368results about How to "Inhibit functioning" patented technology

Hepatitis C virus inhibitors are disclosed having the general formula:

• • wherein R₁, R₂, R₃, R′, B, Y and X are described in the description.

Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

A transmissive display apparatus 21 comprises a liquid crystal display unit 22 and a plane light source unit 23. The unit 23 comprises a tubular light source 24, a light guide 25 having a wedge-shaped reflecting groove formed at the bottom thereof, and a light-diffusing film 27 having anisotropy and/or ultraviolet (UV) absorbability. In the film, a light-scattering characteristic F(theta) representing the relationship between the light-scattering angle theta and a scattered light intensity F fulfills Fy(theta)/Fx(theta)>=1.01 over a range of theta=4 to 30°, wherein Fx(theta) and Fy(theta) represent the light-scattering characteristics in the X-axial direction and the Y-axial direction of the film, respectively. The film comprises a light-diffusing layer composed of a plurality of resins which are different from each other in refractive index, and a transparent layer laminated on at least one side thereof. The transparent layer at least may contain a UV absorber. Such a light-diffusing film ensures simplification of structures of a plane light source device and a liquid crystal display apparatus. When the film has anisotropy, the luminance in the display surface can be uniformized. A UV absorbable light-diffusing film absorbs UV from a light source (fluorescent tube) of the plane light source device (backlight), and can prevent deterioration of a prism sheet and a liquid crystal display cell.

Hepatitis C virus inhibitors are disclosed having the general formula:

wherein R₁, R₂, R₃, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

The present invention relates to a method and composition for generating an artificial intron and its components capable of producing microRNA (miRNA) molecules and thus inducing specific gene silencing effects through intracellular RNA interference (RNAi) mechanisms, and the relative utilization thereof. The miRNA-producing intron so generated is not only useful for delivering desired miRNA function into the intron-mediated transgenic organisms or cells but also useful for suppressing unwanted gene function in the transgenic organisms or cells thereof. Furthermore, the derivative products of this novel man-made miRNA-producing intron have utilities in probing gene functions, validating drug targets, generating transgenic animals and gene-modified plants, developing anti-viral vaccines and treating as well preventing gene-related diseases (gene therapy).

Nucleic acid drug carriers comprise a nucleic acid carrier complexed with a drug, wherein the nucleic acid carrier and the drug are associated non-covalently, and optionally other agents such as spacer, transfection agents, and targeting agents. The nucleic acid drug complex are discovered to have permissive or refractory uptake depending on many factors including cell type, proliferation rate, among others. The refractive uptake of the nucleic acid drug complex are shown to be useful in the nucleic acid targeting of drugs, both in vitro and in vivo. Novel drug compositions are disclosed that effectively reduce the toxicity of drugs while maintaining drug activity and enhancing a drug's therapeutic index.

A pull-out step assembly for a cargo box vehicle is disclosed. The assembly provides one or two steps to access the cargo box of a pickup truck or similar vehicle. The pull-out step assembly can be deployed with the tail gate of the cargo box in a closed or open condition. The pull-out step assembly attaches to the vehicle frame and stores beneath the cargo box when not in use. Also disclosed is a protective box member that covers the step assembly when stored beneath the cargo box.

This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

Macrocyclic peptides are disclosed having the general formula:

• • wherein R₃, R₃′, R⁴, R₆, R′, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

A system for transmission of at least power using inductive wireless coupling includes an environmentally sealed dongle and a mounting component which releasably mates with the dongle. The dongle is sized for use with one hand, and may be coupled by an umbilical to either a garment of the user or to a vehicle structure for example a seat, in which case the mounting component is coupled to the vehicle structure or to the garment respectively. The dongle and the mounting component include first and second inductive coils respectively and corresponding ferrite cores. The coils are positioned within the dongle and mounting component so that they are aligned for their inductive coupling when the dongle and mounting component are mated. The positioning and alignment of the coils provides a substantially closed magnetic path between the coils. The mounting component may be a receptacle.

A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of Gram negative, Gram positive and acid fast bacilli in general and tuberculosis (TB), mycobacterium avium complex (MAC), and anthrax in particular. Thus, the invention relates to modulation of cellular activities, including macrophage activity, and the like. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made inhibitors of serine protease.

Disclosed are peptides, which inhibit the enzymatic activity of tyrosinase, as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory peptides in a topical formulation. The peptides are characterized by sequences RADRADC and PLG-OH. Methods of skin treatment are also provided, the methods further including use of a peptide characterized by the amino acid sequence SFLLRN.

The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.

The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-1) and insulin like growth factor 2 (IGF-2) to bind to IGF-1R, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.

Macrocyclic peptides are disclosed having the general formula:

wherein R₃, R′₃, R₄, R₆, R′, X, Q and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Disclosed are peptides that inhibit the enzymatic activity of tyrosinase, as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory peptides in a topical formulation. Peptide sequences disclosed include KFEKKFEK and YRSRKYSSWY.

In a device for supplying secondary air in a gas turbine engine provided with an inner shaft (8) supporting a low pressure compressor and a low pressure turbine and a hollow outer shaft (7) coaxially nested with the inner shaft and supporting a high pressure compressor and a high pressure turbine, a seal air introduction passage (41, 45, 48) for introducing a part of high pressure air drawn from the high pressure compressor into a seal section provided in each of the bearing boxes is provided with a high pressure air introduction turbine (62) attached to the outer shaft in a rotationally fast manner. Owing to the use of the high pressure air introduction turbine, work is extracted from the seal air and cooling air derived from the supplied air and having a high temperature and high pressure air so that an excessive rise in the seal pressure at the normal rotational speed can be avoided and, at the same time, the supplied air can be reduced in temperature thereby avoiding an excessive rise in the temperature of the lubricating oil for the bearing.

The purpose of this invention is absolute elimination of medical cross-infection by endoscopy. It offers an endoscope system with a disposal sheath. The disposal sheath via anterior end cap connects the capsule which covers the outside of the endoscope and the disposal channel which sheathe in the endoscope channel and the fluid-air channel, and all these parts are joined together in a whole body. After the disposal channel is passed through the endoscope channel, its posterior disposal channel can be blocked into the elastic sealing cap via the guide tube, the posterior disposal channel's orifice need to be heated and melted and cut up simultaneously and its cut edge is in shape of V-shape by using one kind of heat fusion forceps after the use and before the retracting from the endoscope channel. A fluid-air exit and a sucking channel adapter are set on the posterior endoscope, convenience to connect with the fluid-air channel and the three-way sealing cap, the fluid-air channel may be single cavity channel or double cavity channel or two single cavity channels join in one channel together at nearing jet channel site, the channel sizes may be cylinders, or flat sizes. Both the outer surface of the endoscope and the inner surface of the endoscope channel are protected from pollution by the disposal sheath, thus ensures patients to safely use the permanent endoscope.