113results about "Organic cyclisation" patented technology

Grafting a polymer at the surface of a carbonated material containing carboxyl, amine and / or hydroxyl functions at its surface. This material is suspended in a solution comprising the polymer to be grafted, which includes a carboxyl, amine and / or hydroxyl function, the solution also comprising a solvent of the polymer. This is followed by a treatment causing dehydration into a carboxyl function, an amide and / or hydroxyl function and the polymer is thus grafted on the carbonated material by means of ester or amide bonds. Utilization in the cathode or anode of an electrochemical generator, in a polymer material with low polarity, in an ink, and as a conductive deposit on flexible plastic used as electrical contact, electromagnetic protection and antistatic protection.

The invention relates to a method for synthesizing a phenanthrene compound shown as a formula (I). The structural formula is as shown in the specification. The method comprises the following steps: enabling a compound shown as a formula (II) to react with a compound shown as a formula (III) in a solvent under an inert atmosphere in the presence of a catalyst, an organic ligand and base, thereby obtaining the compound shown as the formula (I), wherein the structural formula is as shown in the description; R1 and R2 are respectively and independently selected from H, C1-C6 alkyl, C1-C6 alkoxy or halogens; R3 refers to C6-C10 aryl or C5-C8 heterocyclic aryl; the C6-C10 aryl or C5-C8 heterocyclic aryl is optionally substituted by 1-3 substituent groups; and the substituent groups refer to C1-C6 alkyl or halogens. The method achieves good effects due to the selection of the proper catalyst, organic ligand, base and solvent and has wide industrial application prospects.

The present application discloses methods for the production of organic compounds comprising a linear series of five fused carbon rings. Such compounds are useful in the production of electronic components, devices and materials. For example the methods disclosed permit the production of 2,9- and 2,10-disubstituted pentacene compounds that present particularly advantageous properties for the manufacture of semiconductor materials, and may be used in devices such as for example thin film transistors and solar cells. Also disclosed are compounds that are excellent candidates for use in the manufacture of semiconductor materials, and other components of electronic systems, by virtue of their solubility, crystal packing geometries, and electronic properties.

Grafting a polymer at the surface of a carbonated material containing carboxyl amine and / or hydroxyl functions at its surface. This material is suspended in a solution comprising the polymer to be grafted, which includes a carboxyl amine and / or hydroxyl function, the solution also comprising a solvent of the polymer. This is followed by a treatment causing dehydration into a carboxyl function, an amide and / or hydroxyl function and the polymer is thus grafted on the carbonated material by means of ester or amide bonds. Utilization in the cathode or anode of an electrochemical generator, in a polymer material with low polarity, in an ink, and as a conductive deposit on flexible plastic used as electrical contact, electromagnetic protection and antistatic protection.

The present invention relates to a process for carrying out olefin ring-closing metathesis (RCM) wherein compressed carbon dioxide (gaseous, liquid or supercritical) acts as solvent for the liquid or solid reactant and the products obtained therefrom, while additionally one or more ionic liquids are introduced as the 2nd phase in which homogeneous olefin metathesis catalysts are immobilised.

Processes for creating build sequences are described which use computational chemistry algorithms to simulate mechanosynthetic reactions, and which may use the mechanosynthesis process conditions or equipment limitations in these simulations, and which facilitate determining a set of mechanosynthetic reactions that will build an atomically-precise workpiece with a desired degree of reliability. Included are methods for error correction of pathological reactions or avoidance of pathological reactions. Libraries of reactions may be used to reduce simulation requirements.

A novel palladium-mediated carbon-carbon bond forming reaction has been discovered using DNA-templated chemistry. The inventive reaction involves the palladium-mediated coupling of a terminal alkyne with an alkene to form an enone. A catalytic amount of palladium may be used in the reaction if an oxidant is present. The reactions is also compatible with a variety of organic solvent as well as aqueous solution. Both intermolecular and intramolecular reactions have been demonstrated. This novel carbon-carbon bond forming reaction is particularly useful in the synthesis of macrocycles. Kits, reagents, catalysts, solvents, oxidants, salts, acids, instructions, and other materials useful in the practice of the inventive reaction are also provided.

