235 results about "Ortho position" patented technology

To provide camptothecin compounds and their conjugates with novel structures, improved efficacy and improved safety.SOLUTION: The present invention provides a compound having the structure of the upper formula in the figure, or a pharmaceutically acceptable salt, ester, stereoisomer, polymorph, solvate, nitrogen oxide, isotope-labeled product, metabolite or prodrug thereof. In the formula, R1 and R2 are each hydrogen, halogen, C1-6 alkyl, C1-6 alkoxyl, or the like, or are connected with adjacent carbon atoms to form a 5- to 6-membered oxygen-containing heterocyclic ring; R3 is hydrogen or is connected with an ortho-carbon atom of R1 to form a 6-membered carbocyclic ring; and A is selected from one of the lower two formulas in the figure.SELECTED DRAWING: None

To provide camptothecin compounds and their conjugates with novel structures, improved efficacy and improved safety.SOLUTION: The present invention provides a compound having the structure of the upper formula in the figure, or a pharmaceutically acceptable salt, ester, stereoisomer, polymorph, solvate, nitrogen oxide, isotope-labeled product, metabolite or prodrug thereof. In the formula, R1 and R2 are each hydrogen, halogen, C1-6 alkyl, C1-6 alkoxyl, or the like, or are connected with adjacent carbon atoms to form a 5- to 6-membered oxygen-containing heterocyclic ring; R3 is hydrogen or is connected with an ortho-carbon atom of R1 to form a 6-membered carbocyclic ring; and A is selected from one of the lower two formulas in the figure.SELECTED DRAWING: None

The invention discloses a method for detecting related substances in imaric acid dihydrochloride by HPLC (High Performance Liquid Chromatography), and belongs to the technical field of chemical engineering and pharmacy, the related substances in the imaric acid dihydrochloride are detected by high performance liquid chromatography, a phosphate buffer solution (0.05 mol / L of monopotassium phosphate solution, and pH adjusted to 2.5 by phosphoric acid) is used as a mobile phase A, acetonitrile is used as a mobile phase B, gradient elution is carried out, the flow rate is 1.0 ml / min, the detection wavelength is 250nm, and the detection wavelength is 250nm. The column temperature is 40 DEG C, and the detection wavelength is 235nm; the method can be used for effectively separating and quantitatively detecting imatamide, demethylated imaric acid dihydrochloride, ortho-imaric acid, meta-imaric acid, p-hydroxymethyl benzamide, an intermediate B, p-hydroxymethyl benzoic acid, an imaric acid dimer, p-cyanobenzyl alcohol, p-chloromethyl benzamide, p-toluic acid and p-chloromethyl benzoic acid in the imaric acid dihydrochloride. The method disclosed by the invention is simple and convenient to operate, strong in specificity, high in sensitivity and accuracy, good in linearity and capable of effectively controlling the quality of a p-imaric acid dihydrochloride product.

The invention relates to the technical field of catalytic synthesis, in particular to a chloromethylation catalyst, a preparation method of the chloromethylation catalyst and a method for preparing high-purity ortho-position, meta-position and para-position chloromethyl styrene through the chloromethylation catalyst, and the chloromethylation catalyst is prepared by loading sulfonic acid compounds and (or) pyridine compounds and (or) copper salt on a molecular sieve. The method can improve the localization selectivity of chloromethylation. The method for preparing high-purity ortho-position, meta-position and para-position chloromethyl styrene comprises the following steps of: reacting beta-bromophenylethane, paraformaldehyde and lewis acid in the presence of the chloromethylation catalyst to generate chloromethyl beta-bromophenylethane, and then performing elimination reaction under an alkaline condition to generate a chloromethyl styrene crude product; the high-purity ortho-position, meta-position and para-position chloromethyl styrene is obtained after the crude product is rectified, the brand-new catalyst is adopted in the method, the reaction selectivity is enhanced, the process is simple, and industrial production is facilitated.

