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2 results about "Hcv ns3 protease" patented technology
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HCV NS3 protease is a 180-amino acid chymotrypsin-like serine protease. Its function is the auto-proteolytic cleavage of HCV viral polyprotein (~3000 aa) into individual, non-structural (NS) proteins with various functions. Thus it is an essential component of HCV replication and infectivity.
A pharmaceutically acceptable salt of macrocyclic quinoxaline compound as an HCV NS3 protease inhibitor
Owner:MERCK SHARP & DOHME CORP
Fusion constructs for controlling protein function
To provide a simple and effective method for rapidly shutting off the production and / or function of specific proteins in eukaryotes.SOLUTION: Described herein are engineered fusion proteins comprising a variant protease (e.g., an HCV NS3 protease) fused to a polypeptide of interest and a cognate protease cleavage site. The cleavability of the cognate protease cleavage site enables the controllability of one or more functions of the polypeptide of interest. Additionally, disclosed are methods for generating engineered fusion proteins as well as their therapeutic use.SELECTED DRAWING: None
Owner:SENTI BIOSCI INC