40 results about "Ortho position" patented technology

This invention discloses a novel molecular fingerprinting algorithm for assisting in the design of MOFs for acid gas separation, comprising the following steps: S1, using drawing software to draw 17 possible ortho, meta, and para positions of benzene rings, five-membered rings, and six-membered rings, obtaining their .mol ​​files; S2, converting the .mol ​​files to .smart format and writing a separate .py file for the new fingerprint; S3, calling the original fingerprint in the newly written .py file, adding the two results to obtain a new 184-bit fingerprint; S4, using the new fingerprint to test multiple CoRE-MOFs using various machine learning methods. This invention can determine whether the N-bond in a five-membered or six-membered ring of a macromolecule is ortho, meta, or para, which is beneficial for identifying differences in molecular structure between molecules with different performance characteristics, thereby accelerating the screening of high-performance materials, effectively saving time and costs, and shortening the development cycle.

A polypropylene composition (PC) comprising: a. from 95.0 to 99.99 wt.-%, of a polypropylene (PP), preferably a propylene homopolymer (HPP); and b. from 0.01 to 5.0 wt.-%, of a compound according to Formula (I), wherein each R is independently selected from C1 to C6 alkylene, C2 to C6 alkenylene and a single bond, each R′ is independently selected from H and C1 to C6 alkyl, each R″ is independently selected from H and C1 to C22 alkyl, wherein each alkylene, alkenylene and alkyl group may optionally be substituted by deuterium or fluorine, and the two substituents on the central benzene ring may be either positioned in an ortho, meta or para relationship; wherein the polypropylene composition (PC) has an MFR2 of from 400 to 5000 g / 10 min and a melting temperature Tm of from 140 to 170° C.

The present invention relates to an aqueous adhesive composition comprising a thermosetting resin based on: - at least one aromatic hydrocarbon compound A1 comprising at least one aromatic hydrocarbon compound comprising at least two aromatic rings bearing a single hydroxyl function, it being understood that at least one of the ortho or para positions of each aromatic ring is unsubstituted; - at least one aromatic compound A2 comprising a single phenol which is unsubstituted or substituted by a single alkyl or a single alkenyl group; and - a formaldehyde compound A3. According to the invention, the aromatic compound A2 is present in a weight content of the dry extract of the adhesive composition of less than or equal to 0.18.

The present application belongs to a curing agent structure. An epoxy resin curing agent, an insulating epoxy resin, and a preparation method thereof are provided, including at least two benzene ring structures or at least two non-coplanar rigid alicyclic structures. Two adjacent benzene ring structures or non-coplanar rigid alicyclic structures are connected by methylene, and an amino functional group is arranged on each side of the integral structure. An ortho position of the amino functional group is provided with an electron-withdrawing substituent group or several sterically hindered substituent groups. By introducing benzene rings, the thermal stability of the obtained epoxy resin is enhanced. By introducing a high electron-withdrawing group and a large sterically hindered group or using a non-coplanar alicyclic structure with saturated electrons instead of a benzene ring, it can maintain good electrical properties in an environment with a high temperature gradient and a large electric field.

The objective is to provide a resin composition that can produce a film with good colorless properties using monomers that do not fall under the category of PFAS. [Solution] A resin composition comprising one or more resins selected from aromatic polyimide resins, aromatic polyamideimide resins, and aromatic polyamide resins, and an antioxidant comprising at least one antioxidant selected from lactone-based antioxidants and antioxidants having a t-butyl group at one ortho position of an oxygen atom bonded to a benzene ring and an alkyl group which may be substituted at the other ortho position, wherein the resin has a structure in which a carbon atom having a hydrogen atom is directly bonded to a benzene ring.

This invention relates to a catalyst for preparing ortho-methylated products of phenol. The catalyst is a composite oxide containing indium oxide, with the composition In₂O₃ / X, where X is a promoter. The promoter is selected from one or more of ZrO₂, HfO₂, ZnO, Cr₂O₃, CeO₂, and MgO, and the amount of the promoter metal is 0.01 to 100 times the molar amount of indium. This invention also discloses the application of this catalyst in the reaction of carbon dioxide hydrogenation coupled with phenol methylation to prepare o-cresol and 2,6-dimethylphenol. Compared with traditional catalytic methods, the catalyst of this invention has low energy consumption, long service life, and can highly selectively convert phenol to o-cresol and 2,6-dimethylphenol with almost no byproduct formation.