The invention relates to the technical field of high polymer materials, and discloses a solvent-resistant polyurethane composite material and a preparation method thereof, and the material is prepared by reacting the following components: an isocyanate component, a polyol component and a functional chain extender component; the functional chain extender is a derivative of ortho-amino aromatic carboxylic acid protected by a thermally unstable ester group, and the protecting group is decomposed under a thermal treatment condition and releases a functional group in situ, wherein the functional group can be subjected to cyclization reaction with ureido on a polymer chain to form a heterocyclic cross-linked structure; the preparation method comprises the following steps: (a) reacting an isocyanate component, a polyol component and a functional chain extender to obtain a soluble and processable linear polyurethane precursor; and (b) carrying out high-temperature heat treatment on the molded precursor. Through the design of the latent functional group and the two-step process, the contradiction between the processability and the final performance of the cross-linked polyurethane is solved, and the prepared material has excellent solvent resistance, thermal stability and good mechanical properties.

The application refers to a novel combination treatment / combination medicament for PF-ILD treatment, comprising as a first combination partner a therapeutically effective amount of Nintedanib or a pharmaceutically acceptable salt thereof and as a second combination partner a therapeutically effective amount of a PDE4B-inhibitor of formula Iwherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms andwherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A,wherein S* is a sulphur atom that represents a chiral center or a pharmaceutically acceptable salt thereof.Hereby the second combination partner is preferably a therapeutically effective amount of the PDE4B-inhibitior of formula IIIor a pharmaceutically acceptable salt thereof.

The invention provides a high-activity adjustable solid catalyst as well as a preparation method and application thereof. The preparation method of the adjustable solid catalyst comprises the following steps: mixing and stirring hexadecyl trimethyl ammonium bromide, ferric chloride hexahydrate and water according to a solid-to-liquid ratio of (1-3): (1-3): (30-40) to prepare a mixed solution; and dipping transition metal salt into the prepared mixed solution, and then carrying out hydrothermal crystallization reaction to prepare the high-activity adjustable solid catalyst. The product prepared by the invention is doped with transition metal, so that the coupling effect is strong; and the structure morphology of the catalyst and the distribution of transition metal elements are more uniform. Metal ions in the regular octahedral structure are located at the vertex, so that reactant adsorption is more facilitated, the selectivity of ortho-alkylation of aromatic compounds is higher, and the activity of catalyzing ortho-alkylation of the catalyst is obviously improved. The metal salt-loaded high-activity adjustable solid catalyst prepared by the invention can be applied to production of hindered phenol antioxidants from phenolic substances.

The invention discloses 4-hydroxy-3-methyl benzoic acid monooxygenase, a strain and a preparation method and application thereof, and relates to the technical field of bioengineering, the nucleotide sequence of the 4-hydroxy-3-methyl benzoic acid monooxygenase is shown as SEQ ID NO: 1, and the amino acid sequence of the 4-hydroxy-3-methyl benzoic acid monooxygenase is shown as SEQ ID NO: 2 and / or SEQ ID NO: 3. The gene of the 4-hydroxy-3-methyl benzoic acid monooxygenase disclosed by the invention can be used for encoding to obtain the 4-hydroxy-3-methyl benzoic acid monooxygenase, and the obtained 4-hydroxy-3-methyl benzoic acid monooxygenase can be used for effectively catalyzing continuous oxidation of ortho-methyl of hydroxyl in 4-hydroxy-3-methyl benzoic acid; the selective continuous oxidation of the ortho-position methyl of the 4-hydroxy-3-methylbenzoic acid can be realized, the 4-hydroxyisophthalic acid is generated, and the compound 4-hydroxyisophthalic acid with industrial added value is synthesized while the selective oxidation of the methyl is solved.

The present disclosure aims to provide a perovskite composition that can obtain a crystalline film that is flat, free of voids, and has high power generation efficiency. [Solution] The perovskite composition according to this embodiment comprises a perovskite compound precursor, a first component which is a solvent for the perovskite compound precursor, and at least one second component selected from the group consisting of nitrogen-containing pyridines and 4-tert-butylpyridine. The nitrogen-containing pyridines are compounds in which a first nitrogen-containing group is bonded to one of the ortho, meta, or para positions of a pyridine ring, and a hydrogen atom is bonded to a position other than the position to which the first nitrogen-containing group is bonded, or at least one of the positions other than the position to which the first nitrogen-containing group is bonded is bonded to one selected from the group consisting of a carbon-containing group, a second nitrogen-containing group, and an alkoxy group.

