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3 results about "Macrocyclic peptide" patented technology
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*2) Macrocyclic peptide. A peptide consists of several to dozens of amino acids chemically connected by peptide bond to form a chain-like structure. A macrocyclic peptide has a chemical bond between two constituent amino acid residues; hence it has a ring-like structure.
Macrocyclic peptide compounds having cell membrane permeability and metabolic stability and libraries containing the same
PendingCN122094968AImprove permeabilitygood metabolic stabilityPeptide librariesPeptidesCyclic peptideMacrocyclic peptide
The present invention provides a cyclic peptide compound optionally linked to a nucleic acid, the cyclic peptide compound having a cyclic moiety wherein: (1) the cyclic moiety is composed of 13 or 14 amino acid residues; (2) among the amino acid residues constituting the cyclic moiety, the number of N-substituted amino acid residues is 7 or more, the number of amino acid residues in a single side chain is 3 or fewer, and the number of native amino acid residues is 4 or fewer; and (3) the ClogP / total amide bond (ClogP / total AB) is 1.0 to 1.8.
Owner:CHUGAI PHARMA CO LTD
Macrocyclic peptide compound having cell membrane permeability and metabolic stability, and library containing same
The present invention provides a cyclic peptide compound optionally linked to a nucleic acid, wherein the cyclic peptide compound contains a cyclic portion, (1) the cyclic portion is composed of 13 or 14 amino acid residues, (2) among the amino acid residues composing the cyclic portion, the number of N-substituted amino acid residues is 7 or more, the number of amino acid residues having the same side chain is 3 or less, and the number of natural amino acid residues is 4 or less, and (3) ClogP / total amide bond (ClogP / total AB) is 1.0 to 1.8.
Owner:CHUGAI PHARMA CO LTD
Antibiotic macrocyclic peptides
The present invention provides compounds of formula (I): (I) wherein X, Y, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further, the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by bacteria.
Owner:F HOFFMANN LA ROCHE & CO AG +1