The invention discloses an empty micropin array chip which comprises a substrate and an empty micropin, wherein the empty micropin comprises a pin head and a pin rod, the empty micropin is fixed on the substrate through the pin rod and is inclined to the substrate at a certain angle, the pin head is provided with an oval-shaped annular plane, one end of the pin head is a pinpoint, one part of the oval-shaped annular plane is embedded into the substrate, the pin rod is an empty circular pipe which is embedded into the substrate or is penetrated through the substrate, the bottom of the pin rod is parallel with the lower surface of the substrate or is convex or concave, and the empty micropin penetrates through the two sides of the substrate to be formed into the hole-shaped micropin or the bottom of the pin rod is sealed to be formed into a blind hole type micropin. The empty micropin array chip is firm in structure, sharp in pinpoint, convenient in puncture, low in cost, high in yield, and suitable for manufacture in bulk. The micropin in the array has good consistency, is free of pain feel and blooding when in use, and is safe and reliable since the minimally-invasive skin can fast heal after in use.