The invention belongs to the technical field of organic synthesis, and discloses a symmetric disulfide compound containing a sulfoxide group and application of the symmetric disulfide compound in glycosylation reaction, and the structural general formula of the compound is as shown in formula (I). According to the present invention, the compound represented by the structural general formula (I) contains sulfoxide and disulfide structures, and the sulfinyl forming the sulfoxide and the disulfide bond-containing group are located at the ortho-position of the aromatic ring, such that the compound can be used as the activation reagent for the glycosylation reaction, and particularly, activation of the glycosyl donor and glycosylation reaction can be efficiently promoted by only using 0.25 times of equivalent weight of the glycosyl donor, so that the use of a highly toxic, expensive, unstable or metal-containing activating reagent is avoided, and the problems that the activating reagent of the thioglycoside donor in the existing glycosylation reaction is unstable, is not easy to prepare and often needs equivalent weight or excessive amount are solved.

This invention discloses a migration C(sp²)-H / C(sp³)-H cross-coupling reaction achieved using metal / photoredox catalysis, belonging to the fields of organic chemistry and medicinal chemistry. Under the action of a nickel source, photocatalyst, ligands, base, and additives, this invention enables the reaction of alkanes with ortho-alkenyl-substituted aryl halides or ortho-pyridine-substituted aryl halides in an organic solvent under light irradiation, yielding a series of polysubstituted olefins or polysubstituted aromatic compounds with excellent regioselectivity, stereoselectivity, and good yields, which can serve as active pharmaceutical molecules. This invention uses inexpensive transition metal nickel as a catalyst, readily available alkanes and haloaromatics as raw materials, and features mild and simple conditions, good functional group compatibility, and easy operation.

The invention concerns a composite comprising fibre materials with a density of less than or equal to 450 kg / m3 bonded by an aqueous adhesive composition. The composition comprises a thermosetting resin based on: - at least one aromatic compound A1 comprising at least one aromatic ring bearing at least two functions, one of these functions being an aldehyde function or a hydroxymethyl function and the other being an aldehyde function or a hydroxymethyl function; - at least one aromatic phenol compound A2 bearing at least one aromatic ring bearing at least two hydroxyl functions, said functions being in the meta position relative to one another, the two positions ortho to at least one of the hydroxyl functions being unsubstituted; in which the amount of resin is at least 3.5% by weight of dry extract of resin relative to the total weight of the composition.

The present invention relates to the use as perfuming ingredient of a compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof, and wherein, when R 1 represents a C 1‑2 1-4 alkyl group, X represents a CHO group; or, when R 1 represents a hydrogen atom or a C 1‑2 1-4 alkyl group, X represents a CH(R 6 )CHO group; R 2 , R 3 , R 4 , R 5 and R 6 independently of one another represent a hydrogen atom or a C 1‑2 1-4 alkyl group, or R 3 and R 4 together represent an ethanediyl group; and, relative to position 1, the -C(R 3 )(R 4 )-CH(R 5 )-OH group is an ortho, meta, para substituent of the aromatic ring or a mixture thereof. Furthermore, the compound of formula (I) as part of a perfuming composition or of a perfumed consumer product is also part of the invention.

The application provides a synthesis method of 1-substituted phenanthrene compounds, which comprises the following steps: mixing ortho-substituted aryl diazonium salt with KI, adding a palladium acetate catalyst, adding norbornadiene, adding a base, adding an organic phosphine ligand, adding 2-halobenzoic acid, heating to 80-150 DEG C in an aprotic solvent under a nitrogen atmosphere, and reacting for 2-10 hours to obtain the 1-substituted phenanthrene compounds. The method uses cheap and easily obtained ortho-substituted aryl diazonium salt instead of expensive aryl iodide to prepare 1-substituted phenanthrene compounds, and has the characteristics of easy raw material, mild conditions and simple operation, and is a simple synthesis method of 1-substituted phenanthrene compounds.

The application provides an alpha-diamino nickel complex for catalytically preparing polyethylene, realizes control of polymer molecular weight and branching degree by regulating N-aryl ortho groups in the alpha-diamino nickel complex molecules and polymerization conditions, and has the advantages of high catalytic activity, low cost, stable performance and the like. The prepared polyethylene has high molecular weight, narrow molecular weight distribution, high branching degree and excellent mechanical mechanical performance.

