Z-selective ring-closing metathesis reactions

A reaction and selection technology, applied in the field of Z-selective closed-loop metathesis reaction, which can solve the problem of high cost
CN103797009AInactive Publication Date: 2014-05-14MASSACHUSETTS INST OF TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
MASSACHUSETTS INST OF TECH
Publication Date
2014-05-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates generally to olefin metathesis. In some embodiments, the present invention provides methods for Z-selective ring-closing metathesis.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of U.S. Provisional Application No. 61 / 492,996, filed June 3, 2011, and U.S. Provisional Application No. 61 / 598,307, filed February 13, 2012, the entire contents of each provisional application Incorporated herein by reference.

[0003] Statement Regarding Federally Sponsored Research or Development

[0004] This invention was made with support under the following government contracts: GM59426 and GM52496, both awarded by the National Institute of Health. The Government has certain rights in this invention. technical field

[0005] The present invention generally relates to Z-selective ring-closing metathesis reactions. Background technique

[0006] Catalytic olefin metathesis has transformed chemical synthesis and provides an exceptionally efficient route to olefin synthesis. Many bioactive molecules are macrocycles containing alkenes or other commonly occurring functional gr...

Claims

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