66results about "Cyclic peptides" patented technology

The invention provides an anti-wrinkle combined cyclic peptide and application thereof in cosmetics, the anti-wrinkle combined cyclic peptide comprises cyclic pentapeptide-4, cyclic tripeptide-5 and cyclic hexapeptide-9, the combined cyclic peptide has a remarkable synergistic effect in the aspects of promoting expression of collagen genes Collagen I, Collagen III and Collagen IV and inhibiting acetylcholine secretion, the skin elasticity and glossiness are remarkably improved, and the anti-wrinkle combined cyclic peptide has a good anti-wrinkle effect. The generation of wrinkles is inhibited, and good anti-aging and wrinkle-removing effects are achieved.

To provide an amino acid capable of improving the membrane permeability of peptide compounds, as well as a peptide compound including the amino acid.SOLUTION: The present invention provides an amino acid having a side chain capable of forming at least one intramolecular hydrogen bond.SELECTED DRAWING: None

Disclosed is a peptide-immobilized bead library from which peptides are more likely to be obtained as candidates of useful substances such as pharmaceuticals, and with which the amino acid sequence bound to a target substance can be more easily analyzed, compared to known OPOB libraries. The peptide-immobilized bead library has a structure of General Formula [I]. In General Formula [I], X is an amino acid residue; n is an integer of 4 to 8; Y is a cyclization structure; A is a spacer structure; B is a specific cleavage site-containing structure; and the 4 to 8 amino acid residues of X are each independently randomly selected.

The present invention provides a flavor enhancing composition that can enhance a flavor of a food product when blended with the aforesaid food product, a method for producing the same, and a method for enhancing a flavor of a food product. A first embodiment of the present invention relates to a flavor enhancing composition containing one or more heat-treated spices selected from cumin, paprika, asafoetida and mustard seed. A second embodiment of the present invention relates to a method for producing the aforesaid flavor enhancing composition, comprising heating, under a specified condition, the one or more spices selected from cumin, paprika, asafoetida and mustard seed. A third embodiment of the present invention relates to a method for enhancing a flavor of a food product, comprising blending the aforesaid flavor enhancing composition with the food product.

The invention discloses a peptide with an anti-photoaging effect as well as a preparation method and application of the peptide. The cyclic dipeptide cyclo (LO) and the linear dipeptide LO disclosed by the invention can be used for remarkably inhibiting the activity of MMP-1 and efficiently blocking collagen degradation. In addition, the cyclic dipeptide and the linear dipeptide have no cytotoxic effect when being co-cultured with fibroblasts, so that the cyclic dipeptide and the linear dipeptide have no stimulation and side effects on cells, and are high in safety and good in stability. The cyclic dipeptide and the linear dipeptide disclosed by the invention can resist UVA (Ultraviolet A) damage, have a promoting effect on cell proliferation activity after UVA irradiation and have an anti-aging effect on cells after UVA irradiation. The two peptides disclosed by the invention can be used for preparing medicines or cosmetics for resisting light aging, resisting aging, beautifying and protecting skin. The peptide fragment disclosed by the invention has a good application prospect in the fields of medicines, cosmetics and the like.

The present invention provides therapeutic compounds, such as compounds of formula I, or pharma- ceutically acceptable salts, hydrates or solvates thereof, pharmaceutical compositions thereof, methods of use thereof, and methods for making these compounds, as therapeutic or anti-cancer agents.

The invention discloses a sulfur-containing gem-difluoroallyl compound as well as a preparation method and application thereof. The invention provides a preparation method of a compound as shown in a formula C. The preparation method comprises the following step: in a solvent, in the presence of alkali, carrying out gem-difluoroallylation reaction on a compound as shown in a formula A and a compound as shown in a formula B to obtain the compound as shown in the formula C. According to the method, the sulfydryl in the sulfydryl-containing compound can be mildly and efficiently gem-difluoroallylated, metal catalysis is not needed, the reaction can be performed in a water phase, the operation is simple, and the method is suitable for performing rapid fluoroalkylation modification and further functional modification on polypeptide, protein, complex bioactive molecules and the like; the method has very important application prospects in the fields of medicine, life science and the like.

