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Multi-phase large-aperture bone regeneration bracket material transformed from cuttlebone and preparation method thereof

A scaffold material, a technology of cuttlefish bone, which is applied in the field of medical bionic materials, can solve the problems of difficult bone defect repair, poor osteoinductive effect, and high brittleness of coral bones, and achieves low price, good biocompatibility, and no damage to the ecological environment. Effect

Inactive Publication Date: 2011-03-23
NINGBO UNIV
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  • Application Information

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Problems solved by technology

However, coral bone itself is brittle, has poor osteoinductive effect, and degrades too fast, so there are some difficulties in repairing large and complex bone defects and bone defects in bearing areas.

Method used

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  • Multi-phase large-aperture bone regeneration bracket material transformed from cuttlebone and preparation method thereof
  • Multi-phase large-aperture bone regeneration bracket material transformed from cuttlebone and preparation method thereof

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Embodiment Construction

[0015] Realize the preferred scheme of the specific embodiment of the present invention:

[0016] Fresh cuttlefish from the East China Sea was taken, and its backbone was taken after cleaning, and then subjected to degreasing treatment: (1) Soak in analytically pure chloroform I for 24 hours; (2) Soak in analytically pure chloroform II for 24 hours; (3) Soak in analytically pure acetone I for 24 hours; ( 4) Soak in analytically pure acetone II for 24 hours.

[0017] Dry naturally at room temperature as the reaction raw material.

[0018] The raw material after above-mentioned processing is cut into about length x width x height be 15x10x6mm piece and diameter x height is the cylinder of 10x15mm, then above-mentioned material is put into reaction kettle, add ammonium dihydrogen phosphate simultaneously (Ca: P is 1.0:0.6), reacted at 180 degrees Celsius for 24 hours, cooled to room temperature, transferred to a crucible and heated and dried at 120 degrees Celsius. Soak the dri...

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Abstract

The invention discloses a large-aperture bone regeneration bracket material and a preparation method thereof, and belongs to the technical field of medical biomimetic material engineering. A natural porous inorganic biological material (cuttlebone) and ammonium dihydrogen phosphate undergo a full reaction at high temperature under high pressure so as to be transformed into a multi-phase biological ceramic (consisting of calcium carbonate, hydroxyapatite and calcium phosphate). The preparation method for the material is simple in process, the material source is abundant, and the cost is low. In addition, the prepared material has good biological compatibility and high compression strength, and is environmentally-friendly. The bone cell experiment shows that the material has bone conduction activity, can promote and induce bone regeneration self-repair, can be degraded step by step in vivo, is an ideal bone transplant replacement material, and has wide application range and obvious social and economic benefits in bone surgical operation.

Description

Technical field: [0001] The invention relates to the technical field of medical bionic materials, in particular to a bioactive, degradable bone regeneration scaffold material with a large pore size and a preparation method thereof. Background technique: [0002] Bone defects due to accidents, trauma, war, or orthopedic surgery require bone grafting. In addition, as people age, bone strength gradually decreases, the probability of fractures gradually increases, and the number of cases requiring bone grafts is also increasing. At present, bone graft materials can be roughly divided into autologous bone, allogeneic bone and artificial bone replacement. Autologous bone transplantation is the best way to treat bone defects, but the source of autologous bone is limited, which adds new trauma to the patient, and there will be certain complications in the bone harvesting area; although allograft bone has osteogenic conduction, it is easy to Inducing antigenicity and spreading path...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/56
Inventor 李星李亚屏许海平查美琴邴月潘建国
Owner NINGBO UNIV
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