3 results about "Ring-closing metathesis" patented technology

Ruthenium complexes include those represented by Formula 1. A new process for producing the ruthenium complexes represented by the Formula 1. The ruthenium complexes represented by the Formula 1 are useful as precatalysts and / or catalysts in olefin metathesis reactions such as ring-closing metathesis, homometathesis, cross-metathesis, ethenolysis, isomerization reaction, diastereoselective ring-rearrangement metathesis, “alkene-alkyne” type metathesis, ring-opening metathesis polymerization, and metathetic depolymerization.

The present invention provides a novel ring-closing metathesis reaction for constructing a peptide structure having a medium ring. The present invention provides a method for performing the ring-closing metathesis reaction, wherein the ring-closing metathesis reaction is carried out at a low dilution condition (for example, a concentration of 0.1 mol / L). The present invention provides a method for performing a ring-closing metathesis reaction suitable for mass production.

The present invention provides stapled polypeptides of the Formulae (I) and (VI):and salts thereof; wherein the groups ; R1a, R1b, R1c, R2a, R3a, R2b, R3b, R4a, R4b, RA, RZ, L1a, L1b, L2, L3, XAA, v, w, p, m, s, n, t, and q are as defined herein. The present invention further provides methods of preparing the inventive stapled polypeptides from unstapled polypeptide precursors. The present invention further provides pharmaceutical compositions comprising a stapled polypeptide of Formula (I) or (VI), and methods of using the stapled peptides. The present invention also provides modifications of the staples post ring closing metathesis.