To provide a new molecular modality capable of modulating the function of an undruggable target.SOLUTION: A compound (e.g., a macrocyclic compound comprising 14 to 40 ring atoms as shown below) capable of modulating a biological process by binding to presenter proteins (e.g., members of the FKBP family, members of the cyclophilin family, or PIN1) and target proteins (e.g., eukaryotic target proteins such as mammalian target proteins or fungal target proteins or prokaryotic target proteins such as bacterial target proteins).SELECTED DRAWING: None

The invention discloses a colla corii asini in-vivo bioactive component cyclic dipeptide and a discovery method thereof, and belongs to the technical field of bioactive component analysis and application. The method comprises the following steps: establishing a rat donkey-hide gelatin administration model and collecting a sample, performing solid-phase extraction on the sample, performing LC-MS / MS peptidomics analysis and PEAKS database search, screening exogenous oligopeptides based on a feature-based molecular network (FBMN), performing cyclic dipeptide targeted metabonomics identification, and verifying cell viability. According to the method, 29 cyclic dipeptides are produced by metabolism in donkey-hide gelatin, and the cyclic dipeptides containing hydroxyproline (Hyp) can significantly improve the survival rate of HT-22 cells damaged by glutamic acid or hydrogen peroxide induction and have neuroprotective activity.

The invention belongs to the technical field of gene engineering, and particularly relates to an NRPS gene, a vector and construction and preparation of a high-yield cyclic dipeptide compound recombinant strain of the NRPS gene. According to the invention, an NRPS core gene is excavated from a sea squirt-derived fungus Diapothesp.SYSU-MS4722, a recombinant strain is constructed by using the gene and using Aspergillus oryzae as a heterologous expression host, the cyclic dipeptide natural product cyclo (Phe-Ala) is successfully separated, and the yield can reach 110 mg / L, which is increased by 20 times compared with the yield of cyclo (Phe-Ala) in reported marine bacteria Pseudomonasputida. Therefore, the aspergillus oryzae recombinant strain disclosed by the invention can be used for efficiently preparing the cyclic dipeptide compound cyclo (Phe-Ala) and has an important application value.

The present disclosure relates to compositions and methods useful for the functionalization of surfaces in the absence of a metal catalyst. The compositions include compounds of formula (I), which react with strained alkene-containing compounds, before or after molecular assembly catalyzed by tyrosinase, to afford cycloadducts. The strained alkene-containing compound may further comprise any molecule of interest, including small molecules and macromolecules, thereby enabling surface functionalization. In certain embodiments, the strained alkene-containing molecule comprises a moiety selected from the group consisting of a trans-cyclooctene (TCO), cyclopropene, cyclobutene, and norbornene.

A bicyclic peptide composition and its application are disclosed, relating to the field of peptide technology. The cyclic peptide composition comprises component X and component Y, wherein component X is cyclic octapeptide-69, and component Y is selected from one or more of the following cyclic peptides: Cyclo-(Pro-Lys-Glu-Lys) and Cyclo-(Val-Leu-Gln-Trp-Val-Lys). Specifically, the cyclic peptide composition and its use in the preparation of cosmetics are disclosed.

Described herein is the monohydrochloride salt and the free zwitterion of the macrocyclic peptide antibiotic 4-[(11S,14S,17S)-14-(4-aminobutyl)-11-(3-aminopropyl)-17-(1H-indol-3-ylmethyl)-16-methyl-12,15,18-trioxo-2-thia-4,10,13,16,19-pentazatricyclo[19.4.0.03,8]pentacosa-1(25),3(8),4,6,21,23-hexaen-22-yl]benzoic acid. Also described are amorphous and crystalline forms of the hydrochloride salt and the free zwitterion, as well as methods of making them and using them in medical therapy.