The present application relates to a kind of small molecule probes and its preparation method and application, the chemical structure of the probe is as shown in the following formula: Wherein, R1 is 1-propyl sulfonic acid or 1-butyl sulfonic acid;R2 independently selected from trifluoromethyl or sulfur pentafluoride group, the substitution position of R2 is the ortho, para or meta of hydroxyl on benzene ring;Preparation method is by the condensation reaction of salicylaldehyde containing fluorine substituent group and indoline, directly introduce containing fluorine substituent group into the spiro-pyran molecule structure with pH response, prepared with 19 F MRI and fluorescence imaging pH-responsive bimodal imaging small molecule probe.Compared with the prior art, the small molecule probe of the present application exhibits significantly different 19 F NMR chemical shift and fluorescence intensity, high-resolution 19 F MRI imaging and fluorescence imaging, greatly improve the sensitivity and accuracy of imaging, has important application prospect in the field of biosensing, cell imaging, medical diagnosis etc.

A resin composition, including: a resin component containing propylene units, and a resistance-imparting agent, wherein the resistance-imparting agent is a monomer having a phenol skeleton with hydrogen or an alkyl group having 1 to 3 carbon atoms, bonded to at least one of ortho positions to the hydroxyl group of the phenol skeleton, and has a melting point of 215° C. or less and a molecular weight of 200 or more and 500 or less, a content of the resistance-imparting agent is 0.4 parts by mass or more and 10 parts by mass or less with respect to 100 parts by mass of the resin component, and a content ratio of metal impurities is 0.02% by volume or less.

A new class of dimeric 2-aminoimidazole (2-AI) compounds that potentiate macrolide antibiotics against A. baumannii. A parent dimer lowers the MIC of clarithromycin (CLR) from 32 μg / mL to 1 μg / mL at a concentration of 7.5 μM (3.4 μg / mL), while a structure activity relationship (SAR) study on the dimeric 2-AI scaffold resulted in the identification of several compounds with increased activity. Substitution of fluorine on a central phenyl ring resulted in the most potent activity, with the lead compound, containing a fluorine ortho to each of the 2-AIs, that lowered the CLR MIC to 2 μg / mL against AB5075 at 1.5 μM (0.72 μg / mL), exceeding the activity of both the parent dimer and the lead aryl-2-AI. Furthermore, these dimeric 2-AI analogs exhibit favorably low mammalian cell toxicity.

The present invention relates to a composition of matter comprising: a) at least one compound of formula (I), in the form of any one of its isomers or a mixture of these isomers; wherein R 1 represents a hydrogen atom or a C 1‑2 alkyl group; and R represents a group of formula -CH2C(Me)2OH; said R being a meta or para substituent of the aromatic ring with respect to position 1 or a mixture thereof; and b) at least one compound of formula (II), in the form of any one of its isomers or a mixture of these isomers; wherein R 1 and R have the same meaning as defined in formula (I); said R being an ortho, meta or para substituent of the aromatic ring with respect to position 1 or a mixture thereof; as well as their use as perfuming ingredient, as well as compositions and consumer products comprising such composition of matter and a process for the preparation thereof.

The present application relates to the field of photocatalytic organic synthesis, and particularly to a visible light induced tandem radical addition-cyclization reaction for constructing an aromatic heterocycle linked indole ketone compound and a preparation method thereof.By introducing an unsaturated group at the ortho position of a ketoxime ester, a new intramolecular cyclization pathway is generated to realize the construction of a new aromatic heterocycle radical, and a preparation method of the aromatic heterocycle linked indole ketone compound is further provided, and the specific molecular structure is shown in the following formula (I). The present application has the advantages of easy availability of raw materials, simple operation, mild conditions, simple synthesis route, high synthesis efficiency, strong functional group adaptability of the substrate, potential application value in the biological and medical fields due to the particularity and designability of the aromatic heterocycle linked indole ketone structure.

