58 results about "Disulfide group" patented technology

Disclosed is a method of making conjugates of cell binding agents and small molecule drugs comprising reacting a cell binding agent with a bifunctional cross-linking moiety to thereby provide the cell binding agent with a reactive disulfide group and then reacting the modified cell binding agent with a small molecule drug comprising a free thiol group. Bifunctional cross-linking moieties are also disclosed.

An electrode includes an electrically conductive matrix containing a disulfide group, wherein an S-S bond of the disulfide group is cleaved by electrochemical reduction and reformed by electrochemical oxidation. A plurality of carbon nanotubes is dispersed in the electrically conductive matrix. The electrode can be used as a cathode of a lithium battery.

An electrode includes an electrically conductive matrix containing a disulfide group, wherein an S--S bond of the disulfide group is cleaved by electrochemical reduction and reformed by electrochemical oxidation. A plurality of carbon nanotubes are substantially disentangled and dispersed in the electrically conductive matrix. The electrode can be used as a cathode of a lithium battery. A method for producing disentangled carbon nanotubes includes the steps of: adding a plurality of aggregates of carbon nanotubes to a liquid; and providing sheer force (e.g. passing the liquid through a narrow gap at a high speed) onto the liquid for disentangling the aggregates of carbon nanotubes therein.

It is an object of the present invention to provide a polyion complex used as a non-viral gene vector, which achieves sufficiently high gene expression efficiency to a target cell. The polyion complex of the present invention comprises a block copolymer formed by binding polyethylene glycol to polycation via a disulfide group and a nucleic acid.

Novel compositions are described for use in nitrate removal and treatment of water such as water and wastewater streams produced by processes in mining operations, agriculture industries operations, industrial operations, military operations, etc. These novel compositions are also useful for the treatment of water and wastewater streams associated with the running of industries and with the production and maintenance of livestock. Advantages of these novel compositions include use of them without need for pH adjustment and / or the presence of electropositive metals, inorganic acid, or alkaline compounds. One embodiment of these novel compositions comprises: (1) a sufficient amount of organic modified clay, (2) a highly crosslinked carbohydrate polymer with branched-chain structure containing sulfide and / or disulfide groups, or an alloy or blend of such a polymer with triazine-trithione sodium salt, (3) high swelling sodium bentonite or calcium bentonite, and (4) activated carbon.

Prodrugs containing lipid moieties attached to drug derivatives, such as anti-cancer drug derivatives, via linkers comprising disulfide groups are described. Also described are nanoparticles coated with a lipid layer containing the prodrugs, formulations comprising the nanoparticles, and the use of the nanoparticles in methods of treating diseases, such as cancer, alone or in combination with additional drug compounds, targeting agents, and / or immunotherapy agents, such as immunosuppression inhibitors that target the CTLA-4, PD-1 / PD-L1, IDO, LAG-3, CCR-7 or other pathways, or multiple immunosuppression inhibitors targeting a combination of such pathways. Optionally, the nanoparticles can comprise a photosensitizer or a derivative thereof and can be used in methods involving photodynamic therapy. Synergistic therapeutic effects result from combinations of multiple modalities provided by the disclosed nanoparticles and / or nanoparticle formulations.

The invention relates to corrosion-inhibiting sol-gel coating systems and methods. Corrosion-inhibiting coating materials comprise a sol-gel and a corrosion-inhibiting compound with at least one disulfide group. The corrosion-inhibiting compound is contained within the sol-gel. Coated and / or laminated structures may include the corrosion-inhibiting coating materials on a metal substrate, and may include a secondary layer (e.g., a paint, etc.) adhered to the coating material opposite the metal substrate. Methods of forming a corrosion-inhibiting sol-gel comprise mixing organo-metallic compounds and the corrosion-inhibiting compound into a sol solution and incubating (e.g., reacting) the sol solution to form the corrosion-inhibiting sol-gel with the corrosion-inhibiting compound contained within the sol-gel. Generally, corrosion-inhibiting coating materials are hexavalent chromium free.

The invention relates to a graphene oxide drug carrier and an anti-tumor drug as well as a preparation method of the anti-tumor drug. The graphene oxide drug carrier comprises multiple nano-particles, wherein each nano-particle comprises an inner core formed by graphene oxide and a shell formed by pyrenyl disulfide group polyethylene glycol, and the pyrenyl disulfide group polyethylene glycol is adhered to the surface of the graphene oxide through the pi-pi conjugative effect of pyrenyl and the graphene oxide. The modification effect of the pyrenyl disulfide group polyethylene glycol ensures that the graphene oxide drug carrier has the characteristics of relatively high space stability, electrostatic stability and has relatively high stability.

It is an object of the present invention to provide a polyion complex used as a non-viral gene vector, which achieves sufficiently high gene expression efficiency to a target cell. The polyion complex of the present invention comprises a block copolymer formed by binding polyethylene glycol to polycation via a disulfide group and a nucleic acid.

