The invention discloses a pulping and papermaking process through a multiple-composition biological enzyme method. The method is a biopulping method, which adopts a production process for preparing paper pulp through pulping and fermenting by using a multiple-composition biological enzyme method (phanerochaete, phanerochaete chrysosporium, xylanase, glucoamylase, yeast), adopts agricultural straws, rice and wheat straws, cotton stalks, rape stalks, reeds, bamboo, wood and the like as main raw materials, and comprises treatments of glass cutting, impurity removing, puffing, fermenting through multiple-composition biological enzyme, pulp washing, pulp selecting, defibrination and separation to form the pulp. According to the present invention, no black liquid is generated during the pulping process, the water from fermenting and pulping is recycled so as to achieve zero discharge of wastewater.