Z-selective ring-closing metathesis reactions

Abstract

The present invention relates generally to olefin metathesis. In some embodiments, the present invention provides methods for Z-selective ring-closing metathesis.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 61 / 492,996, filed June 3, 2011, and U.S. Provisional Application No. 61 / 598,307, filed February 13, 2012, the entire contents of each provisional application Incorporated herein by reference. [0003] Statement Regarding Federally Sponsored Research or Development [0004] This invention was made with support under the following government contracts: GM59426 and GM52496, both awarded by the National Institute of Health. The Government has certain rights in this invention. technical field [0005] The present invention generally relates to Z-selective ring-closing metathesis reactions. Background technique [0006] Catalytic olefin metathesis has transformed chemical synthesis and provides an exceptionally efficient route to olefin synthesis. Many bioactive molecules are macrocycles containing alkenes or other commonly occurring functional gr...

AI Technical Summary

Problems solved by technology

In most cases, however, macrocyclic RCM proceeds with minimal control over olefinic stereoselectivity; this drawback is especially costly in the case of complex molecules, since ring closure typically follows a long chain of transformations

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