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147results about How to "Fast self-healing" patented technology

Antibacterial adhesion injectable hydrogel dressing, preparation method and applications thereof

The invention discloses an antibacterial adhesion injectable hydrogel dressing, a preparation method and applications thereof, and belongs to the technical field of biodegradable biomedical materials.According to the method, 2,3-epoxypropyltrimethylammonium chloride (GTMAC) is grafted onto chitosan to obtain a quaternized chitosan polymer (QCS) as the main raw material of a hydrogel, p-carboxybenzaldehyde is grafted onto a triblock copolymer Pluronic< >F127 to obtain an aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) as the cross-linking agent of the gel, and the aldehyde group-terminated Pluronic< >F127 polymer (PF127-CHO) and the quaternized chitosan polymer (QCS) are subjected to a cross-linking reaction under a physiological environment to obtain the antibacterial adhesion injectable hydrogel dressing (QCS/PF) with advantages of rapid self-healing, easy extending and easy compression. According to the present invention, the method has advantages of simple process, wide raw material source and low preparation cost; and the hydrogel dressing prepared by using the method has advantages of good adhesion, good pH responsiveness, good mechanical property, good self-healing property, good bleeding stopping property and good antibacterial property so as to be used in the field of skin injury treatment drugs.
Owner:XI AN JIAOTONG UNIV

Water-based polyurethane self-repairing coating material based on double-selenium dynamic covalent bond and hydrogen bond

The invention discloses a preparation method of a water-based polyurethane self-repairing coating material based on double-selenium dynamic covalent bond and hydrogen bond. The material is prepared bythe following steps: firstly, performing reaction on diisocyanate, macromolecular diol, dihydromethyl propionic acid, a UPy-based chain extender and double-selenium diol to obtain a polyurethane prepolymer; then adding triethylamine and performing neutralization; finally adding deionized water and diamine, and performing emulsification and chain extending. The self-repairing property of the material is based on the visible light dynamic reversible characteristic of the double-selenium bond and the rapid breakage-recombination characteristic of the hydrogen bond, damage can be self-repaired rapidly and repeatedly under mild and visible illumination, damage to the material by the conditions such as high temperature and ultraviolet irradiation needed by the traditional self repairing is avoided, the hydrogen bond with rapid recombination and weak bond energy is combined with the double-selenium bond with slow recombination and strong bond energy, rapid and slow combination of the self repairing is realized, and better self-repairing effect is achieved. The material can be applied to coating in many fields and has wide application prospect.
Owner:SICHUAN UNIV

Doxorubicin hydrochloride loaded temperature-sensitive self-healing hydrogel and preparation method thereof

The invention relates to a doxorubicin hydrochloride loaded temperature-sensitive self-healing hydrogel and a preparation method thereof. The doxorubicin hydrochloride loaded temperature-sensitive self-healing hydrogel comprises chitosan, sodium beta-glycerophosphate, and polyethylene glycol with two ends respectively carrying a benzaldehyde group. The preparation method comprises the following steps: forming an imide bond with a self-healing performance through using a reaction of an amino group in the structure of chitosan and the benzaldehyde groups at two ends of the polyethylene glycol, combining the imide bond with chitosan / sodium beta-glycerophosphate temperature-sensitive gel, and loading doxorubicin hydrochloride into the obtained material through physical clathration to prepare the novel temperature-sensitive self-healing hydrogel administration system. The administration system is a liquid at room temperature, and rapidly gelates at a human body temperature after being injected to a tumor position in order to form a medicine reservoir ; and compared with traditional in situ gels, the temperature-sensitive self-healing hydrogel has the advantages of strong mechanical strength, realization of rapid self restoration under the action of outside force or tissue damages to avoid burst release of a medicine, further delay of release of the medicine and prolongation of the detention time of the medicine in the tumor position, medicine effect enhancement and reduction of toxic and side effects.
Owner:CHINA PHARM UNIV

Self-repairing water-based epoxy compound elastic coating material and preparation method thereof

The invention relates to a self-repairing water-based epoxy compound elastic coating material and a preparation method of the material and belongs to the technical field of paint. The method comprisesthe steps of dispersing macroporous adsorbent resin adsorbing a saturated HMDI (hexamethylene diisocyanate) prepolymer, a latent curing agent and a catalyst mixture and a high water absorber in a paraffin molten mass to prepare macroporous adsorbent resin-water absorber microcapsules, dispersing the microcapsules in water to form microcapsule dispersing liquid, and mixing and curing the microcapsule dispersing liquid, water-based epoxy resin, a water-based epoxy curing agent and the like for film formation to form the water-based epoxy compound elastic coating material with a self-repairing function. When a coating layer is scratched, or a base material deforms and generates a crack, the high water absorber in the microcapsules can adsorb moisture in the air to expand; and the HMDI prepolymer and the latent curing agent can quickly react with groups, such as alkylol amine, generated by the moisture or the water to generate a polyurethane-urea cured substance for synergic repair of thecrack. The material can be used for the highway fields of tunnels, bridges, concrete fender walls, metal guardrails and the like and has effects of corrosion resistance, water resistance, attractiveness, visual fatigue reduction and the like.
Owner:TAIYUAN LUBANG TECH CO LTD