The present application discloses methods for the production of organic compounds comprising a linear series of five fused carbon rings. Such compounds are useful in the production of electronic components, devices and materials. For example the methods disclosed permit the production of 2,9- and 2,10-disubstituted pentacene compounds that present particularly advantageous properties for the manufacture of semiconductor materials, and may be used in devices such as for example thin film transistors and solar cells. Also disclosed are compounds that are excellent candidates for use in the manufacture of semiconductor materials, and other components of electronic systems, by virtue of their solubility, crystal packing geometries, and electronic properties.

The present invention relates to a process for carrying out olefin ring-closing metathesis (RCM) wherein compressed carbon dioxide (gaseous, liquid or supercritical) acts as solvent for the liquid or solid reactant and the products obtained therefrom, while additionally one or more ionic liquids are introduced as the 2nd phase in which homogeneous olefin metathesis catalysts are immobilised.

The present invention provides methods by which carbon nanotubes can be functionalized via Diels-Alder reactions under solvent free conditions. Such methods include reacting carbon nanotubes with Diels-Alder dienes or dienophiles to obtain adducts that includes the diene or dienophile moiety bound to the carbon nanotubes. Functionalized carbon nanotubes and dispersions containing functionalized carbon nanotubes are provided. The present invention provides functionalization methods of carbon nanotubes through gas phase, liquid phase, or solid phase reactions without any solvents other than the reactants. Such processes are also amenable to a wide variety of chemical reactions that use other functionalizing agents. Additionally, such methods are cost effective, easily scalable and can provide for functionalized CNTs in large, industrial-scale quantities.

The invention provides spiro bis(oxazoline) ligands with a plurality of chiral centers, a preparation method and application. The ligands are provided with axial chirality of a spiro backbone and central chirality of an oxazoline ring. The ligands can be prepared by condensation of chiral spiro diacid and corresponding alkamine. The invention also provides application of the spiro bis(oxazoline) ligands in synthesizing pyrazolidine derivatives in high regioselectivity and high enantioselectivity.

The invention provides a synthesis method of cyclopropane compounds. The cyclopropane compounds have a structure as shown in a general formula I which is described in the specification. The synthesismethod comprises the following step: reacting olefin compounds A with ethyl diazoacetate under the catalytic action of a supported rhodium catalyst to obtain the cyclopropane compounds, wherein the structural formula of the olefin compounds A is shown in the specification. The synthesis method provided by the invention has the advantages of high reaction efficiency, short time, yield even reaching90% or above, and good repeatability. In addition, copper halide or an acetyl halide similar additive is not needed in the synthesis method, and the supported rhodium catalyst is adopted, so that theenvironmental protection property is relatively high.

A process for separating one or more cyclic products from a reaction product fluid comprising one or more cyclic reactants, a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, a non-polar solvent and said one or more cyclic products, wherein said process comprises: (1) reacting said one or more cyclic reactants in the presence of said metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand and non-polar solvent to form a multiphase reaction product fluid; and (2) separating said multiphase reaction product fluid to obtain a non-polar phase comprising said one or more cyclic reactants, metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand and non-polar solvent and a polar phase comprising said one or more cyclic products.

The invention relates to a high-regioselectivity free radical cyclization reaction method for 1,6-eneyne compounds and sulfonyl hydrazide compounds under mild conditions. The method comprises the following steps: adding one 1,6-eneyne compound, one sulfonyl hydrazide compound, a catalyst, an oxidant and a solvent into a Schlenk reaction flask, and performing a reaction under stirring under a certain temperature and air atmosphere condition to obtain one corresponding sulfone-containing cyclization product.

