5 results about "Ring-closing metathesis" patented technology

Re(V) alkylidyne-based catalytic systems for alkyne metathesis reactions capable of effecting alkyne metathesis, such as homo- and cross-metathesis of alkynes or diynes, ring closing metathesis and ring-opening metathesis, at room temperature to moderate temperatures. The catalysts are stable to air and moisture and tolerate a variety of functional groups in substrates and can be readily prepared on a large scale, and thus are practical catalytic systems of Re(V) alkylidynes.

Ruthenium complexes include those represented by Formula 1. A new process for producing the ruthenium complexes represented by the Formula 1. The ruthenium complexes represented by the Formula 1 are useful as precatalysts and / or catalysts in olefin metathesis reactions such as ring-closing metathesis, homometathesis, cross-metathesis, ethenolysis, isomerization reaction, diastereoselective ring-rearrangement metathesis, “alkene-alkyne” type metathesis, ring-opening metathesis polymerization, and metathetic depolymerization.

The present invention provides a novel ring-closing metathesis reaction for constructing a peptide structure having a medium ring. The present invention provides a method for performing the ring-closing metathesis reaction, wherein the ring-closing metathesis reaction is carried out at a low dilution condition (for example, a concentration of 0.1 mol / L). The present invention provides a method for performing a ring-closing metathesis reaction suitable for mass production.

A rhenium (V) carbine-based catalytic system for alkyne metathesis reactions that enables alkyne metathesis, such as homologous metathesis and cross metathesis, ring closing metathesis and ring opening metathesis of alkyne or diyne, at room temperature or mild conditions. The catalyst is stable to air and moisture, has wide tolerance to various functional groups in a substrate, and is easy to prepare on a large scale, so that the catalyst is a practical catalytic system based on rhenium (V) Carbai.

The present invention provides stapled polypeptides of the Formulae (I) and (VI):and salts thereof; wherein the groups ; R1a, R1b, R1c, R2a, R3a, R2b, R3b, R4a, R4b, RA, RZ, L1a, L1b, L2, L3, XAA, v, w, p, m, s, n, t, and q are as defined herein. The present invention further provides methods of preparing the inventive stapled polypeptides from unstapled polypeptide precursors. The present invention further provides pharmaceutical compositions comprising a stapled polypeptide of Formula (I) or (VI), and methods of using the stapled peptides. The present invention also provides modifications of the staples post ring closing metathesis.