Self-repairing hydrogel based on di-selenium dynamic covalent bond and quadruple hydrogen bond

The invention discloses a preparation method of a self-repairing hydrogel based on double-selenium dynamic covalent bond and quadruple hydrogen bond. The hydrogel is prepared from the following steps:enabling the diisocyanate, polyethylene glycol, di-selenium diol, UPy-based chain extender and crosslinking agent trimethylolpropane to react in tetrahydrofuran to obtain organic gel, and soaking theorganic gel in deionized water to remove the solvent and unreacted micromolecule. The hydrogel can realize the repeatable fast self-repairing on the injury under the mild visible irradiation based onthe dynamic feature of the di-selenium dynamic covalent bond under the visible irradiation and the UPy quadruple hydrogen bond fast fracturing-recombining feature, the damage on the material structure by the high-temperature, ultraviolet irradiation and other stronger external stimulus required by the traditional self-repairing is avoided. The hydrogel is a polyurethane structure taking the polyethylene glycol as the hydrophilia soft segment, and has excellent biocompatibility and molecular structure designability; the actual application requirement can be well satisfied, and the hydrogel hasa extensive application prospect in the field of the biological tissue engineering.
Owner:SICHUAN UNIV

High-transparency self-repairing self-adhesion conductive elastic material and preparation method thereof

The invention discloses a high-transparency self-repairing self-adhesion conductive elastic material and a preparation method thereof, and belongs to the technical field of high polymer materials. The preparation method comprises the following steps: firstly, mixing a hydrogen bond acceptor and a hydrogen bond donor to prepare a polymerizable eutectic solvent, then adding a photoinitiator, uniformly stirring to obtain a prepolymer solution of a mixed liquid, and finally, polymerizing the prepared prepolymer solution through ultraviolet irradiation to obtain the high-transparency self-repairing self-adhesion conductive elastomer. Wherein the hydrogen bond donor comprises an acrylic acid monomer and an imidazole monomer. According to the preparation method, cross-linking agents of other components do not need to be additionally added, and the conductive elastomer which has the light transmittance of 90% or above, can be rapidly self-repaired and is easily adhered to ceramics, metal and skin can be prepared only by adding the photoinitiator and performing ultraviolet irradiation. The high-transparency self-repairing self-adhesion conductive elastomer prepared by the invention is non-toxic, has high mechanical strength and adhesion performance, and can be applied to the fields of flexible electronic devices, adhesive materials and the like.
Owner:JIANGNAN UNIV

Preparation method of high-strength self-healing hydrogel

The invention discloses a preparation method of high-strength self-healing hydrogel and belongs to the technical field of preparation of medical materials. The preparation method comprises the following steps: dissolving polyvinyl alcohol, adding an acrylamide solution, by taking N,N'-methylene bisacrylamide as a crosslinking agent and nano titanium dioxide as a free radical initiator, firstly polymerizing acrylamide under ultraviolet light condition to form polyacrylamide network gel, then carrying out freeze-thraw cycle to form polyvinyl alcohol network gel, then carrying out oxidation crosslinking on the surface of a prefabricated hydrogel network by utilizing self-polymerization effect of dopamine, so that a polydopamine composite layer strongly adhered on the surface of a gel network is formed, and self-made nano hydroxy calcium phosphate is adsorbed, and the aim of further strengthening the hydrogel network is achieved. Meanwhile, the formed polydopamine surface layer and the adsorbed nano hydroxy calcium phosphate have good biocompatibility, and the problem that the traditional self-healing hydrogel is poor in mechanical strength and biocompatibility is effectively solved, so that the high-strength self-healing hydrogel has better application prospect.
Owner:CHANGZHOU YAHUAN ENVIRONMENTAL PROTECTION TECH

Waterproof, breathable, high-elastic and self-repairing double-layer nanofiber membrane for skin dressing and preparation method of nanofiber membrane