This invention belongs to the field of catalytic materials technology, specifically relating to a pyridinediimide cobalt complex and its preparation method, as well as a method for preparing 1-hexene. A pyridinediimide cobalt complex has the structural formula: ; wherein, R... 1 Selected from fluorine, chlorine, bromine, ester, cyano, benzyl, and hydrogen; R 2 Selected from methyl, ethyl, isopropyl, fluorine, hydrogen, trifluoromethyl, methoxy, R 2 The positions are ortho, para, and meta of aniline; R 3 Selected from cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and hydrogen. This cobalt pyridine diimine complex, under the co-catalysis of methylaluminoxane (MAO), can catalyze the selective oligomerization of propylene to prepare 1-hexene. The oligomerization reaction conditions are mild, and the resulting polyethylene significantly reduces the symmetry and regularity of the polymer chain segments, thereby weakening its crystallinity. While maintaining mechanical strength, it also exhibits excellent flexibility, resistance to environmental stress cracking, and low-temperature impact resistance.

The invention relates to a composite comprising at least one reinforcing element having a surface comprising an alloy of copper, of zinc, the reinforcing element being embedded in an elastomeric composition based on at least one diene elastomer, a reinforcing filler, a sulphur-based crosslinking system comprising a metal oxide, stearic acid or one of the derivatives thereof and a vulcanisation accelerator, and a phenol-aldehyde resin based on: - at least one aromatic polyphenol comprising at least one aromatic ring bearing at least two hydroxyl functions in the meta position relative to one another, wherein the two ortho positions of at least one of the hydroxyl functions is unsubstituted; and - at least one dialdehyde compound comprising two aldehyde functions, wherein the phenol-aldehyde resin content ranges from 0.5 to 2 phr, and the weight ratio of metal oxide to stearic acid or one of the derivatives thereof is greater than or equal to 8.

This disclosure relates to the use of di(alkyl-substituted phenyl)amine antioxidants as additives in lubricant compositions having good oxidizing properties in engine crankcase applications, particularly in compression ignition and / or spark ignition applications, wherein the antioxidant comprises 0 to 10% by weight of mono-C9-alkyl-substituted diphenylamine and 90 to 100% by weight of di-C9-alkyl-substituted phenylamine, based on the weight of mono- and di-C9-alkyl-substituted phenylamines, wherein preferably, tri-C9-alkyl-substituted phenylamines are minimized, and ortho-substituted di-C9-alkyl-substituted phenylamines are minimized.

This application belongs to the field of furan resin modification technology, and specifically relates to a low-free-formaldehyde furan resin and its preparation method. This application uses ortho-substituted phenols, including ortho-methylphenol and ortho-allylphenol, to condense with furfural, introducing formaldehyde for hydroxymethylation. Subsequently, hydroxyl-containing acrylate monomers are introduced to participate in formaldehyde elimination under the action of a solid acid catalyst. Simultaneously, they undergo etherification with the hydroxymethyl groups of the modified furan resin segments, ultimately yielding an acryloyl-terminated modified furan resin. This resin possesses advantages such as low free formaldehyde content (not exceeding 0.5 wt%), low curing shrinkage, high crosslinking density, and high anti-corrosion performance, making it suitable as a film-forming material for electrochemical corrosion protection coatings on metal surfaces.

The present application relates to the field of environmental functional materials and advanced oxidation technology, and discloses a kind of hydroxylated one-dimensional pyrene-based covalent organic framework material and its preparation method and application.The preparation method includes: using 1,3,6,8-tetra (4-aminophenyl) pyrene and 5-hydroxy m-dimethylol as precursor, in the reaction system of acetic acid catalyst and organic solvent, under the condition of oxygen removal, Schiff base condensation reaction is carried out, by accurately arranging hydroxyl between imine bond, the corresponding one-dimensional pyrene-based covalent organic framework is obtained.The material can be used for activating peroxymonosulfate to degrade organic pollutants, and its catalytic activity is better than that of one-dimensional pyrene-based covalent organic framework material without hydroxyl and hydroxyl located in the ortho position of imine bond, and has the advantages of high degradation efficiency, good cycle stability, strong water matrix interference resistance, etc., and has application prospect in the field of environmental remediation.

The present application relates to the chemical technology field, specifically to a method for synthesizing vanillin and ortho-vanillin by one-step method, which uses o-methoxyphenol as starting material, and carries out one-step reaction with formaldehyde under the action of composite catalyst, and then separates vanillin and ortho-vanillin by post-treatment of the reaction solution. By using the composite catalyst with specific composition, the present application realizes high-selectivity formylation of formaldehyde at the ortho position of the hydroxyl group of o-methoxyphenol, increases the generation proportion of ortho-vanillin from the source, avoids the use of toxic reagent, and has mild reaction conditions. By using the difference in solubility of specific mixed solvent system and adjusting the temperature, the present application can efficiently separate vanillin and ortho-vanillin, and solves the separation problem caused by the similar properties of isomers in the prior art. The overall process is simple and efficient, and the yield and product purity are significantly improved, which has excellent industrial application prospect.