Disclosed are methods of producing conditionally active proteins that target senescent cells and are conditionally active in the extracellular environment of senescent cells. The methods include methods of using an evolved protein library and testing using physiological concentrations of bodily fluid components. Also disclosed are conditionally active proteins, antibodies, and antibody fragments for killing or removing senescent cells, conjugates and pharmaceutical compositions using these conditionally active proteins, and methods of treating age-related diseases, conditions, or disorders using the pharmaceutical compositions. Conditionally active proteins can be further evolved, conjugated to other molecules, masked, and reduced in activity by linking cleavable moieties.

Novel cyclic peptides, cyclic peptide conjugates and compositions containing them for treating neurological diseases in a subject include an Odorranalectin (OL) sequence or modified OL sequence as a scaffold and a biologically active peptide or protein and / or therapeutic agent conjugated thereto. Methods of treatment of neurological diseases are based on intranasal delivery of a cyclic peptide or cyclic peptide conjugate as described herein. Combinatorial libraries that include a plurality of cyclic peptides have also been developed and can be used to screen for a ligand(s) for a receptor of interest.

Disclosed are a bicyclic peptide composition and application thereof, and relate to the technical field of polypeptides, the ring peptide composition comprising component X and component Y, the component X being a ring hexapeptide-8, and the component Y being selected from one or more of the following ring peptides: a ring octapeptide-69, Cyclo-(Pro-Lys-Glu-Lys), Cyclo-(Val-Leu-Gln-Trp-Val-Lys). Specifically, the ring peptide composition and the use thereof in the preparation of cosmetics are disclosed.

Aspects of the present invention disclose compounds that modulate the aggregation of amyloidogenic proteins or peptides. In some aspects, disclosed compounds modulate the aggregation of disease-associated proteins and natural β-amyloid peptides. In a preferred embodiment, the compounds can inhibit natural amyloid aggregation. Pharmaceutical compositions comprising the compounds of the embodiments, and diagnostic and treatment methods for diseases (e.g., amyloidogenic diseases) using the compounds, are also disclosed. In addition, there is provided an integrated bacterial platform for the discovery of rescuers of disease-associated protein misfolding.

The invention discloses a sponge cyclic peptide compound and cyclic dipeptide, which comprise two amino acid fragments, namely proline and methionine sulfoxide, and provides application of the sponge cyclic peptide compound in an anti-Parkinson medicine, and the sponge cyclic peptide compound can obviously improve the movement speed of lesion zebrafish. Compared with the prior art, the invention has the advantages that a new compound is provided for developing and researching an anti-Parkinson medicine, and separation, synthesis and application of the active sponge cyclic peptide compound are provided.

This provides a novel, highly specific molecular probe for tumor diagnosis. [Solution] A compound having the structure shown in the following formula (A) is provided. Its use in the preparation of radionuclide labeling or radionuclide labeling reagents is further provided. Furthermore, a radionuclide preparation comprising the compound shown in formula (A) is provided. TIFF2026102884000026.tif67170

The present invention discloses a cyclopeptide glass and a pharmaceutical composition glass containing a cyclopeptide. The cyclopeptide glass of the present invention can exert both the effect of a drug and the function of a drug adjuvant, and compared with crystals and conventional pharmaceutical dosage forms and adjuvants, it can effectively accelerate the dissolution rate of a drug and improve the bioavailability of a drug, and is widely applied in the fields of drug delivery and sustained release, such as antitumor, antiviral, antibacterial, blood sugar control, immunoregulation, and neuroregulation.

Embodiments of the disclosure include methods and compositions related to use of compound comprising a particular peptide linked to a dye. In specific embodiments, the peptide DIRG is linked to the BODIPY dye. In specific embodiments, the compositions are utilized for treatment of neurological conditions and secondary pathologies related therewith, such as spinal cord injury and Alzheimer's Disease, as examples.