The invention features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components is attached to an internucleotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains one or more bulky groups proximal to the disulfide group. The invention also features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components (i) is attached to an internucleotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains at least 4 atoms in a chain between the disulfide linkage and the phosphorus atom of the internucleotide bridging group or the terminal group; and where the chain does not contain a phosphate, an amide, an ester, or an alkenylene. The invention also features methods of delivering a polynucleotide to a cell using the polynucleotide constructs of the invention.

The invention discloses a REDV polypeptide modified amphiphilic comb-type gene vector and a preparation method thereof. The preparation method includes: (1) preparation of hydroxyethyl methylacrylate comb-type macroinitiator (II) with a benzene ring group; (2) preparation of a hydrophobic polyester kernel (III); (3) preparation of a carboxyl terminal hydrophobic polyester kernel (IV); (4) preparation of a comb-type polymer (V) modified by two hydrophilic segments; (5) reaction of the comb-type polymer (V) and heterodoxy polyethylene glycol modified by a pyridine disulfide group and a succinimide ester group, and addition of CREDVW for a polypeptide reaction to generate the REDV polypeptide modified amphiphilic comb-type gene vector. The REDV polypeptide modified amphiphilic comb-type gene vector is capable of efficiently loading genes, and the REDV polypeptide can be effectively combined with proteins on the surfaces of endothelial cell membranes to improve adhesion of the polymer material on the surfaces of the endothelial cell membranes, and the content of polypeptides linked on the surface of the polymer can be detected by means of fluorescence.

The present invention provides a chemical sensor for dopamine detection. The chemical sensor comprises gold-containing nanoparticles, wherein the surface of the gold-containing nanoparticles is modified by class A organic function small molecules and class B organic function small molecules, the class A organic function small molecules contain a boric acid group capable of acting with o-diphenol hydroxyl in the dopamine molecule, the class B organic function small molecules contain one or a plurality of materials selected from a crown ether group, an aldehyde group, succimide activated carboxyl, a phosphate ion group and a sulfonate ion group and capable of acting with the protonated terminal amino group in the dopamine molecule, and the class A organic function small molecules and the class B organic function small molecules further contain one or a plurality of materials selected from pyridine, mercapto, a primary amine group and a disulfide group so as to modify the gold-containing nanoparticles. The invention further provides a preparation method for the chemical sensor, a method for detecting dopamine, and an application of the chemical sensor in dopamine detection apparatuses.

The present invention provides compositions for and methods of delivering a therapeutically-effective dose of a malodorous, sulfide or disulfide group-containing compound, for example glutathione (reduced) and / or glutathione disulfide, in a vehicle that is effective to reduce the unpleasant odor and / or taste of the compound. The invention further provides methods for reducing the amount of oxidation occurring when sulfide group-containing compounds, such as glutathione, are incorporated into sugar and or sugar-free hard candies without subjecting the glutathione to thermal and or moisture degradation where degradation is expressed as oxidation. The invention further provides vehicle compositions including the protected sulfide group-containing compounds and their use as medicaments. The sulfide group-containing compounds are protected from degradation by their dispersion into fats, oils, and / or fractionated or partially hydrogenated oils prior to their blending into the vehicle.

The present invention discloses a linked disulfide group substituted deuteroporphyrin, metal complexes, preparation method and uses thereof, wherein linked disulfide group substituted deuteroporphyrin and metal complexes thereof, first using thionyl chloride and cystineto prepare cystine methyl ester hydrochloride solid; then using deuteroporphyrin, cystine methyl ester hydrochloride, dicyclohexylcarbodiimide DCC and N, N-dimethylformamide DMF to prepare linked disulfide group substituted deuteroporphyrin in the presence of catalyst pyridine. Then dissolving the linked disulfide group substituted deuteroporphyrin solid in chloroform, adding metal salts and proceeding refluxing reaction to get the linked disulfide group substituted deuteroporphyrin metal complexes. The invention provided linked disulfide group substituted deuteroporphyrin and metal complexes thereof are novel compounds capable of improving catalyst activity and selectivity, shorting reaction time, improving cyclohexane transformation ratio and selectivity of the cyclohexanone (cyclohexanol) in products.

The invention discloses an electrolyte of high-elongation electrolytic copper foil. The electrolyte contains copper sulfate, sulfuric acid, deionized water and an additive, wherein the additive contains a sulfur-containing organic matter and chloride ions; the head group of the sulfur-containing organic matter at least contains one thiol group or disulfide group, and the tail end of the sulfur-containing organic matter at least contains one acidic sulfonic acid group; and the chlorine ions are introduced by adding hydrochloric acid or copper chloride. The concentration range of sulfur-containing organic matter in the electrolyte is 0-5mg / L, and the concentration range of the chloride ions is 1-40mg / L. The invention also discloses a method for preparing the electrolytic copper foil by usingthe electrolyte, the (220) surface texture coefficient of the electrolytic copper foil prepared with the method accounts for 50%-70%, the normal-temperature elongation is 7%-11%, and the normal-temperature tensile strength is greater than 300 MPa.