The present invention provides a method for obtaining a dealkoxyphenylated product in high yield from a substrate such as a sugar bonded via an oxygen atom to an alkoxyphenyl group. By reacting a lambda 3 -iodide with a substrate bonded via an oxygen atom to a phenyl group substituted with a C1-C5 alkoxy group in the para or ortho position in a fluorine-containing alcohol and water, a dealkoxyphenylated product can be obtained in high yield under mild conditions.

The application discloses a hydroxylase DmpAB, a coding gene and a preparation method and application thereof, a recombinant expression vector and a recombinant strain, relates to the technical field of genetic engineering, and the hydroxylase DmpAB comprises a first component and a second component, the amino acid sequence of the first component DmpA is shown in SEQ ID NO. 1, and the amino acid sequence of the second component DmpB is shown in SEQ ID NO. 2. The hydroxylase DmpAB provided in the application can effectively catalyze a substrate into an aromatic ring compound with a hydroxyl substituent, especially selectively catalyze hydroxylation of a hydroxyl substituent ortho position, in addition, the hydroxylase DmpAB also has good catalytic activity on a substrate with a carboxyl or methyl substituent para position and meta position of the hydroxyl substituent, the catalytic substrate range is wide, the action site is accurate, and the catalytic activity is not easily affected by the substituent.

The present invention relates to the field of asymmetric catalysis and organic synthesis, and specifically provides a general method for generating axial chirality by means of a chiral companion strategy. The features and concept of the method are: a chiral aromatic tertiary amine compound without a nitrogen chiral center is subjected to intramolecular chiral oxidation to induce the formation of a new aromatic tertiary amine N-oxide (NO) chiral center. Due to the structural rigidity of the chiral aromatic tertiary amine N-oxide compound, when the steric hindrance of different substituents Rb and Rs connected to ortho positions of an aromatic ring is relatively large, the rotation of the aromatic ring is hindered, and new rotation-hindered axial chirality is generated while an aromatic tertiary amine chiral N-oxide center is formed. By means of the method and by regulating the structural and functional characteristics of the different substituents Rb and Rs, various axial chiral ligands, chiral small-molecule catalysts, pharmaceutical and agrochemical intermediates, and chiral synthons can be prepared. The present invention has important scientific and application values for the design, synthesis, and application of chiral ligands, chiral catalysts, especially ligands and catalysts containing axial chirality, and chiral compounds having special functions.

This invention relates to the application of an iron complex containing an ortho-carborane Schiff base ligand in the synthesis of 2,4,6-trisubstituted pyrimidine compounds, characterized in that the 2,4,6-trisubstituted pyrimidine compounds have the following general structural formula: ; wherein Ar1, Ar2, and Ar3 are independently selected from phenyl or substituted phenyl groups, and the substituents in the substituted phenyl groups are selected from C 1‑10 Saturated alkyl, C 1‑10 Unsaturated alkyl groups, halogens, methoxy groups, ethoxy groups, nitro groups, and hydroxyl groups are used. The synthesis method of the 2,4,6-trisubstituted pyrimidine compounds is as follows: an iron complex, a 1,3-dione, an aromatic aldehyde, and ammonium acetate are dissolved in an organic solvent and reacted. After separation and purification, the 2,4,6-trisubstituted pyrimidine compounds are obtained. Compared with the prior art, the iron complex obtained by this invention can catalyze the reaction of a 1,3-dione, an aromatic aldehyde, and ammonium acetate at room temperature to synthesize triarylpyrimidine derivatives, exhibiting high reaction efficiency and being environmentally friendly.

A composition containing 1,1-dicyanovinylene, which contains 1,1-dicyanovinylene and a specific ortho-substituted phenolic compound represented by formula (I) (A-1). A composition containing 1,1-dicyanovinylene, which contains 1,1-dicyanovinylene, a specific phenolic compound represented by formula (II) (A-2), and a compound (C) having a proton affinity (Epa) of 780 kJ / mol or less and a pKa of 5 or less when made into an aqueous solution.