The invention relates to a waterproof, breathable, high-elastic and self-repairing double-layer nanofiber membrane for skin dressing and a preparation method of the nanofiber membrane. The preparationmethod comprises the following steps: firstly, carrying out electrostatic spinning on a precursor spinning solution I consisting of a synthetic polymer solution, an alcohol-soluble hydrophobic agent,an environment-friendly cross-linking agent and a functional drug to prepare a hydrophobic fiber membrane; then carrying out electrostatic spinning on a precursor spinning solution II consisting of anatural polymer solution, a catechol-based molecular solution and anhydrous ferric trichloride powder, and receiving the obtained material on the hydrophobic fiber membrane to prepare a composite fiber membrane; and finally carrying out aftertreatment on the composite fiber membrane to obtain the nanofiber membrane. The water pressure resistance of the prepared double-layer nanofiber membrane is5-50kPa, the air permeability is 5-15kg/m<2>/d, the elastic modulus is 5-15MPa, the tensile strength and elongation at break of a self-repaired fiber membrane are 50-90% of an initial fiber membrane,and the adhesion and comfort of a wound surface can be guaranteed while the healing promoting capability of the dressing is improved.
Owner:DONGHUA UNIV

Self-repairing waterborne epoxy/asphalt compound waterproof coating and preparation method thereof

The invention relates to a self-repairing waterborne epoxy/asphalt compound waterproof coating and a preparation method thereof, belonging to the technical field of a coating. According to the technical scheme, the method comprises the following steps: utilizing polyether polyol and MDI-50 to compound a polyurethane prepolymer with -NCO content of 20%; dipping 30-50 micron of water absorbent in the polyurethane prepolymer till being saturated; dispersing in paraffin molten mass; atomizing, quickly freezing and generating paraffin for wrapping a high water absorbent microcapsule containing the polyurethane prepolymer; dispersing the microcapsule in water, thereby forming a microcapsule dispersing solution containing the high water absorbent microcapsule; mixing the water-borne epoxy resin emulsion, waterborne epoxy curing agent, emulsified asphalt, butadiene-acrylonitrile latex, microcapsule dispersing solution, padding and additives and curing into a film, thereby forming the waterborne epoxy/asphalt compound waterproof coating with a self-repairing function. When the waterproof material is scratched and cracked, the high water absorbent in the microcapsule can quickly absorb water for swelling and the polyurethane prepolymer can participate into chain extension reaction for generating solid while meeting water, so that the purposes of quickly repairing the cracks and preventing water leakage can be achieved.
Owner:TAIYUAN LUBANG TECH CO LTD

Method and device for soft capsule micro-jet type micro-needle transdermal delivery

The invention relates to the technical field of micro-needle transdermal delivery, in particular to a method and a device for soft capsule micro-jet type micro-needle transdermal delivery. The drug deliver device comprises a soft capsule which is used for storing medicine liquid, a micro-jet micro-needle unit which is capable of undergoing mechanical reciprocating vibration, a fixing unit and a controller, wherein one side of the soft capsule is bonded with and connected to a membrane of the micro-jet micro-needle unit and the other side of the soft capsule is bonded with and connected to the fixing unit; the micro-jet micro-needle unit is connected to the controller by virtue of a signal line; and the controller is used for controlling a delivery dosage of the medicine liquid and for controlling the micro-jet micro-needle unit to do mechanical reciprocating vibration before each drug delivery. With the implementation of the method disclosed by the invention, by precisely controlling the drug delivery dosage and by controlling the micro-jet micro-needle unit to do mechanical reciprocating vibration before each drug delivery, various pores can generate in skin cuticula, which is conducive to the medicine liquid to permeate skin epidermis; and in addition, the device disclosed by the invention can achieve change the medicine liquid safely without pollution, and the device is simple and convenient to operate and use.
Owner:唐晨

Ultraviolet self-healing polyamide material, and preparation method and self-healing method thereof

The invention discloses an ultraviolet self-healing polyamide material. The ultraviolet self-healing polyamide material is formed by compounding metal ions with a ligand polyamide through coordinationbonds, wherein the polyamide contains an azodipyridine structure; and a molar ratio of azodipyridine units in the polyamide to the metal ions is 1:(0.1-1). A preparation method of the ultraviolet self-healing polyamide material comprises the following steps: reacting azodipyridinecarboxylic acid with thionyl chloride under a 80 DEG C refluxing condition to synthesize azodipyridyl acyl chloride; synthesizing polyamide from the azodipyridinecarboxylic acid and long-chain diamine at room temperature under the catalysis of triethylamine with dichloromethane as a solvent; and stirring mixed solution of the obtained dichloromethane solution of the polyamide containing the azodipyridine structure and a methanol solution of a metal salt at room temperature for 24 h, and then heating the obtainedsolution to remove the organic solvent in order to obtain the ultraviolet self-healing polyamide material. The self-healing polyamide material can be rapidly self-healed through the reversible metal coordination bonds under the irradiation of ultraviolet light, and the healing efficiency is close to 100%.
Owner:SOUTHWEST PETROLEUM UNIV
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