The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1) where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.

Provided is a thin film transistor array which does not employ photolithography for the formation of an interlayer insulating film and has few defects in the interlayer insulating film. This thin film transistor array is provided at least with an insulating substrate (10), a gate electrode (11), a gate insulating film (12), a source electrode (13B), a drain electrode (14), a semiconductor layer (15), a protection layer (16) that covers the semiconductor layer (15), a pixel electrode (18), and an interlayer insulating film (17) that is formed between the drain electrode (14) and the pixel electrode (18). The interlayer insulating film (17) is an organic film or an organic-inorganic mixed film, and in order to connect the pixel electrode (18) to the drain electrode (14), the interlayer insulating film (17) has a via hole (40) in a part of the portion where the drain electrode (14) is formed. The drain electrode (14) has an opening portion that is positioned within the via hole (40) and is obtained by forming an opening in the electrode material, and a thiol group or a disulfide group is present on the drain electrode (14) within the via hole (40).

Provided are an etching fluid that is capable of suppressing side etching while not impairing the linearity of copper wiring, a replenishing fluid for the same, and a method for forming copper wiring. This etching fluid is a copper etching fluid characterized in being an aqueous solution containing acid, oxidizing metal ions, and a compound (A), the compound (A) having in molecules thereof an amino group and at least one sulfur-containing functional group selected from the group consisting of thiole groups, sulfide groups, and disulfide groups (where the sulfide and disulfide groups are groups in which the sulfur atoms and the heteroatoms linked thereto are linked by a single bond, and which do not form π conjugates).

The invention discloses a nanoemulsion of N-[4-(2,4 dimethoxy phenyl)-5-oxygroup-4,5-dihydro-[1,2] disulfide group-[4,3-b]-6-pyrryl]-3,5-di-trifluoromethyl benzamide and a preparation method thereof. The nanoemulsion is prepared from medicines, a water phase, an oil phase, an emulsifier, an assistant emulsifier, and the like and can enhance the dispersity of the medicines and promote the absorption of the medicines so as to further enhance the bioavailability of the medicines. The nanoemulsion has low toxicity, no hemolysis, and the like, is beneficial to the absorption of the medicines and has the advantages of simple and easy preparation method, safe and non-toxic operation, low preparation cost, high medicine content and no medicine loss. The invention is used for preparing the nanoemulsion of the N-[4-(2,4 dimethoxy phenyl)-5-oxygroup-4,5-dihydro-[1,2] disulfide group-[4,3-b]-6-pyrryl]-3,5-di-trifluoromethyl benzamide.

The graft copolymer comprises a polymerizable monomer (A1) represented by general formula (III) and a polymerizable monomer (B1) containing a pyridyl group, and a ligand can be bonded via the functional group at the terminus of R3a. In the formula, R1a represents a polymerizable group, R2a represents an alkylene group having a carbon number of 2-5, R3a represents an organic group having at a terminus a functional group selected from among an azide group, a phenyl azide group, a carboxyl group, a primary to quaternary amino group, an acetal group, an aldehyde group, a thiol group, a disulfide group, an active ester group, a trialkoxysilyl group, and a polymerizable group, and n represents any integer from 5 to 20,000.

The invention discloses a targeted anti-bladder-cancer albumin carrying mitomycin drug and a preparation method thereof. The targeted anti-bladder-cancer albumin carrying mitomycin drug is characterized in that drug molecules contain albumin molecules, anti-human-bladder-cancer monoclonal antibodies (BDI-1) and mitomycin (MMC), and the synthetic method of the drug molecules comprises the following steps: using glutaraldehyde as a cross-linking curing agent, and combining mitomycin molecules with bovine blood albumin molecules to be prepared into albumin carrying mitomycin (MMC-NS) nanoparticles with the particle size being 280-350 nanometer; then using a heterogenic bifunctional coupling agent N-succinimido-3-(2-pyridyl disulfide) propionate (SPDP) to causes the albumin carrying mitomycin molecules to be coupled with a pyridyl disulfide group (PDP) to obtain MMC-NS-PDP molecules; and finally, causing MMC-NS-PDP to reacting with BDI-1-SH molecules to obtain the drug with the molecules containing anti-human-bladder-cancer antibodies, the albumin molecules and the mitomycin, namely the targeted anti-bladder-cancer albumin carrying mitomycin drug, (BDI-1-MMC-NS for short). The drug has strong targeting to bladder cancer, a strong curative effect on bladder cancer, and a smaller influence on normal tissue cells.