The application provides a synthesis method of a key intermediate of florfenicol, and particularly relates to a preparation method of (1R,2R)-2-amino-1-(4-methylsulfonyl)phenyl-1,3-propanediol. The application utilizes the selectivity of ketoreductase to the substrate carbonyl ortho position chirality, realizes dynamic kinetic resolution (DKR) while reducing the carbonyl group to obtain a pure chiral compound, and then reduces the chiral compound to obtain a target product. The method is simple in process, high in selectivity, and greatly improves the product yield.

This invention relates to the field of chemical engineering, specifically to a method for the highly selective synthesis of high-quality ortho-vanillin. Using 3-methoxysalicylic acid as a starting material, a hydroxyl group protection reaction is performed under weakly alkaline conditions to generate compound 2. Compound 2 undergoes esterification, followed by reductive hydrogenation under a strong reducing agent to generate compound 3. In the presence of a nitrile radical catalyst, compound 3 reacts with an oxidizing agent to generate compound 4. In the presence of an acidic catalyst, compound 4 undergoes aldehyde group protection to generate compound 5. In the presence of a transition metal catalyst, the hydroxyl protecting group of compound 5 is removed to generate compound 6. Under strong acid conditions, compound 6 undergoes acetal hydrolysis to generate ortho-vanillin. This method achieves high regioselectivity and a simple process flow from the source through directional functional group transformation and protecting group strategies, avoiding the use of toxic and harmful reagents; it meets the requirements of industrial production for selectivity, environmental friendliness, and economy.

The invention relates to an aqueous adhesive composition, characterised in that it comprises a thermosetting resin based on: - at least one aromatic compound A1 comprising at least one aromatic ring bearing at least two functions, one of these functions being an aldehyde function or a hydroxymethyl function, the other being an aldehyde function or a hydroxymethyl function; - at least one compound (C) of formula R3-NH-(C=X)-N(R1R2): in which, independently of one another, each group R1, R2, R3 represents an alkyl, alkenyl, aryl, arylalkyl, alkylaryl, cycloalkyl or hydrogen group, X represents S, O or N-R4, with R4 representing an alkyl, aryl, arylalkyl, alkylaryl or cycloalkyl group, or the compound (C) is melamine or uracil; and in that the aqueous adhesive composition comprises an aromatic polyphenol A2 comprising at least one aromatic ring bearing at least two hydroxyl functions in the meta position relative to one another, the two ortho positions of at least one of the hydroxyl functions being unsubstituted, and the ratio of aromatic polyphenol A2 to compound A1 and compound (C) ranging from 0.1 to 20%.

The subject invention pertains to a method of halogenating phenols, yielding a range of halogenated phenols with enantiomeric ratio of up to 99.5:0.5. In certain embodiments, the subject invention pertains to a method of asymmetric halogenation of bisphenol, yielding a range of chiral bisphenol ligands. The novel chiral bisphenols are potent privileged catalyst cores that can be applied to the preparation of ligands for various catalytic asymmetric reactions. The catalyst library can easily be accessed because late-stage modification of the scaffold can readily be executed through cross-coupling of the halogen handles on the bisphenols.

This invention relates to the field of organic chemical synthesis technology, specifically to a method for preparing 2,4-dinitroaniline. The method comprises: S1, nitrification of benzene in a concentrated sulfuric acid system to obtain a system containing nitrobenzene; S2, dilution of the nitrobenzene-containing system with water, followed by catalytic hydrogenation to convert the nitrobenzene to aniline; after the reaction, the catalyst is filtered off to obtain a system containing aniline; S3, para-nitration of the aniline-containing system with concentrated nitric acid; after the reaction, dehydration of the system, followed by ortho-nitration of the system with concentrated nitric acid; and post-treatment to obtain 2,4-dinitroaniline. This preparation method is green, safe, efficient, simple to operate, low in cost, uses inexpensive raw materials, and yields high purity of the target product, making it more suitable for industrial applications.

The present invention relates to an ortho-alkylation catalyst, an extrusion-molded ortho-alkylation catalyst, and a method for producing an ortho-alkylation product using the same. More specifically, the present invention relates to an ortho-alkylation catalyst, an extrusion-molded ortho-alkylation catalyst, and a method for producing an ortho-alkylation product using the same, which can minimize the material diffusion resistance of the catalyst in the ortho-alkylation reaction of a phenolic compound, thereby obtaining an ortho-alkylation product with high selectivity and conversion rate.