The invention relates to a diaryl compound and a preparation method thereof, particularly a method for intramolecularly coupling aryl carboxylic acid or carboxylate with aryl bromide. The invention implements intramolecular decarboxylation or degreasing and coupling reaction with aryl bromide under mild conditions (70-120 DEG C), thereby forming multiple diaryl compounds in different structures.

The present invention discloses a preparation method of chirality imidazolinone which is supported by silica gel and is modified by oligoamino acid, more specifially, the present invention discloses a friend-environment type chirality organic catalyst which can be circularly used in the asymmetric Diels-Alder reaction, and belongs to the catalyst preparation and application technology field. The NCA polymerisation of a plurality of amino acid is initiated by using chirality imidazolinone as initiator, and the polymeric amino acid has excellent adhesion property on silicon gel, so that the chirality imidazolinone catalyst can be effectively solid supported on the silicon gel surface by means of the adhesion property of the polymeric amino acid, and then the product is obtained. The obtained product is especially adapted to be used as catalyst in asymmetric Diels-Alder addition reaction, and has excellent catalytic activity and antipode selectivity which is up to 96% ee, furthermore the catalyst can be recovered for circular use.

The invention relates to a compound production method, particularly to a synthesis method and apparatus of hexahydric cyclocompounds by using a continuation method. Dienophile and diene mixtures are added in a multi-segment tubular reactor according to a mol ratio of 1-2:1 to perfrom reaction, the reaction temperature of a first segment is controlled in 50-200 DEG C, the cycle ratio is circulation:discharge=15:1, the discharged portion enters into a second segment of reactor, the temperature is controlled in 100-300 DEG C to perform reaction, the cycle ratio is 5:1, the discharged portion enters into a third segment of reactor, the temperature is controlled in 150-350 DEG C to perform reaction, the discharged material of the end reactor is separated, cooled and then materials are educed to be rectified so as to obtain products, the non-reacted materials is cycled to continue reaction. The invention improves the reaction conversion rate and safty performance, largely reduces energy consumption, enhaces product quality and yield, ensures subsequent product quality.

A method for high stereo and regioselective synthesis of medium-ring compounds of 9 to 12 rings. The product is prepared by the reaction of allenes with nucleophilic group substitution at terminal with aryl iodides or alkenyl iodides, and then mixing at 80 DEG C under the condition of taking four (triphenylphosphine) palladium chloride as catalyst, potassium carbonate as alkali, N, N-dimethyl acetamide as solvent. The invention of simple operation, high area and stereoselectivity of the reaction, easy obtained raw material and reagent, easy separation and purification products, and no need ofusing a high degree of dilution reaction conditions, which is suitable for synthesis of medium-ring compounds of 9 to 12 rings.

Processes for creating build sequences are described which use computational chemistry algorithms to simulate mechanosynthetic reactions, and which may use the mechanosynthesis process conditions or equipment limitations in these simulations, and which facilitate determining a set of mechanosynthetic reactions that will build an atomically-precise workpiece with a desired degree of reliability. Included are methods for error correction of pathological reactions or avoidance of pathological reactions. Libraries of reactions may be used to reduce simulation requirements.

The present application discloses methods for the production of organic compounds comprising a linear series of five fused carbon rings. Such compounds are useful in the production of electronic components, devices and materials. For example the methods disclosed permit the production of 2,9- and 2,10-disubstituted pentacene compounds and 2,6,9,13- and 2,6,10,13-tetrasubstituted compounds that present particularly advantageous properties for the manufacture of semiconductor materials, and may be used in devices such as for example thin film transistors and solar cells. These features are enhanced by π-π parallel stacking in the solid state. Also disclosed are compounds that are excellent candidates for use in the manufacture of semiconductor materials, and other components of electronic systems, by virtue of their solubility, crystal packing geometries, and electronic properties.

Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and / or release of carbon monoxide occur at a temperature of about 37 C and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.