The present disclosure provides a tyrosine kinase inhibitor having the general formula (I).R1 is C1-C6 alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, mono-substituted phenyl, poly-substituted phenyl, trifluoromethyl, 2,2,2-trifluoroethyl, CH3O(CH2)n-,R being methyl, ethyl, isopropyl, trifluoromethyl, 2,2,2-trifluoroethyl, cyclopropyl, acetyl or acryloyl, and n being an integer from 1 to 6. R2 and R3 are respectively halogen, hydrogen, amino, substituted amino, cyano, hydroxyl, sulfonic acid group, sulfonamide, trifluoromethyl, 2,2,2-trifluoroethyl, methyl, methoxy or ethynyl. R2 and R3 are in an ortho, para or meta position. Y is NH, O, S or Z—N, where Z is methyl, ethyl, isopropyl, trifluoromethyl, 2,2,2-trifluoroethyl or cyclopropyl. X is Cl, Br or F.

The purpose of the present disclosure is to provide a perovskite composition with which it is possible to obtain a void-free and flat crystal film having high power generation efficiency. A perovskite composition according to an embodiment of the present invention contains: a perovskite compound precursor; a first component that is a solvent of the perovskite compound precursor; and at least one second component selected from the group consisting of pyridines having a nitrogen-containing group and 4-tert-butylpyridine, wherein the pyridines having a nitrogen-containing group are compounds in which a first nitrogen-containing group as a nitrogen-containing group is bonded to any one of an ortho position, a meta position, or a para position of a pyridine ring and hydrogen atoms are bonded to positions of the pyridine ring other than the position at which the first nitrogen-containing group is bonded, or one selected from the group consisting of a carbon-containing group, a second nitrogen-containing group, and an alkoxy group is bonded to at least one position of the pyridine ring other than the position at which the first nitrogen-containing group is bonded.

The invention provides a novel method for preparing an intermediate compound of aromatic sesquiterpenes Commiphoranes C-D. The method comprises the following steps: substituting the ortho-position of a compound 1 with iodine through n-butyllithium and diiodoethane to obtain a compound 2; removing methoxyl by using boron tribromide to obtain a compound 3; performing nucleophilic substitution on 3-allyl bromide and potassium carbonate to synthesize a compound 4; carrying out Grignard reaction to obtain a compound 5; oxidizing into a compound 6 through a Dess-Martin oxidizing agent; finally, (CH3Si) 3SiH and triethyl boron are subjected to intramolecular free radical series cyclization, so that synthesis of an aromatic sesquiterpene Commiphoranes C-D intermediate compound is successfully completed, sufficient preparation is made for follow-up total synthesis of the natural product, key intramolecular free radical series cyclization has the capacity of efficiently constructing a polycyclic system, and the synthesis process is simple and convenient. According to the preparation method, the defects of expensive reagents, long 14-step linear synthesis route, low yield and the like in the existing synthesis route are overcome; the popularization potential is high.

The invention belongs to the technical field of preparation of p-tert-butylbenzoic acid, and provides a rectification preparation process of p-tert-butylbenzoic acid, which comprises the following steps: detecting whether purity misjudgment of ortho-isomers occurs in the rectification preparation process of p-tert-butylbenzoic acid or not, if so, determining that the purity of the ortho-isomers is misjudged; if so, triggering an ortho-isomer concentration monitoring deployment process in subsequent preparation; the ortho-isomer concentration monitoring deployment comprises setting of fixed monitoring points and dynamic monitoring points; wherein the fixed monitoring points are deployed in advance based on the characteristics of p-tert-butylbenzoic acid and ortho-isomers thereof, the purity misjudgment caused by the ortho-isomers is accurately recognized, the monitoring deployment process is specifically triggered, the problem of purity misjudgment caused by the fact that the p-tert-butylbenzoic acid and the ortho-isomers are difficult to separate due to the fact that boiling points are close is solved, and the purity of the p-tert-butylbenzoic acid and the ortho-isomers are accurately recognized. The interference of inconsistent purity of products in different batches on downstream production is reduced, and the stability of a downstream process is guaranteed.

