin-based quantum system (4), an integration of the measurement signal (5') over an integration window (231) containing a signal time of a light pulse (222) of the pulsed excitation light (13; 320) between the first magnetic field pulse sequence (211) and the second magnetic field pulse sequence (212) and between the second magnetic field pulse sequence (212) and the first magnetic field pulse sequence (211) to obtain a first and a second signal value, and a determination of a measured value from the first and the second signal value.

The invention relates to a high-temperature position sensor based on NV centers in diamond. The special features of the position sensor are, firstly, the thermal separation between the sensor elements with the NV centers on the one hand and the evaluation electronics on the other, and secondly, the ability to detect up to six degrees of freedom, for example, when implemented as a magnetic field camera, by evaluating the contrast of different areas of a fluorescence image, each of which represents different areas of the surface of a magnetized body with different area magnetization.

A system and method for increasing the nuclear spin polarization of a target compound are disclosed. According to such a system and method, a first non-thermal equilibrium nuclear spin polarization may be imparted to source atoms of at least one source compound, the source atoms having a nuclear gyromagnetic ratio of at least 12 megahertz per Tesla (MHz / T). A first solution including a source compound and a target compound can be obtained. The at least one source atom can be present in the first solution at a source concentration of at least 0.1 molar (M). A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to at least one target atom of the target compound via a Nuclear Overhauser Effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to at least one target atom.

Described herein is a molecular imaging system comprising two or more MRI coils or coil arrays, where at least one coil is tuned to 1H resonance frequency and at least one coil is tuned to the resonance frequency of a nuclei such as 19F, 31P, 129Xe, 13C or 23Na. The imaging system may also contain passive frequency-selective flux focusing RF elements that are utilized to amplify the generated RF signal and, therefore, maximize the sensitivity and overall performance of the imaging system.

Systems and methods are disclosed for increasing a nuclear spin polarization of a target compound. In accordance with such systems and methods, a first non-thermal equilibrium nuclear spin polarization can be imparted to at least one source atom of a source compound, the source atom having a nuclear gyromagnetic ratio of at least 12 megahertz per tesla (MHz / T). A first solution can be obtained that includes the source compound and a target compound. The at least one source atom can be present in a source concentration of at least 0.1 molar (M) in the first solution. A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to the at least one target atom of the target compound via a nuclear Overhauser effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to the at least one target atom.

The present invention relates to a determination method (training method) for determining configuration parameters for a sensor system for determining compensated measured values ​​of physical quantities. The method uses sensor elements with crystals and color centers and comprises the following steps: providing the sensor elements, a training computer system, a temperature control device, and a magnetic field generation device; irradiating the sensor elements with a modulated pump beam; adjusting the magnetic flux density and temperature of the sensor elements; detecting the fluorescence radiation and determining measured values ​​in the form of fluorescence vectors. The determined data is stored and used to carry out an artificial intelligence training process to determine optimized configuration parameters. These parameters are stored, kept ready, and output for use in the sensor system.The method enables the precise mapping of fluorescence and microwave vectors to sensor element state vectors and supports the optimization of sensor performance.

The invention relates to a device for measuring intracorporeally generated magnetic fields, comprising: a catheter, wherein a fiber optic device is arranged within the catheter, a sensor unit for measuring magnetic fields, the sensor unit is a nitrogen vacancy center magnetometer, which, as a sensor medium, comprises diamond crystals having one or more nitrogen-vacancy centers, wherein one or more diamond crystals are arranged within the optical fiber device, wherein the sensor unit comprises a magnetic field generation device for generating a magnetic field in the area of ​​the sensor medium, wherein the sensor unit comprises an excitation light source for shining excitation light into the light guide device in order to excite the sensor medium, wherein the sensor unit comprises a microwave source for generating microwaves to excite the sensor medium with microwaves, and wherein the sensor unit comprises a photodetector for detecting resonance-dependent fluorescence light from the sensor medium and an evaluation unit which is set up to determine a magnetic field at the respective location of one or more diamond crystals based on the detected fluorescence light. The invention relates to a method for measuring intracorporeally generated magnetic fields, a computer program and a machine-readable storage medium.