The invention provides a synthesis method for preparing a naphthalenone compound with the advantages of simple process, low cost and wide reaction substrate reaction range. According to the method, 2-brom-acetophenone compounds are used as raw materials; heating reaction is performed under the conditions of copper catalysts, ligand, alkali, organic solvents and inert atmosphere; the naphthalenonecompound can be conveniently prepared at excellent yield.

The invention relates to a method for preparing a series of novel phosphinimine ruthenium carbine complexes with high thermal stability and application of the novel phosphinimine ruthenium carbine complexes to the metathesis reaction of olefin, and mainly overcomes the disadvantages that the asymmetric transformation exists and the reaction still cannot be effectively realized at high temperature in the metathesis reaction for forming tetrasubstituted olefin under the catalysis of a ruthenium carbine complex, the ruthenium carbine complex is not applicable to basic functional groups (such as NH2- and CN-) and the initiation rate and increment rate are low in the previous literature. The problems can be well solved by adopting the technical scheme of metal ruthenium carbine complex ligands which have a general formula of Ru(=CHAr)Cl2L(R<1>P=NR<2>) and the synthesis thereof, wherein Ar is (C6-C14) aryl; L is an uncharged electron donor, namely a phosphino or aza five-membered ring carbine ligand; R1 is phenyl, cyclohexyl, tert-butyl, ortho-pyridyldiphenyl, and ortho-furyldiphenyl; and R2 is aryl, pyridyl and picolyl.

The invention discloses a fluorine-containing three-membered ring compound shown in the formula V-a, V-b or V-c and a preparation method thereof. The preparation method comprises that in an organic solvent, fluoroalkyl sulfur ylide shown in the formula III' and a double-bond compound shown in the formula IV-a, IV-b or IV-c undergo an annulation reaction to produce the fluorine-containing three-membered ring compound shown in the formula V-a, V-b or V-c. The invention also discloses a preparation method of a fluoroalkyl sulfonium salt shown in the formula III or IV. The preparation method comprises that sulfur ether shown in the formula I and fluoroalkyl sulfonate shown in the formula II or a compound shown in the formula II' undergo a nucleophilic substitution reaction in a solvent or without a solvent. The preparation method has simple processes, utilizes easily available raw materials, has short reaction time, a high product yield, high product purity, mild conditions and simple and convenient post-treatment processes and can be industrialized easily.

The present invention relates generally to olefin metathesis. In some embodiments, the present invention provides methods for Z-selective ring-closing metathesis.

A process is disclosed for converting levulinic acid to gammavalerolactone with increased selectivity. The process is based on the recognition of the reaction intermediate, 4-hydroxyvaleric acid, and improved conversion thereof.

The invention discloses a preparation method of an axially chiral biaryl compound and a chiral fluorenol compound. The preparation method comprises the following steps: stirring and reacting aryl iodide, aryl bromide and olefin which are taken as starting raw materials in an organic solvent at 50-150 DEG C under the action of a palladium catalyst, a phosphine ligand, a chiral norbornene derivativeand an alkali to obtain the biaryl axial chiral compound and the chiral fluorenol compound. The method has the advantages of cheap and easily available raw materials, mild reaction conditions, good substrate universality, high yield and simple preparation process. The prepared biaryl axial chiral compound can be applied to synthesis of novel chiral ligands and chiral catalysts.

The invention relates to the chemical reaction course of multi-phase catalysis and oxidation for preparing epoxide, concretely, a method for generating epoxide by catalysis and oxidation and functionalization for alkene. Use inedible in organic solvent as epoxidinf agent, potassium fluoride carried on alumina as solid alkali, catalyze alkene to generate epoxide in the temperature of 0~80deg.C for 0.1~20h. Its advantages include: high conversion rate of raw material, good selectivity of target products, short time for reaction high efficiency, friendly condition for reaction, low cost, can be easily controlled, and no pollution to the environment.