Embodiments of the present application provide a method for preparing a hydroxyl ortho-hydroxymethyl-substituted methylene-bridged substituted phenol, the method comprising the following steps: A1, reacting a substituted phenol with formaldehyde in the presence of a Lewis acid catalyst to prepare a substituted salicylaldehyde compound (2); A2, condensing the substituted salicylaldehyde compound (2) in a system containing formaldehyde and a Brønsted acid catalyst to prepare a methylene-bridged substituted salicylaldehyde compound (3); A3, reducing the methylene-bridged substituted salicylaldehyde compound (3) to prepare a hydroxyl ortho-hydroxymethyl-substituted methylene-bridged substituted phenol (4). Embodiments of the present application can improve the yield and chemical purity of the prepared hydroxyl ortho-hydroxymethyl-substituted methylene-bridged substituted phenol. According to other embodiments of the present application, a method for preparing a polyphenol compound containing multiple phenol units is also provided.

The present invention discloses a heteroleptic carborane-substituted iridium (III) complex having the following structural formula: wherein R represents or represents an ortho-closed carborane. The present invention utilizes the transition metal iridium (III) as the core and introduces carboranes into its cyclometallated ligands C^N or auxiliary ligands X^Y to develop two novel green and red iridium (III) complexes. The introduction of the carborane group hinders intermolecular interactions, reduces self-quenching, and inhibits non-radioactive quenching and concentration quenching, resulting in high fluorescence quantum yields (PLQY) for the iridium (III) complexes described herein, with potential application value in organic light-emitting diodes (OLEDs).

The invention belongs to the technical field of electrolysis, and discloses a method for preparing p-hydroxyanisole through electrolytic oxidation of anisole. The method comprises the following steps: S1, adding anisole, an acylation reagent, an organic alkali proton trapping agent and an alkaline amine group-containing solvent into a single-chamber electrolytic bath together, starting electrification, carrying out electrolysis, and obtaining a product liquid containing p-methoxytrifluoroacetic acid phenyl ester in the single-chamber electrolytic bath after electrolysis is finished; the organic base proton trapping agent is at least one of N, N-diisopropylethylamine, tributylamine and tripropylamine; and S2, adding a saturated sodium bicarbonate aqueous solution into the product liquid containing p-methoxytrifluoroacetic acid phenyl ester in the step S1 to hydrolyze p-methoxytrifluoroacetic acid phenyl ester, and extracting to obtain p-hydroxyanisole. The selectivity of para-position and ortho-position products of methoxyl on anisole is regulated and controlled, so that the selectivity of p-hydroxyanisole prepared by the method is higher.

The present invention relates to a class of lipase mutations based on hinge region and tunnel engineering and their applications. Based on computer-aided design, the invention analyzes the amino acids in the hinge region of the lipase lid through molecular dynamics simulation and uses CAVER 3.0 software to analyze the amino acids in the amine channel. Using single-point mutagenesis, iterative, and combinatorial mutagenesis techniques, the obtained mutants contain one or more mutations at amino acids 37, 206, 207, 211, 212, and 213 of the amino acid sequence. The amino acid sequence of the lipase is shown in SEQ ID NO: 1. The mutants of the present invention can be used to catalyze the synthesis of corresponding aromatic amides from ortho-substituted anilines and have broad application prospects.

Acylated benzene sulfonated compounds with dual functionality can have the following structure:wherein each R is independently hydrogen or a C1 to C11 alkyl, each X is independently an alkali metal ion, an alkaline earth metal ion, and / or a quaternary ammonium cation, n is 1 to 3, and m is 1 to 2, with the proviso that when m is 2, the —OC(O)R groups are not located in an ortho configuration at positions 1 and 2 of the benzene ring. Cleaning compositions including the acylated benzene sulfonated compound are also disclosed.

The invention relates to the technical field of electronic chemicals, in particular to high ortho-ortho '-position four-component phenolic resin and a preparation method and application thereof, the high ortho-ortho'-position four-component phenolic resin has a structure shown in a formula 1, in the formula 1, m, n, o and p are polymerization degrees and are all 0.2-50, the high ortho-ortho '-position four-component phenolic resin is a random copolymer, and no certain connection sequence exists among polymerization monomers; the phenolic resin prepared by the preparation method has high ortho-ortho'position connection degree, so that an I-line photoresist product containing the phenolic resin has obviously improved resolution ratio, the heat resistance is ensured by matching with a cross-linking agent, and the practical application requirements are better met.