The present invention describes a method for determining compensated measured values ​​of at least two physical quantities using a sensor system. The sensor system comprises at least one sensor element (SE) with crystals containing color centers. Both the first and the second physical quantity act on the sensor element (SE). A computer system (RSYS) controls the method. First, the sensor element (SE) is irradiated with modulated pump radiation (LB). A program code and configuration parameters for implementing a correction method are provided, these parameters being stored in a memory of the sensor system or the computer system (RSYS). The fluorescence radiation (FL) of the color centers, which is influenced by the physical quantities, is recorded. From the fluorescence radiation intensity values ​​(F i (t)) and fluorescence radiation delay values ​​(F φ (t)) and the pump radiation frequency (fpmp ) become vector components of a fluorescence frequency vector (F fv ). A first measured value of the first physical quantity is determined by mapping the fluorescence frequency vectors (F fv ) to a sensor state vector (S z ), for example, using a neural network model, using configuration parameters determined by a training program. As a result, the first measured value depends only on the first and not on the second physical quantity, resulting in a compensated measured value. This compensated measured value is ultimately output, stored, transmitted, or reused.

Systems and methods are disclosed for increasing a nuclear spin polarization of a target compound. In accordance with such systems and methods, a first non-thermal equilibrium nuclear spin polarization can be imparted to at least one source atom of a source compound, the source atom having a nuclear gyromagnetic ratio of at least 12 megahertz per tesla (MHz / T). A first solution can be obtained that includes the source compound and a target compound. The at least one source atom can be present in a source concentration of at least 0.1 molar (M) in the first solution. A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to the at least one target atom of the target compound via a nuclear Overhauser effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to the at least one target atom.

The invention relates to a method for generating a useful signal (11) from a signal (5') emanating from a spin-based quantum system (4), comprising exciting the spin-based quantum system (4) by an excitation light (13), exciting the spin-based quantum system (4) by an electromagnetic field (3) which oscillates between two measurement frequencies at a modulation frequency, wherein the two measurement frequencies have a first measurement frequency difference from an expected resonance frequency, detecting the signal (5') emanating from the spin-based quantum system (4) to obtain a measurement signal (7), multiplying the measurement signal (7) with a modulation signal (9) which oscillates between two modulation signal states at the modulation frequency to generate a modulated measurement signal (7'), demodulating the modulated measurement signal (7') to generate the useful signal (11), and determining a reference signal.and determining whether the expected resonant frequency value is correct, based on the reference signal.

In a general aspect, a magnetic resonance system performs a magnetic resonance measurement. In some examples, a magnetic resonance system includes data processing apparatus and a superheterodyne spectrometer system. The data processing □ apparatus generates digital intermediate frequency (IF) signal information based on a pulse profile. The digital IF signal information is configured to suppress an image sideband in a magnetic resonance control signal. The superheterodyne spectrometer generates the magnetic resonance control signal based on the digital IF signal information.

The present invention relates to a determination method (training method) for determining configuration parameters for a sensor system for determining compensated measured values ​​of physical quantities. The method uses a sensor element with crystals and color centers and comprises the following steps: providing the sensor element, a training computer system, a temperature control device, and a magnetic field generation device; irradiating the sensor element with a modulated pump beam; adjusting the magnetic flux density and temperature of the sensor element; detecting the fluorescence radiation and determining measured values ​​in the form of fluorescence vectors. The determined data is stored and used to carry out an artificial intelligence training process to determine optimized configuration parameters. These parameters are stored, kept ready, and output for use in the sensor system.What makes it special is that only one sensor element is used and the measured values ​​are determined from the time course at different temperatures, including 0°C ± 3°C.

Sensor device (10) comprising a crystal body (12), in particular a diamond, with a number of color centers, a light source (18) for generating a light beam (20) for irradiating the crystal body (12) with the light beam (20), a high-frequency device (16) for generating microwaves for irradiating the crystal body (12) with the microwaves, a detector (52) configured to detect fluorescence light generated by irradiating the crystal body (12) with the light beam (20) and with the microwaves from color centers, and a beam guidance system (22) for guiding the light beam (20) from the light source (18) to the crystal body (12). The crystal body (12) has an input coupling area (38) for coupling the light beam (20) into the crystal body (12) and an output coupling area (40) for coupling the light beam (20) out of the crystal body (12).The beam guidance system (22) is designed to guide the light beam (20) coupled out of the coupling area (40) back to the coupling area (38).