20results about "Organic cyclisation" patented technology

The present invention provides novel compounds that release carbon monoxide and compositions thereof for use in the treatment of medical conditions responsive to carbon monoxide, such as inflammation, pain, and dermatological conditions.

Disclosed herein are palladium-catalyzed dehydrogenation processes of carboxylic acids to make α, β-unsaturated carboxylic acids or γ-alkylidene butenolides. The processes allow the chemoselective dehydrogenation of carboxylic acids in the presence of other enolizable functionalities such as ketones, providing reactivity that is inaccessible with existing carbonyl desaturation protocols.

This invention utilizes mechanical vapor compression and / or thermal vapor compression, integrating compression loops across multiple process stages. A sequential network of compressors is used to increase the pressure and condensation temperature of vapor within each process stage as an internal vapor flow, and as an inter-vapor flow branching between process stages. Because available vapor is shared between compressor stages, the number of compressors can be reduced, improving economics. By separating vapor between compressor stages to balance the vapor mass flow rate across multiple process stages in the incremental compressor stages, the entire vapor compression system can be customized to individual process energy requirements and adapt to dynamic fluctuations in process conditions.

Provided is a method that allows for a safer production of a naphthylsilole for use as a starting material for GNR, which involves reacting a compound of formula (1):(wherein R1a and R1b are the same or different and represent a hydrogen atom, an alkyl group, a cycloalkyl group, a (poly)ether group, an ester group, a halogen atom, an aromatic hydrocarbon group, or a heterocyclic group; R1a and R1b are optionally bound to each other to form a ring; R2 represents an aromatic hydrocarbon ring or a heterocyclic ring; and X represents a bromine or iodine atom) with a lanthanide- and lithium-containing ate complex to produce a lanthanide complex of the compound of formula (1); and then reacting it with a silyl compound of formula (2):R3aR3bSiCl2  (2)(wherein R3a and R3b are the same or different and represent an optionally branched C1-C4 alkyl group or a phenyl group).

The invention provides an improved process for the preparation of fluoxastrobin and intermediates thereof. The present invention provides a process for the preparation of fluoaxastrobin, 4,6-dichloro-5-fluoro-pyrimidine and diethyl 2-chloromalonate that are substantially free of unwanted impurities.

A thermoreversible photocurable composition is disclosed that has high strength at low temperatures but melts at high temperatures, making it well suited as an investment casting pattern composition.

Provided herein are nano-emulsion compositions comprising a cannabinoid, a solvent, a lipid source, and a surfactant. Methods of making the nano-emulsion compositions and methods of use are also provided herein. Compositions comprising the nano-emulsion compositions, such as food and beverage compositions and topical compositions, are also provided herein.

Disclosed are methods for forming a cyclopropyl or cyclopropenyl ring in a compound by, for example, contacting an unsaturated hydrocarbon and an active methylene compound with an oxidant and a catalytically effective amount of a photocatalyst; and irradiating the photocatalyst with a light source to form a cyclopropyl or cyclopropenyl-containing product. Also described herein are methods for forming a cyclopropyl or cyclopropenyl ring in a compound by contacting an unsaturated hydrocarbon and an active methylene compound with an oxidant under conditions effective to form a cyclopropyl or cyclopropenyl ring. Additionally disclosed herein are compounds comprising a cyclopropyl or cyclopropenyl ring formed by the methods disclosed herewith.

The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles of formula I, which can be obtained through reaction of amidoxime compounds of formula II with a haloacetic ester in the presence of a solvent and a base.

Provided is a method that makes it possible to more safely produce a naphthylsilole for use as a starting material for GNR, the method comprising: reacting a compound represented by formula (1): (wherein R1a and R1b are the same or different and represent a hydrogen atom, an alkyl group, a cycloalkyl group, a (poly)ether group, an ester group, a halogen atom, an aromatic hydrocarbon group, or a heterocyclic group; R1a and R1b are optionally bound to each other to form a ring; R2 represents an aromatic hydrocarbon ring or a heterocyclic ring; and X represents a bromine atom or an iodine atom) with a lanthanide- and lithium-containing ate complex to produce a lanthanide complex of the compound represented by formula (1); and then reacting the lanthanide complex with a silyl compound represented by formula (2):         R3aR3bSiCl2     (2) (wherein R3a and R3b are the same or different and represent an optionally branched C1-C4 alkyl group or a phenyl group).

The present invention refers to new air-stable molybdenum alkylidyne catalysts, a process for the preparation thereof and their use for high performance alkyne metathesis.

A fast automated iterative cross-coupling platform utilizing stable borate structural units and separable borate intermediates is disclosed. Methods for activating boronic acid ester reagents are also disclosed.

The present invention relates to novel air-stable molybdenum alkyl Carbayer catalysts, processes for their preparation and their use in high performance alkyne metathesis.

The invention discloses a method for preparing a cyclobutene skeleton compound through visible light catalysis. The invention specifically discloses a preparation method of a cyclobutene compound, which comprises the following step: in a solvent, in the presence of a photocatalyst and under the irradiation of visible light, carrying out cyclization reaction on a conjugated diene compound I to obtain a cyclobutene compound II. According to the preparation method, a cheap catalytic system is adopted, the reaction condition is mild, the electro-cyclization reaction of the conjugated diene compound can be efficiently realized, and the preparation method has good functional group compatibility, substrate applicability and atom economy and meets the development requirements of green chemistry. In addition, the method needs a small amount of a photocatalyst, the reaction process is simple and efficient, and the method has good operation convenience and industrial application potential.

The invention discloses a green synthesis method of a triarylmethane compound, which comprises the following steps: by taking 1, 6-alkyne aldehyde, an aryl compound and boron trifluoride acetic acid as raw materials, adding the raw materials into a reaction container filled with a trichloromethane solution, and stirring and reacting at 80 DEG C for a period of time; after the reaction is finished, extracting, drying an organic phase, and concentrating by a rotary evaporator to obtain residues; and separating residues by column chromatography to obtain the target product triarylmethane compound. Meanwhile, the prepared triarylmethane is further functionalized, so that a derivative of a medicine molecule containing a triarylmethane skeleton is synthesized. The novel triarylmethane compound is efficiently synthesized by adopting a boron trifluoride promotion strategy and reacting in trichloromethane, and the method has the advantages that the operation is simple, the raw materials are cheap and easy to obtain, the reaction condition is mild, the product is easy to separate, the compatibility of functional groups is better, and the like; a foundation is laid for further application of the triarylmethane compound in the fields of medical chemistry and the like.

Thermally reversible, photocurable compositions is disclosed. The photocurable composition has high strength at low temperatures but also melts at elevated temperatures and is well suited as investment casting pattern composition.

Disclosed is a rapid automated iterative cross-coupling platform that utilizes stable boronate building blocks and isolable boronate ester intermediates. Also disclosed are methods for activating boronate reagents.