A formulation for decreasing aldehyde content in a polymeric material includes a compound which includes at least three moicties of formula (A) wherein each moiety (A) includes an amine moiety (—NH2) bonded ortho or meta to the amide moiety (—CONH); wherein each R1I independently represents a substituent and m is an integer from 0 to 4; and wherein the three moieties (A) are bonded, via their respective amide nitrogen atoms, to respective carbon atoms of a Main Fragment, wherein the Main Fragment includes carbon and hydrogen atoms only and is saturated.

This invention discloses a novel molecular fingerprinting algorithm for assisting in the design of MOFs for acid gas separation, comprising the following steps: S1, using drawing software to draw 17 possible ortho, meta, and para positions of benzene rings, five-membered rings, and six-membered rings, obtaining their .mol ​​files; S2, converting the .mol ​​files to .smart format and writing a separate .py file for the new fingerprint; S3, calling the original fingerprint in the newly written .py file, adding the two results to obtain a new 184-bit fingerprint; S4, using the new fingerprint to test multiple CoRE-MOFs using various machine learning methods. This invention can determine whether the N-bond in a five-membered or six-membered ring of a macromolecule is ortho, meta, or para, which is beneficial for identifying differences in molecular structure between molecules with different performance characteristics, thereby accelerating the screening of high-performance materials, effectively saving time and costs, and shortening the development cycle.

The invention discloses a method for detecting components of a 1, 4-bis (4-phenoxy benzoyl) benzene reaction solution by high performance liquid chromatography, which belongs to the technical field of analysis and detection methods, and the set chromatographic analysis conditions are as follows: separation by adopting a C18 chromatographic column subjected to end capping treatment, detection by adopting a diode array detector, and detection by adopting a chromatographic column subjected to end capping treatment. The contents of paraphthaloyl chloride, diphenyl ether, 1, 4-bis (4-phenoxybenzoyl) benzene (EKKE), EKKE ortho-isomer, 4-(4-phenoxybenzoyl) benzoic acid and 4-(4-phenoxybenzoyl) benzoate are simultaneously determined by using a single-point external standard method, and a determination method is provided for central control analysis and reaction endpoint judgment in a synthesis process of the 1, 4-bis (4-phenoxybenzoyl) benzene. The method is high in separation degree; the accuracy rate of a determination result is high, and the recovery rate of each substance is within the range of 95-105%; result repeatability RSD is less than 2%, and repeatability is good.

The application discloses a kind of big steric hindrance C-C coupling palladium ligand and synthesis method, ligand is used naphthyl as the main group of stable ligand, this group provides big plane rigid configuration during ligand use, simultaneously, it provides big π electron for complex molecule to stabilize complex;In addition, the configuration of pyridofuran is used, the N coordination point of traditional N-P bidentate ligand is introduced O by furan this functional group in ortho position to adjust the chemical environment of intramolecular N coordination point, so as to modify the traditional N-P bidentate ligand to tridentate ligand, this change can effectively increase the penetration ability of Pd active center in actual ligand use to improve catalytic activity.

The invention discloses a copper-catalyzed aryl aldehyde ortho-position direct C-H etherification method, which comprises the following steps: by taking aryl aldehyde as a raw material, adding alcohol or phenol as shown in a formula (II), a copper catalyst, a guiding group, alkali and a solvent into a reactor, and reacting in an argon gas atmosphere to prepare an aryl ether compound as shown in a formula (III), a substituent group R1 is hydrogen, methyl, trifluoromethyl, methoxyl, phenyl, iodo, isopropyl, trimethylsilyl, dimethylamino, fluoro, chlorine, ester, tourmaline, naphthyl, isoquinolyl, benzothienyl or phenanthryl; a substituent group R2 is hydrogen, methyl, trifluoromethyl, methoxyl, phenyl, iodo, isopropyl, trimethylsilyl, dimethylamino, fluoro, chlorine, ester, tourmaline, naphthyl, isoquinolyl, benzothienyl or phenanthryl; and a substituent group R2 is methyl, 4-fluorophenyl, cyclobutane methyl, 4-tert-butyl phenyl, pentafluorophenyl, 4-cyanophenyl, 4-methyl ester phenyl, 3-nitrophenyl, adamantane methyl, cyclohexyl or an oestrone analogue. The copper catalyst and amino acid which are low in cost and easy to obtain are used as guiding groups, the operation process is simple and efficient, and the corresponding aryl ether compound can be obtained with the good yield.