The invention discloses a tetrapeptide-7 cyclic peptide as well as a composition and application thereof, and relates to the technical field of polypeptides, and the cyclic peptide has the following structure: Cyclo-[Gly-Gln-Pro-Arg]. In particular, the invention relates to the cyclic peptide or the salt thereof, or a composition of the cyclic peptide and the salt thereof, and application of the cyclic peptide and the salt in preparation of a composition for caring skin or mucosa.

Methods of generating conditionally active proteins that target senescent cells and which are conditionally active in an extracellular environment of a senescent cell. The methods include methods using libraries of evolved proteins and assays employing physiological concentrations of components of bodily fluids. Also disclosed are conditionally active proteins for killing or removing senescent cells, antibodies and antibody fragments, conjugates and pharmaceutical compositions employing these conditionally active proteins and methods for treatment of age-related diseases, conditions or disorders using same. The conditionally active proteins may be further evolved, conjugated to other molecules, masked, reduced in activity by attaching a cleavable moiety.

Provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein (I) can inhibit TNFR1 and is expected to be useful as a therapeutic agent for treating, for example, inflammatory bowel disease, rheumatoid arthritis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, and hidradenitis suppurativa.The present disclosure also provides a pharmaceutical composition comprising the compound disclosed herein or a pharmaceutically acceptable salt thereof.The present disclosure also relates to a method of using the compound or a pharmaceutically acceptable salt thereof in the treatment and prevention of inflammatory bowel disease, rheumatoid arthritis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, and hidradenitis suppurativa, as well as a method of preparing a medicament for this purpose. [Case 1] TIFF2025534571000233.tif82167

The present invention relates to a novel peptide derivative, which is a partially modified adiponectin receptor peptide and has higher stability and superior p-AMPK activity than existing adiponectin receptor peptides, and has the advantage of being advantageous for drug formulation due to improved physical properties and activity. Therefore, the peptide derivative of the present invention can be used for preventing or treating skin inflammatory diseases, wounds, hair loss, fibrosis, metabolic diseases, or cancer, and for preventing or improving aging, sensitive skin, wrinkles, or moisture.

This invention belongs to the field of genetic engineering technology, specifically relating to the construction and preparation of an NRPS gene, a vector, and a recombinant strain that produces high-yield cyclic dipeptides. This invention identifies an NRPS core gene from the sea squirt-derived fungus Diaporthesp. SYSU-MS4722, and uses this gene with Aspergillus oryzae as a heterologous expression host to construct a recombinant strain. The cyclic dipeptide natural product cyclo(Phe-Ala) was successfully isolated, with a yield reaching 110 mg / L, which is 20 times higher than the reported yield of cyclo(Phe-Ala) from the marine bacterium Pseudomonas putida. Therefore, the Aspergillus oryzae recombinant strain of this invention can be used for the efficient preparation of the cyclic dipeptide compound cyclo(Phe-Ala), and has significant application value.

The present invention relates to Muramyl dipeptide compounds having adjuvant activity. The present invention also discloses the process for the preparation of Muramyl dipeptide compound and their intermediates. The immuno-modulating properties of the Muramyl dipeptide compound and their use as NOD2 agonistic adjuvants in vaccine formulations is also disclosed.

To provide a method for identifying a cancer subject for treatment with a Psap peptide.SOLUTION: A subject is identified based on a level of CD36. Further provided herein are a composition and a method for treating a cancer subject based on the level of CD36.SELECTED DRAWING: Figure 2

The present disclosure relates to the technical field of polypeptides. Disclosed are a cyclic peptide, and a composition and the use thereof. The cyclic peptide of the present disclosure has a structure as shown in formula (I): Cyclo-[Gly-His-Lys-Lys] (I). The present disclosure specifically relates to the cyclic peptide or a salt thereof, or a composition thereof, and the use thereof in the preparation of a composition for caring or treating skin or mucosa.